Synthetic biomolecular condensates are appealing candidates to replicate key features and functions of intracellular membrane-less organelles. Their dynamic phase-separation control provides crucial insights into the regulation of fundamental cell processes. Via integration with ambitious cell-like features and behaviors, synthetic biomolecular condensates offer innovative solutions for engineering active materials with sophisticated functions.

This Minireview summarizes recent advances in the development of hybrid biocatalysts by integrating enzymes with reticular frameworks, with specific emphasis on how framework architecture and host-guest interactions influence bioreactivity. Three key regulatory mechanisms are highlighted: 1) guiding mass transfer through pore structures, 2) regulating enzyme conformation via interfacial interactions, and 3) enabling photoactivated biocatalysis by leveraging photoactive reticular frameworks.

The controlled introduction of iron ions into the electrolyte, coupled with a suitable host material to facilitate in situ iron deposition, opens new strategies for creating highly efficient and dynamically stable electrochemical interfaces to continuously catalyze the oxygen evolution reaction at a steady rate, thereby breaking the trade-off between catalytic activity and material stability.

We reveal an exciting contrast: the electric field response of the binding strength of *OCHO on Sn−N₄−C and polyatomic Sn displays opposite behaviors. This response results in a fascinating, opposite pH-dependent volcano evolution for Sn−N₄−C and polyatomic Sn. Most importantly, we propose that distinct strategies are necessary for designing catalysts using single-atom versus polyatomic metal catalysts.

This study examines how current collector chemistry and electrodeposition rate affect microstructure of sodium metal and its solid electrolyte interphase. Synchrotron X-ray nanotomography, grazing-incidence wide-angle X-ray scattering, and cryogenic focused ion beam microscopy reveal differences in film morphology, internal porosity, and crystallographic preferred orientation. Mesoscale modeling delineates the role of SEI on electrodeposit growth and onset of electrochemical instability.

A two-enzyme-catalyzed dynamic kinetic resolution (DKR) of racemic secondary alcohols in water—a ′Holy Grail of DKR′—was accomplished using an engineered alcohol dehydrogenase (ADH) for racemization through a hydrogen-borrowing sequence and variants of the acyltransferase from Mycobacterium smegmatis (MsAcT) for enantioselective acylation.

Two novel organic–inorganic hybrid materials (CETAB)₂[CuCl₄] (1) and (CETAB)₂[CuBr₄] (2) (CETAB=(2-chloroethyl)trimethylammonium) possess superior magnetocapacitance and a record thermal hysteresis width of 97 K. The magnetocapacitance comes from their intrinsic nature, rather than the composite results found in inorganic materials. Meanwhile, this is still the first time so far to study magnetocapacitance in molecule-based materials.

We reported a strategy that utilizes a ruthenium-phosphorus synergistic catalytic system, mimicking enzyme-coenzyme functionality, to efficiently catalyze the air-mediated oxidation of the C4 diol, 1,4-butanediol, to produce the intermediate monomer γ-butyrolactone. This monomer is then used in ring-opening polymerization to synthesize high molecular weight polyhydroxyalkanoate (PHA) products extracellularly.

Here, we create a genetically-encoded force probe by engineering a coiled-coil domain flanked by fluorescent proteins that undergo FRET. These probes are fully tunable and calibrated by modeling and single-molecule force spectroscopy and allow one to measure forces within living systems.

Mirror-image RaPID (MI-RaPID) technology was developed for the discovery of innate protease-resistant macrocyclic peptides. Metalloproteinase 7 (MMP7) plays a crucial role in cancer, making it an attractive target for therapeutic development. Using MI-RaPID technology, we identified a highly selective and stable macrocyclic peptide, which consists of D-amino acids, one β-amino acid, and a thioether bond, and inhibited MMP7 with an IC₅₀ of 90 nM.

A unique supramolecular spring-like Fe(II)-SCO complex has been reported, showcasing multiple dynamic factors, including SCO events, ring rotation, and flexible Au⋅⋅⋅Au distances. This synergy results in various switchings in magnetism and structure, along with a remarkable “breathing” thermal expansion feature across two temperature regions, highlighting its potential as a multifunctional dynamic material for future devices.

A first application of chemometric methods in the field of electrochemical ammonia synthesis: this work explores new salts and electrolyte formulations, studied in a reactor operating under mild conditions and able to provide ≈40 % efficiencies of molecular nitrogen conversion into ammonia.

A bioactive benzothiazole-modified glycyrrhetinic acid (BPGA) and cucurbit[7,8]uril (CB[7,8]) undergo self-assembly, culminating in the fabrication of a multifunctional hexagonal prism supramolecular bactericidal material, BPGA@CB[8]. This smart supramolecular assembly effectively disorganizes Clavibacter michiganensis (Cmm) biofilms and enhances foliar affinity, thereby enabling a highly effective management strategy for tomato bacterial canker.

The DOL-based electrolyte, with dominant SSIP and CIP structures, achieves 1.78×10⁻³ S cm⁻¹ Na⁺ conductivity and strong low-temperature kinetics. Kinetic analysis identifies cation transport as the key factor in battery operation. High-loading full cells cycled stably for 600 cycles at −40 °C and 50 cycles at −78 °C, showing promise for high-voltage sodium batteries in extreme conditions.

We developed a single-atom cobalt doped copper catalyst (Co₁Cu) that achieved a methane (CH₄) Faradaic efficiency exceeding 60 % with a partial current density of −482.7 mA cm⁻². In situ spectroscopic experiments and density functional theory simulations demonstrated that the modulation of the *CO adsorption configuration, with stronger bridge-binding, favours deep reduction to CH₄ over the C−C coupling or CO desorption pathways.

The first construction of orthorhombic three-dimensional covalent organic frameworks (3D COFs) with fmj topology has been realized on the basis of rotatable monomers. Significant isomeric effects on protonation, optoelectronic properties, and photocatalytic activity have been revealed for 3D COFs and a high photocatalytic hydrogen evolution rate has been achieved.

Inspired by the natural process of glutathione peroxidase in scavenging peroxides, we designed a single selenium site-modified carbon moiety, which shows a nearly-100 % 4-electron selectivity and significantly increased consecutive 2+2 electron selectivity in oxygen reduction reaction.

A highly efficient, stable, and reusable Cu(0) catalyst for the difunctionalization of alkynes using different electrophiles and bis(pinacolato)diboron (B₂pin₂) as chemical feedstocks to afford di- and trisubstituted vinylboronate ester derivatives under mild reaction conditions with excellent regio-, chemo-, and stereo-selectivity has been developed.

Photochemical reactions of the spiropyran coacervates in aqueous solution, in cells, and in animals enable dual-wavelength-switchable ROS generation and cancer treatment.

CF₂O-compounds are prepared via photoinduced, Cu-catalyzed defluorinative coupling between readily available trifluoromethylarenes and alcohols. A molecule displaying liquid crystal property was synthesized through this convergent and step-economical method. Mechanistic studies suggested that a homoleptic Cu-bisphosphine complex serves as the photocatalyst, and the two salt additives are crucial in orchestrating this dual-cycle system.

Trotz umfangreicher Forschungsarbeiten an kovalenten Kinaseinhibitoren bleibt ein Großteil des „Cysteinoms“ der Proteinkinasen unerforscht. Hier skizzieren wir einen verallgemeinerbaren Ansatz zur Adressierung von Cysteinen der ATP-Bindetasche mit fragmentartigen kovalenten Inhibitoren. Auf diese Weise erweitern wir das Repertoire der adressierbaren Cysteine im Kinom erheblich, geben Einblicke in einzigartige Bindungsmodi und präsentieren wertvolle Hits für die Entwicklung kovalenter chemischer Sonden und Medikamente.

By integrating operando electrochemical methods with (micro)kinetic modelling, the dynamic local pH effect for the oxygen evolution reaction is clarified. An unconventional reversible hydrogen reference electrode is employed, enabling a clearer interpretation of intrinsic electrochemical kinetics. This approach offers deeper insights into the microscopic electrode processes in the electrified electrode-electrolyte interface with dynamic local pH.

Chiral Se/DPNUCNPs films have been successfully developed with circularly polarized luminescence (CPL) activity under laser excitation at 980 nm. By controlling the assembly sequence and layer number, the chiral film exhibited strong circular dichroism (CD) signals and CPL activity, with a high luminescence dissymmetry factor (g_lum) of 0.68.

Bis(aren)koordinationsverbindungen von Zirconium und Hafnium wurden in großen Ausbeuten durch 4-Elektronenreduktion von Tetrachloridaddukten mit einem Germylen-Phosphor-Lewis-Paar synthetisiert. Ein gefalteter Koordinationsmodus einer Areneinheit wird im Hinblick auf strukturelle und spektroskopische Daten diskutiert. Carbonylkomplexe wurden hergestellt. Dimethylbutadien reagiert unter Bildung eines Cyclohexadienyl- und Triorganogermatliganden. Diese Addition ist im Falle des Zirconiums bei Raumtemperatur reversibel.

The article investigates UiO-66 synthesis over time using deuterium NMR, focusing on three modulators: acetic acid, benzoic acid, and hydrochloric acid. It reveals that slow linker incorporation results in the fastest and most defect-free MOF formation due to an acid-assisted dissociative mechanism. Deuterium NMR was crucial, enabling separate probing of components without altering the synthetic protocol.

The photoreaction dynamics of p-phenylenediacrylic acid dimethyl ester in single crystals were examined, revealing a reaction front propagation from the edge to the center. As the photoreaction progresses, the crystal undergoes a distinctive shape transformation, changing from a parallelogram to a distorted “fluttering flag” shape and eventually becoming a rectangle. Density functional theory calculations predict the post-reaction crystal structure, explaining this unique shape change through the spatially heterogeneous nature of the photoreaction.

A strategy based on carbon locking and sulfur embedding has been used to construct a high-performance red multiple resonance (MR) emitter. The fabricated organic light-emitting diode (OLED) based on the target molecule exhibits Commission Internationale de l’Éclairage coordinates of (0.67,0.33) and a record-high power efficiency of 50.1 lm W⁻¹.

Mn²⁺-doped (CdSe)₁₃ nanoclusters synthesized with Se-NaBH₄ and Se-urea exhibit distinct magnetic and photoluminescent properties. Se-NaBH₄-derived nanoclusters demonstrate superior Mn²⁺ doping efficiency (12.3 %) compared to Se-urea-derived clusters, leading to exceptional magnetic moments (40 μB at 180 K) and pronounced spin fluctuations.

Bridged Carbolong Modulating for high-performance perovskite solar cells: A bridged carbolong modulating strategy to regulate the perovskite/C₆₀ to accelerate interfacial electron transfer, reduce non-radiative recombination and suppress ion migration. The photo- and thermal-stable devices reached 25.80% of efficiency and maintained 98% of its initial efficiency over 1400 h of illumination, and the efficiency of modules achieved 20.72% (25.25 cm² active area) with robust operational stability.

Basophilic alcalase is creatively developed to fabricate ultrastable protein-based chiral stationary phases that can efficiently work under alkaline conditions. Upon incorporating CSPs into chiral separation columns, we enable high-precision chiral chromatographic separation with exceptional stability.

In this work, we report a push-and-pull synthesis strategy for designing the heterogeneous catalyst denoted as TiO_x/cluster@SBA, where the three functional units of clusters, SBA-15 and TiO_x are combined into one heterogeneous catalyst, and thereby we learn how the atom-by-atom tailoring of a heterogeneous catalyst can switch on elusive heterogeneous mechanisms with cluster catalysis.

Here, we present a rare instance of a soluble high-nuclearity polyoxometalate exhibiting Zn²⁺-triggered structural transformation from 0D nanocluster to 2D layer in ZnSO₄ solution. Further, we showcase that such a kind of polyoxometalate, possessing Zn²⁺-triggered structural transformation properties, represents a new-type and promising class of additives for aqueous zinc battery electrolytes with significant potential applications.

Molecular strain has an adverse or conducive effect on catalytic activity. Strained cobalt tetraaminophthalocyanine improves *CO binding for subsequent hydrogenation, attaining methanol Faradaic efficiency up to 52 %. However, strained iron phthalocyanine exacerbates *CO poisoning, leading to inferior CO production. We proposed *CO binding strength as an indicator for activity prediction.

Gas-solid reaction system with high selectivity, controllability and compatibility enables fast etching, doping and transformation of MAX phases and the large-scale production of MXenes and their derivatives. The as-obtained samples exhibit excellent capability in effectively reducing the shutting effect of lithium polysulfides via chemical adsorption and catalytic conversion as evidenced by both of theoretical and experimental results.

Establishing a dynamically photoresponsive dichroic competition between two achiral dyes within a chiral cholesteric liquid crystal has led to an excitation-dependent material. Excitation at 365 nm generates a negative CPL signal (g_lum=−0.16) at 650 nm, while excitation at 430 nm results in inversion of the CPL signal and an increase in the g_lum value to +0.26, with the helical superstructure and handedness of the materials remaining unchanged.

The direct use of ammonia as engine fuel faces challenges like low flame velocity and high NO_x emissions. We propose a novel scenario for converting a conventional “CH₄-fueled” engine to “NH₃-fueled” engine. Specifically, CH₄ is used to power the internal combustion engine and release CO₂ as the exhaust which then reacts with NH₃ to generate N₂ and CH₄ for enclosing the carbon cycle.

This work provides a facile method to fabricated hierarchical composite M-CAT/LDH/CF, the well-ordered NiCoCu-LDH acts as interior templates to create an interface by embedding c-MOFs and aligning two crystal lattice systems, facilitating the graft growth of c-MOFs/LDH heterostructures along the LDH. This improves ion accessibility, speeds up ion transfer, and enhances ion transport pathways for excellent desalination performance.

A two-step aging method for preparing ultra-small nickel nanoparticles on dealuminated Beta zeolite has been developed. These nanoparticles show high performance in catalytic dehydrogenation of cyclohexane into hydrogen and benzene.

A perfectly alternating sequence-controlled polymerization of cyclic esters with remarkably different reactivities be a challenge, in this work, a remarkable enantiomorphic site effect on chain end control was successfully utilized to balance the reactivities of highly reactive S, S-lactide and low reactive R, R-ethylglycolide, and a perfectly alternating copolymer with a high alternating level was achieved and exhibited a high break strain.

A Co single-atom catalyst (SAC) with a C-defect-evoked CoP₄ distorted configuration was fabricated. The N₂ adsorption pattern on the Co-SAC switched from an “end-on” to a “side-on” mode, notably decreasing the N₂ adsorption/activation energy barrier. In the absence of sacrificial agents, the Co SAC achieved excellent photocatalytic overall N₂ fixation performance via an enzymatic pathway.

To unify the selectivity and activity of CO electroreduction for C₂₊ alcohols, a Cu/Zn alloy catalyst was developed to balance the competition between CO reduction and hydrogen evolution on Cu sites. Zn alloying increases CO coverage on Cu and facilitates hydrogen spillover from Zn to Cu, synergistically promoting alcohol formation, achieving a 50 % Faradaic efficiency for alcohol synthesis at a current density of 1.1 A cm⁻².

The electrode potential adjust the interaction between active sites and intermediates for enhancing NO-to-NH₃ conversion over V_O−TiO_2−x.

Sulfoximine werden als selektive N- und O-Transferreagenzien für Alkine bei der goldkatalysierten Umwandlung von N-(2-Alkinylphenyl)sulfoximinen zu 3H-Indol-3-onen eingesetzt. Die Art des Reaktionsmechanismus wird anhand experimenteller und theoretischer Studien diskutiert. Da externe Oxidationsmittel vermieden werden, weist die Methode eine ausgezeichnete Toleranz gegenüber funktionellen Gruppen auf und kann mit weiteren Transformationen in Eintopfverfahren kombiniert werden.

The impact of π-electrons in the carbonyl-containing aromatic materials on their passivation ability was thoroughly investigated. With the increase of aromatic conjugated system, the increased π-electrons mainly enhance the defect passivation of the carbonyl group, although they do not directly present strong passivation with the defects in the perovskite films. Finally, perovskite solar cells incorporating pyrene-1-carbaldehyde achieved power conversion efficiencies of 25.67 % (0.09 cm²) and 21.76 % (14.0 cm²) with excellent long-term stability.

The first ruthenium-catalyzed regioselective α-boration of allenes has been achieved. Moreover, this unusual selectivity is not only limited to α-boration, but also generally applicable to the unprecedented α-alkynylation and the rarely explored α-silylation of allenes.

As configurational entropy increases, bulky functionalities progressively block the apertures in sod-ZIF-1 series, enabling programmable control over the pore structure. This controlled reduction in porosity enhances selective interactions with hydrogen isotopes. The gradual tightening of apertures directly impacts gas adsorption and separation performance, particularly in hydrogen isotope separation.

A new “double-gene” small molecule L-DBDD is synthesized based on the concept of “structural-gene“ engineering by combination of the parent structures of donor and acceptor. It is employed as a guest component and a bridge to enhance the donor-acceptor interaction and accelerate exciton dissociation and transmission, enabling efficiency of solar cell reaching 19.51 %.

A copper(I) and chiral phosphoric acid (CPA) relay catalyzed enantioselective skeletal editing of indoles with 1,2-aminoarenes to quinoxaline ring has been developed to prepare various axially chiral aminoaryl quinoxalines in good yields and excellent enantioselectivity. Moreover, axially chiral aminoaryl quinoxalines could be converted into various axially chiral building blocks and aminoaryl quinoxaline derived ligand is demonstrated to be applicable to asymmetric catalysis.

Reduction of the divalent precursor (κ^P,κ^C,κ^P'-2,6-(i-Pr₂PO)₂C₆H₃)NiBr has given the diamagnetic trinuclear complex [Ni₂Hg] featuring two (formally) monovalent Ni centers bonded to a bridging mercury atom. The thermally stable but fairly labile Ni−Hg−Ni core in [Ni₂Hg] facilitates a smooth disproportionation of CO₂, according to the net equation “2 CO₂+2 e⁻→CO₃²⁻+CO”. This process begins with an initial CO₂ insertion that expels Hg to give the intermediate [Ni₂CO₂], whereas the latter can promote a second CO₂ insertion followed by CO gas release to give [Ni₂CO₃]. This μ-carbonate species can be reduced with Na/Hg to regenerate the original complex [Ni₂Hg].

A photosensitizer/catalyst dual regulation strategy was proposed based on POM@MOF molecular platform to construct the highly efficient catalysts for photocatalytic H₂ evolution. Impressively, the resulting Ni−Sb₉@UiO−Ir−C6 can efficiently drive water splitting into H₂ with a TON of 326923, representing a record value among all the POM@MOF composites.

An orthorhombic niobium pentoxide (T-Nb₂O₅) based lithium-ion capacitor diode (CAPode) with thoroughly improved response frequency and rectification ratio has been successfully developed. It is demonstrated to be fully competent in typical AND and OR logic gates over a wide frequency range of 1–100 Hz, validating great potential in the burgeoning field of multifrequency ion/electron-coupling logic operations.

Dimethyl ether (Me₂O) gas can be condensed through ion-dipole interactions with lithium bis(fluorosulfonyl)imide at sufficiently high concentrations, which elevates the boiling of point Me₂O, imparting enhanced physical and electrochemical properties for battery applications. The approach of Coulombic condensation by facilitating ion-dipole interactions with weakly coordinating solvents offers a promising strategy for next-generation electrolyte design.

Through interfacial fluorination and introducing F ions to bulk phase as anchors, the high-voltage high-rate cycling performance of high nickel cathodes is boosted. The fluorinated surface induces the formation of a thin, dense CEI layer to facilitate Li⁺ migration and hinder electrolyte erosion. Additionally, the substitution of F for O in bulk phase forms strong TM−F bonds, thereby enhancing surface and internal structural stability, and hindering the formation of microcracks and gas evolution.

Synergistic modulation of π-conjugation and electron-donating strengths has been used to induce hybridized localized electronic and charge-transfer characters. This has led to donor-acceptor-donor (π-DAD) structures showing a maintained elevated two-photon absorption cross-section value and highly efficient thermally activated delayed fluorescence.

Semiconductor 2H Molybdenum disulfide (MoS₂) nanosheets with high chiroptical activity have been produced using a novel synthetic strategy based on phase engineering. Our approach is based on the conversion of chiral metastable metallic 1T MoS₂ nanosheets into the thermodynamically stable 2H phase via a thermal annealing step specifically designed to preserve the chiral morphology during the metallic-to-semiconductor phase transition.

We explore the initial CO₂ activation processes on the reduced TiO₂(110) surface by using in situ ambient-pressure techniques. The interactions between oxygen vacancy, Ti³⁺ interstitial, and CO₂ molecules are revealed depending on CO₂(g) pressure and observation time. The oxygen vacancy diffusion mechanism and dynamics of physisorbed CO₂ modes are unraveled.

We have successfully constructed two linear tetramer-type acceptor materials, G-1 and G-2, terminating in the strongly electron-withdrawing INCN-2F. Both tetramers have molecular weights in excess of 7,000. DFT calculations and experimental results show that the fully alkene-bonded tetramer G-1 has an almost completely planar molecular structure and relatively strong crystallinity. In addition, G-1-based OSC achieved high PCE (19.6 %) and high stability (T₈₀ lifetime over 10000 hours).

The azidofunctionalization of alkenes using a hypervalent iodine reagent and various nucleophiles (Nu) under photoredox conditions is described. This method enables the synthesis of 1,2-difunctionalized products from a wide range of alkenes and nucleophiles significantly improving the synthesis of pharmaceutical intermediates. The generality and limitations of the approach in the alkene and nucleophile dimensions were examined through a standardized, unbiased substrate selection.

This work reveals the contribution of the atomic ordering strategy to the favorable reconstruction in acidic OER. The in situ confined reconstruction layer with strong covalent Ir−O−Mn units induced by the rich strong heteroatomic bonds of Ir−Mn intermetallics (IMC) optimizes the adsorption of oxygen intermediates and suppresses the participation of lattice oxygen, thus achieving a double breakthrough in activity and stability.

By utilizing isomeric molecular engineering to tune electronic and vibrational spin-orbital coupling effects, several chiral molecules have been developed to exploit both thermally activated delayed fluorescence (TADF) and room-temperature phosphorescence (RTP) mechanisms for efficient luminescence. The TADF-based OLEDs achieve a high external quantum efficiency of 30.1 %, and by modulating the TADF and RTP emissions, single-molecule white emission has been realized.

An atomic-level bilateral regulation strategy was developed to optimize the electronic environment of Mn−O and Ru−O in Ga/MnRuO₂ by doping Ga to overcome the activity-stability restriction of bifunctional electrocatalysts and thus achieving the high bifunctional performance for ORR/OER and zinc-air battery.

The role of vacancies and lattice distortion induced by ionic doping in layered transition metal chalcogenides is elucidated as a key factor in enhancing charge transfer during the Li−S reaction, providing valuable insights for designing advanced cathode materials for next-generation sulfur-based batteries.

Two high-nuclearity Au(I) cluster photocatalysts (Au₄ and Au₁₆) were precisely synthesized using a multicomponent collaborative self-assembly strategy. Both supramolecular clusters demonstrated photocatalytic capabilities for the oxidative hydrolysis of phenylboronic acid and the oxidative coupling of benzylamines under mild conditions, achieving catalytic efficiencies exceeding 90 %. Notably, the photocatalytic efficiency for the oxidation of arylboric acid is currently the highest.

Through-space conjugation in a series of tetraphenylalkanes-based nonconjugated clusteroluminogens is engineered via high-pressure structural regulation. Abnormal blue shift and remarkable emission enhancement are realized, exhibiting distinct structural factors. Intense white-light emission is realized after high-pressure treatment, disrupting the typical excited-state even-odd effects in ambient study.

In this paper, dual-effect based on electronic structure engineering and interface engineering, cascade Se substitution drives the formation of active species Se−CoS₂ and CoS₂/CoSe₂ heterojunction. The optimized Se−CoS₂/CoSe₂ delivers a high sodium storage performance in half/full cells.

For the first time, the cage-confinement effect is established to exploit new high-T_c ferroelectrics, of which the T_c is dramatically promoted to 402 K (>BaTiO₃, 393 K). Further, Deep understanding of cage-confinement effect and high-T_c ferroelectricity is well elaborated by combining in situ solid-state NMR spectroscopy and theoretical calculations on potential energies. This paves a new pathway and makes a breakthrough in the field of molecular ferroelectrics.

The sluggish redox kinetics of polysulfides significantly impeded the performance of sulfur-based aqueous batteries (SABs). We proposed an effective redox regulation strategy via a thiosulfate-mediated ligand-chain interaction within the K₂S₂O₃ electrolyte, which accelerates the polysulfide redox process (S⁰/S²⁻) and provides an additional capacity contribution through the thiosulfate redox pair (S₂O₃²⁻/S₄O₆²⁻). The thiosulfate-mediated SAB exhibits an unprecedented K⁺ storage capacity of 2470 mAh g⁻¹ and a high energy density of 616 Wh kg_S+Zn⁻¹, surpassing both organic K–S batteries and conventional aqueous battery systems.

A tyrosinase-catalyzed side-chain to side-chain peptide stapling between p-amino phenylalanine (Z) and tyrosine (Y) amino acids has been developed.

The spherical dopant (Na-TFPB) was developed to improve the stability and efficiency of perovskite solar cells via adjusting various factors such as defect passivation ability and doping effect. The doping uniformity of spherical Na-TFPB is better than that of linear Li-TFSI. The devices fabricated with the shape- and radius-regulated p-dopant achieve remarkable efficiencies of 24.49 % and 24.31 % for CJ-01 and spiro-OMeTAD, respectively, representing the highest efficiency values recorded for organic dopants to date.

Die vielseitigen Fluormethylierungsreagenzien Fluormethyltriflat (Superfluormethyl, SFM, FH₂COSO₂CF₃) und Fluormethylfluorsulfonat (Magisches Fluormethyl, MFM, FH₂COSO₂F) wurden einfach zugänglich gemacht. Beide enthalten lange O−CH₂F-Bindungen, die für die elektrophile Monofluormethylierungsreaktivität charakteristisch sind, und sind in der Lage, verschiedene Nukleophile auf Chalkogenbasis in kurzen Reaktionszeiten, hohen Ausbeuten und mit einfacher Aufarbeitung zu fluormethylieren.

A unique redox mediator (RM) molecule ethyl viologen (EtV²⁺), owning two well matched redox couples (EtV²⁺/EtV⁺, EtV⁺/EtV⁰) towards redox chemistry of sulfur species, is demonstrated to function as multifunctional catalysts for reducing S, modulating Li₂S nucleation and oxidizing Li₂S simultaneously. Its electropositive nature in oxidation state allows the synergetic inhibition of shuttle effect of EtV²⁺/ EtV⁺ when coupling with separator modification with electronegative -SO₃Li groups and the electrically-charged EtV²⁺ and LiPSs.

A mutually reinforcing microglia energy modulator is developed by repurposing lonidamine and hollow mesoporous Prussian blue for synergistic clearance of amyloid-β in Alzheimer's disease. The modulator improves microglial phagocytic function, decreases amyloid-β deposits, mitigates neuroinflammation, and ameliorates cognitive deficits in Alzheimer's disease mouse model.

The multilevel capacitor-like character of a novel Au₄₄Cd₂₀ nanoparticle (NP) is identified by NPA charge calculations, charge carrier transport, voltammetry and electrocatalytic reduction of CO₂ to CO. Intra-NP anti-galvanic reduction leads to the unanticipated innermost Cd occupation in the cannula-like Au−Cd nanoclusters with Au−Cd segregation.

Photocatalysis seeing red! A copper-based complex [Cu(bathocupSani)₂]BF₄ exhibits two-photon upconversion promoting energy transfer photocatalysis enabling oxidative dimerization of benzylic amines, sulfide oxidation, phosphine oxidation, boronic acid oxidation and atom-transfer radical addition.

Eight phenyl groups were fused into carbazole to give a novel π-extended azahelicene. Boron incorporation furnished a B,N-embedded helical nanographene showing an ion-triggered chiroptical switch between the three-coordinate boron and four-coordinate boron species with the change in the color and g_lum values.

The photoionization efficiency spectrum of B₉ was measured by using VUV free electron laser. B₉ was characterized to be the smallest 3D neutral boron cluster with a heptagonal bipyramid D_7h structure, quite different from the planar molecular wheel of B₉^-. A single-electron B-B bond between the capping atoms is found to be crucial in stabilizing the D_7h structure of B₉.

A spirobipyridine ligand bearing a hydroxy group recognizes pyridine and quinoline substrates through hydrogen bonding, and in combination with an iridium catalyst enables C−H borylation with site selectivity that can be switched by changing the position of the hydroxy group on the ligand. The catalyst also accelerates the reaction, overrides steric bias, and selectively recognizes the pyridine substrate in a manner reminiscent of enzyme catalysis.

We report a magnesium-mediated ring expansion of donor-acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane. Mechanistically, the coordination of a magnesium-Lewis acid to the DAC promotes nucleophilic ring opening with a putative Mg-amide species generated from the iminoiodinane under the reaction conditions to furnish the azetidine products.

A facile solution spray method is developed for spontaneous synthesis of microgels without confined emulsion, additional initiators/catalysts and deoxygenation. The strategy is applicable to a variety of monomers and enables the synthesis of microgels with tunable chemical structures and variable sizes. Moreover, this strategy allows the in situ encapsulation of biologics into microgels, enabling enzyme catalysis and controlled drug release.

Electrochemical, fully stereoselective P(V)-hydrophosphorylation of olefins and carbonyl compounds using a P(V) reagent is disclosed. By strategically selecting the anode material. Radical reactivity is accessible for alkene hydrophosphorylation, whereas a polar pathway operates for ketone hydrophosphorylation. A comprehensive investigation into the mechanistic intricacies of the chemoselectivity was conducted, providing deeper insight into the underlying reaction pathways and selectivity factors.

This study presents a “lipid droplet fusion” strategy for engineering macrophages, promoting their antitumor activation. The mildly synthesized sp²C-conjugated covalent organic framework (COF) UM-101 induces lipid droplet fusion and metabolic reprogramming of macrophages. The intravenous injection of UM-101–engineered macrophages effectively inhibited CT26 tumor progression.

A NIR-triggered cascade effect system is developed to achieve precise spatiotemporal gene silencing and gas-synergistic cancer therapy. This strategy harnesses the power of NIR-induced NO release to orchestrate the relocation of APE1, thereby achieving enhanced efficiency and spatiotemporal controllability of gene silencing.

YES WE CAN – die elektrochemische Iodierung von elektronenarmen Aromaten unter Lewis-Säure-freien Bedingungen in einer geteilten Zelle wird durch die Oxidation der Iod-Quelle Bu₄NI an der Anode erreicht in Anwesenheit von katalytischen Mengen Bu₄NCl um das postulierte Iodierungsreagenz [I₂Cl]⁺ zu erzeugen. Die Iodierung kann auf eine Reihe interessanter halogenierter Aromaten, aromatische Aldehyde, Benzoesäuren, Benzoesäureester, Arylnitrile, Arylketone und Nitrobenzolderivative angewendet werden, um die gewünschten iodierten Produkte zu erhalten.

Two unprecedented cyclic [4]catenanes, 1 and 2, were prepared based on the selection of naphthalenediimide (NDI)-based Cp*Rh/Ir building blocks E1/E2 (Cp*=pentamethylcyclopentadienyl) and diimidazole ligand L1. 1, exhibiting a broad-band absorption in UV/Vis to NIR regions and a remarkable photothermal conversion was used to build new 1 membrane. The solar power-induced water steam generation performance of 1 membrane could reach a value of 2.37 kg ⋅ m⁻² ⋅ h⁻¹.

Behind bioorthogonal chemistry: micelles constructed with amphiphiles bearing bioorthogonal reactants allowed non-bioorthogonal chemistry in a confined environment. Application of this strategy was made with the synthesis of an FDA-approved anticancer drug inside living cells. Apart from this application, this strategy could represent a change of paradigm, allowing an extension of the concept of bioorthogonal chemistry.

More than just pushing and squeezing the pore space, the core of ligands can communicate with each other and self-organize to determine the ultimate path of MOF crystallization.

Sequential incorporation of an organic photocatalytic cofactor and a metal cofactor into streptavidin leads to artificial metalloenzymes (ArMs) that catalyze tandem abiotic transformations such as enantioselective formal C−H hydroxylation and photooxidation-Michael addition. This work introduces a programmable approach for the construction of ArMs that can catalyze tandem abiotic reactions.