The diversity of water pH values is a key factor that restricts the practical application of photocatalytic water purification. The construction of liquid (water)–liquid (oil)–solid (semiconductor) (L–L–S) triphase interface microenvironment makes the organic molecule adsorption pH independent and prevents the semiconductor from being corroded by strong acidic/alkaline solutions, leading to a stable and efficient photocatalytic reaction over a wide pH range (1–14). These findings reveal a promising path for the development of high-performance catalysis systems applicable in complex water environments. More details are discussed in the article by Feng et al. on pages 3349—3354.

A chemical investigation of the deep-sea-derived fungus Penicillium allii-sativi resulted in the discovery of four new (1—4) and one known (5) meroterpenoids. Compound 3 significantly blocked the mTOR signaling pathway, resulting in the arrest of cell cycle at G0-G1 phase and triggering mitochondrial apoptosis in Hela cells. While macrophorin A effectively triggered cell death in MDA-MB-231 cancer cells by activating apoptosis pathways involving death receptors, mitochondria, mTOR, and TNF. More details are discussed in the article by Yang et al. on pages 3283—3292.

A facile and efficient free-radical polymerization induced grafting-to method for grafting polymer chains onto Al NPs has been developed. By optimizing polymerization conditions, we were able to achieve a polymer brush layer with a weight loss fraction of up to 43.3%. This method is applicable to a broad range of vinyl monomers and photoinduced organocatalyzed atom-transfer-radical polymerization.

Cu doping significantly improved the photocatalytic activity and stability of FeVO₄ for peroxymonosulfate (PMS) activation, as it could boost the photogenerated electrons transferring to PMS and the adsorption of PMS on FeVO₄

Euphomillanols A—E (1—5), five oxygenated ent-rosane diterpenoids, were isolated from Euphorbia milii. Compounds 1 and 2 are unprecedented 7/7/6-fused tricyclic 5,10-seco-ent-RDs and possess a unique 11-oxabicyclo[4.4.1]undeca-1(10),5-diene moiety. Compound 3 contains a 1-methyl-6-oxabicyclo[3.2.1]oct-2-ene motif of ring A. All compounds exhibited strong to moderate antiadipogenic effects in 3T3-L1 adipocytes.

Binary crosslinked materials TLD1-4 were synthesized. The electro-optical coefficient of TLD1-4 was as high as 312 pm/V. The T_g of TLD3-4 was as high as 174 °C.

An amide-substituted quinuclidine-borane has been identified as a more efficient hydridic hydrogen atom transfer (HAT) catalyst for the hydroalkylation of unactivated olefins under visible light irradiation. Mechanistic studies reveal that the reaction yield correlates well with the association constant between the borane catalyst and the carbonyl substrate.

Thieno[3,4-b]thiophene (TT) was employed as the solid additive to synergize with the widely used solvent additive, CN, for fine-tuning the morphological characteristics and the photovoltaic performance of OSCs. The PM6:Y6 based devices treated by the hybrid additive of CN+TT demonstrated an impressing PCE of 18.52%. Furthermore, the PM6:Y6:PC₇₁BM based ternary devices achieved an outstanding PCE of 19.05%.

A mechanistically distinctive visible-light-promoted metal-free aerobic oxidation of alkenyl silanes with alcohols was disclosed to efficiently construct α-alkoxy ketones under mild conditions. The primary, secondary, and tertiary alcohols could be used as reactants. The protocol could be carried out on a gram-scale. Various derivatizations of products could be conducted. Mechanistic studies indicated the reaction was initiated by single-electron oxidation of the alkenyl silanes, rather than radical addition to alkenyl silanes.

A general strategy for cobalt-catalyzed methylative coupling of aldehydes/aldimines with reversal of the inherent regioselectivity to afford a broad scope of allylic alcohols and allylic amines is presented.

This work uses a solvent-free method to prepare multicolored phosphorescent CDs with corresponding chiral signals. In particular, the YCDs have white light excitation properties and have very promising applications in anti-counterfeiting.

Chemical synthetic approach toward acyl group-free escin derivatives has been successfully established, which would speed up the process of pharmaceutical applications of these valuable natural D/E-ring simultaneously functionalized oleanane-type saponins.

Chiral phosphine-catalyzed asymmetric (4+2) annulation of the amide-based Morita–Baylis–Hillman (MBH) carbonates with β,γ-unsaturated butenolides has been developed to give enantiomer-enriched bicyclic δ-lactam γ-butyrolactone compounds. In this reaction, the amide-based MBH carbonates were first used as acceptor and aza-C4 synthon in phosphine catalysis.

The synthesis, supramolecular gelation ability and stimuli-responsive properties of a new gelator (BAzo-Chol) were reported. The resulted gels exhibited excellent photo-responsive gel-sol transition and remarkable light-induced chromic properties. The distinct changes in colour and transparency of the gel-sol transitions signified the potential applications of BAzo-Chol in smart windows.

Four new meroterpenoids (1—4) were isolated from the deep-sea-derived fungus Penicillium allii-sativi, along with a known derivate (5). These five meroterpenoids and a previously reported co-metabolite (macrophorin A, MPA) were tested for anti-tumor effects. Compounds 3 and MPA showed potent effect in different tumor cells by mitochondrial and mTOR pathways.

Fifteen new polyprenylated acylphloroglucinols (1—15, PPAPs), along with 36 known PPAP derivatives were obtained from Hypericum kouytchense. Compound 1 was a rare PPAP with a fused 6/6/6/5/5 pentacyclic ring system. The primary mechanistic study of compound 34, implied that this compound could prohibit the function of P-gp transport rather than its expression.

A novel solid polymer electrode of 1% PH-PEO with multiple fast Li⁺ channels was constructed by synergistic effect of PHATN and PEO, which has rich lithium friendly structures and active sites.

An unprecedented nickel-catalyzed regioselective hydroalkynylation of unsymmetrical internal alkynes was realized with steric hindered resistance selectivity via the cyano-directing group strategy. Significantly, 1,3-enyne products could be employed in the construction of the complex chemical space, which provided the potential candidate compound 8a in the discovery of innovative anti-tumor drug.

The porous chelators for iron ions, COOH@TpPa-1, could maintain a multiple hydrogen bonding structure to block the channels in the stomach and disrupt the hydrogen-bonded structure in the alkaline to regulate the chelation of iron.

This study supplies a generalized strategy to construct synergistic noninvasive photoresponsive instead of no synergistic invasive pH-responsive assembly materials by using water-soluble macrocyclic calixpyridinium as a photoacid. It exhibits many fascinating functions and will greatly expand the application range of photoresponsive sustainable system.

Fluorescent fingerprint powders can achieve colour-changing visual development of latent fingerprints by grease response with high contrast and applicability. The fluorescent fingerprint powders cause no damage to genetic information, and can be used in complex criminal investigation environments.

Building upon the successful stereoselective gridization of grids with two or three chiral centers (earth), we utilize supramolecular interactions and steric effect (two stage rockets) to achieve the stereoselective gridization of grids with four chiral centers (moon).

In this work, via interface microenvironment modulation, we have developed a pH–independent, efficient and stable photocatalytic system with a unique L–L–S triphasic interface micro-environment.

Two reaction modes for metal-free [3 + 2] cyclization of N-aminopyridinium derivatives with β-alkoxyvinyl trifluoromethylketones have been described through selective C—O or C—O/C—C bond cleavage. This strategy can also be extended to the [3 + 2] cyclization of N-aminopyridinium derivatives with enaminones and bromoalkynes.

The enantioselective synthesis of spirooxindole δ-lactone has been disclosed via [4+2] cyclization of hydroxyphenyl indolinone with azlactone, representing the first catalytic asymmetric reaction of hydroxyphenyl indolinone.

In this work, we have achieved the arylation and carbonylation of activated alkenes without transition metal catalysis. This protocol not only exhibits broad substrate scope and functional group tolerance, but also achieves high chemo- and regio-selectivity.

A visible-light-induced decarboxylative radical cascade cyclization reaction between N-(2-cyanoaryl)-acrylamides and alkyl N-(acyloxy)phthalimide (NHPI esters) for the construction of phenanthridine derivatives has been developed. A series of primary, secondary, and tertiary alkyl-substituted phenanthridines are prepared in up to 82% yield without transition-metal catalysts, chemical oxidants, or metal-/organic dye-based photocatalysts.

The 2D highly-aligned cocrystal nanomeshes are firstly developed to afford an exceptional RGB trichromatic system through epitaxial growth strategy, triggering cross-modulation white light emission. The transformation from 1D to 2D nanomeshes can be attributed to the regulatory competitive intermolecular interactions, which can be utilized as multicolor inks for promising photonic dynamic recognition, information encryption, and decryption.

The study presents a new synthetic approach to chiral α-tertiary alkyl aminonitriles via catalytic asymmetric isomerization of cyanoketimines. It features a complementary method to the catalytic asymmetric Strecker reaction and umpolung addition of cyanoketimine. The utility of this method was illustrated by the development of a concise enantioselective synthesis of vildagliptin.

The Pd-catalyzed asymmetric [4+4] cycloaddition reaction between 2-alkylidenetrimethylene carbonate and electron-deficient indole-2,3-quinodimethanes (IQDMs) results in the formation of indole-fused eight-membered oxa-rings with high enantioselectivity and excellent yield (up to 98% yield, 95% ee). The practicality of the method is evidenced by the successful gram-scale reaction and efficient product transformation.

An oxidative alkylarylation of N-aryl bicyclobutyl amides with C(sp³)–H feedstocks has been disclosed, allowing for rapid diversity-oriented synthesis of functionalized 3-spirocyclic oxindoles via a cascade C(sp³)–H/C(sp²)–H functionalization and cyclization process.

Three copolymer donors, PTVT-T-xCl (where x = 20%, 50%, 100%), were designed and synthesized in this work. As the chlorine content increases, the V_oc of PTVT-T-xCl-based OSCs is enhanced, accompanied by progressively reduced non-radiative energy losses. Notably, the OSC comprising a blend of the completely non-fused photovoltaic materials PTVT-T-20%Cl and A4T-16 achieved a remarkable PCE of 11.8%.

Asymmetric radical chemistry has attracted considerable interest in recent years, and has become one of the most powerful methods for the synthesis of chiral molecules. This review paper aims to highlight and discuss breakthroughs and recent advances in asymmetric hydrogen atom transfer (AHAT), showcase the great potential of AHAT in asymmetric synthesis, and inspire further developments in this emerging field.

The transformation of easily accessible carboxylic acids and their derivatives via decarboxylative/decarbonylative borylation process has received increasing attention. This review summarizes the recent advances in this field.

The review presents a thorough review on two aspects: the electrocatalytic urea synthesis and urea oxidation reaction and summarizes in turn the recently reported catalyst materials, multiple catalysis mechanisms and catalyst design principles for electrocatalytic urea synthesis and urea oxidation.

This review summarized the methodology development on the cycloaddition of ynol ethers and thioynol ethers in every sort of catalytic cycloaddition.

This review summarizes the recent developed strategies for the catalytic selective functionalization of poly(organoborons), encompassing Pd- or Cu-catalyzed coupling reactions, radical coupling reactions, as well as stereoselective transformations of these compounds.

Transition-metal-mediated cross-electrophile coupling between carbon electrophiles and fluoroalkyl electrophiles has emerged as a straightforward and efficient route for the synthesis of a wide range of fluoroalkylated compounds. Moreover, alkenes or alkynes-involved three-component cross-electrophile couplings provide rapid and effective access to carbonfunctionalized fluoroalkylated alkanes and alkenes.

The review outlines how the utilization of transition metal catalysis, photochemical and electrochemical reaction methodologies enhances the selectivity and efficacy of XEC reactions among halides, carboxylic acids, and alcohols, predominantly belonging to the same class of electrophilic reagents.

Tuning electrolyte properties is a well-established strategy to improve electrocatalytic activity and selectivity, though debates continue regarding the impact of different electrolyte components on reactions. This review briefly examines these discussions and explores the kinetic modeling of solvent effects, aiming to establish a strong correlation between electrolyte structure and reactivity.

Repurposing naturally occurring enzymes with visible light represents one of the most exciting avenues for developing new enzyme reactivity. This Emerging Topic highlights seminal work in reshaping various classes of enzymes, categorized under three mechanistic scenarios: excitation of enzymatic EDA complexes, visible-light excitation of flavoproteins, and synergistic dual photo-enzyme catalysis.

A medium bandgap polymer acceptor (P-ITTC) as guest was developed, showing a complementary absorption and matched energy levels with NIR-absorbing binary host. The P-ITTC-based ternary all-PSCs achieved a high efficiency of 17.64% and a high photovoltage of 0.96 V, both of which are among the highest values in LBL-type all-PSCs.

Twelve new limonoids, trichilitins A—L (1—12), together with ten reported congeners (13—22) were isolated from Trichilia connaroides. Compounds 6, 7, 13, 14, and 19 exhibited significant cytotoxic effects, especially 7 exhibited significant cytotoxic effects against HCT-116 with an IC₅₀ value of 0.035 μmol·L^–1 and induced cell cycle arrest by promoting the expression levels of p53 and p21.

In this work, an additive strategy based on DTBF is proposed to form intermolecular interactions with BTP-4F, which can improve the crystallization of BTP-4F, promote charge transport and inhibit recombination, obtaining a high PCE of 19% for organic solar cells.

Vicinal stereogenic centers are common scaffolds in organic synthesis, yet their construction with precise control over both absolute and relative stereochemistry presents significant challenges. Transition metal-catalyzed enantioselective borylative functionalization of internal alkenes offers a powerful platform for generating vicinal stereogenic centers. This review highlights recent advancements in this field.

Maleimides are multisite-reactive scaffolds that have stimulated a growing interest in the field of synthetic organic chemistry. The present review covers the utilization of maleimides as electrophilic partners and pro-nucleophilic partners in metal-catalyzed or organocatalyzed functionalizations with the control of either central and/or axial chirality.

Aluminum nanoparticles have significant potential applications in various fields due to their unique LSPR. A facile and efficient free-radical polymerization induced grafting-to (FRPIGt) method for grafting polymer chains onto Al NPs by Al—C bonds has been reported. This method paves a new path for the preparation of a wide range of polymer-functionalized Al NPs and their polymer composites to be utilized in various fields. More details are discussed in the article by Liu et al. on pages 3193—3200.

In this picture, the Chinese classical mythic figure Red Boy, holding a red tasseled gun (adriamycin), is attacking a lots of monster (live balls, multidrug resistance cancer cells) with the help of the Samadhi fire (polycyclic polyprenylated acylphloroglucinols, PPAPs). This indicates that PPAPs along with adriamycin show good cytotoxic activity on multidrug resistance cancer cells. More details are discussed in the article by Yuan et al. on pages 3293—3307.