REVIEW
Amazonian fruits with potential effects on COVID-19 by inflammaging modulation: A narrative review
Maria F. Manica-Cattani,
Ana L. Hoefel,
Verônica F. Azzolin,
Marco A. Echart Montano,
Ivo E. da Cruz Jung,
Euler E. Ribeiro,
Vitória F. Azzolin,
Ivana B. M. da Cruz,
Corresponding Author
Maria F. Manica-Cattani
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
FSG University Center (FSG), Nutrition School, Caxias do Sul, Rio Grande do Sul, Brazil
Correspondence
Maria F. Manica-Cattani, Third Age Open University (UnATI), 1048 Jose Aloysio Brugger Av – Jardim America, Caxias do Sul, RS, Brazil.
Email: [email protected]
Ivana B. M. da Cruz, Post-Graduate Program in Pharmacology, Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
Email: [email protected]
Search for more papers by this authorAna L. Hoefel
FSG University Center (FSG), Nutrition School, Caxias do Sul, Rio Grande do Sul, Brazil
Search for more papers by this authorVerônica F. Azzolin
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorMarco A. Echart Montano
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorIvo E. da Cruz Jung
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorEuler E. Ribeiro
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorVitória F. Azzolin
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorCorresponding Author
Ivana B. M. da Cruz
Post-Graduate Program in Pharmacology, Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil
Post-Graduate Program in Gerontology, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil
Correspondence
Maria F. Manica-Cattani, Third Age Open University (UnATI), 1048 Jose Aloysio Brugger Av – Jardim America, Caxias do Sul, RS, Brazil.
Email: [email protected]
Ivana B. M. da Cruz, Post-Graduate Program in Pharmacology, Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
Email: [email protected]
Search for more papers by this authorMaria F. Manica-Cattani,
Ana L. Hoefel,
Verônica F. Azzolin,
Marco A. Echart Montano,
Ivo E. da Cruz Jung,
Euler E. Ribeiro,
Vitória F. Azzolin,
Ivana B. M. da Cruz,
Corresponding Author
Maria F. Manica-Cattani
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
FSG University Center (FSG), Nutrition School, Caxias do Sul, Rio Grande do Sul, Brazil
Correspondence
Maria F. Manica-Cattani, Third Age Open University (UnATI), 1048 Jose Aloysio Brugger Av – Jardim America, Caxias do Sul, RS, Brazil.
Email: [email protected]
Ivana B. M. da Cruz, Post-Graduate Program in Pharmacology, Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
Email: [email protected]
Search for more papers by this authorAna L. Hoefel
FSG University Center (FSG), Nutrition School, Caxias do Sul, Rio Grande do Sul, Brazil
Search for more papers by this authorVerônica F. Azzolin
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorMarco A. Echart Montano
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorIvo E. da Cruz Jung
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorEuler E. Ribeiro
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorVitória F. Azzolin
Open University Foundation for the Third Age (FUnATI), Manaus, Amazonas, Brazil
Search for more papers by this authorCorresponding Author
Ivana B. M. da Cruz
Post-Graduate Program in Pharmacology, Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil
Post-Graduate Program in Gerontology, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil
Correspondence
Maria F. Manica-Cattani, Third Age Open University (UnATI), 1048 Jose Aloysio Brugger Av – Jardim America, Caxias do Sul, RS, Brazil.
Email: [email protected]
Ivana B. M. da Cruz, Post-Graduate Program in Pharmacology, Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
Email: [email protected]
Search for more papers by this authorAbstract
The COVID-19 pandemic had a great impact on the mortality of older adults and, chronic non- transmissible diseases (CNTDs) patients, likely previous inflammaging condition that is common in these subjects. It is possible that functional foods could attenuate viral infection conditions such as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the causal agent of COVID-19 pandemic. Previous evidence suggested that some fruits consumed by Amazonian Diet from Pre-Colombian times could present relevant proprieties to decrease of COVID-19 complications such as oxidative-cytokine storm. In this narrative review we identified five potential Amazonian fruits: açai berry (Euterpe oleracea), camu-camu (Myrciaria dubia), cocoa (Theobroma cacao), Brazil nuts (Bertholletia excelsa), and guaraná (Paullinia cupana). Data showed that these Amazonian fruits present antioxidant, anti-inflammatory and other immunomodulatory activities that could attenuate the impact of inflammaging states that potentially decrease the evolution of COVID-19 complications. The evidence compiled here supports the complementary experimental and clinical studies exploring these fruits as nutritional supplement during COVID-19 infection.
Practical applications
These fruits, in their natural form, are often limited to their region, or exported to other places in the form of frozen pulp or powder. But there are already some companies producing food supplements in the form of capsules, in the form of oils and even functional foods enriched with these fruits. This practice is common in Brazil and tends to expand to the international market.
CONFLICT OF INTEREST
The authors declare they have no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are openly available in PubMed at https://pubmed.ncbi.nlm.nih.gov/.
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