ORIGINAL ARTICLE
Curcumin nanoemulsion counteracts hepatic and cardiac complications associated with high-fat/high-fructose diet in rats
Marawan Abd Elbaset,
Maha Nasr,
Bassant M. M. Ibrahim,
Omar A. H. Ahmed-Farid,
Rofanda M. Bakeer,
Nabila S. Hassan,
Rania F. Ahmed,
Marawan Abd Elbaset
Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorCorresponding Author
Maha Nasr
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
Correspondence
Maha Nasr, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Egypt.
Email: [email protected]
Search for more papers by this authorBassant M. M. Ibrahim
Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorOmar A. H. Ahmed-Farid
Department of Physiology, National Organization for Drug Control and Research, Giza, Egypt
Search for more papers by this authorRofanda M. Bakeer
Department of Pathology, Faculty of Medicine, Helwan University, Helwan, Egypt
Search for more papers by this authorNabila S. Hassan
Department of Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorRania F. Ahmed
Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorMarawan Abd Elbaset,
Maha Nasr,
Bassant M. M. Ibrahim,
Omar A. H. Ahmed-Farid,
Rofanda M. Bakeer,
Nabila S. Hassan,
Rania F. Ahmed,
Marawan Abd Elbaset
Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorCorresponding Author
Maha Nasr
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
Correspondence
Maha Nasr, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Egypt.
Email: [email protected]
Search for more papers by this authorBassant M. M. Ibrahim
Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorOmar A. H. Ahmed-Farid
Department of Physiology, National Organization for Drug Control and Research, Giza, Egypt
Search for more papers by this authorRofanda M. Bakeer
Department of Pathology, Faculty of Medicine, Helwan University, Helwan, Egypt
Search for more papers by this authorNabila S. Hassan
Department of Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorRania F. Ahmed
Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Search for more papers by this authorAbstract
The relationship between the incidence of cardiovascular abnormalities and non-alcoholic fatty liver disease (NAFLD) has long been postulated. Curcumin (CUR) is a potential anti-atherosclerotic agent but its poor water solubility hinders its pharmacological use. Therefore, the present study aimed to investigate the effect of formulation of CUR nanoemulsion prepared using the spontaneous emulsification technique on high fat high fructose (HFHF)-induced hepatic and cardiac complications. Fifty Wistar rats were divided into five groups. CUR nanoemulsion at doses of 5 and 10 mg/kg and conventional powdered CUR at a dose of 50 mg/kg were orally administered daily to rats for two weeks, and compared with normal control and HFHF control. Results revealed that the high dose level of CUR nanoemulsion was superior to conventional CUR in ameliorating the HFHF-induced insulin resistance status and hyperlipidemia, with beneficial impact on rats' recorded electrocardiogram (ECG), serum aspartate aminotransferase (ALT) and alanine aminotransferase (AST) levels, leptin, adiponectin, creatine phosphokinase, lactate dehydrogenase and cardiac troponin-I. In addition, hepatic and cardiac oxidative and nitrosative stresses, oxidative DNA damage and disrupted cellular energy statuses were counteracted. Results were also confirmed by histopathological examination.
Practical applications
The use of curcumin nanoemulsion could be beneficial in combating hepatic and cardiac complications resulting from HFHF diets.
CONFLICT OF INTEREST
The authors declare that they have no competing interests.
Open Research
DATA AVAILABILITY STATEMENT
The corresponding author will provide the data used in the present work upon request.
Supporting Information
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Figure S1 |
| jfbc14442-sup-0002-Figure S2.docxWord 2007 document , 86.1 KB |
Figure S2 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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