The cover image is based on the Original Article Natural remedies medicine derived from flaxseed (secoisolariciresinol diglucoside, lignans, and α-linolenic acid) improve network targeting efficiency of diabetic heart conditions based on computational chemistry techniques and pharmacophore modeling by Fatemeh Hajibabaie et al., https://doi.org/10.1111/jfbc.14480.

The mechanism of action of Melatonin and EGCG nutraceuticals in alleviating severe symptoms of COVID-19 illness by reducing oxidative stress and inflammation is elucidated in this review. Both phytochemicals provide a safe alternative to medications for preventing SARS-CoV-2 infection and increasing patients' immunity by modifying signaling pathways via upregulation of Sirtuin1 protein.

The literature shows that phenolic compounds maintain an adequate immune response, by regulating the expression and activity of pro- and anti-inflammatory mediators in various organs and tissues. Their activities in the central nervous system are particularly notable since uncontrolled central inflammation can be potentially life-threatening. Some compounds can even act therapeutically, if administered within hours of an acute inflammatory event.

Key points: Kaempferol (KMP) exerts its ameliorative actions via attenuating oxidative stress and inflammation, reducing Aβ-induced neurotoxicity, and regulating the cholinergic system.

The TMA/TMAO pathway represents one of many microbe-dependent pathways that will ultimately be linked to CHD pathogenesis Molecular docking results found that baicalein, fisetin, acacetin, and myricetin in flavonoid aglycones, and baicalin, naringin and hesperidin in flavonoid glycosides had good binding effects on TMA-lyase, which were the most active and could be used as lead compounds for structural modification.

Sources, extraction and application of inulin.

Breast cancer (BC) is one of the most challenging cancers to treat. Nutraceuticals acting by attenuating Hedgehog, NF-κB, and Wnt/β-catenin pathways. Nutraceuticals have medical characteristics and may cure cancer

Phenolics from oregano: potential adjuvants against diabetes mellitus.

Pictorial represenatation of disogenin in diabetes management.

Black garlic and its biological significance.

Neuroprotective role of Naringenin in Alzheimer's and Parkinson's Disease.

Alzheimer's disease (AD) is a neurological illness that causes memory loss over time. Preclinical and clinical studies were investigated for the Anti-Alzheimer's activity of nutraceuticals. This review showed therapeutic approaches of Nutraceuticals in the prevention of AD.

• Osteoarthritis caused by aging articular cartilage functions until homeostatic systems fail.
• Nutraceuticals offer anti-inflammatory and antioxidant characteristics.
• Nutraceuticals target Wnt/β-catenin and NF-κB pathways that may cure osteoarthritis.

Hovenia acerba Lindl. contains abundant phytochemicals (flavonoids, triterpenoid saponins, organic acids, other compounds) and possesses multiple biological activities (anti-alcoholism, hepatoprotective, anti-oxidant, hypoglycemic, immunomodulatory, and other activities). This review may provide essential guidance for the further utilization of H. acerba Lindl. in food and pharmaceutical industry.

An overview of nutritional, pharmaceutical, and economical importance of Euryale ferox.

• Liver fibrosis is a global health concern and dysregulation of key signaling pathways are reported in activated hepatic stellate cells.
• Phytochemicals offered hepatoprotection and modulated signaling pathways that are dysregulated in hepatic stellate cells during liver fibrosis.

This review summarizes the volatile compounds generated by lipid degradation, influencing factors on lipolysis and lipid oxidation, and the application of lipidomics analysis in the flavor formation of meat and meat products.

In many regions of India, Arenga pinnata and its allied species are used as food, household products, medicines, pharmaceuticals, fiber, and many more. However, they have not received proper recognition in conventional commercial markets as researchers and policymakers do not consider them so-called industrial crops. But scientists in many different countries have done a lot of clinical, biochemical, and application-based tests on them, and the results have led to them being widely used as medicine and industrial crops.

Moringa oleifera extract was prepared using various parts of the moringa plant, and oral administration in rats produced neuroprotective action against various neurological disorders via increasing the expression of Nrf2/HO-1 signaling and decreasing NFκB expression. As a result, it inhibits ROS generation, apoptosis, and inflammation. In the future, for enhancing the bioavailability of moringa, nanoparticle-based approach could be used to treat brain disorders.

A variety of naturally occuring sesquiterpenes could be promising lead moieties for the development of potent anti-viral drugs.

Quercetin is a flavonoid widely found in numerous vegetables, fruits, and foods and has antioxidant and anti-inflammatory properties. Quercetin improves chemotherapy sensitivity of pancreatic cancer. Quercetin prevents chemotherapy resistance of pancreatic cancer by regulating oxidative-inflammatory networks, which induce immune escape of cancer cells.

• Aging is a significant risk factor for the majority of prevalent human illnesses.
• α-klotho upregulation extends life and slows the onset of many age-related illnesses.
• We studied the mechanism of the combination of quercetin and dasatinib as senolytic.
• Senolytic drugs boost aging animals' adipose and cardiac progenitor cell activity.

Amazonian fruits have bioactive molecules, which present antioxidant activity, modulate inflammatory cytokines and assist in tissue regeneration and functions. Thus, they can help reduce the clinical complications caused by aging and aggravated by COVID-19, and may even decrease SARS-COV-2 infection.

A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described.

• Chlorogenic acid improved food allergy in the BALB/C mice.
• Chlorogenic acid improved food allergy by the regulation of AMPK/ACC/CPT-1 pathway.
• Fatty acid oxidation is related to food allergy.

The different active fresh-keeping forms of essential oils on peaches and other fruits were reviewed, which provided ideas and methods for the future preservation of essential oils.

This paper discuss about the nephroprotective effect of daphnetin against the hyperoxaluria-induced renal injury in rats via alteration of oxidative stress, inflammation and gut microbiota.

Cardioprotective effect of Gongronema latifolium leaves extract.

Chrysin ameliorated obesity, insulin resistance, kidney injury, decreased renal function, lipid accumulation, inflammation, and oxidative stress, commonly found in DN. Chrysin could modulate lipid metabolism and regulate the AMPK signaling pathway in the kidney and it is necessary for the effects of chrysin on DN. Chrysin improved DN by regulating lipid metabolism, and the effects partially depend on the activation of AMPK.

Lutein reduced the level of oxidative stress and regulated the apoptosis cascade triggered by MGO in PC12 cells via the PI3K/Akt signaling pathway.

Different commercial sources of hydrolyzed collagen (fish, porcine, and bovine) showed antioxidant bioactivity, analyzed by ORAC, ABTS, and DNA protection; and inhibition of glucose gastrointestinal enzymes (alpha-amylase and alpha-glucosidase inhibition). Porcine collagen was more effective on in vitro antioxidant activity, while fish collagen showed significant DNA protection. For the first time, the inhibitory activity of collagen hydrolysates against gastrointestinal hypoglycemic enzymes was shown.

A surplus of unused parts of vegetables (e.g., white cabbage cores and outer leaves) is generated daily by factories of fresh-cut vegetables. Anaerobic fermentation of these vegetable residues with protease (Sumizyme FP) and Pediococcus pentosaceus did not produced l-ornithine, however, when eggshell was added to them, large amounts of l-ornithine were stably produced. These fermented products are sustainable food ingredients with the potential health benefits of l-ornithine.

This study for the first time reported antidiabetic potential of Hawaijar, an indigenous fermented soybean food of Northeast India. Supplementation with aqueous extract of Hawaijar stimulated phospho-PI3K/phospho-AKT/phospho-AMPK/GLUT4 signaling cascades of glucose metabolism in high-glucose-treated cultured myotubes and muscle tissues of high-fat-diet-fed diabetic rats. Higher abundance of bioactive compounds (isoflavones/proteins/peptides) in Hawaijar may be responsible for the alleviation of impaired glucose metabolism associated with diabetes. This finding may be helpful for the development of a novel antidiabetic therapeutic.

BRE from Berberis lycIum and berberine markedly decreased the paw diameter and inflammatory mediators in carrageenan and formaldehyde-induced inflammation. The levels of antioxidant enzymes were recovered with remarkable downregulation in mRNA and protein expression of inflammatory biomarkers. It is suggested that BRE obtained by microwave-assisted extraction technique is a natural, green, and therapeutically bioequivalent to berberine that could be used as an economical phytomedicine in the treatment of inflammatory disorders.

This project aims to optimize the NSPI extraction process and evaluate its physicochemical and functional properties for potential applications in the food industry. The methodology used ground Nigella sativa seeds, which underwent Soxhlet extraction to produce defatted seedcake flour. The NSPI extraction from defatted seedcake flour was optimized using the RSM approach, and the final product was characterized for its properties.

After being fed with sea cucumber polysaccharides, the serum levels of TC, TG, LDL-C and MDA in the high-fat group were significantly increased, the serum levels of HDL-C, SOD, CAT, GSH-Px, ALT and AST were decreased; HLP inhibited the expression of ACC, CD36, TNF-α and NF-κB, decreased the accumulation of lipid and the secretion of inflammatory factors in liver. HLP relieved hyperlipidemia mainly by regulating lipid metabolism and regulating inflammatory factors.

C. fragile extract (CFE) is effective in inducing weight loss and suppressing adipocyte differentiation, along with the improvement of obesity-associated fatty liver in mice fed with a high-fat diet (HFD).

The underlying anti-inflammatory mechanism of Prunus cerasifera Ehrhart was investigated through network pharmacology in combination with Western Blot and ELISA experiments. The Network pharmacology analysis results indicated that P. cerasifera was related to TNF signaling pathway, inflammatory cytokine, and MAPK signaling pathway. In vitro experiment results showed that P. cerasifera exerted anti-inflammatory effect via NF-κB (p65), MAPKs, cell pyrolysis, and Nrf2/HO-1 pathways. It could be further applied as a safe anti-inflammatory agent from the natural source.

• Exercise and green tea reduced BNIP3, IGFBP3, Bax, and caspase-3 in the aging heart.
• Exercise and green tea provide a cardioprotective effect with increasing MDA.
• The interaction of green tea with exercise decreased Bax/Bcl-2 ratio.

• The expression of sodium–potassium pump in heart, kidney, and aortic tissues
• The activity of renin–angiotensin II–aldosterone system in kidney
• Antioxidant and anti-inflammatory activities in the heart, aorta, and kidneys, and metabolic factors.
• The expression of eNOS and increase in NO bioavailability

Hibiscus sabdariffa ameliorates oxidative hepatic injury via mitigating oxidative stress and facilitates muscle glucose uptake while inhibiting carbohydrate digestive enzymes and intestinal glucose absorption.

MdMCs had varying expression patterns in “Golden delicious” and “Fuji” during ripening. PCD was initiated earlier in “Golden delicious” than in “Fuji” based on TEM and DNA ladder assay.

PSAE showed protective effects on the indicators of glycolipid metabolism. PSAE significantly increased the protein levels of p-IRS1, PI3K, p-AKT, and p-GSK3β in a dose-dependent manner in the model mice. PSAE can effectively regulate glucose and lipid metabolism during the development of T2DM in mice via regulation of IRS1/PI3K/Akt/GSK3β pathway.

In order to provide a basis for application of Walnut diaphragm in functional food, the chemical constituents and activities of it were conducted. Seven phenolic compounds were isolated and activity experiments showed that compounds 1 and 2 had the strongest inhibitory activity against α-amylase in a mixed-competitive inhibition manner.

Citric acid decreased liver index, HDL-C blood, glucose and insulin resistance index, while reduced levels of TG, TC and LDL-C. Citric acid down-regulated mRNA and protein expression levels of G-6-Pase, while up-regulated mRNA and protein expression levels of GLUT-4. Citric acid increased the contents of acetic, propionic and butyric acids.

Flavourzyme addition accelerated the hydrolysis of protein in fermented grass carp. Flavourzyme addition promoted the generation of water-soluble flavor substances. Flavourzyme addition gives fermented products a more intense umami taste and odor.

To achieve effective encapsulation of black pepper essential oil and an excellent anti-triple negative breast cancer activity, nanoparticles loaded with BP-EO were prepared using Eudragit L100 as the carrier by the nanoprecipitation method. The results showed that the developed nanoparticles had an average size of around 178 nm, a zeta-potential of −57 mV, and an encapsulation efficiency equal to 89% with a loading capacity of 0.46 mg·mg⁻¹. The in vitro study revealed that BP-EO NPs inhibited proliferation, migration and invasion of MDA-MB-231 cells via inhibiting the Wnt/β-Catenin signaling pathway.

• The ketogenic diets (KD) and different doses of curcumin and Oldenlandia diffusa extract (ODE) could induce apoptosis and the Akt/mTORC1 pathway and inhibit inflammation, oxidative damage, and angiogenesis in the gastric tissue.
• The KD could significantly increase the efficacy of ODE and curcumin which may be due to an increase in miR-340 expression.
• It suggested that the KD as adjunctive therapy along with conventional therapies in traditional medicine could be considered a useful solution to prevent and treat gastric cancer.

• Nar-SLNs protected PC12 cells against STZ-induced neurotoxicity.
• Nar-SLNs decreased autophagic markers, including LC3-II, Beclin1, Akt, ATG5 genes, as well as miR-21 and miR-22.
• Nar-SLNs reversed mitochondrial dysfunction by augmenting MMP.

Euryale ferox Salisb acts primarily against DKD through oleic acid and vitamin E, targeting the protein encoded by PPARA, LPL, FABP1, MAPK1 to regulate TNF, apoptosis, MAPK, and other signaling pathways.

In silico is an efficient approach to screening ACE inhibitory peptides and studying their properties. Four novels ACE inhibitory peptides were screened from the walnut protein hydrolysates. Amino acids such as Pro have essential effects on ACE inhibitory activity of bioactive walnut peptides.

1. Fucoidans from four different brown seaweeds have been isolated studied for cardioprotective properties.
2. Fucoidan from S. wightii increased the cytoprotection through increasing Nrf2 and its regulated genes expression against high glucose-induced oxidative stress in H9c2 cells.
3. Fucoidan from S. wightii protected the cells via increasing the MMP by decreasing the intracellular ROS generation.

This work was focused on the isolation and characterization of earthworm thrombolytic peptides from the hydrolysate of Pheretima vulgaris. Novel thrombolytic peptides showed excellent potential in preventing the formation of thrombus, degrading existing thrombus.

In the present study, epigallocatechin gallate (EGCG) showed the significant cross-linking effects on carp myofibrillar protein and further improved its physicochemical properties. All results suggested that EGCG had the potential to increase the cross-linking degree of fish myofibrillar protein and improve its properties, so as to ameliorate the quality of fish meat during processing and storage.

Mechanisms of health benefits of physical activity and hemp seed: 1. Exercise a) could improve the lipid profile and anthropometric indices by regulating lipoprotein lipase, diminishing lipid stress by increasing TCA cycle flux and coupling ligand-induced PPAR activity with PGC1 mediated remodeling of downstream metabolic pathways, leading to an enhanced mitochondrial performance in restoring insulin sensitivity; b) enhance BDNF expression in the hippocampus 2. Hemp seed a) may modulate lipid profile by its high content of phytosterols and proper ɷ-6/ɷ-3 ratio b) upregulate BDNF expression.

Ginkgo biloba exerts synergistic effects in treating T2DM combined with NAFLD through multi-ingredients, multi-targets, and multi-pathways.

The administration of two amino acids (L-alanine and L-glutamine) shows a remarkable improvement in circulating blood glucose, important biochemical parameters, and histological features in diabetes.

In this study, anti-inflammatory activity of GEP from Lactobacillus fermentum-fermented water solution of rice bran was evaluated on lipopolysaccharide-activated macrophage model. The anti-inflammatory activity of GEP was determined due to suppressing Toll-like receptor 4-mitogen-activated protein kinase/nuclear factor-κB signaling cascades, leading to the attenuation of inflammatory mediator production.

This paper reported the chemoprotective effect of 6- Shogaol, 6-[S] derived from ginger extract on azoxymethane (AOM) and dextran sulphate sodium (DSS)-induced colorectal adenoma in mice. Treatment with 6-[S] prevented tubular adenoma and dysplasia in the colon of AOM/DSS treated Mice. 6S prevented colonic oxidative stress in AOM/DSS treated mice as well as colonic inflammation in AOM/DSS treated mice.

The antidiabetic activity of tiger nut and date fruit blend (TDB) was reported in both in vitro and in vivo models. At the end of the study, TDB demonstrated promising anti-hyperglycemic, anti-hyperlipidemic and antioxidant activities, as well as improved pancreatic β-cell function and ameliorated insulin resistance. In addition, TDB showed potent inhibition against the α-amylase and α-glucosidase activities.

Experimental illustration of lactic acid bacteria hydrolysis of casein or β-casein.

In this study, a D-galactose-induced aging mouse model was used to investigate the effects and potential mechanisms of RRT glucosides and quercetin on antioxidant stress and inflammation in aging, as well as to assess their protective effect in conjunction with pathological sections of the liver and brain. The results show that the anti-aging activity of RRT glycoside and quercetin could be linked to the Nrf2/HO-1 signaling pathway.

Biochanin A reduces the fat accumulation in OA-treated HepG2 cells by activating SIRT3/AMPK/ULK-1-mediated autophagy. This study provides a theoretical basis for the effect of Bio-A on hepatic steatosis-related diseases.

This work show the effect of fructose on adipose differentiation. High levels of fructose increase the expansion of genes such as C/EBPβ, PPARγ, and NOX4 as well as the increase in XOR activity and high production of ROS during the differentiation process.

This study showed that boiled unripe plantains were effective to restore the biochemical impairment caused by diabetes mellitus as well as to raise HDL-c levels and reduce lipid peroxidation in the studied animal models.

BG decreased the serum and liver TG concentration and serum LDL levels. BG reduced the serum levels of IL-6 and TNF-α and the hepatic expression of α-SMA and Col1α1. BG exerted a liver protective effect via regulating the TLR4/NF-κB pathway.

Ultrasonic assisted extraction of swertisin from sour Jujube seed and comprehensive revelation of its antioxidant activity.

Treatment and outcome paradigm.

The mechanism of trypsin on the WRKY TFs during H. undatus storage was investigated. To verify the hub WRKY gene of H. undatus in trypsin preservation, joint analysis of transcriptome and protein–protein interaction (PPI) network was carried out, and virus-induced gene silencing (VIGS) was conducted.

Anti-inflammatory potential of an oregano phenolics extract.

The high dose level of curcumin nanoemulsion (CH) was superior to the low dose (CL) and conventional curcumin (CC) in ameliorating the high-fat/high-fructose-induced insulin resistance status and hyperlipidemia.

This study investigated the volatile flavor substances of cattle by-products from various parts (heart, liver, lung, rumen and intestine) by HS-SPEM/GC-MS. 16 volatile compounds were labeled as the major characteristic off-flavor substances in 5 different parts of cattle. The best deodorization effect of ultrasound + chitosan composite method.

Hesperidin ameliorates rat splenic apoptosis caused by diabetes. This effect is associated with suppression of oxidative stress and inflammatory status, and modulation of the Bcl-2 family proteins.

Hyphaene thebaica fruit in rat model of colon carcinogenesis.

GPs can significantly protect hypoxia-induced PC12 cell injury by regulating the content of NO and Ca²⁺ and protecting the normal function of mitochondria. In addition, GPs can also significantly enhance the tolerance of C57BL/6 mice to hypoxia.

Antidiabetic and ACE inhibitory peptides from fermented dromedary camel milk (Indian Breed) with Lacticaseibacillus paracasei (M11) and anti-inflammatory property in RAW 264.7 cells.

In comparison to subcutaneous insulin, CMCNPs and AuNPs showed a favorable effect on pyruvate kinase and Glucokinase gene expressions. Additionally, we found that conjugating insulin to CMCNPs and AuNPs enables controlled bioavailability by protecting insulin from the physiological barriers. We also focused at their histological effects on the liver and pancreas and numerous other criteria. Revealed that both had a considerable impact in vivo, enabling glucose level management, and enhancing the functions of the rats' organs.

Mechanisms of inhibiting lipid accumulation of Schisandrin C in 3T3-L1 adipocytes.

Effect of ethanolic extract of root from Arctium lappa L (ALE) on obesity-related hepatic steatosis. ALE inhibits hepatic steatosis by enhancing fatty acid β-oxidation through AMPK/ACC/CPT-1 pathway.

Our data demonstrated that bitter melon saponins exerted the anti-aging and anti-oxidation abilities represented by strengthening the locomotive activities, delaying muscle fiber damage with age, reducing ROS accumulation, and improving the SOD and CAT levels, accompanied by the extension of lifespan. The mechanistic study revealed that the IIS pathway linked with sir-2.1 and hlh-30 transcriptional factors jointly to activate the downstream targets to increase the survival rate under oxidative stress.

• A total of 50 compounds were detected and tentatively identified in a methanol–water (60:40, v/v) extract of hawthorn.
• A feasible compound–target–pathway network pharmacology model was established.
• The potential core active compounds, targets, and pathways of hawthorn in the prevention and treatment of atherosclerosis were screened.
• Further molecular docking results indicated that the potential core active compounds had strong hydrogen bonding abilities with the core targets.

• The effect of simulated digestions on Huangshan Gongju phenolics and their activity was explored.
• The content and antioxidant activity of the phenolics varied with the digestion steps.
• One phenolic acid and two flavonoids showed higher recovery (>64.29%) after simulated digestions.

Poly I:C, a dsRNA viral analog, mimics viral infection and induces an innate immune response. Pectic oligosaccharides activated mucosal immunity in mice by stimulateing the production of IgA, anti-inflammatory cytokines and SCFA, thereby alleviating virus-like infection in poly I:C induced mice

Forsythia suspensa (Thunb.) Vahl (Oleaceae) leaves are valuable sources of phillygenin. Phillygenin was successfully extracted and isolated from F. suspensa leaves after fermentation and reduced the number of writhing induced by acetic acid, prolonged the latency period in the hot plate test, inhibited the xylene-induced ear edema and carrageenan-induced paw edema, decreased inflammatory mediators production, and regulated iNOS and COX-2 and NF-κB signal proteins expressions. Our study suggest that phillygenin may contribute to managing pain and inflammation-mediated disorders.

Dietary modifications combined with aerobic exercise are currently an effective method for weight loss. Tea seed saponins (TSS) are a variety of biologically active oleanolane-type pentacyclic triterpenoid saponins that naturally exist in tea seeds. In this study, the high fat diet-induced obese mice model to explore the mechanism of TSS with aerobic exercise (AE) in regulating lipid metabolism and its associated oxidative stress damage will help provide reliable data for the application of dietary nutrition combined with AE in anti-obesity.

(a) Experimental design and (b) research timeline of the study.

Resveratrol inhibited hepatic stellate cells (HSCs) activation by inducing autophagy and apoptosis in a dose-dependent manner. The Sirtuin1 (SIRT1) inhibitor EX527 reversed autophagy, and the c-Jun N-terminal kinase (JNK) inhibitor SP600125 reversed both autophagy and apoptosis induced by resveratrol. These findings suggest that the SIRT1 and JNK signaling pathways may be involved in the resveratrol-mediated inhibition of HSC activation by regulating autophagy and apoptosis.

Nerolidol and cisplatin generates increased ROS and leads to early apoptosis in Hep 2 cells

Administration of FPD (Fruit extract of Pithecellobium dulce) significantly reduced metastatic cascade via regulating EGFR/STAT/ NFκB /AKT signaling axis, thus representing a promising strategy against cancer progression and metastasis.

Figure 10. Schematic representation of the mechanisms by which garlic and Citrullus colocynthis reduce testicular damage in diabetic rats. Diabetes mellitus causes testicular damage through AGEs/RAGE/Nox-4 pathway and subsequent oxidative stress, inflammation, and apoptosis. The combination of garlic and C. colocynthis could significantly inhibit this pathway and the resulting complications.

Schematic illustration of the inhibitory effect of caryophyllene oxide (CPO) on the invasion of fibrosarcoma cells through the inhibition of MAPKs such as ERK and p38 as well as the suppression of MMP-2 and MMP-9.

The black-bone silky fowl peptide (BSFP) was produced by enzymatic digestion of black-bone silky fowl. The peptide sequences in BSFP were identified by HPLC-MS/MS technique and found to contain four peptides (EF, EEL, EHPT, and AGGF). The positive effects of BSFP and the four characteristic peptides in antioxidant and immunomodulation were verified experimentally.

This study investigated the differences in meat quality during postmortem aging of yak meat at different altitudes and the relationship between hypoxic factor HIF-1α release and meat quality. As Journal of Food Biochemistry has a long-standing interest in publishing research related to the meat quality field, we feel your readership will be interested in this study that contributes to further understanding changes in meat quality during aging.

Fructose drinking water (FDW) altered the serum leptin, triacylglycerol, and C-reactive protein levels of the rats, inducing hypertriglyceridemia, oxidative stress, and inflammation in their liver (but not their skeletal muscle) and insulin resistance which was modulated by tert-butylhydroquinone (tBHQ). These biochemical findings were corroborated by liver and muscle histology.

Boehmeria nivea (BN) extracts showed antioxidant, anti-cancer cell proliferative, neuroprotective, and estrogenic activity. Moreover, BN has inhibitory effects on pro-inflammatory gene expression and lipid accumulation. Four active constituents (isoquercitrin, caffeic acid, p-coumaric acid, and rutin) were isolated and identified from the BN leaf extract, and they exhibited potent antioxidant activity.

Gingko biloba supplement suppresses the effect of low blood oxygen tension in hypothyroidism. Gingko biloba supplement prevents endothelial abnormalities via nitric oxide release and endothelin decrease in hypothyroidism.

Metabolomic analysis reveals the quality characteristics of Yi Gong tea leaves at different harvesting periods.

This study explored that SAL compounds improved the function and myogenesis of H9c2 cells in hyperlipidemic and hyperglycemic conditions. Our data suggested that phytochemicals obtained from flaxseed might have proposed potential complementary treatment or preventive strategies for MI. Moreover, we found druggable candidate proteins based on the chemoinformatics analysis. This study displayed that the TNF-α, IL6, SIRT1, NRF1, NPPA, and FGF7 are vital hub genes in MI induced by hyperlipidemic and hyperglycemic.

Postharvest qulaity preservation and shelf life extension of mango fruit using hydrocollod edible coating.

Treatment of cultured skin fibroblasts with fresh garlic extract enhanced the UV-B-induced reduction of cell viability, whereas that with aged garlic extract (AGE) inhibited the reduction of cell viability. The protective effects against UV-B-induced cell death were observed not only in the non-volatile fraction but also in the volatile fraction of AGE. This is the first report demonstrating that characteristic volatile compounds generated during the aging process of garlic have a high potency for improving skin health.

We first isolated a new 16-amino-acid peptide from Eucheuma and named EZY-1, which can inhibit IPF. In vitro and in vivo assays show peptide EZY-1 is safe.

Hesperetin, neohesperidin, naringenin and naringin exhibited higher inhibitory activities than kojic acid. Hesperetin and naringenin were reversible inhibitors on tyrosinase in the mixed-type manner. H-bond and hydrophobic interactions were found to drive the binding of tyrosinase with hesperetin or naringenin, which subsequently decreased the α-helix ratio and increased the β-turn, β-sheet and random coil ratio in tyrosinase.

Pigeon pea was hydrolyzed and subjected to high performance liquid chromatography (HPLC) purification and sequencing to obtain bioactive peptides which possesses multifunctional properties namely functional ingredient, antioxidant property and ability to inhibit activities of angiotensin-converting enzyme (ACE) and Renin.

Catechin, rutin and quercetin in Quercus mongolica Fisch leaves exert inhibitory effects on multiple cancer cells by inducing apoptosis of tumor cells and inhibiting tumor cell growth.

Overall pictorial summary of protective effect of the test WT-F samples on in-vitro RA, oxidation, inflammatory cytokines, inflammatory markers of p-STAT3 expression, colon cancer cell lines proliferation comparing with GT-F.

• VEGFα, GATA4, GJA1 axis and associated miRNAs modified by exercise and proanthocyanidin in rats with myocardial ischemia.
• Exercise training and Proanthocyanidin has protective role.

The study mainly includes three key findings: (1) The extraction rate of Chinese yam peel polysaccharides (CYPP) was up to 8.81 ± 1.48% after optimization; (2) CYPP-1 was the main purified peak of CYPP, and its physicochemical properties were researched; and (3) CYPP-1 showed excellent antioxidant, immunoregulatory, and hypoglycemic effects in vitro.

Regular intake of C. rubens leaf interrupts the physiologic build-up of systemic oxidative stress and ameliorates the deleterious biologic effects of environmental chemical toxicants on major organs.

Based on the basic theory, the combination of network pharmacology and experimental evaluation, this study demonstrated the superiority of phlorotannins in the effective substance of T2DM through multi-target and multi-channel comprehensive regulation. Exploring the potential functional factors and mechanisms of action in seaweeds can provide a new way to develop new biological agents for treating on T2DM.

Ark shell protein hydrolysate was prepared using Alcalase®, and it showed promising anti-inflammatory activity through regulating the MAPK-dependent HO-1/Nrf2 pathway in LPS-stimulated RAW264.7 murine macrophages.

The effects of olive leaf extract in diabetic cardiomyopathy were evaluated. Diabetes was induced by single dose STZ-injection in rats. FBS and Heart-to-body weight ratio were reduced in all treated rats. Olive leaf extract ameliorated oxidative stress in heart tissue of diabetic rats. Cardiac hypertrophy and fibrosis were diminished in treated rats. Left ventricular dysfunction was improved in treated rats.

This study reports the first large-scale acetylome analysis of wheat seeds after artificial aging treatment. The results show that lysine-acetylation results in a weaker oxidative stress response and lower energy production efficiency, resulting in the apoptosis of wheat seed cells, insufficient energy supply, and consequently, marked loss of seed vigor.

Protective effects of Dendrobium huoshanense polysaccharide on D-gal induced PC12 cells and aging mice, in vitro and in vivo studies.

Benincasa hispida extract significantly attenuate high salt-induced hypertension in Dahl salt-sensitive rats.

Aqueous extracts from Ecklonia maxima and Ulva rigida exhibited antiproliferative and apoptotic-inducing effects by exerting cytotoxic effects, inhibiting uncontrollable cell proliferation, induction of apoptosis, production of reactive oxygen species, reduction mitochondria membrane potential and alteration in antioxidant defense mechanism.

Effect of yoghurt supplemented with rice dietary fibers (RDF), rice bran (RB), wheat dietary fibers (WDF), or wheat brans (WB) on hypercholesterolemic rats.

• The marine-derived β-glucan laminarin alleviates liver damage of ALD mice;
• Laminarin regulates hepatic ALD-related gene expressions;
• Laminarin ameliorates ALD through regulation of CYP450, retinol metabolism, Wnt, and cAMP pathway.