Hyperkouytones A—O, New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity
Hua-Yong Lou
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Those authors contribute equally.
Search for more papers by this authorMei-Jun Chen
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Those authors contribute equally.
Search for more papers by this authorPing Yi
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorJun Jin
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorYan-Rong Zeng
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Chinese Ethnic Medicine, Guizhou Minzu University, Guiyang, Guizhou, 550025 China
Search for more papers by this authorWei Gu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorZhan-Xing Hu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorCorresponding Author
Jue Yang
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Xiao-Jiang Hao
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Kunming, Yunnan, 650201 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Chun-Mao Yuan
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorHua-Yong Lou
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Those authors contribute equally.
Search for more papers by this authorMei-Jun Chen
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Those authors contribute equally.
Search for more papers by this authorPing Yi
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorJun Jin
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorYan-Rong Zeng
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Chinese Ethnic Medicine, Guizhou Minzu University, Guiyang, Guizhou, 550025 China
Search for more papers by this authorWei Gu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorZhan-Xing Hu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
Search for more papers by this authorCorresponding Author
Jue Yang
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Xiao-Jiang Hao
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Kunming, Yunnan, 650201 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Chun-Mao Yuan
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, 550014 China
Natural Products Research Center, Guiyang, Guizhou, 550014 China
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 561113 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
Given the lack of systematic polyprenylated acylphloroglucinols (PPAPs) research on traditional Chinese medicine of Hypericum kouytchense, this plant was applied for the phytochemical study, which led to fifteen new PPAPs (1—15, PPAPs), along with 36 known PPAP derivatives. Their structures and absolute configurations were established by comprehensive spectral analysis and theoretical ECD and NMR calculations. Structurally, compound 1 possesses a rare fused 6/6/6/5/5 pentacyclic ring system. Eleven compounds exhibited good multidrug resistance reversal activity (RF ranging from 5 to 53) in HepG2/ADR cells. Importantly, compound 34, the most potential MDR modulator, showed better reversal effect (RF: 53) than positive control, verapamil. The primary mechanistic study of compound 34, implied that this compound could prohibit the function of P-gp transport rather than its expression. The possible recognition mechanism between compound 34 and P-gp was predicted by molecular docking.
Supporting Information
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Appendix S1: Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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