Volume 42, Issue 24 pp. 3553-3558
Emerging Topic

Repurposing Naturally Occurring Enzymes Using Visible Light

Yuanyuan Xu

Yuanyuan Xu

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China

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Fulu Liu

Fulu Liu

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China

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Beibei Zhao

Beibei Zhao

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China

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Xiaoqiang Huang

Corresponding Author

Xiaoqiang Huang

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China

E-mail: [email protected]Search for more papers by this author
First published: 04 November 2024
Citations: 12

Abstract

Enzymes are natural treasure troves that hold multiple superiority. Enzymatic catalysis has become a powerful tool for asymmetric synthesis, though it is typically limited to a relatively narrow range of reaction types. By integrating the advantages of enzymatic catalysis with photocatalysis, photoenzymatic catalysis not only expands the catalytic capabilities of enzymes but also provides an effective strategy for the stereo-control of photochemical reactions, thereby emerging as a significant research field. Herein, we focus on new-to-nature photoenzymatic catalysis by repurposing naturally occurring enzymes with visible light. We highlight the seminal work in reshaping various classes of enzymes, emphasizing their catalytic mechanism and synthetic potentials.

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