ORIGINAL ARTICLE

Effects of Se-enriched Chrysanthemum morifolium on lifespan and antioxidant defense-related gene expression of Drosophila melanogaster model

Jing Feng

National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Provincial Research Station of Se-enriched Foods in Hanyin County of Shaanxi Province, International Joint Research Center of Shaanxi Province for Food and Health Sciences, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, PR China

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Xiao Li,

Xiao Li

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Ying Xiao,

Ying Xiao

State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, PR China

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Fei-Ran Zhang,

Fei-Ran Zhang

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Zi-Qi Liu,

Zi-Qi Liu

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Hua-Feng Zhang,

Corresponding Author

Hua-Feng Zhang

[email protected]

orcid.org/0000-0001-5745-1783

Correspondence

Hua-Feng Zhang and Xiao-Hua Yang, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Provincial Research Station of Se-enriched Foods in Hanyin County of Shaanxi Province, International Joint Research Center of Shaanxi Province for Food and Health Sciences, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, PR China.

Email: [email protected] and [email protected]

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Xiao-Hua Yang,

Corresponding Author

Xiao-Hua Yang

[email protected]

Research Station of Selenium-enriched Tea of Shaanxi Province, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China

Correspondence

Email: [email protected] and [email protected]

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Jing Feng,

Jing Feng

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Xiao Li,

Xiao Li

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Ying Xiao,

Ying Xiao

State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, PR China

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Fei-Ran Zhang,

Fei-Ran Zhang

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Zi-Qi Liu,

Zi-Qi Liu

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Hua-Feng Zhang,

Corresponding Author

Hua-Feng Zhang

[email protected]

orcid.org/0000-0001-5745-1783

Correspondence

Email: [email protected] and [email protected]

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Xiao-Hua Yang,

Corresponding Author

Xiao-Hua Yang

[email protected]

Research Station of Selenium-enriched Tea of Shaanxi Province, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China

Correspondence

Email: [email protected] and [email protected]

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First published: 04 November 2022

https://doi.org/10.1111/jfbc.14503

Citations: 3

Jing Feng and Xiao Li contributed equally to this study.

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Abstract

Chrysanthemum morifolium is a well-known edible medicinal plant in Asia and some other regions. Content of selenium in Se-enriched C. morifolium (SeCM) is significantly higher than that in traditional C. morifolium (non-Se-enriched C. morifolium, TCM). In order to understand health effects of SeCM, its chemical composition, lifespan-prolonging activities, and impacts on antioxidant defense-related gene expressions of model organism D. melanogaster were systematically studied. A total of eight phenols, including luteolin-7-O-glucoside, linarin, luteolin, apigenin, diosmetin, acacetin, 3-caffeoylquinic acid and 4,5-dicaffeoylquinic acid, were identified in SeCM extract. Compared with TCM, SeCM exhibited superior antioxidant properties. Intake of SeCM dramatically reduced malondialdehyde level and increased activities of endogenous antioxidant enzymes in fruit flies. SeCM was able to upregulate gene expressions of Cu/Zn-superoxide dismutase, Mn-superoxide dismutase and hydrogen peroxide catalase, and extend lifespans of fruit flies. Comparatively high antioxidant capacities and lifespan-prolonging activities of SeCM might be attributed to its abundant phenols and selenium, which probably ameliorated accumulation of free radicals and susceptibility to oxidative stress. These findings provide clues on further exploitation and utilization of Se-enriched C. morifolium.

Practical applications

Chrysanthemum morifolium has been used for nutraceutical and curative purposes in China for thousands of years. Se-enriched C. morifolium typically contains more selenium than traditional C. morifolium, and is widely consumed in Asia and some other regions. Selenium is an essential micronutrient for humans, and selenium deficiency may result in several diseases such as myocardial infarction. SeCM is one of important selenium supplements. In this study, SeCM was found to upregulate gene expressions of Cu/Zn-superoxide dismutase, Mn-superoxide dismutase, and hydrogen peroxide catalase, and extend lifespans of experimental animals. These results provide supporting information for developing SeCM-based functional foods with distinct health benefits.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

Open Research

DATA AVAILABILITY STATEMENT

The authors declare that the data supporting the findings of this study are available within the article.

Supporting Information

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Effects of Se-enriched Chrysanthemum morifolium on lifespan and antioxidant defense-related gene expression of Drosophila melanogaster model

Abstract

Practical applications

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

Citing Literature

References

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Effects of Se-enriched Chrysanthemum morifolium on lifespan and antioxidant defense-related gene expression of Drosophila melanogaster model

Abstract

Practical applications

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

Citing Literature

References

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