This review provides a comprehensive account of the use of backbone N-protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.

This review explores the Janus superiority of membrane materials in chemical engineering processes, with a focus on their design and fabrication principles, transport mechanisms, and diverse applications. It highlights their roles in chemical engineering and their multiscale impacts and concludes by discussing current challenges and future research directions.

To overcome the challenges of conventional proteolysis-targeting chimeras (PROTACs), various “unconventional PROTACs” including PROTACs with unconventional binding ligands, PROTACs with unconventional linkers, pro-PROTACs, and self-assembled PROTACs have been proposed. These unconventional PROTACs show great promise for targeted protein degradation in cancer therapy. This review summarizes recent advances in the development of unconventional PROTACs.

Porous conductive ion-selective membranes (PCIMs) enable low-resistance, high-selectivity ion transport in sustainable energy devices. This review explores emerging PCIMs with sub-nano/nanometer pores, focusing on ion transport mechanisms, key pore characteristics, and design strategies. It also highlights advances in PCIM applications, including fuel cells, flow batteries, and Li—S batteries. By integrating theory with design principles, this review provides insights for optimizing PCIMs and advancing membrane-based energy technologies.

This minireview discussed the recent developments in basic knowledge, structure design strategies, and applications of 1D COFs, and also provided insights into the challenges and prospects of 1D COFs for the further development of this field.

“Electricity” plays a pivotal role in efficiently converting solar energy into fuels. This review proposes a dual-path framework for solar-to-fuel conversion: cross-space charge transport systems (external/self-powered driving forces) and local electric field regulation systems (static intrinsic/dynamic fields), elucidating their roles in bridging light absorption and fuel synthesis through distinct electricity-mediated catalytic mechanisms.

Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects. This work provides a comprehensive overview of the current landscape of nanoparticle-mediated targeted degradation, outlining recent advances, key challenges, and future opportunities to guide progress in this rapidly evolving field.