Zuschrift
α-Difluoroalkylation of Benzyl Amines with Trifluoromethylarenes
Wen-Jun Yue,
Prof. Ruben Martin,
Wen-Jun Yue
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain
Universitat Rovira i Virgili, Departament de Química Analítica i Química Orgànica, c/Marcel⋅lí Domingo, 1, 43007 Tarragona, Spain
Search for more papers by this authorCorresponding Author
Prof. Ruben Martin
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain
Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys, 23, 08010 Barcelona, Spain
Search for more papers by this authorWen-Jun Yue,
Prof. Ruben Martin,
Wen-Jun Yue
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain
Universitat Rovira i Virgili, Departament de Química Analítica i Química Orgànica, c/Marcel⋅lí Domingo, 1, 43007 Tarragona, Spain
Search for more papers by this authorCorresponding Author
Prof. Ruben Martin
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain
Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys, 23, 08010 Barcelona, Spain
Search for more papers by this authorAbstract
An α-difluoroalkylation of benzyl amines with trifluoromethylarenes is disclosed herein. This protocol is characterized by its operational simplicity, excellent chemoselectivity and broad scope—even with advanced synthetic intermediates—, thus offering a new entry point to medicinally-relevant α-difluoroalkylated amines from simple, yet readily accessible, precursors.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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