Tao Li and co-workers reported a material based on metal–organic framework nanocrystals which contains the largest reported permanent pores for a liquid. They described the CO₂ and water adsorption, as well as the thermal switching properties of the porous liquid. This is the first example of a dual micro-macroporous liquid created using design rules of hierarchical porosity.

Nascent proteomics selectively analyzes newly synthesized proteins (NSPs) by labeling them with either isotopes or chemical tags, allowing for the detection of rapid changes in translational profiles upon acute biological modulations. Programmable variants of nascent proteomics enable the control of NSP labeling via optical or genetic manipulations, ensuring selectivity towards cell types and/or cellular states.

Inspired by paired metal sites in enzymes, dual-atom catalysts (DACs) were developed as a frontier in heterogeneous catalysis. DACs possess many unique advantages and surpass their counterparts in various catalytic processes. Herein, we summarize the up-to-date advancements in synthesis, characterization, structure-activity relationship of DACs and outlook the future development in this field with combination from computational insights.

Modification of non-activated esters represents interesting opportunities in polymer science. While early attempts indicated severe synthetic challenges in this area, recently several researchers have made significant progress, thus enabling structural diversification and synthetic upcycling of various polymers. This review summarizes this progress, and highlights unique structural features that can be exploited in a macromolecular context.

Flexible perovskite solar cells have attracted wide attention because of their unique advantages, such as light weight and high flexibility. This review article discusses the routes toward improvement of the recoverability and environmental stability of flexible perovskite solar cells, and highlights the practical applications. The outlook and challenges of durable flexible perovskite devices in future commercialization are also considered.

An atypical thermoresponsive feature is incorporated into a rigid Mg-MOF, which realizes ppm-level CO₂ capture and ultra-pure CO enrichment (≥99.99 %) at elevated working temperature. The property is demonstrated by comprehensive in situ variable-temperature tests showing outstanding performance in syngas purification and CO upgrading through an induced-fit-identification mechanism.

The peculiar reactivity of [CpMn(CO)₂(N₂)] (Cp=η⁵-cyclopentadienyl) is revisited to shed light on the proposed nucleophilic attack of PhLi on its N₂ ligand. Our study shows that such reactivity doesn't happen while the attack of the carbanion on CO is favored, albeit giving rise to a very labile compound. The latter decomposes above −20 °C into a N₂-free phenyl manganate that was erroneously proposed to be an anionic phenyldiazenido complex.

Ni−Pt nanoparticles supported on P-doped TiO₂ mediate visible-light-driven ammonia borane hydrolysis. The optimized Ni₄₀Pt₆₀/P-TiO₂ catalyst exhibits a high turnover frequency of 967.8 mol_H2 mol_Pt⁻¹ min⁻¹. P doping enhances the visible-light absorption and modulates the electronic states of the metals to enhance the strong metal-support interactions, thereby promoting the hydrogen-evolving activity and stability of the catalyst.

A 2D platinum-anchored tungsten trioxide (Pt/WO₃) catalyst with abundant vacancies and acidic sites activates high-density polyethylene (HDPE) polymer chains by forming C=O intermediates. Hydrocracking occurs when the intermediates are hydrogenated by the dissociated H₂ on Pt/WO₃ to form alkanes. The well-dispersed Pt on 2D WO₃ nanosheets achieved almost complete HDPE conversion with a yield of 88.9 % fuel at a low temperature of 200 °C.

For the first time, we report a tuning C₁/C₂ selectivity of CO₂ electrochemical reduction over in situ electrochemically evolved CuO/SnO₂ heterostructure. Specifically, the synergetic absorption of *COOH and *CHOCO intermediates at the interface of the newly evolved Cu/SnO_2-x facilitates ethanol generation.

A time-resolved operando electrochemical mass spectrometry platform was developed to elucidate the unique reactivities of alternating current (AC) electrosynthesis. Minimization of over-oxidation and effective reaction of the electrogenerated intermediates in AC electrolysis was demonstrated. Notably, the kinetics of reactive N-centered radical intermediates in multistep sequential AC electrosynthesis could be controlled to minimize side reactions.

Here, we report a novel synthetic methodology for covalent organic frameworks (COFs) that utilizes an electrogenerated acid (EGA), which is produced at an electrode surface by electrochemical oxidation of a precursor, acting as an effective Brønsted acid catalyst for imine bond formation from amine and aldehyde monomers. Simultaneously, it provides the corresponding COF film deposited on the electrode surface with high crystallinity and porosity.

A simple and drug-free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO₃ NPs), was obtained to regulate lactic acid metabolism through acid-base neutralization, and thus to reverse the mildly acidic immunosuppressive tumor environment. Furthermore, it can release high amounts of Na⁺ ions and induce a surge in intracellular osmolarity to activate the pyroptosis pathway and improve immune responses.

The mechanism of different saccharide molecules as non-sacrificial electrolyte additives in regulating Zn²⁺ desolvation and Zn deposition was investigated for the first time through experimental and theoretical studies.

Guided by theoretical prediction of the “E-Lock” and “E-Channel” at sulfur vacancy and intercalation carbon, we report a universal sub-nanoreactor strategy to precisely regulate the spatial location and local microenvironment of metal single atoms (Co, Ni, Fe, Zn, W, Cu, Mn, and Cd) over yolk-shell C−MoS₂ dual-support for robust hydrogen-evolution reaction in acid.

Rational and coordinated side chain modification and backbone extension, by replacing α-amino acid residues with β-amino acid residues, enables favorable interaction between a His side chain on a target protein and an aromatic side chain on a synthetic peptide ligand. This strategy, which enhances affinity, is showcased with peptides that bind to the parathyroid hormone receptor 1.

A setup for wireless detection of early and mature microbial biofilms has been developed by combining inkjet printing of nanomaterials, chip-less antenna, and electrogenicity of biofilms. Wireless sensing relies on the biofilm ability to electro-reduce antenna integrated AgCl to Ag. Detection of medically relevant biofilms formed by S. aureus and P. aeruginosa has been demonstrated, aiming for wireless wound infection sensing in clinics.

The sonodynamic cytokine nanocomplexes (SPN_AI) can not only specifically activate effector T cells (Teffs) rather than regulatory T cells (Tregs), but also generate ¹O₂ under sono-irradiation for induction of immunogenic cell death, which synergistically elevates the ratio of Teffs/Tregs for effective antitumor immunity.

Three-dimensional solids were developed to optimize the nanoscale structure of the active layer in organic solar cells by offering ample assembly space during the phase-transition process, yielding a high power-conversion efficiency of over 19 %. This research not only established a valuable pre-selection approach for solid additives but also deepened our understanding of the underlying working mechanism.

Using a combination of theoretical techniques, we separated the bulk and surface contributions of ionisation potentials of metal oxides, highlighting the critical role of electrostatics. Low bulk ionisation potentials and a high degree of tunability from surfaces were found in CeO₂, HfO₂, and ZrO₂, explaining the discrepancies from measurements and guiding the future design of band-edge-related photocatalytic, photovoltaic, and electrochemical devices.

A new principle of regulating p-band center of metal oxide protective layer to balance Zn adsorption energy and migration energy barrier for effective Zn anode with long lifetime and low overpotential.

The existence of p-d and s-p antibonding states near the Fermi level as well as metavalent bonding provide an ultra-low lattice thermal conductivity while maintaining a high electrical conductivity, resulting in a high thermoelectric performance of the cubic AgSnSbTe₃ single crystal.

Elastic polymer-coated nanoparticles (NPs) were developed as novel contrast agents for ¹⁹F MRI. These NPs encapsulated liquid perfluorocarbon, resulting in high elasticity and robust sensitivity in ¹⁹F NMR and MRI. Moreover, in vivo imaging of these NPs implied that elastic NPs suppressed long-term accumulation in the liver.

The stepwise method proposed to synthesize non-fullerene oligomer acceptors via consecutive Stille coupling reactions offers significant advantages compared to the traditional approach, resulting in fewer unwanted by-products and easier purification processes. By utilizing this method, the obtained Tri-Y6-OD-based organic solar cells achieved a high power conversion efficiency of 18.03 %, along with excellent stability.

The introduction of defect-rich structures (stacking faults, twin boundaries, lattice distortion, steps, and edges), low coordination number (CN), and tensile strain in three-dimensional (3D) urchin-like palladium nanoparticles through chlorine bonded with sp-C in graphdiyne (Pd-UNs/Cl-GDY) can regulate the arrangement of metal atoms. The as-prepared Pd-UNs/Cl-GDY are highly efficient and durable methanol oxidation reaction electrocatalysts.

The molecular Z-scheme artificial photosynthesis with a photocathode of CO₂ reduction and a photoanode of two-electron water oxidation into H₂O₂ by visible light as the only energy input was developed for the first time.

Efficient and photostable furan-based n-type semiconductors were developed for organic solar cells. Important photodegradation mechanisms were revealed and analyzed and the findings lead to effective strategies to improve the photostability of non-fullerene electron acceptors.

Highly stable π-extended nickel corrole radicals and their cations exhibiting superior absorbing capacities across the visible-to-near-infrared (NIR) spectral region are synthesized via the radial fusion of aromatic rings. The nanoparticles encapsulating corrole radicals are high-performance photothermal agents and enable efficient NIR-triggered photoacoustic imaging and photothermal therapy in vivo.

A fluorescence-quenched substrate for glucocerebrosidase that can be conveniently fixed using standard conditions enables quantitative measurement of enzyme activity within lysosomes in both live and fixed cells, as well as antibody co-staining of cellular proteins.

One electron reduction of the 1,2-diphospha-1,3-butadiene unit in heterocycle 2 with KC₈ yields the corresponding 1,2-diphospha-1,3-butadiene radical anion, which can be re-oxidized with [Fc][B(C₆F₅)₄].

Illustration of the relative speed with which a large chemical space of bicyclic dienes can be screened for molecular solar thermal energy storage candidates. Density Functional Theory (DFT) is as illustrated not a feasible route due to computational cost, while extended tight binding (xTB) methods are much faster and can give estimates.

Batrachotoxin is an extremely potent cardio- and neurotoxic steroidal alkaloid. Its 6/6/6/5-membered carbocyclic framework is functionalized with two double bonds, a six-membered hemiacetal, a seven-membered oxazepane, and a dimethylpyrrolecarboxy group. By a novel and simple convergent strategy involving Pd/Ag-promoted Suzuki–Miyaura coupling and Dieckmann condensation reactions, the total synthesis of batrachotoxin was realized in 22 steps.

In this work, by using P and S-doped Ni−Fe mixed oxides as model catalysts for oxygen evolution reaction (OER), we discover that heteroatom doping triggers the OER mechanism transition from the adsorbate evolution mechanism (AEM) to the lattice-oxygen-mediated mechanism (LOM) by enlarging metal-oxygen covalency.

A photocatalytic protocol was developed for the dearomatization of substituted naphthalenes, indoles, and related heteroaromatic compounds through a radical-polar crossover mechanism induced by single-electron transfer from photoexcited polysulfide anions in the presence of methanol. The catalytic turnover is maintained by hydrogen-atom transfer between polysulfide radical anions and formate.

An inorganic molecular crystalline Sb₂O₃ film with an ultrathin thickness of 10 nm serves as an effective protection layer for Zn anodes to enable uniform under-layer Zn deposition with suppressed side reaction and tip growth effect, achieving a long-term cycling lifespan over 1000 h.

We designed a lactosylated Aza-BODIPY compound that self-assembles in situ to form J-aggregate nanofibers acting as type I photosensitizers. The J-aggregate nanofibers exhibited remarkable superoxide anion radical (O₂^−.) generation efficiency, the ability to damage the tumor cell membrane, and long-term retention at tumor sites. This efficient synergistic therapeutic effect was confirmed in HepG2 cells and tumor-bearing mice.

We have developed a series of new self-assembled monolayers (SAMs) based on Zn^II porphyrin for use as hole-selective layer (HSL) in inverted perovskite solar cells (PSCs). Our study successfully demonstrates the superior performance of dual carboxylic acid functionalized porphyrins can boost the solar efficiency of PSCs. The outstanding performance of these porphyrin SAMs lies in their inherent self-assembled properties and the presence of dual carboxylic acid groups that facilitate effective anchoring to both the ITO surface and perovskites.

We developed a Ni_xCr_yO electrocatalyst that can dynamically restructure itself during the alkaline oxygen evolution reaction (OER) and increase its porosity by Cr leaching. The enhancement of porosity improved electrolyte penetration and boosted electronic interaction between OH⁻ and active sites, resulting in 2000, 275, and 100 h stability at 10, 100, and 500 mA cm⁻², respectively, in real seawater.

Continuous saline water electrolysis increases the concentration of Cl⁻, leading to severe anode corrosion. In this work, we have developed the anodes that could efficiently catalyze water oxidation in alkaline saturated saline water at ultra-high current densities up to 2 A cm⁻² over hundreds of hours. To the best of our knowledge, this is one of the most stable brine oxidation electrodes reported to date.

A charging metal–organic framework (MOF) membrane realizes charge inversion from negative to positive by including crown ethers to capture cations. The result is enhanced Li⁺/Mg²⁺ selectivity. The improved Li⁺/Mg²⁺ selectivity is associated with the expanding of energy-barrier deviation between Li⁺ and Mg²⁺ caused by the steric effect and the electrostatic repulsion.

An anhydrous room temperature CAS-Suzuki–Miyaura cross-coupling reaction between (hetero)aryl boronic esters and aryl sulfides was explored, of which universality was exemplified with thirty small molecules and twelve alternating conjugated polymers. Mechanism studies revealed the importance of room temperature and anhydrous condition in reducing the homocoupling defects and enhancing the optoelectronic properties of the conjugated polymers.

The various spiro-locks were introduced into the nitrogen/carbonyl-based multi-resonance thermally activated delayed fluorescence (MR-TADF) system via a designed synthetic route. The introduction of spiro-locks increased molecular rigidity and suppressed intermolecular interactions. Thus, narrowband deep-blue electroluminescence spectra and improved device efficiencies were achieved simultaneously.

We report a solvent-controlled rhodium-catalyzed tunable arylation of 1-bromo-2,2-difluoroethylene, which allows the synthesis of monofluoroalkenes and gem-difluoroalkenes from readily available feedstocks. This study provides a useful strategy for the divergent synthesis of fluorine-containing scaffolds and sheds light on the importance of solvent selection in catalytic reactions.

Herein, we report a practical and cost-efficient electrochemical method for the highly selective monooxygenation of benzylic C(sp³)−H bonds using continuous flow reactors. The electrochemical method demonstrates excellent scope and scalability by producing 115 g of one of the alcohol products.

Electrochemically promoted functionalization of unactivated chloroarenes without light is achieved by using novel tetraarylcumulene-based redox mediators.

Herein, we report asymmetric allylic substitution-isomerization for the regio- and atroposelective synthesis of axially chiral N-vinylquinazolinones. The catalysis system was achieved by means of asymmetric transition-metal catalysis and organocatalysis which afforded trisubstituted as well as E- and Z-tetrasubstituted N-vinylquinazolinone atropisomers, respectively.

A novel near-infrared (NIR) fluorescent probe for crossing the blood–brain barrier was constructed via a rational molecular design strategy. The probe allowed the investigation of the biothiol-mediated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway in cerebral ischemia-reperfusion injury mice models.

It is found that singlet oxygen (¹O₂) can react with benzobisthiazole-based photocatalysts via [4+2] cycloaddition, leading to the formation of endoperoxide intermediate species, which promotes the separation of charge carriers and reduces the barrier for hydrogen peroxide (H₂O₂) production. The H₂O₂ production rate of the catalyst is as high as 7274 μmol g⁻¹ h⁻¹ in pure water in air.

A triple-function eutectic electrolyte is designed by introducing tetramethylene sulfone (TMS) as hydrogen bond acceptor. The preferentially adsorbed TMS on the Zn surface provides a shielding buffer layer to retard the sedimentation and suppress dendrite growth. TMS modulates the primary solvation shell of Zn²⁺ to realize a novel solvent co-intercalation situation, and the intercalated TMS remains in the cathode as a “pillar” to stabilize the structure.

A series of isoreticular tetraphenylethylene(TPE)-based multicomponent metallacages were prepared using TPE derivatives as the faces and different tetracarboxylic ligands as the pillars. The integration of TPE-based photosensitizers and open Re catalytic sites into a single metallacage promoted the directional electron transfer within the metallacage, offering good photocatalytic hydrogen production performance.

The large-scale synthesis of chiral polymeric carbon nitride (CN) powder and electrode capable of enantioselective recognition from chiral supramolecular assemblies as monomers is reported. The optimized chiral CN exhibits good chiral recognition for tartaric acid, with an enantioselective preference of ca. 14 % for the D enantiomer.

A new family of Janus-type ESIPT chromophores with distinctive hydrogen bonding selectivity between competitive hydrogen bond acceptors (HBAs) were reported. Single-crystal structures and theoretical studies unveiled the molecular origins of the biased intramolecular hydrogen bonds (H-bonds) and their impact on the ESIPT process. This Janus-type ESIPT chromophore skeleton provides new opportunities for the design of solid luminescent materials.

Cu-Omega (MAZ) ist ein sehr aktives und selektives Material für die Methan-to-Methanol (MtM) Umwandlung mittels dem Saurestoff-Looping Verfahren. Durch Determination der Produktivität mittels einer neuen Screening Methode welche Operando XAS und Massenspektrometrie vereint, zeigt diese Arbeit das Potential welches dieses Material für eine potenzielle industrielle Anwendung besitzt, sowie einen neue Screening Methode für Materialien welche auch im Sauerstoff-Looping Verfahren benutzt werden.

Die Stapelung von einem, zwei, drei oder vier Diketopyrrolopyrrol-Farbstoffen (DPP) wurde durch die jüngsten Fortschritte in der Pd(II)-vermittelten Selbstassemblierung erreicht. Wir berichten über zwei bisher nicht bekannte, selbstpenetrierende Motive: einen Pd₂L₃-Dreifach- und einen Pd₂L₄-Vierfachstapel. Mit zunehmender Stapelgröße verschiebt sich die Absorption bathochrom und die Emission nimmt ab, mit Ausnahme von Verbindung Pd₂L₂L′₂, die sich durch eine außergewöhnliche Lumineszenz-Quantenausbeute von 51 % auszeichnet.

Wir berichten über die einfache Synthese des ersten Lithium Peraryldiboriranids c-(DurB)₂CPh⁻ über das entsprechende nicht-klassische Diboriran (Dur=2,3,5,6-Tetramethylphenyl; Bn=Benzyl) ausgehend von einem Diboran(4). Wir zeigen die ausgeprägte Tendenz des Diboriranids zur σ-Koordination zu Hauptgruppen- und Übergangsmetallen (Au, Cu, Zn und Sn) unter Erhalt des 2e⁻ π-Systems des B₂C-Rings.

Mesoionische N-heterocyclische Olefine (mNHOs) wurde synthetisiert und ihre Reaktionen mit Michael-Akzeptoren und CO₂ untersucht. Die außerordentlich hohe Nucleophilie der mNHOs wurde durch kinetische Messungen bestimmt. Die Integration der mNHOs in die Mayrsche Nucleophilie-Skala zeigt, dass sie zu den stärksten bisher eingruppierten Kohlenstoff-Nucleophilen gehören.

Die Stärke von sog. „Action Plots“ wird durch die Vorstellung eines reaktionsselektiven Fensters zwischen zwei verschieden substituierten Triazolindionen demonstriert, welche nahezu identische Absorptionsspektren aufweisen. Der bemerkenswerte Unterschied in der Photoreaktivität wird mittels eines zweifach gesteuerten Reaktionspfades genutzt, welcher das regioselektive (photo)chemische Verhalten beider Triazolindion-Substrate innerhalb eines einzigen Moleküls demonstriert.

Steady-state isotopic transient kinetic analysis lieferte die Grundlangen der In situ-Umwandlung von M(W, Mo oder Re)O_x in M-Carbene bei der C₂H₄−2-C₄H₈-Metathese zu C₃H₆. Ihre Konzentration und intrinsische Aktivität folgen der Reihenfolge Re>Mo≫W. Die Konzentration, nicht aber die intrinsische Aktivität, kann durch die Verwendung eines metatheseinaktiven ZrO₂-Cokatalysators erhöht werden. Sein steigernder Effekt hängt von seiner Fähigkeit ab, CH-Bindungen in 2-Butenen zu aktivieren.

Chelocardin und das aus dessen manipulierter Biosynthese stammende Derivat Amidochelocardin besitzen eine breite antibakterielle Aktivität. In diesem Artikel beschreiben wird die Korrektur der absoluten Konfiguration von Amidochelocardin und Chelocardin auf Basis einer Kombination aus XRD, NMR, ECD und TDDFT-ECD Berechnungen. Die mit XRD Analyse bestimmte absolute Konfiguration des strukturell eng verwandten semisynthetischen Analogs von 6-desmethyl-chelocardin (1) unterstützt ebenfalls unser Ergebnis.

Benchtop-NMR-Spektrometer sind kompakt, kostengünstiger und arbeiten kryogenfrei. Die vorgestellte Methode mit photoinduzierter Hyperpolarisation ermöglicht den Nachweis einer Protein-Fragment-Wechselwirkung durch eine Verringerung des Ligandensignals, einfach durch den Vergleich der in Abwesenheit und Anwesenheit von Protein gemessenen Spektren. Unser Ansatz ermöglicht ein Screening bei mikromolaren Ligandenkonzentrationen und niedrigen mikromolaren Proteinkonzentrationen auf einem Benchtop-NMR.

High performance dynamic X-ray flexible imaging in extremely humid environments was achieved using copper iodide cluster-based MOF microcrystal scintillator, which shows a high X-ray absorption efficiency, environmental friendliness, good stability and excellent processability.Twitter: High Performance Dynamic X-ray Flexible Imaging Realized Using a Copper Iodide

An asymmetric hydrophosphination of 3,3-disubstituted cyclopropenes catalyzed by Cu(I)-(R,R)-QUINOXP* is developed, affording a series of phosphine derivatives in high to excellent diastereo- and enantioselectivities.

Two new two-dimensional conjugated metal–organic frameworks (2D c-MOFs) were synthesized via coordination of a new ligand (HAOTP) with metal ions (Ni²⁺ and Cu²⁺). The resulting HIOTP-Ni MOF has a large pore aperture of 3.3 nm and a high surface area of 1300 m² g⁻¹. As a result, it has exceptional performance as a chemiresistive sensor, with a highly selective (405 %) and rapid response (1.69 min) towards 10 ppm NO₂ gas.

Efficient and selective recovery of gold and copper is achieved using triphenylphosphine oxide and 2,3-pyrazinedicarboxylic acid, respectively from 2 M HCl e-waste leach solutions. The selectivity of these precipitation methods, together with their ease of operation and capacity to recycle and reuse the precipitants, offers potential applications in the purification of Au and Cu from various metal sources.

Photocaged glutamic acid analogues are genetically encoded into proteins for the first time, opening up new opportunities for directly and effectively generating photoactivatable proteins.

Photothermal conversion enables thermal gradients that facilitate high activation barrier reactions, such as the Newman Kwart Rearrangement. Substrates normally requiring bulk temperatures >250 °C are easily converted via visible light irradiation with short reaction times. Wavelength and intensity tunability enable selective product formation.

In this study, the application potential of magnetic circular dichroism (MCD) techniques is showcased through the inaugural application of MCD-based magneto-optical thermometry. Leveraging the intrinsic temperature dependence of the MCD C-term, the presence of dual-signaled bands, and the amalgamation of multiparametric thermal read-out with multiple regression, remarkable sensitivities of up to 95.3 % K⁻¹ are achieved with the [Ho(acac)₃(phen)] complex. This achievement establishes a new benchmark for thermal sensitivity values within the cryogenic range.

Solvent-dependent light-assisted divergent reactivities of cyclic diazo imides and thiols have been disclosed. In dichloromethane, an indane-fused pyrrolidine is formed via triplet a carbene intermediate. By switching the solvent to acetonitrile, the aryl thiol acts as a reductant and leads to the reduction of the diazo functional group to a hydrazone.

A ketone-catalyzed reaction for the enantioselective oxidation of N atoms was developed and effectively applied to the atroposelective kinetic resolution of QUINAPOs and related compounds. Both highly enantioenriched QUINAPO N-oxide products could be readily converted into QUINAPs without loss of chiral integrity. QUINAPO N-oxide was also shown to act as a chiral Lewis base catalyst in a series of enantioselective transformations.

Continuous-wave Raman lasing is realized in a metal-linked organic dimer microcrystal. It has much enhanced Raman gain and notably improved stability. By virtue of the wide transparency window of the microcrystal, broadband tunable Raman lasing is achieved.

This work shows that alkyl MIDA- and TIDA-boronates have a notable stabilizing effect on α-radicals that arises via B−N hyperconjugation. This is supported by DFT radical stabilization energy and spin density studies, development of a site-selective bromination reaction, and LED NMR kinetic analysis of bromination rates for different alkyl boronic esters.

Aldehydes underwent cross-coupling with unactivated alkyl halides in the presence of an NHC organocatalyst, thus enabling the rapid synthesis of various ketones from readily available starting materials under mild conditions. This method was also applied to the late-stage functionalization of pharmaceutical derivatives. Mechanistic investigations suggest a closed-shell nucleophilic substitution mechanism for this organocatalytic reaction.

We report here a general method for the regio- and enantioselective Cu-catalyzed anti-Markovnikov hydroaminocarbonylation of unactivated alkenes under mild conditions. The reaction tolerates a wild range of functional groups and applicable to different classes of alkenes. Alkynes are also compatible under this catalytic system with the cascade hydrogenation-hydroaminocarbonylation process to alkyl amides.

Cobalt-catalyzed atroposelective C−H arylation/DKR reaction was realized. This strategy provides an efficient and sustainable method for the synthesis of axially chiral biaryl-2-amines in good yields (up to 99 %) with excellent enantioselectivities (up to 99 %ee).

A highly modular technique that streamlines the synthesis of α-difluoroalkylated amines from benzyl amines and trifluoromethylarenes has been developed. This protocol demonstrates remarkable operational simplicity, excellent chemoselectivity, and wide applicability, including with advanced synthetic intermediates, thus providing a novel pathway to access medicinally-relevant α-difluoroalkylated amines from readily available and simple precursors.

Anion-(π)_n-π catalytic micelles are introduced to expand the collection of systems catalysts compatible with anion-π catalysis with a rich topic of general importance. They are of interest to realize anion-π catalysis, anion-(π)_n-π catalysis and anion-(π)_n-π autocatalysis in water. Classics in supramolecular chemistry are installed to control substrate binding and positioning within the confined micellar space for access to emergent properties.

Two complex hasubanan alkaloids were synthesized from inexpensive cyclohexanedione monoethylene acetal by a divergent route featuring a palladium-catalyzed cascade cyclization. Regioselective Baeyer–Villiger oxidation followed by MeNH₂-triggered skeletal reorganization formed the benzannulated aza[4.4.3]propellane, and late-stage regio- and diastereoselective oxidative annulation of a sp³ C−H bond formed the challenging tetrahydrofuran ring system.

A one-pot hydrothermal zeolite synthesis using metallosiloxane precursors enables a quantitative encapsulation of metal species into the zeolite. For Fe-MFI zeolite the approach facilities a homogeneous distribution of the Fe species throughout the zeolite framework and leading to improved catalytic activity with good tolerance to H₂O/SO₂ in the NH₃-selective catalytic reduction (SCR) of NO_x across a wide temperature range.

Ligand-enveloped tetragold(0) clusters have been successfully synthesized via a nucleophilic substitution reaction between a Au₃ anionic cluster and PMe₃AuCl. A novel stabilization mode, intramolecular σ-aromatization has been discovered, in which the intramolecular σ-aromatization has now been observed for the first time in homometallic clusters, and the polarity of the exo-Au−Au bonds can be tuned via the strength of σ-aromaticity.

The biosynthetic pathway of the strained dipeptide (+)-azonazine A from marine-derived Aspergillus insulicola, which features a rarely observed benzofuranoindoline ring system, was uncovered. Heterologous reconstitution of the fourth-enzyme pathway showed a P450 enyzme catalyzes an oxidative cyclization of cyclo-(l-Trp-N-methyl-l-Tyr) to form the hexacyclic ring system. Analogs of azonazine A were generated by supplementing the producing strain with different indole-substituted tryptophan analogs.

A few-layer fullerene C₆₀ network was successfully synthesized and explored for photocatalytic water splitting into H₂ and H₂O₂ under visible-light irradiation. The mechanism for water splitting of the few-layer C₆₀ catalyst was investigated.