Rücktitelbild: Eine makrozyklische Hybrid-PET/MRT-Sonde für die quantitative Perfusionsbildgebung in vivo (Angew. Chem. 48/2024)
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Eine makrozyklische Hybrid-PET/MRT-Sonde für die quantitative Perfusionsbildgebung in vivo
- Jan Kretschmer,
- Remy Chiaffarelli,
- Marta Vuozzo,
- Jonathan Cotton,
- Jan Blahut,
- Jan Ráliš,
- Martin Dračínský,
- Stanislava Matějková,
- Ulrike Seeling,
- Andreas M. Schmid,
- André F. Martins,
- Miloslav Polasek,
- Volume 136Issue 48Angewandte Chemie
- First Published online: October 14, 2024
Dr. Jan Kretschmer
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Faculty of Science, Department of Organic Chemistry, Charles University Praha 2, Albertov 6, 12800 Prague, Czech Republic
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
These authors contributed equally to this work.
Search for more papers by this authorRemy Chiaffarelli
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
These authors contributed equally to this work.
Search for more papers by this authorMarta Vuozzo
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
Search for more papers by this authorDr. Jonathan Cotton
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
Search for more papers by this authorDr. Jan Blahut
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorDr. Jan Ráliš
Nuclear Physics Institute of the CAS Řež 130, 250 68 Řež, Czech Republic
Search for more papers by this authorDr. Martin Dračínský
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorStanislava Matějková
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorDr. Ulrike Seeling
Institute for Engineering, Electronics and Analytics (ZEA-3: Analytics), Research Center Jülich GmbH, Wilhelm-Johnen-Str., 52428 Jülich, Germany
Search for more papers by this authorDr. Andreas M. Schmid
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
Search for more papers by this authorCorresponding Author
Prof. Dr. André F. Martins
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
German Cancer Consortium (DKTK), partner site Tübingen, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120 Germany
Search for more papers by this authorCorresponding Author
Dr. Miloslav Polasek
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorDr. Jan Kretschmer
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Faculty of Science, Department of Organic Chemistry, Charles University Praha 2, Albertov 6, 12800 Prague, Czech Republic
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
These authors contributed equally to this work.
Search for more papers by this authorRemy Chiaffarelli
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
These authors contributed equally to this work.
Search for more papers by this authorMarta Vuozzo
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
Search for more papers by this authorDr. Jonathan Cotton
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
Search for more papers by this authorDr. Jan Blahut
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorDr. Jan Ráliš
Nuclear Physics Institute of the CAS Řež 130, 250 68 Řež, Czech Republic
Search for more papers by this authorDr. Martin Dračínský
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorStanislava Matějková
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorDr. Ulrike Seeling
Institute for Engineering, Electronics and Analytics (ZEA-3: Analytics), Research Center Jülich GmbH, Wilhelm-Johnen-Str., 52428 Jülich, Germany
Search for more papers by this authorDr. Andreas M. Schmid
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
Search for more papers by this authorCorresponding Author
Prof. Dr. André F. Martins
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13/1, 72076 Tübingen, Germany
Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
German Cancer Consortium (DKTK), partner site Tübingen, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120 Germany
Search for more papers by this authorCorresponding Author
Dr. Miloslav Polasek
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00 Prague 6, Czech Republic
Search for more papers by this authorGraphical Abstract
A novel hybrid PET/MRI probe integrating stable gadolinium chelate with radioactive fluorine-18 was designed for precision imaging of perfusion and excretion dynamics. In their Research Article (e202409520), André F. Martins, Miloslav Polasek et al. demonstrate how merging quantitative PET signal with MRI contrast within a single molecule improves diagnostic capabilities. Employing sophisticated image analysis, this innovative probe can reveal hidden health issues, such as early stages of kidney dysfunction.
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