Association of Neutrophil Count, Lymphocyte Count and Neutrophil-to-Lymphocyte ratio (NLR) with All-cause Mortality. We enrolled 4702 ambulatory patients referred to a local HF clinic in the UK (The Hull LifeLab), of whom 813 had detailed echocardiographic assessment (top left). Lymphocyte count correlated inversely with NTproBNP (r = −0.31) and markers of congestion (left atrial volume index (r = −0.25), inferior vena cava diameter (r = −0.24) and positively with right ventricular function (TAPSE); neutrophil count correlated positively with hsCRP (r = 0.31, P<0.001) (bottom left). On the right panel, we report the adjusted hazard ratios (HR) per 1 unit change assessed over the complete follow-up duration with corresponding forest plots for visualization. Further right, we assessed model discrimination at 2 years of follow-up using the C-index. ΔC-index represents the difference between the “C-index of the fully adjusted model + neutrophil count/lymphocyte count/NLR” and the “C-index of the fully adjusted model alone”. Abbreviations used; NLR: neutrophil-to-lymphocyte ratio, BMI: body mass index, HR: heart rate, DM: diabetes mellitus, IHD: ischaemic heart disease, NYHA: New York heart association classification, NTproBNP: N-Terminal Pro-B type natriuretic peptide, hsCRP: high sensitivity C-reactive protein, C-index: concordance index, LVEF: left ventricular ejection fraction, HFrEF: heart failure with reduced left ventricular ejection fraction, HFmrEF: heart failure with mildly reduced left ventricular ejection fraction. HFpEF: heart failure with preserved left ventricular ejection fraction.

Graphical representation of main findings and article highlights.

Training-induced change of diastolic function in HFpEF. HIIT, high-intensity interval training; HFpEF, heart failure with preserved ejection fraction; LVEF, left ventricular ejection fraction; MCT, moderate continuous training; TAPSE, tricuspid annular plane systolic excursion; V̇O₂peak, peak oxygen uptake.

Mitral valve transcatheter edge-to-edge repair in elderly patients is safe and offers comparable mitral valve regurgitation reduction and symptom relief to younger patients. At 3 years, increased all-cause mortality is observed in elderly patients with advanced heart failure and elevated EuroSCORE II.

Atrial fibrillation (AF) was observed in almost half of patients with insertable cardiac monitor and symptomatic heart failure (HF). One-fourth of the patients had new onset AF and a higher rate of HF events compared with patients without AF. AF incidence was similar in HF patients with preserved versus reduced left ventricular ejection fraction.

• The HFFS is a new multidimensional tool for the identification of frailty in patients with HF developed through a Delphi process involving 54 international experts in the management of HF and frailty.
• Two versions of the HFFS have been developed after the third round of the Delphi process.
• The shorter version (S-HFFS) can be easily used in busy clinical practice.

The prognostic impact of the muscle parameters gait speed, handgrip strength and appendicular skeletal muscle index on cardiovascular outcomes was investigated. We prospectively analyzed a cohort of 205 heart failure patients with a median left ventricular ejection fraction of 37% and a median follow-up of 4.7 years. Fine and Gray regression modeling identified only gait speed as an independent predictor of the combined outcome of cardiovascular death or worsening heart failure.

Non-scaled Venn diagram of iron deficiency (ID) according to various definitions and associated outcomes. The prevalence of iron deficiency was high, irrespective of the definition applied. ID defined by TSAT <20% or serum iron <13 μmol/L, rather than the guideline definition, was associated with worse outcomes.

In this retrospective, observational study of a real-life cohort of patients with heart failure with reduced ejection fraction, long-term survival was improved in patients who achieved sustained reverse remodeling. Greater increases in ejection fraction (EF) and reductions in left ventricular end-systolic diameter at the time of EF recovery, greater septal thickness, higher blood pressure, absence of diuretic need, and maintenance of NYHA class I/II were predictors of sustained recovered ventricular function.