From Natural Product Derivative to Hexagonal Prism Supermolecule: Potent Biofilm Disintegration, Enhanced Foliar Affinity, and Effective Management of Tomato Bacterial Canker
Xue Chen
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
These authors contributed equally to this work.
Contribution: Data curation (lead), Visualization (lead), Writing - original draft (lead)
Search for more papers by this authorRun Yang
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
These authors contributed equally to this work.
Contribution: Data curation (equal), Software (equal), Visualization (equal)
Search for more papers by this authorCorresponding Author
Prof. Dr. Kongjun Liu
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000 China
Contribution: Formal analysis (lead), Validation (lead), Writing - review & editing (lead)
Search for more papers by this authorMin Liu
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Data curation (supporting), Visualization (supporting)
Search for more papers by this authorQingchuan Shi
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Data curation (supporting)
Search for more papers by this authorJinghan Yang
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Visualization (supporting)
Search for more papers by this authorProf. Gefei Hao
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Resources (equal)
Search for more papers by this authorProf. Dr. Laixin Luo
Beijing Key Laboratory of Seed Disease Testing and Control, Department of Plant Pathology, China Agricultural University, Beijing, 100193 China
Contribution: Project administration (supporting), Resources (equal)
Search for more papers by this authorProf. Dr. Fengpei Du
Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193 China
Contribution: Resources (supporting)
Search for more papers by this authorCorresponding Author
Prof. Dr. Peiyi Wang
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Conceptualization (lead), Formal analysis (lead), Funding acquisition (lead), Investigation (lead), Methodology (lead), Project administration (lead), Resources (lead), Validation (lead), Writing - review & editing (lead)
Search for more papers by this authorXue Chen
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
These authors contributed equally to this work.
Contribution: Data curation (lead), Visualization (lead), Writing - original draft (lead)
Search for more papers by this authorRun Yang
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
These authors contributed equally to this work.
Contribution: Data curation (equal), Software (equal), Visualization (equal)
Search for more papers by this authorCorresponding Author
Prof. Dr. Kongjun Liu
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000 China
Contribution: Formal analysis (lead), Validation (lead), Writing - review & editing (lead)
Search for more papers by this authorMin Liu
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Data curation (supporting), Visualization (supporting)
Search for more papers by this authorQingchuan Shi
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Data curation (supporting)
Search for more papers by this authorJinghan Yang
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Visualization (supporting)
Search for more papers by this authorProf. Gefei Hao
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Resources (equal)
Search for more papers by this authorProf. Dr. Laixin Luo
Beijing Key Laboratory of Seed Disease Testing and Control, Department of Plant Pathology, China Agricultural University, Beijing, 100193 China
Contribution: Project administration (supporting), Resources (equal)
Search for more papers by this authorProf. Dr. Fengpei Du
Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193 China
Contribution: Resources (supporting)
Search for more papers by this authorCorresponding Author
Prof. Dr. Peiyi Wang
State National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025 China
Contribution: Conceptualization (lead), Formal analysis (lead), Funding acquisition (lead), Investigation (lead), Methodology (lead), Project administration (lead), Resources (lead), Validation (lead), Writing - review & editing (lead)
Search for more papers by this authorAbstract
Clavibacter michiganensis (Cmm), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid and effective control methodologies. Dense biofilms formed by Cmm shield internal bacteria from host immune defenses and obstruct the ingress of agrochemicals. Even when agrochemicals disintegrate biofilms, splashing and bouncing during application disperse active ingredients away from target sites. Herein, we present a supramolecular strategy to fabricate a hexagonal prism-shaped material, BPGA@CB[8], assembled from an 18β-glycyrrhetinic acid derivative (PBGA) and host molecule—cucurbit[8]uril (CB[8]) via host–guest recognition. This positively charged material manifests multifaceted functionalities, notably the ability to surmount biofilm barriers, annihilate the encased pathogenic bacteria, and enhance foliar affinity of droplets. The strong in vitro potency and effective deposition of BPGA@CB[8] foster optimal conditions for robust in vivo efficacy, demonstrating superior protective and curative activities (56.9 %/53.4 %) against canker of tomato at a low-dose of 100 μg⋅mL−1 compared to BPGA (44.6 %/42.2 %), kasugamycin (30.1 %/28.4 %), and thiodiazole copper (35.4 %/31.0 %). This supramolecular material, based on natural product derivatives, provides a potent treatment for high-risk canker of tomato, and exemplifies the utility of supramolecular strategies in optimizing the attributes of natural products for managing plant bacterial diseases.
Conflict of Interests
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
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