A new bilayer-forming supramolecular amphiphile, reported by Elizebath et al., helps elucidate mechanisms of curvature induction in synthetic membranes. Assembly in water led initially to aggregates but, over time, membrane budding and vesicle formation were observed due to asymmetric protonation of the water-exposed terminal tertiary amines. Insights could lead to the development of new hierarchical life-like materials and artificial cells.

Recently, Bandyopadhyay and co-workers reported new chalcone photoswitches claimed to display advantageous optical and photochemical properties for potential biological applications, i.e., switching with blue, green and red light in aqueous solution. In this Correspondence, we argue that further experimental evidence is required to support the proposed design, data interpretation, and main conclusions.

In a Correspondence, Pina et al. commented on certain aspects of a publication in Angewandte Chemie by Bandyopadhyay and co-workers on visible-light-switchable chalcone-flavylium photochromic systems. In this Reply to the Correspondence, the concerns raised in the Correspondence are addressed.

We explore the difference between enantiomeric excess (ee) and relative Gibbs free activation energies (ΔΔG^≠) as modeling targets in asymmetric catalysis. Through data analysis and application of modern machine learning methods, we unveil the strengths and limitations of each approach. Our results offer critical insights into which target more accurately predicts enantioselectivity, providing a guide for future research in machine learning for catalysis.

This Review analyzes the current trends and challenges in the synthesis and purification of carbon dots prepared through various methods and using a wide variety of precursors. Diverse purification techniques, including centrifugation, filtration, dialysis, column chromatography, and electrophoresis, are systematically and thoroughly described, along with pointing out the gaps in the synthesis, purification, and assessment of CD purity.

An interfacial interlocking structure is designed by introducing protonated chitosan (CS) at the interface between the surface oxidized 3D nanonetwork of bacterial cellulose (BC). This interfacial structure provides enough physical contact sites for hydrogen bonds and electrostatic interactions. The obtained structural material shows better environmental friendliness and mechanical and thermal properties than engineering plastics.

A commercially available ZIF-8 metal–organic framework (ZIF-8) was used to deposit palladium, demonstrating excellent performance in photocatalysis and thermal CO₂ hydrogenation to methanol reactions under various pre-treatment conditions.

Asymmetrically L/D-glutamate-derived PDIs having linear alkyl chains exhibit living supramolecular polymerization in thermodynamically stable chiral molecular orientation, which shows the coupling of Frenkel and charge transfer exciton states, resulting in significantly enhanced fluorescence quantum yield, CD and CPL properties. Meanwhile, PDIs with branched chains only show common H-aggregates. Thus, molecular control on living hybrid exciton nanomaterials is achieved.

Hydronium cation (H₃O⁺) was found to be critical to regulating the observed behaviors of IrO₂ during acidic oxygen evolution reaction. The H₃O⁺ cation induced an internal electric field at the interface, enabling selective bond-tuning to the reaction intermediates. As a result, 0.5 monolayer of *OH species was stabilized under OER operational condition, and the overall conversion was revealed to be hindered by *OH→*O.

A new catalyst of phosphorus doped RuSe₂ (P-RuSe₂) with the enhanced conductivity and the modulation of the d-band center is engineered via a rational screening strategy, which augments its effectiveness in interacting with LiPSs and hence exhibits enhanced electrochemical performance in terms of high capacity, superior rate capability and stable cycle life.

A switchable non-equilibrium dissipative assembly promoting fibroblast adhesion/proliferation and efficient drug delivery was developed using chemical fuel. Nanofibers acted as chiral hydrogel scaffolds for cell adhesion and drug reservoirs. This system transitions between nanofiber and nanospherical forms, enabling targeted drug delivery and recovery, highlighting its scientific significance.

A novel photoactive azobenzene-bridged 2D COF (COF-TPT-Azo) shows an excellent photocatalytic H₂O₂ production rate up to 1498 μmol g⁻¹ h⁻¹ at pH = 11, which is 7.9 times higher than its corresponding imine-linked 2D COF (COF-TPT-TPA), although only one atom is different in the two 2D COFs (−N=N− vs. −C=N−). COF-TPT-Azo exhibits much narrower band gap, enhanced charge transport, and prompted photoactivity, which is benefited from its azo linkages.

The synthesis of three novel C−C bond-fused porphyrin-hexabenzocoronene (HBC) conjugates is presented. By connecting the aromatic systems of the macrocycles via 5-membered rings under standard Scholl conditions, the formation of highly soluble and stable π-extended porphyrins is achieved. The described planarization led to significant alterations regarding the photophysical and optoelectronic characteristics of the molecules.

A straightforward and facile BH₃-mediated skeletal editing of aromatic heterocycles via hydroborative cleavage of C−N bonds is reported. Structurally diverse products, including tetrahydrobenzo azaborinines, diazaboroles, O-anilinophenylethyl alcohols, benzene-1,2-diamines, and more were readily obtained. Density functional theory (DFT) calculations and natural bond orbital (NBO) analysis revealed an interesting and counterintuitive indole hydroboration phenomenon, including −BH₂ shift from C3-position to C2-position. Moreover, the photophysical properties of the synthesized diazaboroles was studied, and an interestingly and pronounced aggregation-induced emission (AIE) behavior was disclosed.

Amorphous high-entropy sulfide catalyst of CuCoNiMnCrS_x/NF, with the manipulated chemical environments and electron states surrounding “soft-acid” sites and the sulfophobic properties of “hard-acid” metal sites, shows excellent sulfion-oxidation reaction performance coupled with hydrogen evolution at the industrial-level current density for long-time stability. This demonstration of the electrochemical-chemical tandem reaction process gives a new avenue for sulfions upgrading from wastewater and simultaneous efficient hydrogen production

This work demonstrates that the capability of hole molecules to strengthen the interface bonding and interactions between molecules and interfaces is crucial to maximally passivate defects, affording robust interface, inhibition of ion migration, and photostable perovskite solar cells. Consequently, the newly developed mDPA-SFX enables cells with a PCE of 24.8 %, and an excellent T₈₀ lifetime of 2,238 h at maximum power point tracking.

Two model Cu₄(MMI)₄ and Cu₈(MMI)₄(^tBuS)₄ clusters with well-defined structures and stable low-coordinated Cu⁺ species are prepared to explore the synergistic effect of Cu⁺ and adjacent S site on CO₂RR. Cu₄(MMI)₄ reduce CO₂ to deep-reduced products with a FE of 91.0 % (including 53.7 % for CH₄) while maintaining remarkable stability. Cu₈(MMI)₄(^tBuS)₄ shows a notable preference for C₂₊ products with a maximum FE of 58.5 % and a J_C2+ of 152.1 mA⋅cm⁻².

MXene with horizontal ionic transport channels (H-MXene) to withstand extreme saline-alkali conditions, significantly outperforms that with vertical ionic transport channels (V-MXene) in ion selectivity and permeability, achieving a current density over three orders of magnitude higher without significant polarization, an osmotic power density of 9.47 W m⁻², and an exceptional energy conversion efficiency of 45.7 %.

Herein we report a novel photocatalytic system for the synthesis of glycine directly from methanol and nitrate. Ba²⁺−TiO₂ nanoparticles show a high glycine photosynthesis rate under mild conditions. The success of this work provides a sustainable pathway for the valorization of green “liquid sunlight” and nitrate waste.

Exchanging a sulfur atom against a methine group in a series of azaacene based diradicals furnishes non-Kekulé, meta-quinodimethane based diradicals with singlet ground states and small singlet-triplet gaps. Zwitterionic contributions are ruled out experimentally and quantum-chemically, and the diradicals display huge two-photon cross sections in the infrared spectral region.

Ultra-small heterostructures (AuNCs@OFTF) with amphiphilicity were developed. They can be rapidly internalized in cyanobacteria and provide a programmable electronic interface, where the strong energetic coupling accelerates electron transfer in living cyanobacteria. Exogenous photogenerated electrons from AuNCs@OFTF enable a five-fold increase in photocurrent and enhance biomass production of cyanobacteria.

A zinc Lewis acid catalyzes asymmetric (3+2) cycloadditions of BCBs with imines to afford aza-BCHs bearing α-chiral amine fragments and two quaternary carbon centers in high yields and er values. Expeirmental studies and DFT calculations provide mechanistic insight.

Our study unveils METTL3’s oncogenic role in melanoma. RM3, a designed peptide inhibitor disrupting METTL3/14 complex, induces proteasomal degradation via STUB1. RM3 reduces melanoma cell proliferation, migration, and invasion, and induces apoptosis in vitro and in vivo. Combined with anti-PD-1 antibody, RM3 elicits significantly enhanced tumor response in vivo, with a favorable safety profile.

The highly selective acylative kinetic resolution of racemic pyrazolone tertiary alcohols catalysed by chiral isothioureas is described (s=>100 in >25 examples). This method was applied to highly functionalised pharmaceutically derived compounds, demonstrated at a decagram scale, and at ppm catalyst loading with DFT analysis indicating an NC=O⋅⋅⋅isothiouronium interaction key to enantiorecognition.

Non-fused ring dipodal phosphonic acids, characterized by non-fused ring backbones and dipodal phosphonic acid anchors, are developed and used as hole-extraction layers in organic solar cells. Such simple and tailorable backbones offer a novel platform to study structural effect on their self-assembly behaviors on ITO, which leads to an impressive performance of 19.66 % owing to optimized interfacial contact and active layer morphology.

A putative α-ketoglutarate-dependent dioxygenase from aculene biosynthesis, AneA, was functionally characterized and explored as biocatalyst for C−H oxidation. AneA exhibits broad substrate promiscuity and is capable of both hydroxylation and desaturation depending on its substrate structure. The utility of the biocatalytic reaction was demonstrated in several oxidative desymmetrizations and in the chemoenzymatic synthesis of complex sesquiterpenoids.

The gas tunnel of PHD2, an iron-based O₂ sensing enzyme, is engineered using a computation-guided rational design approach. The engineered mutants exhibit an increased rate of gas transport to the active site, along with increased catalytic activity in vitro. These mutants also display enhanced intracellular activity demonstrating the ability to reprogram hypoxia signaling by activating PHD2.

The conversion of lignin-derived guaiacyl (G) and syringyl (S) compounds into methoxy-ortho-diphenols through oxidative ortho-hydroxylation and ortho-demethoxylation reactions catalyzed by novel fungal polyphenol oxidases (PPOs) is presented. The formation of o-diphenols rather than reactive quinones can be steered by the addition of a reductant. These PPOs offer new methods to reduce the heterogeneity of G and S lignin-derived product mixtures.

A practical thin (10–40 μm) Li/Mo/Li₂Se anode with concurrently modulated interphase and mechanical properties was achieved via a scalable mechanical rolling process. The Li/Mo/Li₂Se demonstrates ultrahigh-rate performance and ultralong-lifespan cycling sustainability. The Li|LiNi_0.8Co_0.1Mn_0.1O₂ pouch cells deliver enhanced cycling stability with a superior energy density of 329.2 Wh kg⁻¹ even under the harsh cycling conditions.

Regulating the buried interface is crucial for perovskite crystallization and charge transport. An innovative approach, using hydroxylamine salts for interface modification precisely anchors perovskite ions, promoting controlled crystal growth. This approach significantly enhances the efficiency and long-term stability of Sn−Pb perovskite solar cells, critical for future development of all-perovskite tandems.

A conjugated donor-acceptor covalent organic frameworks BTT-PTO-COF containing BTT (p-type) and PTO (n-type) as dual-active centers enable high-rate and high-capacity for LIBs. BTT-PTO-COF with mesoscale porosity and dual redox-active centers promotes fast charge transfer and multi-electron processes, leading to high specific capacity, outstanding rate capability and impressive stability for long-term cycling.

RuS_x/NbS₂ heterostructure was synthesized by the introducing of amorphous RuS_x onto crystalline NbS₂ surface. It shows a Pt-like HER activity with a low overpotential as 38 mV at 10 mA ⋅ cm⁻², which is mainly benefit from hydrogen spillover caused by reversing charge transfer that induced by S−S bonds at RuS_x/NbS₂ heterointerface.

The LSPR effect can efficiently promote interatomic transfer of plasmon hot carriers and the extra hot electrons transferred on Cu atoms from Au atoms effectively enhance the desorption of ammonia molecules, thereby accelerating the ENRR. This study provides an important reference for understanding the distribution and mechanism of plasmon hot carriers on the surface of alloy heterogeneous nanostructure.

High vacuum FTIR experiments at temperatures as low as 13 K, together with divide-and-conquer semiclassical and path integral molecular dynamics simulations, indicate that a short and strong hydrogen bond is formed during the adsorption of HCOOH on the anatase (101) TiO₂ surface. Such unusual H-bond has previously escaped direct spectral detection because of a huge red shift of its vibrational frequency.

By harnessing a chiral radical copper catalytic system, the challenging enantioconvergent and site-selective etherification of carbohydrate polyols is achieved. Besides being broadly applicable over a considerable range of sugars, multiple dimensions of stereocontrol can be tackled simultaneously. Remarkably, when anomeric unprotected reducing sugars were employed, dynamic kinetic resolution is further activated to achieve β-O-glycosylation.

A novel strategy is developed to enhance the stability of aqueous zinc-ion batteries (ZIBs). Incorporation of DTPA-Na additive enables a synergistic formation of robust solid electrolyte interphase (SEI) and cathode electrolyte interphase (CEI). This strategy effectively regulates the solvation structure and interfacial chemistry, promoting uniform zinc deposition, inhibiting detrimental side reactions, and preventing manganese dissolution, ultimately achieving high-performance ZIBs.

This work integrates a CuSn alloy-modified CuSn/TiO₂/Sb₂S₃ photocathode for efficient nitrate-to-ammonia conversion. The photocathode possesses an excellent onset potential of 0.62 V_RHE, achieves the highest ammonia Faraday efficiency of 97.82 % with a yields up to 16.96 μmol h⁻¹ cm⁻² at 0 V_RHE. The excellent charge carrier kinetics and moderate NO₂⁻ adsorption provide an effective strategy for achieving stable and efficient photoelectrochemical ammonia synthesis.

Commonly reported parameters such as time, rpm, and ball mass are often insufficient to replicate mechanochemical syntheses accurately. By demonstrating that reaction outcomes are tied to the cumulative total energy, we can enhance the reproducibility of mechanochemical reactions across various laboratory mills, including planetary and mixer mills. To aid in this, we offer a free online calculator to compute and report all necessary parameters.

By synergistic tuning of lattice magnetic fields and interfacial structure stability, this work provides a green, efficient, and universal strategy of Si gradient doping to overcome the kinetic hysteresis problems that have long-term hindered the development of Co-free Ni-rich cathode materials.

UDP-glycosyltransferase UGT91H enzymes for the regioselective 2“-O-glycosylation of triterpenoids to generate triterpenoid glycosides with a linear trisaccharide are described. Ancestral sequence reconstruction was successfully applied to expand the substrate scope of UGT91H enzymes, and an RTAS loop was identified to affect the substrate specificity of UGT91H enzymes.

A three-component vinylene-linked D-π-A copper-cyclic trinuclear units (Cu-CTUs)-based metal-covalent organic framework (MCOF) with reinforced intramolecular charge separation driving force was designed and prepared, achieving highly-efficient charge spatial separation efficiency and photocatalytic CO₂ reduction performance. The Cu-CTUs active sites can effectively adsorb and activate CO₂ to further enhance photocatalytic performance.

A protonation-modification strategy has been employed to modify imine-linked donor-acceptor (D-A) type covalent organic frameworks (COFs), significantly improving the electron delocalization capabilities of the imine bonds and constructing advanced memory devices. The obtained novel COF-BTT-TAPT@PTSA thin film-based rewritable memristors exhibit high ON/OFF current ratio (ca. 10⁵) and unprecedented endurance (more than 1300 number of cycles).

This report establishes the redox activity of biOx (bi-oxazoline), biIm (bi-imidazoline), and pyIm (pyridine-imidazoline) ligands in stabilizing nickel radical complexes. Direct comparison of the redox potentials of bidentate N-ligands provides crucial benchmarks for controlling catalytic activity and enhancing catalyst stability.

The proposed supramolecular deep eutectic electrolyte (DEE) based on LiTFSI, acetamide and boric acid, improving the oxidation voltage up to 4.5 V, and enhancing the solution phase discharge mechanism by forming Li-bonds and H-bonds with Li⁺ and O₂⁻. The introduction of boric acid also promotes the formation of inorganic-rich SEI, which induces Li⁺ uniform deposition. The Li−O₂ battery with this DEE delivers ultrahigh discharge capacity, improved cycling performance and intrinsic safety.

This study introduces new insights into the heterogeneous lithium nucleation and growth dynamics that directly influence the performance of lithium metal anodes (LMAs). It reveals that high-performance electrodes for LMAs, characterized by a high active lithium adsorption capacity and fast surface diffusion kinetics, can be defined as ′supersaturated electrodes.

A versatile mixed-dimensional assembly approach is proposed to construct nanocrystal-on-nanowire superstructures with accurately tailored biphasic interfaces. Using Au-on-Ag superstructures as a model catalyst for electrochemical CO₂-to-CO conversion, this work establishes a logarithmic linear relationship between catalytic activity and the number of Au/Ag interfaces per unit mass of the catalyst.

This study presents a method for long-term, continuous plasmonic biosensing of oligonucleotides with 5-minute temporal resolution by using regeneration-based reversibility approach. A picomolar limit of detection (LoD) in both buffered and serum complexes is achieved, and reliable performance for over 100 measurements per day and stability over 9 days were demonstrated.

A strongly coupled metal/hydroxide heterostructure was constructed. The heterostructure provides dual-sites for carbon dioxide reduction and nitrate reduction reactions, and thus facilitate efficient C−N coupling toward urea formation. The obtained Ag−CuNi(OH)₂ composite delivers greatly enhanced urea yield rate and Faradaic efficiency compared with individual Ag and CuNi(OH)₂.

We have developed a “Suspension bead loading” (SBL) approach that serves as a general and economical delivery method to address fundamental biological questions. We applied SBL to investigate the cellular behavior of synthetic Ubiquitin related modifier 1 (URM1) under normal and oxidative stress conditions. Created with BioRender.com.

We present a hydrogen isotope exchange reaction using non-directed homogeneous Pd-catalysis. The catalytic system relies on a commercially available pyridine ligand that enables aromatic C−H activation. Labelling of 39 pharmaceuticals was achieved by utilizing D₂O as the deuterium source and solvent, without requiring fluorinated cosolvents. Expansion to T/H exchange on three different pharmaceuticals by using T₂O as isotopic source was demonstrated.

We first proposed the anion effect on steerable production of HMF using metal salts with different anions as catalyst in a biphasic system of THF/NaCl aq, which is attributed to the proximity effect and electron tension. The anion promotes electron transfer through proximity effects and also induces a decrease in the electron cloud density of glucose carbon atoms, generating electron tension, thereby increasing the HMF yield.

Sodiophobic graphite can be converted to sodiophilic graphite intercalation compounds through solvated-sodium-ion co-intercalation mechanisms, thus facilitating dendrite-free sodium metal plating/stripping with enhanced Coulombic efficiencies. This finding propels the achievement of cost-effective and high capacity anodes for advanced sodium ion batteries with energy densities of above 250 Wh kg⁻¹.

The ambocidins are calcium-dependent lipopeptide antibiotics with a unique peptide core that are active against drug-resistant Gram-positive pathogens. Heterologous expression of their biosynthetic gene cluster (BGC) in multiple hosts resulted in production of new metabolites. However, only one heterologous host was capable of supporting production of the ambocidins. The ambocidins bind lipid II at a site distinct from the target of vancomycin.

This work reports a high-voltage p-type organic cathode material of DHTAT for application in aqueous zinc batteries, exhibiting a high capacity of 224 mAh g⁻¹ at a current density of 50 mA g⁻¹. After 5000 cycles at 5 A g⁻¹, the DHTAT electrode retains 73 % of its initial capacity, indicating promising cycling stability. Additionally, DHTAT also exhibits good low-temperature performance and can stably cycle at −40 °C for 4000 cycles at 1 A g⁻¹, making it a competitive candidates cathode material for low-temperature batteries.

A multi-enzyme cascade conversion system was developed using O₂ as the oxidant and ammonium as the amination reagent. This system is based on internal cofactor and H₂O₂ recycling. It is designed to facilitate the one-pot enzymatic conversion from chemically inert hydrocarbons to chiral amino acids under environmentally friendly conditions, which is a highly challenging transformation in traditional organic synthesis.

Diese Arbeit zeigt, dass die Integration von PET und MRT in der molekularen Bildgebung das Potenzial hat, die diagnostische Genauigkeit und die Patientenversorgung zu verbessern. Wir haben eine hybride PET/MR-Sonde, [¹⁸F][Gd(FL¹)], entwickelt, die außergewöhnlich stabil ist, schnell synthetisiert und effizient radioaktiv markiert werden kann und eine gleichzeitige PET/MR-Bildgebung ermöglicht. Das Potenzial für die In vivo-Anwendung wird durch die quantitative Charakterisierung von Gewebe und Nierenfunktion bei Mäusen demonstriert.

Intermolekulare Homo-Kopplungen, aber vor allem Kreuz-Kopplungen sind eine Herausforderung! Wir berichteten über eine elektrochemische [2+2+2]-Annulation von Alkinen mit Nitrilen unter Verwendung von Triarylamin als Redox-Mediator zur Bildung substituierter Pyridine. Unser Verfahren zeigt eine beispiellose Kontrolle der Chemoselektivität und ermöglicht sowohl Homo- als auch Heterokupplungen von Alkinen und Nitrilen. Es wird ein mechanistisches Grundprinzip vorgeschlagen, das durch CV, EPR, NMR und Berechnungsstudien unterstützt wird.

Die Reaktion eines zweifach durch cyclische Alkyl(amino)carbene (CAAC) stabilisierten Dicyanodiborens mit organischen Aziden führt zu stabilen CAAC-Iminoboran-Addukten. Experimentelle und rechnerische Daten bestätigen die entscheidende Beteiligung eines relativ langlebigen terminalen Borylen-Distickstoff-Addukts (d. h. Diazoboran), [(CAAC)B(CN)(η¹-N₂)].

Der gezielte Einsatz der Ferroptose ist ein neuer Weg, um die Grenzen der apoptotischen Krebsbekämpfung zu überwinden. Der hier beschriebene Co(III)-Polypyridin-Sulfasalazin-Komplex wirkt als starker Ferroptose-Induktor für die Krebstherapie. Dieser Komplex reichert sich selektiv in Mitochondrien an, wobei er reaktive Sauerstoffspezies erzeugt, die Lipidperoxidation auslöst, Glutathion abbaut, die Glutathionperoxidase 4 hemmt und schließlich die Ferroptose auslöst.

Ein des auf dem in der Erde häufig vorkommenden Elements Eisen beruhender Katalysator ermöglichte das effiziente elektrochemische Recycling von Polystyrol mit Wasserstoff als einzigem Nebenprodukt, was das Potenzial für eine kreislauforientierte Kohlenstoffwirtschaft mit einer skalierbaren grünen Wasserstoffentwicklung hervorhebt.

Disäquilibrierung durch Sensibilisierung unter Einschluss wird erstmals verwendet, um die Oberflächenspannung von Wasser mit Hilfe von photoschaltbaren Tensiden zu modulieren. Die Tenside POS oder NEG werden zusammen mit einem Photosensibilisator in einem makrozyklischen Käfig eingekapselt, sodass Bestrahlung mit sichtbarem Licht (grün oder rot) eine Isomerisierung induziert und somit die Oberflächenspannung auf Grundlage der veränderten Oberflächenaktivität der Amphiphile steuert.

We report an efficient Cu-catalyzed asymmetric cascade hydrosilylation of arylmethylenecyclopropanes with dihydrosilanes or primary silanes, which gives access to a variety of C-stereogenic and Si-stereogenic silacyclopentanes in decent yields with good to excellent enantioselectivities and diastereoselectivities under mild conditions.

H_ads travels with the motion of a liquid metal surface, allowing it to reach dopant sites (In or Sn) where it reacts with CO₂ to make formate with a low barrier (0.25 eV). H_ads is not mobile on a solid surface, explaining why only liquid metals catalyse the reaction.

For the first time, a ternary cluster consisting of a polyoxometalate cluster sandwiched by two gold clusters protected by N-heterocyclic carbenes was synthesized through ligand exchange, whose atomically precise structures were characterized by single crystal X-ray diffraction analysis. These composite clusters demonstrate excellent catalytic capabilities for reducing H₂O₂ via the intercluster synergistic effects.

Native proteomics enabled the measurement of protein complexes up to 400 kDa from a complex proteome, via online coupling of native capillary zone electrophoresis to an ultra-high mass range Orbitrap mass spectrometer. Mass spectrometry-based native proteomics agreed well with native mass photometry regarding the mass distribution of detected proteins.

The synthesis of oxabicyclo[4.1.1.]octanes is demonstrated via the Lewis acid catalyzed (4+3) annulation of para-quinone methides with bicyclo[1.1.0]butanes. The reaction proceeds with the simultaneous activation of p-QMs and BCBs by Lewis acid. Mechanistically, the reaction entails the activation of the ester enolate of BCB by the Lewis acid. This method is notably straightforward in operation, proceeds efficiently under mild conditions, and exhibits excellent compatibility with various functional groups, demonstrating a broad scope.

Microbial ecosystem engineering enables efficient solar-driven methanogenesis over a biohybrid photocatalyst. The syntrophic coculture of Methanosarcina barkeri (M. barkeri) with the electron transport specialist Geobacter sulfurreducens KN400 (KN400) over carbon nitride produced a semi-biological photocatalyst for the sunlight-driven methane synthesis from carbon dioxide.

Two-step approach to bottlebrush synthesis using α-lipoic acid (LA) enables control over side-chain chemistry and catalyst-free synthesis of degradable bottlebrush polymers.

We have designed a non-local metasurface to achieve vibrational strong coupling (VSC) between surface lattice resonance and the C=O stretching modes of both ethyl acetate and p-nitrophenyl acetate (PNPA). Within this VSC system, we observed a 2.7-fold increase in the solvolysis reaction of PNPA compared to the bare reaction. This finding highlights the robustness of metasurfaces in catalyzing chemical reactions via VSC.

Eine nickelkatalysierte Veretherung von Phenolen mit regioisomeren Gemischen aus racemischen silylierten und germylierten Allylchloriden ermöglicht die enantio- und regiokonvergente Bildung von unsymmetrischen 1,3-disubstituierten chiralen Allylarylethern als einzelnes Regioisomer (siehe Schema). Der Schlüssel zum Erfolg ist die dirigierende Metalloidgruppe, die die Regioselektivität kontrolliert, und die gebildeten hochfunktionalisierten Allylether können anschließend in chemoselektiven Folgereaktionen umgesetzt werden.

Ein modularer Syntheseansatz im Nanomolmaßstab ermöglicht die schnelle Entwicklung fluoreszenter RNA-MTase-Sonden und ermöglicht damit Hochdurchsatz-Screenings für Wirkstoffentwicklungen. Dieser innovative Ansatz erlaubt signifikante Fortschritte in der medizinischen Chemie von RNA-MTasen, wie die Entdeckung der ersten METTL1-Inhibitoren ihrer Klasse eindrucksvoll zeigt.

Die hochauflösender Rotationsspektroskopie in Verbindung mit umfassenden theoretischen Berechnungen ermöglicht eine erste Beobachtung und Analyse des heteroternären Clusters c-C₅H₈−CO₂−H₂O, um das subtile Zusammenspiel der Kräfte, die seine Entstehung bestimmen, zu ergründen.

Die Einführung von Wasserstoffbrückenbindungsdonoren an bestimmten Stellen der Peripherie einer stabilen Helix-Turn-Helix-Tertiärfaltung eines aromatischen Foldamers führte zu seiner Aggregation in Chloroform und dabei zur Bildung von echten, abgrenzbaren abiotischen Quartärstrukturen, in denen die Tertiärfaltungen konserviert sind. Die Quartärstrukturen wurden einem C₃-symmetrischen Trimer entsprechend dem ursprünglichen Entwurf und einem unerwarteten hydratisierten C₂-symmetrischen Dimer zugeordnet.

Entwicklung einer DNA-Polymerase aus Thermus aquaticus, die methylierte von unmethylierter DNA durch einen erhöhten Fehleinbau gegenüber 5-Methylcytosin (5 mC) während der DNA-Synthese unterscheidet. Durch die Erzeugung von 5 mC-abhängigen Mutationssignaturen im PCR-Produkt ist das Enzym in der Lage, methylierte Stellen zu erkennen und ermöglicht den direkten Nachweis durch Auslesen erhöhter Fehlerraten an 5 mC-Positionen nach der Sequenzierung ohne vorherige Umwandlung der Templat-DNA.

Die erste Synthese eines vollständig charakterisierten Dicyanketenimins, Me₃Si−NC−C(CN)₂, wurde durch Einführung einer sperrigen Me₃Si-Gruppe erreicht, während die protonierte Spezies zum Tricyanmethan-Isomer HC(CN)₃ führt. Eine weitere Silylierung mit [Me₃Si−H−SiMe₃][B(C₆F₅)₄] führte zur Bildung eines ungewöhnlichen, persilylierten Dikations [C(CN−SiMe₃)₃]²⁺, das durch ein schwach koordinierendes Anion stabilisiert wird.