Molecular Engineering of Corrole Radicals by Polycyclic Aromatic Fusion: Towards Open-Shell Near-Infrared Materials for Efficient Photothermal Therapy
Dr. Hu Gao
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
These authors contributed equally to this work.
Search for more papers by this authorXu Zhi
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Dr. Fan Wu
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorDr. Yue Zhao
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorFangjian Cai
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorPengfei Li
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorCorresponding Author
Prof. Dr. Zhen Shen
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorDr. Hu Gao
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
These authors contributed equally to this work.
Search for more papers by this authorXu Zhi
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Dr. Fan Wu
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorDr. Yue Zhao
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorFangjian Cai
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorPengfei Li
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorCorresponding Author
Prof. Dr. Zhen Shen
State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China
Search for more papers by this authorAbstract
Open-shell radicals are promising near-infrared (NIR) photothermal agents (PTAs) owing to their easily accessible narrow band gaps, but their stabilization and functionalization remain challenging. Herein, highly stable π-extended nickel corrole radicals with [4n+1] π systems are synthesized and used to prepare NIR-absorbing PTAs for efficient phototheranostics. The light-harvesting ability of corrole radicals gradually improves as the number of fused benzene rings on β-pyrrolic locations increases radially, with naphthalene- and anthracene-fused radicals and their one-electron oxidized [4n] π cations exhibiting panchromatic visible-to-NIR absorption. The extremely low doublet excited states of corrole radicals promote heat generation via nonradiative decay. By encapsulating naphthocorrole radicals with amphiphilic polymer, water-soluble nanoparticles Na-NPs are produced, which exhibit outstanding photostability and high photothermal conversion efficiency of 71.8 %. In vivo anti-tumor therapy results indicate that Na-NPs enable photoacoustic imaging of tumors and act as biocompatible PTAs for tumor ablation when triggered by 808 nm laser light. The “aromatic-ring fusion” strategy for energy-gap tuning of corrole radicals opens a new platform for developing robust NIR-absorbing photothermal materials.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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