Non-Equilibrium Dissipative Assembly with Switchable Biological Functions
Peng Zhao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
These authors contributed equally.
Contribution: Conceptualization (equal), Formal analysis (lead), Funding acquisition (supporting), Project administration (equal), Visualization (lead), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorYuanfeng Zhao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
These authors contributed equally.
Contribution: Data curation (lead), Formal analysis (equal), Investigation (equal), Methodology (lead), Writing - original draft (equal)
Search for more papers by this authorYan Lu
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Software (supporting)
Search for more papers by this authorLinjie Xu
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Methodology (supporting)
Search for more papers by this authorBohan Li
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Software (supporting), Validation (supporting)
Search for more papers by this authorYingshuai Zhao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Validation (supporting)
Search for more papers by this authorWei Zhou
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Methodology (supporting)
Search for more papers by this authorPu Yan
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Data curation (supporting)
Search for more papers by this authorYoufu Wang
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China
Search for more papers by this authorKecheng Cao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Data curation (supporting)
Search for more papers by this authorCorresponding Author
Yijun Zheng
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Funding acquisition (lead), Project administration (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorPeng Zhao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
These authors contributed equally.
Contribution: Conceptualization (equal), Formal analysis (lead), Funding acquisition (supporting), Project administration (equal), Visualization (lead), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorYuanfeng Zhao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
These authors contributed equally.
Contribution: Data curation (lead), Formal analysis (equal), Investigation (equal), Methodology (lead), Writing - original draft (equal)
Search for more papers by this authorYan Lu
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Software (supporting)
Search for more papers by this authorLinjie Xu
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Methodology (supporting)
Search for more papers by this authorBohan Li
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Software (supporting), Validation (supporting)
Search for more papers by this authorYingshuai Zhao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Validation (supporting)
Search for more papers by this authorWei Zhou
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Methodology (supporting)
Search for more papers by this authorPu Yan
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Data curation (supporting)
Search for more papers by this authorYoufu Wang
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China
Search for more papers by this authorKecheng Cao
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Data curation (supporting)
Search for more papers by this authorCorresponding Author
Yijun Zheng
School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210 Shanghai, China
Contribution: Funding acquisition (lead), Project administration (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorAbstract
Natural dissipative assembly (DSA) often exhibit energy-driven shifts in natural functions. However, creating man-made DSA that can mimic such biological activities transformation remains relatively rare. Herein, we introduce a cytomembrane-like dissipative assembly system based on chiral supramolecules. This system employs benzoyl cysteine in an out of equilibrium manner, enabling the shifts in biofunctions while minimizing material use. Specifically, aroyl-cystine derivatives primarily assemble into stable M-helix nanofibers under equilibrium conditions. These nanofibers enhance fibroblast adhesion and proliferation through stereospecific interactions with chiral cellular membranes. Upon the addition of chemical fuels, these functional nanofibers temporarily transform into non-equilibrium nanospheres, facilitating efficient drug delivery. Subsequently, these nanospheres revert to their original nanofiber state, effectively recycling the drug. The programmable function-shifting ability of this DSA establishes it as a novel, fuel-driven drug delivery vehicle. And the bioactive DSA not only addresses a gap in synthetic DSAs within biological applications but also sets the stage for innovative designs of ′living′ materials.
Conflict of Interests
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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