Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice
Tong Liu
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorXuefei Hu
Department of Environmental Health, Naval Medical University, Shanghai, People's Republic of China
Search for more papers by this authorPeng Chen
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorRenlingzi Zhang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorShouqin Zhang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorCorresponding Author
Wenjun Chang
Department of Environmental Health, Naval Medical University, Shanghai, People's Republic of China
Correspondence
Wenjun Chang, Department of Environmental Health, Naval Medical University, Shanghai 200433, People's Republic of China.
Email: [email protected]; [email protected]
Junjie Wang and Sheng Wang, Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Junjie Wang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Correspondence
Wenjun Chang, Department of Environmental Health, Naval Medical University, Shanghai 200433, People's Republic of China.
Email: [email protected]; [email protected]
Junjie Wang and Sheng Wang, Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Sheng Wang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Correspondence
Wenjun Chang, Department of Environmental Health, Naval Medical University, Shanghai 200433, People's Republic of China.
Email: [email protected]; [email protected]
Junjie Wang and Sheng Wang, Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorTong Liu
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorXuefei Hu
Department of Environmental Health, Naval Medical University, Shanghai, People's Republic of China
Search for more papers by this authorPeng Chen
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorRenlingzi Zhang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorShouqin Zhang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Search for more papers by this authorCorresponding Author
Wenjun Chang
Department of Environmental Health, Naval Medical University, Shanghai, People's Republic of China
Correspondence
Wenjun Chang, Department of Environmental Health, Naval Medical University, Shanghai 200433, People's Republic of China.
Email: [email protected]; [email protected]
Junjie Wang and Sheng Wang, Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Junjie Wang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Correspondence
Wenjun Chang, Department of Environmental Health, Naval Medical University, Shanghai 200433, People's Republic of China.
Email: [email protected]; [email protected]
Junjie Wang and Sheng Wang, Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Sheng Wang
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China
Correspondence
Wenjun Chang, Department of Environmental Health, Naval Medical University, Shanghai 200433, People's Republic of China.
Email: [email protected]; [email protected]
Junjie Wang and Sheng Wang, Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorAbstract
Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function. However, its role in healthy states remains unclear. The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice. Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice. In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms. Therefore, the long-term use of PHGG as a nutritional product still requires further investigation.
Practical applications
As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention. While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states. Currently, the scientific community and regulatory authorities are beginning to pay attention to these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties. Studies exploring the rationality of these prebiotics as nutraceuticals for use in health states are essential. This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period. It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent..
CONFLICT OF INTEREST
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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