Antioxidant potential, cytokines regulation, and inflammation-related genes expression of phenolic extracts from Mexican oregano
Nayely Leyva-López
Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Search for more papers by this authorCorresponding Author
Erick P. Gutiérrez-Grijalva
Laboratory of Functional Foods and Nutraceuticals, Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Correspondence
J. Basilio Heredia, Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Erick P. Gutiérrez-Grijalva, Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Search for more papers by this authorCorresponding Author
J. Basilio Heredia
Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Correspondence
J. Basilio Heredia, Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Erick P. Gutiérrez-Grijalva, Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Search for more papers by this authorRosalio Ramos-Payan
Faculty of Biological and Chemical Sciences, Universidad Autónoma de Sinaloa, Culiacán, Mexico
Search for more papers by this authorLaura A. Contreras-Angulo
Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Search for more papers by this authorJose R. Gonzalez-Galaviz
Cátedras CONACYT-Instituto Tecnológico de Sonora, Ciudad Obregón, Mexico
Search for more papers by this authorLibia Z. Rodriguez-Anaya
Cátedras CONACYT-Instituto Tecnológico de Sonora, Ciudad Obregón, Mexico
Search for more papers by this authorNayely Leyva-López
Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Search for more papers by this authorCorresponding Author
Erick P. Gutiérrez-Grijalva
Laboratory of Functional Foods and Nutraceuticals, Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Correspondence
J. Basilio Heredia, Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Erick P. Gutiérrez-Grijalva, Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Search for more papers by this authorCorresponding Author
J. Basilio Heredia
Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Correspondence
J. Basilio Heredia, Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Erick P. Gutiérrez-Grijalva, Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, 80110, Mexico.
Email: [email protected]
Search for more papers by this authorRosalio Ramos-Payan
Faculty of Biological and Chemical Sciences, Universidad Autónoma de Sinaloa, Culiacán, Mexico
Search for more papers by this authorLaura A. Contreras-Angulo
Centro de Investigación en Alimentación y Desarrollo, A.C., Culiacán, Mexico
Search for more papers by this authorJose R. Gonzalez-Galaviz
Cátedras CONACYT-Instituto Tecnológico de Sonora, Ciudad Obregón, Mexico
Search for more papers by this authorLibia Z. Rodriguez-Anaya
Cátedras CONACYT-Instituto Tecnológico de Sonora, Ciudad Obregón, Mexico
Search for more papers by this authorAbstract
The Mexican population traditionally uses oregano infusions to treat oxidative and inflammation-related disorders. Therefore, this study was focused on the examination of the antioxidant capacity and potential against inflammation from three Mexican oregano species (Lippia graveolens [LG], Lippia palmeri [LP], and Hedeoma patens [HP]). The extracts from LG showed a superior total phenolic content. LG, LP, and HP exhibited a higher capacity to inhibit the radical DPPH (up to 90.33 ± 0.25%) and significantly lowered the release of MCP-1 and IL-6. At the same time, LG and HP increased the secretion of IL-10. Extracts from LG, LP, and HP did not significantly diminish the expression of il-1β or inos, although a slight decrease in inos expression was observed. Our findings support that phenolic extracts from L. graveolens, L. palmeri, and H. patens possess antioxidant and anti-inflammatory properties and might be potential therapeutic candidates against oxidative and inflammation-related diseases.
Practical applications
Oregano species have traditionally been exploited as remedies against inflammatory-related diseases, namely headaches, asthma, bowel disorders, and rheumatism. This study explored the antioxidant potential of three Mexican oregano species (Lippia graveolens, Lippia palmeri, and Hedeoma patens) and their anti-inflammatory effects in a murine cell model. Phenolic extracts from oregano showed antioxidant capacity and exerted activity against inflammation by improving anti-inflammatory cytokines secretion or negatively regulating pro-inflammatory cytokines. The results of our study demonstrate that the phenolic extracts from these Mexican oregano species have the potential in treating inflammation-related diseases.
CONFLICT OF INTEREST
The authors declare no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data used to support the findings of this study are included in the article.
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