In this scientific perspective, we intend to provide a coherent framework for the field of magnetocatalysis by highlighting opportunities associated with the use of magnetic fields to activate catalysts. A particular focus will be placed on magnetically induced catalysis, providing an overview on current advances and identifying scientific and technical challenges on the path toward a widespread use of this technology in research and industry.

Chirality plays a crucial role in the biological interactions, safety, and effectiveness of drugs. The increasing use of caged hydrocarbons as bioisosteres for planar benzene moieties in drug design has heightened the need for asymmetric catalysis strategies to produce chiral caged molecules. This minireview showcases recent progress in this rapidly growing research field.

A review about membrane active cationic polymers with antimicrobial properties. A focus is laid on polymeric architecture, stimuli-responsive antimicrobial polymers, as well as synergistic effects of polymers, and other compounds.

In this comprehensive overview of research progress in functional hydrogel coatings, the interfacial mechanisms between hydrogel coatings and substrates are discussed, and the preparation methods with their respective advantages and disadvantages for hydrogel coatings are summarized. Finally, the challenges in terms of large-scale preparation, long-term stability, and multifunctionality are outlined, and a glimpse into future opportunities is offered.

The unique combination of environments within gels, self-assembled from low-molecular-weight gelators, offers the ability to control reactivity in new ways, achieving unique reaction outcomes, leading to the emerging concept of supramolecular gels as nanoreactors. Smart chemical engineering methods enable the use of such gels to fabricate materials and devices potentially capable of transforming the way synthesis is done.

Tetra-ortho-Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all-visible-light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.

Cation vacancy engineering was employed to tune the electronic and surface structures of the materials, thereby inhibiting further O─O bond breakage, which leads to excellent 2e⁻ oxygen reduction reaction (ORR) performance under industrial current density for continuous output of ultra-high H₂O₂ concentrations in excess of 8 wt%. This work is expected to provide illuminating insights for the development of efficient 2e⁻ ORR electrocatalysts.

We herein present the synthesis of a bench-stable Ni(0) complex, [Ni(PFPh₂)₄], stabilized by vastly underexplored fluorophosphine ligands. The application of [Ni(PFPh₂)₄] in Suzuki–Miyaura and Kumada-Tamao-Corriu cross-coupling reactions as well as in Buchwald–Hartwig C─N bond formation reactions, indicates its promising potential as alternative to conventional Ni(0) sources.

A selectivity descriptor based on Cu─O bond length was established to screen highly selective cuprates toward CH₄ electrosynthesis. This descriptor revealed that CH₄ selectivity exhibited a volcano-shaped correlation with the Cu─O bond length, with the optimal value accessible at ∼1.951 Å. Using this descriptor, three new cuprates were predicted, demonstrating better performance compared to the reported Cu-based catalysts in acidic electrolytes.

A data–knowledge-dual-driven framework is proposed for mining high-temperature fast-charging electrolytes, integrating high-throughput calculation, machine learning, and experimental verification. The screened ethyl trimethylacetate-based electrolyte strengthens Li-ion batteries performance at 4.0 C and 45 °C by thermostable solid-electrolyte-interphase.

We develop a tetrahedral DNA framework (TDF) engineered multivalent aptamers (TEA_n) with programmable ligands size and configuration, enabling high-efficiency capture of CTCs and accurate monitoring of clinical treatment progress. The precisely structured TEA_n ensures the size-matching and cooperative hybridization with epithelial cell adhesion molecule (EpCAM) clusters on cell membrane.

A novel catalytic system consisting of a lanthanum complex with a sterically bulky ligand and a manganese silylamide has been developed to prepare high-molecular-weight (>100 kDa) stereoregular cyclic polyesters and block copolyesters with narrow molecular weight distributions (Ɖ < 1.1) and unique physical properties.

A direct synthesis strategy depending on capping effect was proposed for preparing glass-like coordination polymers for the first time. The prepared glassy coordination polymers possessed excellent mechanical properties and fraction resistance comparable with ceramics and plastic-like resilience.

1,3-Benzodithiolylium cation was identified as an alcohol-activating reagent for energy-transfer-driven deoxygenative radical alkylation, avoiding electron transfer. Photocatalytic deoxygenative coupling reactions of alcohols with diverse oxime carbonates involving selective C(sp³)─C(sp³) bond construction are presented, including energy-transfer-driven carboimination of alkenes, energy transfer (EnT)/nickel dual-catalyzed ring-opening cross-coupling, and cyclization cross-coupling.

A structure-based design of a covalent photoswitchable ligand for the β₂-adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket.

Three small-molecule acceptors, AQx, AQx-o-Ac, and AQx-m-Ac, were designed and synthesized, differing in their acridine substitutions. AQx-m-Ac demonstrates minimal static disorder, reduced nonradiative energy loss, and enhanced crystallization, culminating in a PCE of 18.64% in PM6:AQx-m-Ac OSCs. Incorporating AQx-m-Ac as a third component into the PM6:eC9 blend elevated the PCE of the optimal ternary system to 20.28%.

Oligoether chain engineering in covalent organic frameworks with hydrophilic ethylene oxide-based structures enhances mass diffusion and facilitates the formation of OOH* intermediate in the oxygen reduction reaction, leading to accelerated reaction kinetics and high selectivity for the two-electron pathway in hydrogen peroxide production.

Secondary metabolites (SMs) are essential across all life domains, yet those originating from the Archaea domain remain poorly understood. Here, the systematic genome mining and the pioneering heterologous expression of archaeal SMs have revealed the chemical landscape of archaeal lanthipeptides, showing both canonical and non-canonical forms. These lanthipeptides exhibit antagonistic activity and activate the host's motility, likely shaping the archaeal community and mediating environmental adaptation.

A highly efficient synthesis of axially chiral 1-aryl isoquinolines through rhodium-catalyzed C─H activation/annulation of aromatic imines with alkynes is reported. An enantioselective de novo isoquinoline ring formation is involved in this process. Detailed experimental and theoretical studies revealed the turnover-limiting step of the reaction and the origin of enantioselectivity.

A 3D hybrid perovskite ferroelastic shows both temperature- and pressure-triggered $$ phase transitions at 296 K and critical pressure of 0.3 GPa, which enables the temperature/pressure dual stimuli induced on/off switching of birefringence between birefringence-active state in anisotropic ferroelastic $$ phase and birefringence-inactive state in isotropic paraelastic $$ phase. Such a dual-stimuli switchable birefringence is unprecedented.

The structure and biosynthetic origin of the enigmatic “yellow affinity substance” (YAS) from the anaerobe thermophile Clostridium thermocellum (now: Acetivibrio thermocellus) were elucidated. YAS is a complex of unusual antibacterial arylpolyene alkaloids (celluxanthenes) that are produced by various cellulolytic anaerobes.

DNA-templated theranostic manganese nanoparticles synthesized under liquid nitrogen show features of magnetic resonance imaging, gene silencing, and chemodynamic therapy for tumors.

A novel Ru-doped low crystalline-crystalline MoO_3−x/Mo₂AlB₂ hybrid material was designed. The region containing Ru atom and/or O vacancy is innovatively defined as the active microregion. The Ru─O─Mo bonds with shorter bond lengths provide satisfactory preconditions for the electronic structure modulation of O atoms. The ∆G_H* of electron-rich O atoms is close to 0, which can effectively enhance the catalytic activity of HER.

A regiodivergent nickel-catalyzed carbosilylation of 1,3-dienes using aldehydes and silylboranes has been developed, with ligand control influencing the reaction pathway. The employment of triethylphosphine promotes 4,3-addition selectivity, whereas using (2-biphenyl)dicyclohexylphosphine leads to 4,1-addition selectivity.

The glycolaldehyde electrolysis mechanism to alcohols and tetroses is comprehensively studied. Novel insights on the role of glycolaldehyde in the late stages of the overall CO₂ reduction reaction pathways to ethanol and ethylene glycol on copper are presented. We demonstrate for the first time that C₄ sugars (47.2% maximum conversion) can be produced in the electrochemical cell under ambient conditions due to the hydroxide ions produced on the cathode.

The transition of octahedral PtNi nanoparticles (NPs) to a truncated structure enriches the diversity of catalytic sites. The edge sites, featuring facet heterojunctions, leverage geometric and ligand synergies to enhance the oxygen reduction reaction (ORR) and optimize the adsorption of oxygenated intermediates, leading to superior performance in proton exchange membrane fuel cells (PEMFCs).

Genome mining of environmental and pathogenic Pandoraea species identified a conserved NRPS gene cluster and led to the discovery of novel siderophores, pandorabactins, which exert their antibacterial activity by depleting iron from competitors. Bioinformatic analysis of sputum from cystic fibrosis patients coupled with bioassays indicates that pandorabactins outcompete other bacteria in sequestering iron and have an impact on the diseased lung microbiota.

We report the first bis(pinacolato)diboron-enabled Ni-catalyzed regio- and enantioselective reductive [3 + 2] annulation of β-bromoenones with alkynes, providing convenient access to synthetically valuable chiral five-membered cyclic tertiary alcohols via axial chirality transfer to central chirality. A broad substrate scope, late-stage functionalization of complex molecules, and diverse transformations highlight the utility of this reaction.

Herein, we establish a new photoswitching concept called self-triggered photooxidation cascade (STPC). Rhodamine dyes have mild photosensitizing properties that enable subsequent photoactivation and photobleaching of a leuco-rhodamine plasma membrane probe. Upon laser irradiation in the visible range, we successfully performed live SMLM (Single-molecule localization microscopy), allowing to image the plasma membrane at the nanoscale.

The molecular ferroelectric CuCl₄-[R-MPA] (MPA = β-methylphenethylamine) achieves a remarkable 10⁴-fold enhancement in alkane oxidation activity compared to BaTiO₃, with a turnover number (TON) of 6286 under light and ultrasound. Its built-in electric field enables efficient charge separation, while synergistic effects drive reactive oxygen species generation, highlighting its promising application in photocatalysis.

A redox reaction-mediated transient deactivation strategy has been employed to achieve sequential self-sorting of supramolecular structures in solution and inside model protocells—an unprecedented architecture in the field.

We specifically introduced a 4-BBA molecule into the perovskite film to form a multifunctional bridging structure anchored with the SAM layer, which passivated Pb²⁺ ion defects and regulated crystallization of the perovskite film, enhancing interfacial contact and releasing residual strain. The resultant f-PSCs achieved a high PCE of 25.30% (25.13% certified) with a record V_OC of 1.21 V.

A phosphorothioate aptamer-based galvanic redox potentiometric sensor (aptGRP_5-HT) with enhanced sensitivity and selectivity enables real-time monitoring of serotonin in a mouse model of psychosocial stress. It reveals, for the first time, a distinct correlation between serotonin release and social hierarchy, with higher serotonin levels in dominant mice.

Removal of the C_γ─OH in methanol solvolyzed lignin followed by simultaneous cleavage of C_α─OH and β─O─4 bond enables valorization of native lignin in biomass toward prop-1-enyl (79.6% selectivity) and propyl (81.7% selectivity) substituted monomers under N₂ and H₂ atmosphere, respectively.

This study developed a plasma-thermo-catalytic tandem system, optimizing plasma processes in a self-designed reactor to achieve 68.0% methane conversion and 5.2 mol L⁻¹ methanol concentration. A hydrophobic ReRh/ZSM-5-S catalyst minimized byproduct effects, enabling 52.0% acetic acid selectivity and 1.3 mol L⁻¹ concentration, three orders of magnitude higher than traditional methods, meeting industrial criteria and advancing efficient methane utilization.

A new system of generating entirely CO₂-generated abiotic polymers by integrating electrochemical CO₂ reduction (eCO₂R) and organometallic polymerization catalysis is presented, having an overall CO₂-to-polymer conversion of 14% and current-to-polymer efficiency of 51%. A strategy for tuning the product composition obtained from eCO₂R by combining different electrocatalysts is introduced. CO-ethylene copolymerization activity in the presence of potential poisons from eCO₂R is retained.

A one-dimensional ABC-stacking covalent organic framework (PP-COF), integrating perylene diimide (PDI) as a photosensitizer and 1,10-phenanthroline as a metal-coordination site, was synthesized. Post-synthetic cobalt metalation afforded PP-COF-Co, which enhanced single oxygen (¹O₂) generation and electron-hole pair separation, significantly boosting its photocatalytic performance in α-C(sp³)─H activation and CO₂ reduction.

1,2-Azaborines serve as building blocks to enantiomerically enriched δ-aminoboronic esters through the development of the first enantioselective hydrogenation of a boron-containing heteroarene.

A supramolecular thio-naphthalene diimide can be immediately reduced to a supramolecular radical anion by bacteria, leading to a NIR-II absorption. This strategy effectively raises the reduction potential, thereby greatly boosting the reduction speed. This approach has been used as a real-time NIR-II photothermal anti-bacterial and opens new horizons for bio-responsive agents.

A glue-bonding strategy using high-viscosity molten selenium (Se) as an adhesive is reported to bond two fluorine-doped tin oxide (FTO) glasses, creating bifacial solar cells without magnetron sputtering. The Se cells exhibit a bifaciality factor of 90.1%, with efficiencies of 8.61% under 1-sun with an albedo of 0.3 and 26.17% under 1000-lux indoor illumination with an albedo of 0.8.

Three highly stable bodipy-based metal–organic frameworks (BMOFs) were synthesized by treating dicarboxyl-functionalized bodipy ligands with Zr-oxo clusters. Featuring the distinct bodipy scaffold in the framework, these BMOFs displayed high reactivity in heterogenous photocatalytic C─H bond activation of N,N-dimethylanilines to access amides under visible light.

Redox-mediated lithium recovery from spent LiFePO₄ batteries enables high-solubility catholytes (up to 1.74 M [Fe(CN)₆]⁴⁻) for ultra-stable alkaline zinc-ferricyanide flow batteries. This dual-function strategy integrates sustainable lithium recycling with advanced energy storage, achieving enhanced cycling stability and energy density.

An efficient protocol with an excellent s-factor for the preparation of chiral [2.2]paracyclophanes through cobalt-catalyzed enantioselective C─H oxygenation was developed. This approach leverages traceless electrons or oxygen to replace traditional stoichiometric metal oxidants, facilitating the reaction under mild conditions with broad scope.

An automated experimental workflow to accelerate the discovery of metal-organic cages (MOCs), which is often hindered by slow, manual approaches, has been developed. Automation of the synthesis, characterization, and analysis, is supported by computational modelling to rationalize the experimental outcomes, and development of a host–guest assay elucidated trends in MOC binding behavior.

A practical strategy of low-energy visible light-induced desulfurization (LEnVLD) has been developed to enable superfast and clean desulfurization under exceptionally mild conditions. The utility of LEnVLD was demonstrated through the clean desulfurization of a wide range of peptide and protein substrates, and its convenience and robustness facilitated the application of LEnVLD in versatile reaction scenarios such as solid-supported desulfurization and flow chemistry-based desulfurization.

A defect-directed oriented-kinetics transformation strategy is developed to prepare multi-shell hollow aluminosilicate ZSM-5 zeolite (MFI) crystals with single-crystalline feature, hierarchical macro-/mesoporosity, controllable shell number, and high structural stability. The resultant multi-shell hollow Ni-loaded ZSM-5 zeolite catalysts exhibit significantly enhanced catalytic activity in the hydrodeoxygenation of stearic acid into liquid fuels.

A crystalline layer is formed by an amphiphilic decylamine surfactant at the air/water interface. Aldehyde-containing ester oil droplets self-propel by consuming amines from the crystalline layer, thereby generating open channels along which myelin-forming amphiphile droplets chase and ultimately catch the aldehyde droplets in a predator–prey analogy.

We propose a versatile approach for the rapid synthesis of luminescent Mn(II)-based hybrid halide ionogels (Mn-IG) by in situ forming zero-dimensional (0D) hybrid metal halides during monomer polymerization. The Mn─IG exhibits high transparency (with transmittance approaching 90% at 550–1100 nm) and uniform, high-efficiency emission. Leveraging its processability, we have fabricated an 18 cm × 12 cm scintillating film and successfully achieved large-area and high-resolution X-ray imaging. This simple and rapid synthesis method on ionogels paves the way for the low-process preparation of large-area scintillators and also opens up a new avenue for the in situ construction of uniform 0D halide-polymer composites.

The synthesis of cyanocyclopropanes is achieved via asymmetric nitrogen insertion into prochiral cyclobutanones. Key mechanistic steps involve an organocatalyzed asymmetric condensation followed by chirality transfer via an intercepted Neber rearrangement. The reaction can be conducted in a one-pot, stereodivergent manner, allowing access to all possible cyclopropane isomers with precise control of stereochemistry.

To address a critical challenge in electronic specialty gas (ESG) purification, we herein present a zirconium-based MOF with “wiggling pore geometry” featuring alternating narrow apertures and enlarged cavities. This architecture establishes an equilibrium-kinetic synergistic separation mechanism: narrow windows (nw) kinetically hinder C₃F₈ diffusion (D_C3F6/D_C3F8 ≈ 450), while F···H interactions in cavities thermodynamically favor C₃F₆ adsorption.

A novel ordered hetero-nanowire (NW) regulator is presented, which simultaneously couples the merits of the kinetics and thermodynamics in electrocatalysis. The periodical arrangement enables the formation of the local electric field to improve mass transfer kinetics, accounting for a significant boost in MOR performance. In addition, the hetero-NWs undergo the energetically favorable non-CO pathway, which is not susceptible to the invasion of toxic carbonaceous intermediates and thus ensures long-term durability for MOR.

N-(Acyldithio)saccharins are a novel class of highly electrophilic disulfurating reagents. Beyond enabling the disulfuration of diverse N-, S-, and Cnucleophiles, the reagents facilitate the catalytic enantioselective disulfuration/amination of unactivated alkenes. The resulting α-chiral disulfide products can be readily converted into various chiral sulfur-containing compounds.

The intercellular communicating protocell with feedback loop was designed for self-regulating signal transmission in protocell/living cell community. This DNA-empowered protocell provides a bottom-up access route toward synthetic cellular systems with abilities for programming desired cellular behaviors.

Entropy-driven competitive adsorption modulation in perovskite electrocatalysts enables hybrid conversion Zn–air batteries that couple sustainable energy storage and green chemical synthesis.

A strategy utilizing CO₂ to assist NO electroreduction has been proposed to enhance NH₃ synthesis performance. The primary reason for this enhancement is that *CO and *COOH (produced from CO₂ reduction) facilitate the deoxygenation of *NO and the hydrogenation of *N, respectively.

Vanadium and aurintricarboxylic coordination nanoparticles generate singlet oxygen and hydroxyl radicals specifically triggered by acidic H₂O₂ via dual-Russell reaction and Fenton-like reaction while depleting glutathione. Significantly, adenosine triphosphate induces VAP NPs aggregation, strengthens hydrogen-bonding network, and accelerates proton/electron transfer, thereby amplifying ROS level to co-activate ferroptosis and apoptosis.

Self-compartmented electrolyte: A novel electrolyte concept utilizing LiTDI enables a high-concentration, anion-rich interfacial region and a low-concentration bulk electrolyte. This unique design simultaneously enhances interfacial stability and ion transport kinetics in high-voltage lithium-metal batteries.

Bis-Pd(II) complexes of a figure-eight tetrathiadodecaphyrin, featuring different coordination modes (NNCS─Pd versus NNCC─Pd) and electronic states (closed-shell versus open-shell biradical), have been prepared. The two complexes exhibit noteworthy photoacoustic (PA) response to the first and second near-infrared (NIR-I/II) range, respectively, and are interconvertible through a one-electron redox involving a reversible metal coordination rearrangement.

Ultraviolet (UV) irradiation of water generates radicals (H₂O^•+, ^•OH, e⁻_aq, ^•H) that reduce CO₂ to C₁─C₆ hydrocarbons and oxygenates. e⁻_aq activates CO₂ into CO₂^•⁻, while ^•H enables hydrogenation. Oxidative radicals recycle oxygenates back into CO₂^•⁻, sustaining a sustainable network. This process demonstrates ionized water as a reactive matrix for abiotic organic synthesis.

This study innovatively constructs a dual transition metal atoms catalytic system through the strategic anchoring of Ni and Mn atoms on oxygen-doped boron nitride (O-BN), achieving breakthrough performance in simultaneous high ionization potential pollutant degradation and hydrogen evolution for marine energy applications under light condition.

Schematic illustration of two pathways for macromolecular therapeutics delivery: nanoparticle-adopted endocytosis (left) and DNA nanotubule-mediated cytosolic delivery (right). By bypassing conventional endocytic routes, the nanotubules directly transport substantial payloads, including nucleic acids and proteins, across the plasma membrane.

The electrostatic potential matching in the anion-pillared SIFSIX-1-Cu realizes effective anchoring of CF₃CH₂F and CF₃CHF₂ through multiple supramolecular interactions, exhibiting the highest CF₃CH₂F and CF₃CHF₂ adsorption capacity as well as unprecedented CF₃CH₂F/CF₃CF₃ and CF₃CHF₂/CF₃CF₃ selectivity, thereby achieving benchmark separation of ternary CF₃CH₂F/CF₃CHF₂/CF₃CF₃ mixture.

This work not only provides new insights into the design of covalent organic frameworks (COFs) by modulating charge transfer pathways to boost H₂O₂ photosynthesis but also paves the way for practical application of COF photocatalysts to generate H₂O₂ for water decontamination.

Efficient photocatalytic recovery of precious metals from waste catalysts is achieved using decatungstates ([W₁₀O₃₂]⁴⁻) and advanced solvent control, enabling a ∼100% platinum recovery efficiency with sustainable and eco-friendly methods.

Acyclic silagermenides are synthesized through a straightforward desilylation process. Their electronic properties are explored using DFT calculations, revealing a high-lying and polarized Si─Ge π bond. Reactions with electrophiles lead to nucleophilic substitution at the Si atom, giving germylene intermediates, which then undergo further transformation into unique main group compounds and unprecedented metal complexes.

A stable circumtetracene derivative has been successfully synthesized and isolated in crystalline form. A comparison of its electronic properties (both experimentally and by theoretical calculations) with those of previously reported circumacene analogues, led to elucidation of a significant transition in the electronic structure from a closed-shell global aromatic to a singlet open-shell local aromatic configuration upon π-extension.

Solar-driven reversible hydrogen storage of sodium cyclohexanolate/phenoxide pair demonstrated 99.9% conversion and selectivity in both hydrogenation and dehydrogenation via photocatalysis without external heating. The synergy between high- and low-frequency light enhances the overall performance, i.e., low-frequency light provides heat, while high-frequency light facilitates the desorption of product from the catalyst surface.

A high-performance Zn-organic battery (Zn//HATN@CMK-3 battery) is developed by using an I⁻-based active cathodic electrolyte. Benefiting from the high redox potential of the I⁻/I⁰ redox couple, the Zn//HATN@CMK-3 cell harvests a high average discharge voltage (0.75 V vs. Zn/Zn²⁺) and outstanding cycling stability at a high mass-loading (10 mg cm⁻²).

Enantioselective synthesis of compounds featuring an acyclic quaternary stereocenter was achieved through an iron-catalyzed alkylation reaction using unactivated alkyl N-hydroxyphthalimide (NHP) esters. The efficiency of this sterically demanding construction is dictated by an outer-sphere C─C bond formation mechanism, with enantioselectivity regulated by a cooperative triple catalysis system that integrates photoredox, chiral Lewis acid, and iron catalysis.

The introduction of a single 5-methylcytosine into a G-rich sequence originating from the B-cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.

This work well manipulates the ion transport in nanoconfined channels by employing 3D covalent organic frameworks (3D-COFs). Owing to their continuously interpenetrated pathways and well-ordered pore arrangements, 3D-COF nanofluidics demonstrated high ionic flux and cation selectivity. Toward osmotic energy applications, 3D-COF nanofluidics output an ultrahigh power density of 1238.2 W m⁻² under a 500-fold salinity gradient.

The symmetric molecular structure of 4FY has been shown to induce an “asymmetric molecular interaction”, which promotes a higher degree of molecular packing than in Y6. The asymmetry-driven molecular interactions can be leveraged to fabricate large-area semitransparent organic solar modules that are efficient and stable under realistic operating conditions.

Fusogenic nanoliposomes were developed to effectively anchor amphiphilic DNA tetrahedral probes onto the inner leaflet of the cell membrane. By combining this strategy with the direct anchoring of amphiphilic probes on the outer leaflet, precise functionalization of both membrane leaflets could be achieved, thereby enabling simultaneous monitoring of both the inner and outer juxta-plasma membrane environments.

This study successfully developed three distinct 3D extended D-A COFs with a pyr topology by employing a newly designed intrinsic D-A type building block. Among these, the A-D-A structured COF stands out due to its multiple charge transfer channels in 3D space, resulting in an enhanced photocatalytic hydrogen evolution rate. This finding provides valuable insights into designing extended D-A constructs within 3D frameworks to optimize photocatalytic performance.

A D-valine anion interfacial layer reversely regulates the interfacial H-bond network and the interfacial concentration/electric fields, which realizes the synchronous occurrence of inhibition (suppressing H⁺ migration by disrupting the interfacial H-bond interaction and restraining the anion depletion layer formation) and optimization effects (homogenizing the interfacial Zn²⁺ flow and electric field).

Herein, through regiospecific bromination on a helical 7H-dibenzo[c,g]carbazole-based SAM (CbzNaph) featuring a stronger dipole, we study the properties related to intrinsic stability, electrostatic potential (ESP) distribution, and changes in the molecular dipole of the derived SAM molecules. Bromination at the chemically inert sites of 7H-dibenzo[c,g]carbazole (JJ26) helps maximize molecular dipole while maintaining superior intrinsic stability. Together with the dense assembly promoted by enhanced intermolecular interactions and synergistic effects of stronger crystallinity, JJ26 efficiently modulates the work function (WF) of indium tin oxide (ITO) and enhances the stability of SAM under external pressure. The OSC device adopting JJ26 demonstrates significantly improved performance, achieving an efficiency of 19.35% along with notably enhanced stability.

This work demonstrates the efficiency and feasibility of the high-throughput density functional theory (DFT) calculation framework and the role of dopants with various oxidation states for the high-temperature electrochemical dehydrogenation reaction in energy and environment devices.

Vertically aligned sulfur-doped mesoporous carbon spheres achieve outstanding 2e⁻-ORR performance with >99% H₂O₂ selectivity, −3.5 mA cm⁻² current density, and 25 mol g⁻¹ h⁻¹ yield. The sp²/sp³ hybrid network synergized with S-induced charge redistribution creates electron-deficient hotspots for *OOH stabilization, combining metal-like efficiency, chemical robustness, and cost-effectiveness. This structural–electronic paradigm opens a new way for sustainable H₂O₂ electrosynthesis.

Lsd18 is a flavin-dependent monooxygenase from Streptomyces lasalocidi that performs two enantioselective epoxidations during lasalocid A biosynthesis. X-ray crystal structures of Lsd18 bound to a substrate and product analogue illuminate how this enzyme performs multiple epoxidations on the same substrate molecule and how it controls stereoselectivity.

The widely used [2+2] cycloaddition-retroelectrocyclization reaction between tetracyanoquinodimethane (TCNQ) and an activated alkyne has been shown to occur with “inverted” regiochemistry to give exclusive formation of an unexpected regioisomer. A combined experimental and theoretical study helped unravel the peculiar reaction mechanism underlying the regioselectivity switching.

A charge-separated, self-healing, crystalline, porous organic salt with multiple optimizing synergistic electropositive and electronegative sites is reported for benchmark short-chain alkyne/alkene separation with record selectivity.

The intriguing cyclo-P₅⁻ anion, which is isolobal to the well-known cyclopentadienide anion, was characterized for the first time crystallographically in the salts [M([2.2.2]cryptand)][cyclo-P₅] (M = Na, K). The compounds were further characterized by UV/Vis spectroscopy in solution and in the solid state by Raman and ³¹P MAS NMR spectroscopy.

The synthesis of optically pure benzyl trifluoromethoxy (OCF₃) compounds remains a challenging task. Here, we present the first enantioselective intermolecular hydrotrifluoromethoxylation reaction between aromatic alkenes and TFMS, catalyzed by chiral salen-Co complexes. This approach efficiently yields a variety of chiral benzylic trifluoromethoxy compounds with 75%–99% ee.

A donor–acceptor-type two-dimensional poly(arylene vinylene) has been developed, exhibiting a narrow optical band gap and a unique electron-dominating transport with high charge carrier mobility toward ultrasensitive chemiresistors.

We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain-to-serum ratios as high as 6.5. Through fluorescence imaging and polymerase-chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA oligonucleotide to the brains of Balb/cJ mice and demonstrates effectiveness in a human blood–brain barrier cell line model.

A strategy where we integrated spatially and temporally controlled catalysis in one system to promote antioxidant response is reported. We developed a glycoconjugate that is cleaved sequentially by β-galactosidase (β-gal) and 3-mercaptopyruvate sulfurtransferase (3-MST) to produce potent antioxidants persulfide and hydrogen sulfide, and this compound was found to mitigate inflammation in an animal model.

Alternating polarity (AP) is a powerful tool for controlling selectivity in olefin hydrofunctionalization, but this use is underdeveloped. Using electrochemical olefin hydrocarboxylation as a model, we highlight how AP controls product selectivity, yield, and material decomposition. It hinders overreduction, limiting dicarboxylation and electrode passivation, and facilitates a unique electrochemical–chemical–chemical (ECC) mechanism.

The first luminescence radical cluster was constructed with open-shell luminescent radical ligands. The spin-allowed doublet emission endows it with 100% exciton utilization and a short radiation decay lifetime on the nanosecond scale, making it suitable for high-resolution X-ray imaging without residual images.

The first ternary transition metal pernitride was synthesized in a high-temperature high-pressure approach starting from W₂Be₄N₅. The structure features not only the rare structural motif of BeN₆ octahedra but also dinitrogen anions. DFT calculations reveal ultra-incompressible and metallic behavior of the new compound.

A remote spin-center shift process that involves 1,n-radical translocation followed by elimination of a leaving group has been developed to enable distal benzylic C─O and C─N bond activation. By this process, a 4-dimethylaminopyridine (DMAP)-boryl radical promoted radical deoxygenative and deaminative functionalization of free benzylic alcohols and simple benzylic amines to afford a wide range of alkylated products.

By employing complex arylthianthrenium salts and readily available (hetero)aryl (pseudo)halides as starting materials, in conjunction with hypoboric acid as a reductant, structurally diverse (hetero)biaryl motifs can be rapidly synthesized via palladium-catalyzed cross-coupling reaction. Key to this advance is the selective and mild borylation of arylthianthrenium salts, followed by a conventional SMC (Suzuki–Miyaura cross-coupling) reaction with aryl halides.