Recent Advances
Enantioselective Borylative Functionalization of Internal Alkenes: A Platform for Constructing Vicinal Stereocenters†
Yu-Shen Zhu,
Jia-Xin Li,
Hao-Tian Zhao,
Bo Su,
Yu-Shen Zhu
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
Search for more papers by this authorJia-Xin Li
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
Search for more papers by this authorHao-Tian Zhao
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
Search for more papers by this authorCorresponding Author
Bo Su
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
E-mail: [email protected]Search for more papers by this authorYu-Shen Zhu,
Jia-Xin Li,
Hao-Tian Zhao,
Bo Su,
Yu-Shen Zhu
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
Search for more papers by this authorJia-Xin Li
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
Search for more papers by this authorHao-Tian Zhao
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
Search for more papers by this authorCorresponding Author
Bo Su
State Key Laboratory of Medical Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071 China
E-mail: [email protected]Search for more papers by this author†
† Dedicated to the Special Issue of Boron Chemistry.
Comprehensive Summary
Vicinal stereogenic centers are ubiquitous structural scaffolds in both natural products and synthetic compounds, yet their enantioselective construction remains a significant challenge in organic synthesis. Organoboron compounds are of paramount importance in synthetic chemistry due to their ability to undergo facile transformations, yielding diverse essential chemical bonds such as carbon-carbon, carbon-oxygen, carbon-nitrogen, and carbon-halogen bonds. Transition-metal-catalyzed asymmetric borylative functionalizations of internal alkenes offer a promising strategy for the enantioselective installation of two adjacent chiral centers across carbon-carbon bonds. By leveraging the versatile transformations of the newly introduced boryl unit, this approach holds great potential for expanding the structural diversity of vicinal stereogenic scaffolds. In this concise review, we aim to highlight recent advancements in transition-metal-catalyzed asymmetric borylative functionalizations of internal alkenes, underscore their utility as a versatile approach for constructing vicinal stereogenic centers, and discuss unsolved challenges and future directions in this field.
Key Scientists
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