Brønsted Photoacids and Photobases represent a unique class capable of donating or accepting a proton only after excitation. Here, we review the utilization of such molecules to light-trigger the direction and amplitude of functional dynamic systems. We discuss the guidelines of how to use such molecules in various systems and give a futuristic outlook on the current technology gap for further utilization.

Fasten your seat belt! Choose lightning-speed, photoactivated journeys for complexes by selecting the metal, its oxidation state, ligands and geometry. Track complexes through excited singlet (S) states, intersystem crossing (ISC) to triplet (T) states, energy/charge-transfer, luminescence, ligand substitutions and redox reactions. Pathways to novel drugs with new mechanisms of action. Unravelling excited metallomics on the way is challenging.

Carboxylic acids serve as versatile building blocks in organic synthesis. This review highlights recent developments and trends in the late-stage functionalization of complex carboxylic acids and their derivatives enabled by visible light photocatalysis. It discusses a variety of radical decarboxylative and deoxygenative coupling reactions, with particular emphasis on the reaction mechanisms involved, as well as potential future directions for the field.

Using a bifunctional {Fe-H/Cp*-BCy₂} (Cp* = C₅Me₅⁻) complex, which includes both iron-hydride and Lewis acid (borane) components, we demonstrate controlled CO₂ reactivity to yield a formoxy borane-bound ferra(II)lactone [(η⁵-C₅Me₅-CH₂-CO₂(BCy₂O₂CH))Fe^II(diphosphine)] that incorporates two equivalents of reduced CO₂. With excess HBCy₂, we additionally establish catalytic dihydroboration of CO₂ to produce the bis-acetal, Cy₂BOCH₂OBCy₂ at room temperature (TON = 220 h⁻¹).

The multiple structure transformation and phase evolution within MOF provide a vivid example showing the diverse MOF dynamic chemistry under both room and high temperature. The generated disordered hierarchical pores in amorphous and glassy MOFs different to the crystalline precursor, contributes to efficient separation of either C₂H₂/C₂H₄ or C₃H₆/C₃H₈ gases mixture for the first time in breakthrough experiments.

TOC illustrates an approach to hydrogen release using low-load Pt on ALD-TiO₂-modified γ-Al₂O₃ pellets for the dehydrogenation of liquid organic hydrogen carriers (LOHC), such as methylcyclohexane and hydrogenated biphenyl/diphenylmethane mixture. The cost-efficient catalytic reactor is crucial for LOHC import scenarios, enabling effective hydrogen storage, release and transport within existing infrastructure.

Homogeneous and heterogeneous fluorescence with versatile colors were achieved on single crystals of non-stoichiometrically mixed bicomponent hydrogen-bonded organic frameworks with permanent porosity. Focused synchrotron X-ray diffraction analysis and microscopic fluorescence spectroscopy on single crystals reveal structure and property relationship.

Preparation of a thiophene-modified aromatic porous organic cage (T-PAC) with high stability for efficient high-capacity gold recovery. It's also used to selectively recover gold from a variety of complex aqueous solutions in a stable and efficient manner. The theoretical calculations and dedicated experiments suggest that anion-π interactions between the [AuCl₄]⁻ and TFP fractions on T-PAC cooperated with S/N boning and redox effects play the decisive role for the highly efficient gold-recovery performance.

Engineering artificial allosteric protein switches controlled by rare earth elements allows the development of assays, construction of bioelectronic devices, and REE-controlled microorganisms.

Silver nanoparticles multiply via autocatalytic nucleation. They also subsequently self-assemble into percolating chains via spatially restricted attachment. Structural analysis using graph theory (GT) reveals biomimetic organizational patterns akin to those found in biofilms. GT descriptors suggest a fundamental similarity in the mechanisms driving the emergence of complexity in both biological and abiological systems.

We have developed a series of donor-acceptor covalent organic frameworks (COFs) that demonstrate exceptional efficiency in H₂O₂ photosynthesis, coupled with the selective oxidation of organic molecules. These COFs have set a new benchmark for H₂O₂ production, achieving one of the highest performances reported to date. Additionally, they exhibit remarkable selectivity and yield in the oxidation of various organic substrates. This work represents a significant breakthrough in the development of COF-based photocatalytic platforms for dual-function co-production systems.

Spinel oxide, Fe_0.3Co_0.9Cr_1.8O₄ with active lattice oxygen is developed by high-throughput methods. The lattice oxygen activation is facilitated by Cr oxidation (Cr³⁺→Cr⁶⁺), accompanied by cation migration from octahedral to tetrahedral sites. This geometric conversion generates oxygen non-bonding states essential for lattice oxygen oxidation. Oxidized oxygen species are stabilized through dimerization with CrO₄ tetrahedra (d⁰ Cr⁶⁺). The oxide demonstrates high activity and stability at high current densities.

Wir demonstrieren die Fähigkeit, Zugang zu Ruddlesden-Popper- und Dion-Jacobson-2D-Perowskiten zu erhalten, die organische Spacer-Kationen auf Aryl-Acetylenbasis enthalten. Wir bewerten ihre einzigartigen opto(elektro)ionischen Eigenschaften durch eine Kombination von Techniken und verwenden sie in gemischtdimensionalen Perowskit-Solarzellen, die überlegene Leistungen und eine verbesserte Betriebsstabilität aufweisen und den Weg für Multifunktionalität in geschichteten Hybridmaterialien und deren Anwendung ebnen

Guided by Cu⁺, guanosine (G) forms robust, thermoset, and redox-responsive G-quadruplex (G₄.Cu⁺) supramolecular polymers (SPs) through unique metallophilic interactions, π–π stacking, and hydrophobic forces. Interestingly, these SPs undergo aqueous phase transitions into a hydrogel via slow dehydration-driven crosslinking below the cloud temperature (T_cp) and fast, complete dehydration into a solid precipitate above T_cp, exhibiting LCST behavior.

The SARS-CoV-2 frameshift element pseudoknot plays a crucial role in viral replication. Using various techniques, especially NMR spectroscopy and in vitro frameshift assays, we have developed and optimized chemical probes that serve as fundamental structures for potential inhibitors targeting viral RNAs.

A genetically encoded live-cell RNA methylation sensor allowing for dynamically monitoring of RNA m⁶A modification at single-cell resolution is reported, and has been used to elucidate the interaction between host-cell RNA modifications and the infection of SARS-CoV-2 and its variants.

Unlike classical poly(ethylene oxide) (PEO) electrolytes, single ion conductors, and crystalline polymers, this work discovered a novel ion transport mechanism mediated by PEO₃: LiBF₄ nanocrystals with aggregate anionic structure, which decouples the movement of PEO segments. The ultra-thin PEO/LiBF₄ electrolyte exhibits balanced ion conductivity, Li⁺ transference number, and mechanical strength, extending the life of all-solid-state batteries.

Wir präsentieren hier einen bifunktionellen Nanogel-Komplex, der mit dem antimikrobiellen Wirkstoff Triclosan (TCS) und dem pro-angiogenetischen Wirkstoff Deferoxamin (DFO) ausgestattet ist, um mikrobielle Pathogene zu bekämpfen und die Geweberegeneration zu fördern. Durch den synergistischen Effekt von TCS und DFO zeigt der NG-TCS-DFO-Komplex eine signifikante Regeneration des Knochengewebes und eine beschleunigte Heilung der Parodontitis in vivo.

A highly dispersed Co−N/C catalyst has been developed for the efficient hydroaminomethylation of alkenes using CO and H₂. This heterogeneous catalyst enables the synthesis of a broad range of secondary and tertiary amines, including pharmaceutically relevant molecules. The catalyst shows excellent activity, reusability, and scale-up potential, offering a green and cost-effective alternative to noble metal catalysts for amine synthesis.

This work successfully converts Fe−N−C catalyst to an entirely new Fen_nes_sey cluster catalyst, which is highly active, selective, and strong H₂O₂-tolerance for proton-exchange membrane fuel cells.

A bottom-up approach leveraging preexisting m-center-n-electron (mc-ne) bonds enables the synthesis of a highly stable cyclic(alkyl)amino carbene (CAAC) copper-hydride nanocluster, [(CAAC)₆Cu₁₄H₁₂][OTf]₂. With superior stability to Stryker's reagent, DFT calculations attribute this stability to hydride-to-ligand backbonding with π-accepting carbenes. This bench-stable cluster serves as an efficient and selective copper-hydride pre-catalyst in several catalytic applications.

This work presents a method for effective surface functionalization of nanoparticles (NPs) utilizing block copolymers containing nitrogen heterocyclic carbenes blocks and poly(reactive ester) block. This approach enhances NPs′ reactivity and stability, and is applicable to metal, metal oxide, and even rare-earth-doped upconversion NPs, thereby paving new pathways for the design and creation of nanoparticle-based functional materials.

We report a multifaceted assessment of novel cyanine-carborane salts as potent photosensitizers for photodynamic therapy (PDT). These compounds exhibit efficient tumor targeting through uptake by organic anion-transporting polypeptides (OATP). Upon near-infrared (NIR) light irradiation, cyanine-carborane salts generate reactive oxygen species (ROS), triggering apoptosis and significantly suppressing tumor cell proliferation and migration. In vivo studies demonstrate anti-tumor activity with minimal systemic toxicity, highlighting their potential as next-generation PDT therapeutics.

The method described here unlocks the puzzle of the photochemical reduction of aliphatic carboxylic esters by sequential SET/HAT processes under the synergistic action of a phenolate-type photocatalyst and a thiol catalyst. The stepwise reduction of esters to aldehydes and alcohols under mild conditions provides a practical method for fundamental functional group transformation.

The work proposes a self-amplified immune therapy strategy (SITS) for tumors and reports the first activatable photosensitizer immune-prodrug HDIM based on pyroptosis. Unlike existing combination therapies, HDIM demonstrates a significantly enhanced synergistic and cascading anti-tumor effect. Using HDIM, systemic immune activity is successfully remodeled to prevent tumor infiltration and metastasis.

A stable open-shelled Au₂₆ nanocluster with 15 valence electrons has been synthesized, and the presence of an unpaired electron is confirmed by magnetic measurements. This cluster shows high stability and excellent catalytic performance in selective oxidation of benzyl alcohol, achieving a record high TON of 100670 among atomically precise gold nanoclusters.

A synergistic photoredox/cobalt/chromium triple catalysis system have been established, for selective 1,4-hydrocarbonation of readily available 1,3-enyne precursors, providing a modular synthetic platform for various trisubstituted axially chiral allenes bearing an extra central chirality. Furthermore, preliminary mechanistic studies are also conducted.

A facile method for the synthesis of nitridophosphate-based phosphors using hot isostatic pressing is presented. Ion exchange reactions starting from the Li-ion conductor Li₁₀P₄N₁₀ enables the preparation of single crystals and bulk samples of compounds with the general formula AE_xLi_10−2xP₄N₁₀. Upon doping with Eu²⁺, these compounds exhibit remarkable luminescent properties across the green to red spectral range.

This investigation deciphers the pivotal role of main-chain hydrogen bonding in peptide self-assembly as the primary source of intrinsic fluorescence. It demonstrates how pH-induced morphological diversity in peptides maintains fixed fluorescence peaks through the integrity of these bonding networks, while fluorescence intensity is modulated by structural variations. The study preliminarily unveils the fluorescence properties and regulatory mechanisms of self-assembled peptides.

Gold-coordinated polymers of π-extended porphyrins were fabricated by on-surface synthesis and coordination chemistry methods. Each porphyrinoid monomer features antiferromagnetic coupling and no interaction between nearest neighbors within the polymer backbone, behaving as a single magnetic entity.

Dendritic molecular baskets are biocompatible cavitands capable of including toxic methotrexate (MTX) in their aromatic cavity. The binding is chemoselective with the complex forming in competitive cell media. With the unique mode of recognition and modular structure, dendritic baskets are leading candidates for developing effective antidotes against MTX poisoning.

PTZ-SAMs with various aromatic linkers and linking orientations were designed and synthesized as the hole-selective layer (HSL) in inverted wide-band gap perovskite solar cells (PSCs). β-NapPAPT could form dense and highly ordered HSLs, enhancing interfacial interactions and favoring optimal energy level alignment with the perovskite films.

A light-driven chemical cycle to generate ⋅OH buffer, in which SO₄²⁻ moderates ⋅OH concentration by balancing ⋅OH generation from excited-state [Fe^III(SO₄)(H₂O)₅]⁺ and the back reaction between ⋅OH and Fe²⁺.

We report a Cl⁻-assisted active site transfer strategy on Ru_0.1Mn_0.9O_x, achieving high OER selectivity and long-term stability in acidic seawater. Typically, *Cl occupies the Ru site, shifting the OER center to CER-insensitive Mn, preventing metal site dissolution. Additionally, the active Mn sites create an environment that favors OER over CER, offering a selective and durable solution for acidic seawater electrolysis.

Ionic COFs with numerous hydrophilic sites and high water stability were developed, achieving efficient water vapor adsorption and low enthalpy of evaporation at low humidity, offering cost-effective solutions for fresh water collection in desert regions.

A highly active (Fe_xCo_y)₅C₂ structure is developed through the synergistic effect of electronic (sodium) and structural (cobalt) promoters. This strategy facilitates the hydrogenation of carbon dioxide into olefins at a low temperature of 240 °C, achieving the highest STY of olefins at low temperatures, even better than a significant proportion under high-temperature operating conditions. Additionally, it retains the capability to synthesize olefins at 180 °C.

An effective and universal electron transfer-based strategy is introduced to modulate the reactive oxygen species (ROS) generation in porphyrin-based metal–organic frameworks (MOFs). This approach enables the conversion of existing Type II MOFs into Type I MOFs with hypoxic tolerance to function effectively under low-oxygen conditions, providing new insight into the development of Type I MOFs.

Reprocessing of thiol-ene networks was accomplished by carefully tuning the relative distance between two thioether functionalities and elevating the neighboring group participation concept. As a result we achieved a fast bond exchange at high temperatures. This allowed extrusion processing of cross-linked materials, while maintaining structural integrity below 70 °C.

This work designs a perovskite quantum dot (QD)-dye system for efficient energy transfer (ET) from QDs to dyes occurring via the Dexter exchange-type interaction, at minimal donor-acceptor spectral overlap. Dyes containing a dimethyl iminium binding group as part of their conjugated system are chosen for high binding affinity to QD surface, crucial for donor-acceptor spatial wavefunction overlap for efficient ET.

PEG was incorporated into the Cu electrode, achieving an FEC2+ of 90.3 % at 500 mA cm⁻². This modification relaxes Nafion, increasing active site availability and enhancing *CO and *OH adsorption, promoting C−C coupling. Simultaneously, the restructured hydrogen bond network reduces active hydrogen species, suppressing the hydrogen evolution reaction.

A practical synthesis of strained dehydro-[2,2]-paracyclophane, a benzyne analogue of [2.2]paracyclophane was realized and it could be utilized in various strain-release nucleophilic or cycloaddition reactions to synthesize diverse functionalized [2.2]paracyclophanes. A copper-catalyzed enantioconvergent alkynylation of this intermediate generated valuable planar chiral PCP building blocks and heterocycles in good yields with excellent enantioselectivity. This method provides a new general platform for challenging planar chirality construction.

This study presents the first example of a photocatalyzed intramolecular skeletal rearrangement strategy for constructing the xanthene scaffold. This approach has been successfully applied to synthesize highly functionalized xanthenes and to revise the structures of myrtucomvalones E and F. Furthermore, biological studies reveal that a xanthene demonstrates significant antiosteosarcoma activity both in vitro and in vivo.

Copper(II) and copper(III) trifluoromethyl complexes were used to elucidate the mechanism of Cu-mediated C(sp²)−H trifluoromethylation. For electron-rich substrates, a previously unidentified single electron transfer (SET) mechanism is followed, whereas electron-poor substrates follow CF₃ radical release/electrophilic aromatic substitution (S_EAr).

We show that graphitic carbon electrodes exhibit electric-field dependent infrared activity that is sensitive to the bulk mesoscopic intrinsic disorder. Our combined experimental and theoretical work provides a roadmap for elucidating mesoscopic disorder in graphitic carbon electrode materials under potential bias.

We reported a chemical-mechanical in situ interface reconstruction strategy for the fabrication of HTM-free carbon electrode perovskite solar cells (c-PSCs) by laminating a free-standing carbon electrode onto perovskite film. Our new strategy overcomes the contact issues within the perovskite/carbon electrode interface and boosts the efficiency to 20.31 % with enhanced stability.

A MgCl₂ catalyst system exhibits high selectivity and compatibility towards the depolymerization of the aliphatic (co)polyesters and polycarbonates under mild, solvent-free conditions (up to 98 % monomer yields). This approach provides a promising solution to the circular utilization of plastic materials.

A new insight into the mechanism of crystal phase and plane exerts on the transfer of lithium ion in poly(vinylidene fluoride)-hexafluoropropylene (PVDF-HFP) based polymer electrolytes is investigated in depth. β-phase-dominant segments are obtained by regulating dissolving process and the newly exposed (111/201)β crystal planes are conducive to provide more ion transport channels, which is beneficial to the rapid and smooth transfer of lithium ion.

The metastable nanofiber structures triggered by the synergistic effect of π–π stacking and coordination between zinc ions and the organic ligands evolved into nanosheet assemblies over time in water, accompanied by fluorescence changes that enabled visual monitoring. This strategy could be extended to multiple ions and offers applications in temporal dynamic fluorescence encryption.

An acid-enhanced photoiniferter polymerization operating efficiently under visible light is reported. Addition of biocompatible citric acid, accelerates photolysis, eliminating induction periods by enhancing chain transfer agent consumption and reaction rates. This method yields well-defined polymers with near-quantitative conversions in just two hours and demonstrates versatility across various monomers, including the synthesis of high molecular weight polymers.

By tuning the size of the catalyst ligand, a mesoporous aromatic framework, PAF-333, was obtained. It was found that the steric hindrance of larger-sized ligands avoided the framework interpenetration. Thanks to its large pore volume (3.4 cm³ g⁻¹), it could adsorb 13.4 wt % of hydrogen at 77 K, 100 bar and 0.537 g g⁻¹ of methane at 298 K, 98 bar, making it an ideal candidate for large-scale on-board methane storage.

Two isostructural lanthanide-nickel clusters Ln₁₃₂Ni₇₈ (Ln=Gd, Eu) were synthesized by the co-hydrolysis of Ln³⁺ and Ni²⁺ in the presence of iminodiacetate. Both clusters feature a hollow truncated tetrahedral structure with trumpet-shaped passageways that connect the exterior and the interior of the cluster cage. The solution-stable cluster has been shown to catalyze size-selective Knoevenagel condensation and one-pot three-component synthesis of 4H-pyran derivatives.

We highlight the role of local supersaturation in governing the fundamental crystallization chemistry of Zn₄SO₄(OH)₆⋅xH₂O (ZSH) and propose a subtle supersaturation-controlled morphology strategy to tailor the interphase chemistry of Zn anode. Attributed to the supersaturated environment created by caprolactam, ZSH selectively exposes high-energy (001) plane and initiates a pseudo-coincidence interface that significantly boosts the Zn lifespan.

An efficient strategy for embedding catalytically active polyoxovanadate (POV) into supramolecular assemblies was developed by utilizing host-guest interactions between pillararenes grafted on the cluster and ditopic linkers. The amphiphilic nature of the POV in the host-guest complex promoted responsive behavior of the assembly toward the solvent polarity. Lastly, the assembly showed enhanced catalytic properties compared to the parent POV.

Photomodulation of dynamic DNA circuits/networks is demonstrated by photoprotection of an auxiliary caged unit yielding an oligonucleotide intervening with the temporally operating circuits. This is exemplified with photomodulation of DNAzyme or of dynamically operating DNA networks. The concept is applied to photomodulated network-guided inhibition of fibrinogenesis and controlling biocatalytic cascades.

Isolated neutral helicene radical revealed the missing link in highly photoreducing consecutive photoelectron transfer (conPET) mechanism. Extensive mechanistic studies implied interaction of short-lived, non-emissive photoexcited radical and acetonitrile that generates reduced solvent. To that end, numerous extreme photoreduction have been showcased through useful functionalization of aryl halides using reduced solvent mediated conPET method.

Leveraging the robust assembly and broad-spectrum encapsulation of macrocyclic amphiphiles, we developed a FRET-based autophagy imaging platform that demonstrates versatility and convenience as a powerful tool for imaging organelle autophagy.

An in situ constructed Cu@Cu₆Sn₅ core-shell catalyst is shown to enhance redox kinetics of V²⁺/V³⁺ and selectively inhibit hydrogen evolution side reaction, achieving stable operation over 1200 cycles and enabling subzero capacity unlocking for cost-effective vanadium flow batteries.

Unusual heterobidentate coordination generates a novel compound Zn(C₅H₄NO)₂, which shows a uniform alignment of microscopic polarization that generates the record-high bulk SHG among all UV-transparent Zn-containing metal-organic compounds.

By introducing axial organic ligands to modify the atomically dispersed copper single atoms on the surface of Pd-metallene, we have constructed a catalyst with adjacent-ligand regulation effect to significantly enhance the catalytic performance of MOR.

Boronyl radical-catalyzed cycloaddition of o-QMs or p-QMs with bicyclo[1.1.0]butanes in combination with selective Lewis acid-catalyzed rearrangements provides a collective approach for 6 types of medicinally attractive 2D/3D polycyclic compounds featuring bicyclo[n.1.1] bridged scaffolds.

Chlorine-containing RuO₂ catalysts and pure RuO₂ catalysts with comparable morphology and crystallinity were synthesized to clarify the effects of chlorine residues on the performance of RuO₂. Notably, the RuO₂-Cl catalyst exhibited superior activity and stability in acidic OER by lowering the limiting potential and suppressing the LOM pathway, maintaining high performance for over 1200 hours at high current densities.

Guided by binary descriptors, 16 transition metal selenides are screened, and an alloying strategy is subsequently employed to controllably synthesize Mo_0.25Nb_0.75Se₂/NG. This approach significantly reduces the surface energy while precisely tuning the band alignment and lattice matching between polysulfides and Mo_0.25Nb_0.75Se₂/NG, thereby enhancing interfacial reaction kinetics and enabling the successful construction of high-performance lithium−-sulfur batteries.

A sulfur-infused phenolic (RS) resin photocatalyst was meticulously designed at the molecular level to fine-tune its conjugation degree, thereby enhancing both its charge separation capability and hydrophilicity. This structural optimization enables the RS resin to achieve overall photocatalytic H₂O₂ synthesis via non-radical pathways, resulting in an outstanding solar-to-chemical conversion efficiency of 1.4 %.

The slow kinetics of the proton-coupled electron transfer process results in the low conversion efficiency of NO₃RR. Selenium-deficient FeSe₂/Fe₃O₄ heterojunction is synthesized. The Se-deficient FeSe₂ contributes to nitrate-deoxidation and hydrogenation, and Fe₃O₄ promotes water decomposition to provide H protons, which jointly promotes NO₃RR.

Co(5 %)-HPCN/(rGO/Pt) consisting of photoresponsive chip (HPCN), H₂ evolution cocatalyst (rGO/Pt), and cobalt complex capable of reversibly binding O₂ ([Co(II)N₄(H₂O)₂]²⁺) is constructed to achieve the decoupling of particulate photocatalytic overall water splitting under alternating UV and visible light irradiations. Under UV irradiation, the photogenerated holes oxidize [Co(II)N₄(H₂O)₂]²⁺ into [Co(III)N₄(O₂⁻)]²⁺ and H⁺, while the photogenerated electrons transfer to Pt through rGO for reduction of H⁺ to H₂. Under visible irradiation, [Co(III)N₄(O₂⁻)]²⁺ is photolyzed back to [Co(II)N₄(H₂O)₂]²⁺ along with O₂ evolution.

A copper-catalyzed enantioselective and 1,4-selective hydropyridylation has been developed. Using 2-fluoropyridine as the electrophile and a copper catalyst in conjunction with (R)-Tol-BINAP, the desired chiral 1,1-diaryl product was synthesized via a concerted nucleophilic aromatic substitution mechanism.

A photochemical method for “stapling” G-quadruplex (G4) and intercalated motif (IM) structures enhances their stability, locks their topology, and increases enzymatic resistance while preserving biological activity. This method, applied to the Thrombin Binding Aptamer (TBA) model and other G4- and IM-prone sequences, shows promise for future therapeutic applications, including more stable aptamers and molecular decoys in biological systems.

This study provides a forward-looking direction for the economically scalable production of green hydrogen and showcases an innovative insight for the dynamic evolutionary mechanism of interfacial-water dissociation-oxidation. The photovoltaic-electrolysis system efficiently converts renewable energy sources into hydrogen, the integration of durable Ru_ldsNiCr-LDH catalyst promises industrial application viability. And the newly defined PVTH parameter sets a new benchmark for photovoltaic-electrolysis systems.

The optimization of one/two-photon excited fluorescence through linker installation in an interpenetrated TPE-MOF. Both the crystal packing density and ligand conformations can be modulated by linker installation.

An electrocatalyst of Ni_0.1Co_0.9 alloy embedded in nitrogen-doped carbon nanotubes decorated with Ni−Co dual-atoms is constructed for glycerol oxidation reaction (GOR). The active *OH makes the GOR follow a direct oxidation pathway occurring at lower potentials. The optimized electronic state of Co single-atom regulated by Ni single-atom and Ni_0.1Co_0.9 alloy promotes *OH-mediated preferential cleavage of C−C bonds, leading to a high formate yield.

The charge species of the porous coordination cages are regulated by ligand strategy. The charge-tunable porous coordination cages exhibit performance tweaking ability in the electrocatalytic nitrate reduction coupled 5-hydroxymethylfurfural oxidation system, which can not only indirectly adjust the efficiency of nitrate electrosynthesis of ammonia, but also modulate the product selectivity of 5-hydroxymethylfurfural oxidation.

Thermoplastic elastomers: Olefin triblock copolymers based on glassy polystyrene, ethylene butadiene rubber and highly crystalline polyethylene segments are prepared using a switch strategy from anionic polymerization to coordinative chain transfer (co)polymerization. They display low-viscosity above the melting point of PE and high elastic performances upon crystallization of PE segments.

A donor–acceptor polymer (ArMT) consisting of benzene rings and triazine was obtained and modified onto polypropylene (ArMT@PP) as separators for lithium metal batteries (LMBs). Due to the lithiophilic triazine units, this ArMT@PP simplifies the solvation structure of Li⁺, facilitates the migration of Li⁺ and forms a stable solid electrolyte interface. The assembled LMBs achieved a capacity retention of 90.58 % after 1200 cycles at 1 C.

Late-stage oxidation of unsymmetrical benzofuran/benzothiophene-fused s-indacene regioisomers to their corresponding sulfones affords rationally designed molecules with varying degrees of donor/acceptor characteristics and intramolecular charge transfer (ICT). Depending on the fusion orientation of the donors and acceptors, the two most antiaromatic, oxidized isomers exhibit strong evidence of ICT with 30–40 nm solvatochromic shifts.

A universal asymmetric pulse potential strategy was developed to promote the regeneration of active oxygen species which contribute to satble catalysis by noble metal catalysts for various alcohol oxidation reactions. Distinguished from conventional potentiostatic strategy, the operation time of stable glycerol oxidation electrocatalyzed by Pd was extended from 6 h to more than 2800 h under universal asymmetric pulse potential strategy.

Nitrogen (N₂) is regarded as a stable reservoir for the N element in the atmosphere. However, this study finds that the stable N₂ can rapidly react with atmospheric oxygen and ozone on ubiquitous water droplet surfaces via a novel reduction-then-oxidation pathway, resulting in the formation of nitrous oxide – the third most impactful greenhouse gas.

Eine zeitaufgelöste massenspektrometrische Analyse (MS) limitierter Proteolyse (LiP) zeigte Unterschiede in den transienten Interaktionen von Protein-Polymer-Konjugaten mit verschiedenen Polymer- und Linkerstrukturen auf.

Using a selenium-substitution strategy, a new selenium-based ligand, tetraseleno-hydroxyquinone (TSHQ), was synthesized, leading to the construction of a semiconducting three-dimensional Ag−Se coordination polymer (Ag₄TSHQ). Ag₄TSHQ shares the same topological structure as its sulfur counterpart, Ag₄TTHQ, but exhibits superior charge mobility of approximately 350 cm²/V⋅s, which is twice that of Ag₄TTHQ. Additionally, it demonstrates enhanced electrochemical energy storage capabilities. This research underscores the advantages of selenium-ligand-based coordination polymers (c-CPs) in optoelectronic devices and energy storage technologies.

A novel single-molecule oligosaccharide sensor, the OmpF nanopore, was developed for detecting unlabeled neutral oligosaccharides at low concentrations.

A robust regio- and stereoselective ROP approach was developed for the synthesis of isoenriched alt-PLGA (Regioselectivity up to 97 %, P_m up to 0.91) from rac-MG by the exploit of our spiro-salen scandium complexes, which represents a versatile platform for the preparation of high-performance biodegradable PLGA materials with diverse material properties and biodegradability.

A rationally engineered nanopore was constructed to directly discriminate posttranslational proline hydroxylation in native peptides. By modeling the specific binding structure, hydrophobic region was introduced into aerolysin to transduce the hydrophobicity difference induced by hydroxylation. Precise identification of proline hydroxylation in hypoxia-induced factor protein was achieved without interference from adjacent oxidation.

Organofluorine compounds bearing the hexafluoroisopropyl group remain extremely scarce due to the lack of appropriate fluoroalkylation reagents. Herein we report a molecular photoelectrocatalysis method for the C−H hexafluoroisopropylation of indoles and tryptophan peptides, utilizing hexafluoro-2-propanol (HFIP) as the fluoroalkylation reagent.

A new-to-nature enzymatic platform for the enantioselective trifluoromethylazidation of alkenes has been successfully established. Through 11 rounds of directed evolution, an engineered variant of nonheme iron enzyme, BsQueD-CF_3, was developed, enabling the production of a wide range of enantioenriched CF₃-containing molecules. This platform based on metalloenzymes would open a new avenue for biocatalytic trifluoromethylation chemistry.

An unprecedented triphenylamine with three sulfur ortho bridges has been developed as the very first representative of the hitherto elusive family of electron donors. The compound is readily oxidized to the corresponding radical cation with exceptional stability and forms crystalline donor-acceptor complexes with cyano-based acceptors.

Three novel polycyclic pyridine alkaloids (1-3) featuring a unique 2-oxa-6-aza[4.4.3]propellane skeleton were discovered from the twigs and leaves of Flueggea suffruticosa. Guided by a synthesis strategy based on the biogenetic building blocks, the first total synthesis of 1-3 was achieved through vinylogous Mannich-type reaction, Suzuki coupling reaction, and intramolecular aza-Michael addition reaction as key steps.

A Pd-catalyzed C(sp³)−H arylation of peptides has been developed, directed by an amidoxime ether, which can be incorporated into peptides at any amide bond. The backbone-installed directing group facilitates site- and stereoselective arylation of peptides, including at internal residues. Removal of the amidoxime ether generates the parent amide enabling a traceless C−H functionalization process.

A genetically encoded β-lactam-lysine (BeLaK) enables a spontaneous inter-strand crosslinking with a proximal lysine in a supercharged monobody, affording a rigidified cell-penetrating variant with enhanced thermostability, greater cellular uptake, and potent inhibitory activity.

“One monomer for two materials”: Dual dynamic covalent chemistries diversify the pathway of molecular self-assembly and produce distinct polymeric materials as a function of evaporation rate.

This work reports the first ferroelectric of 2D perovskite heterostructures as single crystal by precisely tailoring inorganic sheets via a chemical molecular scissor. Combining its strong ferroelectricity and inherent anisotropy, crystal-based device exhibits an ultrahigh polarized-light sensitivity up to ~37 in self-powered mode. This work will facilitate the further development of ferroelectric materials for optoelectronic device applications.

The simplest organometallic reaction, the coupling of carbon and hydrogen atoms on a metal surface is demonstrated for the first time in a molecular system. Hydride migration to a μ₂-carbido is shown to be favoured over alkyl migration.

Bambusuril macrocycles were functionalized with bile acids of different polarities and studied as anion transporters. The bambusuril with the most polar bile acids was demonstrated to form a unimolecular anion channel. Furthermore, increasing the cholesterol content in the membrane of liposomes drastically decreased the ion transport activity, likely squeezing the bile acid arms together to close the channel.