Volume 136, Issue 48 e202418262
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Rücktitelbild: Eine makrozyklische Hybrid-PET/MRT-Sonde für die quantitative Perfusionsbildgebung in vivo (Angew. Chem. 48/2024)

Dr. Jan Kretschmer

Dr. Jan Kretschmer

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic

Faculty of Science, Department of Organic Chemistry, Charles University Praha 2, Albertov 6, 12800 Prague, Czech Republic

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany

Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany

These authors contributed equally to this work.

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Remy Chiaffarelli

Remy Chiaffarelli

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany

Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany

These authors contributed equally to this work.

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Marta Vuozzo

Marta Vuozzo

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany

Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany

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Dr. Jonathan Cotton

Dr. Jonathan Cotton

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany

Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany

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Dr. Jan Blahut

Dr. Jan Blahut

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic

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Dr. Jan Ráliš

Dr. Jan Ráliš

Nuclear Physics Institute of the CAS Řež 130, 250 68 Řež, Czech Republic

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Dr. Martin Dračínský

Dr. Martin Dračínský

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic

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Stanislava Matějková

Stanislava Matějková

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic

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Dr. Ulrike Seeling

Dr. Ulrike Seeling

Institute for Engineering, Electronics and Analytics (ZEA-3: Analytics), Research Center Jülich GmbH, Wilhelm-Johnen-Str., 52428 Jülich, Germany

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Dr. Andreas M. Schmid

Dr. Andreas M. Schmid

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany

Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany

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Prof. Dr. André F. Martins

Corresponding Author

Prof. Dr. André F. Martins

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany

Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany

German Cancer Consortium (DKTK), partner site Tübingen, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120 Germany

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Dr. Miloslav Polasek

Corresponding Author

Dr. Miloslav Polasek

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic

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First published: 24 October 2024

Graphical Abstract

A novel hybrid PET/MRI probe integrating stable gadolinium chelate with radioactive fluorine-18 was designed for precision imaging of perfusion and excretion dynamics. In their Research Article (e202409520), André F. Martins, Miloslav Polasek et al. demonstrate how merging quantitative PET signal with MRI contrast within a single molecule improves diagnostic capabilities. Employing sophisticated image analysis, this innovative probe can reveal hidden health issues, such as early stages of kidney dysfunction.

    The full text of this article hosted at iucr.org is unavailable due to technical difficulties.