Synthetic Investigation toward Acyl Group-Free Escin Derivatives
Xin Lv
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorCorresponding Author
Jin-Xi Liao
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
E-mail: [email protected]; [email protected]Search for more papers by this authorZhen-Qiang Li
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorZhi-Sheng Xiong
Jiangxi Foodmate Biotechnology Co., Ltd., Jiujiang, Jiangxi, 332000 China
Search for more papers by this authorQi-Shuang Yin
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorHui Liu
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorYuan-Hong Tu
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorCorresponding Author
Jian-Song Sun
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
School of Life Science and Health Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, 214122 China
E-mail: [email protected]; [email protected]Search for more papers by this authorXin Lv
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorCorresponding Author
Jin-Xi Liao
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
E-mail: [email protected]; [email protected]Search for more papers by this authorZhen-Qiang Li
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorZhi-Sheng Xiong
Jiangxi Foodmate Biotechnology Co., Ltd., Jiujiang, Jiangxi, 332000 China
Search for more papers by this authorQi-Shuang Yin
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorHui Liu
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorYuan-Hong Tu
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
Search for more papers by this authorCorresponding Author
Jian-Song Sun
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022 China
School of Life Science and Health Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, 214122 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
With protoescigenin as starting material and through orchestrated application of Yu and Schmidt glycosylation protocols, the synthesis of acyl group-free escin derivatives was achieved for the first time. As the undesired non-specific toxicity, originating from the existence of acyl groups on aglycone, prohibits the wide application of escins, the established strategies toward non-acylated protoescigenin-type saponins would dramatically ease the access to escin derivatives dispense of acyl groups, thereby speeding up the pace of pharmaceutical use of these valuable compounds.
Supporting Information
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| cjoc202400778-sup-0001-supinfo.pdfPDF document, 8.7 MB |
Appendix S1: Supporting Information |
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