Qiao and co-workers recently designed and interpreted the construction of high-density Pt single atoms in the Co₃O₄ host with inter-site interactions via the Hard-Soft Acid-Base principle and further revealed the dynamic structure evolution process of the single atom sites by a series of in situ/ex situ spectroscopic techniques and theoretical computation.

In this Correspondence, we show that the rapid and cyclable atmospheric water harvesting processes in a hydrogen-bonded organic framework (HOF) recently reported by Ben and co-workers involve massive structural rearrangement. Adsorption and desorption of water causes motion of the entire framework in a crystal-to-crystal manner.

A rapid water adsorption/desorption process with low energy consumption was achieved in the nano-confined channels of CPOS-6. The confined water can be regarded as a molecular superfluid.

Efforts to boost tin halide perovskite optoelectronics have focused heavily on the instability of Sn^II, while other inconspicuous chemical processes have remained unexplored. This Minireview highlights the key role of native halide chemistry in the stability, device performance, ecological impact and prospects for visible light emission in this class of materials. Halide management routes towards viable optoelectronics are also proposed.

Research on solar-driven water purification has grown rapidly over the past years and emerging materials such as polymers, MOFs and COFs have been employed in this field recently. This minireview gives an overview of the basic concepts and principles for solar evaporation systems and on the development of novel photothermal materials.

The [2+2]-heterocycloaddition between alkenes and carbonyls is a formidable strategy for the synthesis of complex strained 3D architectures. This Review provides an overview on the recent development of [2+2]-heterocycloadditions driven by visible light. The diverse synthetic approaches are presented with special emphasis on the involved reaction mechanisms along with possible future directions of the field.

As supramolecular chemistry begins to develop dynamic nanostructures that change over time, it becomes imperative to visualize self-assembly processes in solution in real-time. Our Review demonstrates how solution-based visualization techniques, namely optical super-resolution microscopy, atomic force and electron microscopy in liquid, and molecular dynamics simulations, have enriched our understanding of nanomaterials to obtain novel functions.

Addition of parahydrogen to particles comprised of an iridium-based catalyst supported on a metal–organic framework produces dissolved orthohydrogen, but with a twist: a strongly hyperpolarized state is achieved that is enriched in the T₀ sublevel, giving rise to a surprising anti-phase signal with enhancement up to ≈500-fold and significantly increased hyperpolarization lifetime.

Inspired by the active site of CO dehydrogenase (CODH), a novel metalloporphyrin-based mimic has been synthesized combining a multipoint hydrogen bond donor and a bimetallic active centre. The cooperativity between the two metal centres of the catalyst was evidenced for both homo- and heterobimetallic analogues leading to a significant enhancement of the catalytic performances of the heterogeneous CO₂-to-CO electrocatalytic reduction in water.

S-Poly(2,4-dimethyl-2-oxazoline)-based membranes (S-PdMeOx/GO) are prepared via a simple solution-based method on porous substrates for chiral separation. The S-PdMeOx-based network within the graphene oxide scaffold induced homochirality in the membrane. The resulting S-PdMeOx-based membrane displays excellent enantioselectivity in separating racemic limonene mixtures.

Cesium amide catalyst establishes a new bridge between benzylic C−H bonds and D₂/T₂, facilitating deuteration and tritiation of pharmaceutical compounds.

We demonstrate that morphological transitions during radical RAFT-mediated PISA in water do not require unimer exchanges. The monomer present in the polymerization medium enables morphological transitions although it unexpectedly slows down unimer exchange.

Gradually inducing an increase in size from atoms to nanoflat surfaces shows the great power of the conjugated, multi-pore structure of graphdiyne (GDY). An electrode for aqueous zinc-ion batteries obtained by anchoring Zn atoms on graphdiyne shows excellent electroplating/stripping reversibility and lifespan without any Zn dendrites and side reactions, even at high current densities.

SASSY NMR is a novel 2-in-1 technique capable of observing solid and solution phases simultaneously. Gel-like material appears in both fractions with a distribution proportional to the rigidity of the C−H dipoles. SASSY is advantageous when monitoring processes involving multiphase changes, as traditional sequential solid and solution NMR can miss rapid fluctuations. SASSY is easy to use, time efficient and can be applied universally.

Coordinative chain transfer polymerization permits the controlled and efficient polymerization of ethylene, currently the most important monomer for plastic production. The key to the combination of control, very high activity, and an excellent catalyst economy seems to be a Group 4 metal complex stabilized by only one bulky and strongly bound monoanionic ligand. NH⁺B⁻=N,N’-dimethylanilinium tetrakis (pentafluorophenyl)borate.

A binuclear copper-catalyzed (3+2) cycloaddition of 2-aminoallyl cations with indoles was achieved. This transformation featured a unique C1,N-dipolar cycloaddition reactivity for 2-aminoallyl cations. Enantioenriched pyrroloindoline derivatives were prepared by this cycloaddition in high yields with good enantio- and diastereoselectivities.

Chiral 1,4-dicarbonyl compounds can be obtained via the enantioselective bromination of aldehydes and subsequent cross-coupling reactions between the resulting chiral α-bromoaldehydes and α,α-dibromoketones. This cross-coupling reaction is enabled by the chemoselective formation of zinc enolates from α,α-dibromoketones in the presence of α-bromocarbonyl compounds.

The integration of flexibility and room-temperature phosphorescence in an organic single crystal is achieved by the host–guest doping strategy. The centimeter-scale crystals can be repeatedly bent and emit deep-red afterglow. This phenomenon occurs because the guest molecules, as trace impurities, greatly affect the emission properties of the materials, whereas the effect on the molecular packing of the host molecules is negligible.

Herein, we describe the development of a copper-catalyzed C(sp³)-amination of proaromatic dihydroquinazolinones derived from ketone building blocks. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C−C bond-cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.

A triply negatively charged radical species based on a bilayer of a C₉₆ nanographene was synthesized and characterized. It is stabilized as an open-shell doublet ground state with an excited quartet state. It is the largest well-defined open-shell graphenic bilayer and also the first example of a triply negatively charged radical π-dimer. Spin frustration is observed in this species.

The first experimental demonstration that preorganization of inhibitor side chain conformation can favorably impact glycosidase inhibition is reported. By strategic installation of a methyl group at C6, a manno-configured iminosugar with the gauche,gauche side chain conformation was found to be a 27-fold better inhibitor than 1-deoxymannojirimycin.

Rebuilding the core modules of natural K⁺ channels in an artificial system has led to a biomimetic K⁺ channel. This channel possesses similar structural features as the natural version, which enables it to replicate the transport behavior and biological function of natural K⁺ channels.

We used the intensity ratio of the first and second vibronic peaks of semiconducting polymer dots (Pdots) to correlate photoswitching events. Multi-fold localization precision enhancement was achieved by averaging over switching events from the same Pdot. This method was used to count and map two membrane proteins on synaptic vesicles.

Here we report an efficient method for the synthesis of π-extended pyrrole-fused heteropine compounds and investigated their optical and electronic properties. A π-extended pyrrole-fused thiepine exhibited a “pitched π-stacking” structure in the crystal, and exhibited a high charge carrier mobility of up to 1.0 cm² V⁻¹ s⁻¹ in single-crystal field-effect transistors.

Photoexcited nitroarenes ca be used, in conjunction with Pd-mediated hydrogenation, as osmium surrogates for olefin dihydroxylation.

The elusive tetrahedral [Cp*Si(AlCp*)₃]⁺ cation is prepared as its aluminate salts starting from Jutzi's [SiCp*]⁺ cation and Schnöckel's [(AlCp*)₄]. Owing to its good accessibility, [SiAl₃]⁺ can act as starting point towards the synthesis of low-valent silicon-doped aluminium-cluster cores as shown by the preparation of the larger [Si₂(AlCp*)₅]²⁺ cluster cation.

Near-infrared chemiluminophores with high chemiluminescence quantum yields were synthesized and developed into an activatable chemiluminescence probe for real-time turn-on detection of deeply buried tumor tissues in living mice.

Incorporation of MoO₂ enhances the catalytic efficiency of Ni in selective electrochemical hydrogenation of phenol in aqueous 0.1 M H₂SO₄ solutions. The origin of the superior performance is revealed by in situ diffuse reflectance infrared spectroscopy and density functional theory calculations.

A series of dibenzomethanopentacene (DBMP) containing polymers of intrinsic microporosity (PIMs) were synthesised showing both high performance for pure and mixed gas permeability/selectivity and reduced ageing. The data for DBMP-rich PIMs are close to the latest Robeson upper bounds for several important gas pairs indicating their potential for making gas separation membranes.

A polythiophene (PT) with the ability of self-adaptive re-organization is used for the cathode of aluminum ion battery. The polymerization mode can change from C_α−C_α (α-PT) to C_β−C_β (β-PT) which makes the PT obtain fast kinetics and small steric hindrance. PT cathode achieves a high capacity and super long cycle life of 100 000 cycles.

A deep blue boron-, nitrogen- and oxygen-doped nonacene emitter that shows multi-resonant thermally activated delayed fluorescence (MR-TADF) is described. The emitter shows bright, deep-blue narrowband emission in an organic light emitting diode (OLED) device.

The Zn(TFSI)₂-sulfolane-water hybrid electrolytes based on the deep eutectic solvents present an efficient strategy for hydrogen bond network reconstruction and multifunctional interfaces optimization, realizing highly reversible Zn plating/stripping and excellent electrochemical performance.

An I₂-catalyzed unprecedented cycloisomerization of ynamides is developed, allowing various bis(indole) derivatives in good to excellent yields with wide substrate scope, which not only represents the first molecular iodine-catalyzed tandem complex alkyne cycloisomerizations but also constitutes the first chemoselective cycloisomerization of tryptamine-ynamides involving distinctively different C−C (alkyl) bond cleavage and rearrangement.

Tuning the ϵ_p of O in δ-MnO₂ cathode can effectively increase H⁺ intercalation contribution with excellent rate capability for aqueous zinc ion batteries. The ϵ_p could be a significant descriptor for H⁺ intercalation contribution that describes a volcano curve as a function of ϵ_p, and the best cathode is optimized to be the Cu−MnO₂ among Cu−, Ni−, Co−, Zn−MnO₂.

In situ liquid time-of-flight secondary ion mass spectrometry (ToF-SIMS) is established as a molecular probe to unveil the aging chemistry of perovskite precursor solutions. In addition to uncovering the molecular mechanism of chemical aging reactions, it is demonstrated that the structure and stability difference of precursor-additive interactions determines the anti-aging effects of additives.

We report the observation of the intermittent BL blinking of a single bioluminescent bacterium. This study not only demonstrated, for the first time, the intermittent gating dynamics of NhaA antiporters in single native bacteria without any genetic engineering or chemical labeling, but also opened the door for P. phosphoreum to serve as model bacteria for reporting the physiological and metabolic status with spontaneous BL emission.

Helical nanofibers have been prepared from exclusively achiral building blocks upon ultrasonication-induced morphology transformation. The as-made helical nanofibers show a more robust and repeatable control of the helical handedness compared with those generated using common chiral solvents. It was further verified that the helical nanofibers can act as a spin filter with a comparable spin polarization (45 %) at room temperature.

Reported herein are ligand controlled, chemodivergent [4+2] or [2+2] cycloaddition reactions between readily available 1,3-dienes and alkynes. These reactions, catalyzed by cationic Co^I proceed with high regio- and enantioselectivies to give nearly enantiopure functionalized 1,4- cyclohexadienes or cyclobutenes from the same starting materials.

Ordered arrangements and resulting anion-dependent photophysical properties were observed in the dispersed- and solid-state ion pairs of squarylium-based π-electronic cation with an augmented dipole. A completely charge-segregated assembly was formed in the ion pair with a π-electronic anion, exhibiting solid-state photophysical properties and anisotropic electric conductivity according to the stacking structure.

We describe NIR fluorogenic substrates for granzyme A with rapid responses and enzyme sensitivity at physiological levels. We demonstrate that these probes can be used for real-time imaging of CTLs and NK cells in co-cultures with cancer cells and in ex vivo tissues, opening new avenues to monitor the functions of the immune system in the tumor microenvironment.

Two cosolvents, MFSI and TFF, were synthesized and investigated for lithium metal batteries. Among the four different electrolytes, the TFF-containing electrolyte exhibited the highest coulombic efficiency of 99.59 %, which is due to the low redox potential of TFF promoting the anion reduction, leading to an inorganic SEI formation.

A novel non-flammable electrolyte that endows Li-ion battery with high voltage, wide temperature, and fast charging is developed. Moreover, a new solvation chemistry-derived dynamic interfacial model, involving the kinetic and thermodynamic properties of electrolyte components on the cathode and anode simultaneously, was presented for the first time to interpret such excellent performance and guide the electrolyte design at a molecular scale.

The charge, spin, and orbital topological regulation behind attractive physicochemical properties functions as a universal descriptor for determining the geometrical-site-dependent catalysis. By tuning cationic geometric configuration in spinel oxides, the lithium polysulfides (LiPSs) adsorption competition on Mn³⁺_Oh−O−Co³⁺_Td backbones is well leveraged to spark the cooperative catalysis of LiPSs in lithium-sulfur batteries.

A transition-metal-free difunctionalization of bench-stable sulfur salts gives facile access to iodo-substituted sulfides using either diaryliodonium or vinyliodonium salts. The methodology was extended to one-pot syntheses of electron-rich thioanilines and efficient late-stage transformations of medicinally important compounds.

We demonstrate the sensitive, specific, selective, and multiplexed detection of different antibodies in blood serum using electrochemical cell-free biosensors. The platform is based on programmable antigen-conjugated gene circuits that, upon recognition of a target antibody, trigger the transcription of an RNA sequence consequently detected with a disposable electrochemical sensor.

The synthesized macrocyclic chiral photoswitches are capable of reversible photoisomerization driven by visible light. The photoswitches show enhanced helical twisting power (HTP) in liquid crystals and diverse HTP changes upon photoisomerization. The photoswitches with shorter substituents enable visible-light-driven handedness inversion of the self-assembled helical superstructures.

Machine learning provides a powerful and robust approach to remove broadening due to dipolar interactions in proton NMR spectra of solids.

A high-curvature two-dimensional (2D) polymerization is proposed to form a single-layer 2D polymer network as a non-contacting ligand on the surface of nanoparticles for their stabilization and functionalization. The 2D polymer network coated on nanoparticle surfaces can be turned into a non-contact ligand showing excellent shape retention and high nanoparticle-surface accessibility.

Dual-atom Pd₁Cu₁ active center in Pd₁Cu₁−TiO₂ is more favourable for producing urea, and experiences a C−N coupling pathway with a lower energy barrier as compared with single-atom Pd₁ in Pd₁−TiO₂.

Ligand-protected metal clusters composed of silver, gold, and copper integrate the merits of homogeneous and heterogeneous catalysts and exhibit an excellent reactivity and recyclability for CO₂ formylation with secondary amines. Fundamental insights are provided into the heterogeneously catalyzed reaction and design rules are presented for preparation of metal clusters with high stability and recyclability.

We developed a novel cyclometalated Pt^IV-terthiophene complex as the first metal-based zinc homeostatic medicine that regulates zinc homeostasis to activate antitumor immunity.

Substituted manganese oxide nanoparticles, Mn₃O₄:M, were studied as a model system to generalize the electronic effect of redox-inactive substituents on the electrocatalytic activity of the oxides. The oxygen reduction activity of Mn₃O₄:M correlates with the enthalpy of formation of the binary MO oxide and the Lewis acidity of the M²⁺ site. Our work provides a perspective on the design of new compositions for oxygen electrocatalysis.

A ferroelectric two-dimensional (2D) perovskite has been designed based on a pyridine ring as the organic interlayer. Incorporation of the ferroelectric 2D material into 3D perovskite induces an increased built-in electric field and optimized perovskite crystallization, delivering an exceptional efficiency over 23 % for flexible perovskite solar cells.

Two highly robust microporous metal–organic frameworks with high ethane uptake and selectivity, ultrahigh water stability, high chemical stability, and low ethane/ethene adsorption enthalpy were designed and synthesized, which could realize one-step C₂H₄ purification from binary C₂H₆/C₂H₄ mixtures under both dry and humid conditions.

A series of newly synthesized homo- and hetero-tetracene (Tc) oligomers are presented. The molecular design strategy achieves efficient exciton transport in linear tetracene oligomers by promoting correlated triplet pair (TT) dissociation and controlling a sequential exciton trapping process by intramolecular singlet fission.

Built-in circularity can be achieved by integrating closed-loop recycling and upcycling in brush-like thermosets with dynamic crosslinks.

A study of a series of helical β-isoindigo-based B−O−B-bridged chromophores has shown that the bridge leads to distorted conformations. This results in the chromophores having excellent spectroscopic and chiroptical properties, such as tunable circularly polarized luminescence (CPL), with a high luminescence dissymmetry factor (g_lum) of 1.3×10⁻³ and a CPL brightness (B_CPL) of 11.5 M⁻¹ cm⁻¹ in the near-infrared region observed for one of the compounds.

A combination of chiral bidentate boryl ligand (CBL) and iridium precursor was found effective in catalyzing carbamate-directed C(sp³)−H borylation of strained (hetero)cycloalkanols in a site- and stereoselective manner. This method features broad substrate scope (>50 examples), excellent site-selectivity, and high enantioselectivity (up to 95 % ee), providing a robust protocol for access to diverse, densely substituted (hetero)cycloalkanols.

Doping alkali ions (e.g., Na) into Rh₁/ZrO₂ enables complete switching of the reaction product from CH₄ to CO in CO₂ hydrogenation over a broad temperature range. It was found that Na⁺ ions change the surface intermediate from HCOO* to COOH* and render the Rh₁ atoms electron deficient with restrained H₂ activation capability and weakened CO adsorption, thus cooperatively boosting CO formation.

PCN-222(Fe), a metalloporphyrin-based metal–organic framework (MOF), was used for the CO₂ electroreduction reaction. The proposed reaction mechanism necessitated catalyst weight loadings of 1 wt.% to mitigate obfuscations from mass transfer and in situ Raman spectroscopy confirmed the structural and reactive stability of the MOF under operating conditions.

The combination of livingness, dual-initiation, and CSC feature of Lewis pair polymerization enabled the efficient synthesis of well-defined multi-block copolymers from monomer mixtures of methacrylate and acrylates in a one-pot process. Importantly, monomer sequence can be arbitrarily-regulated by changing the composition and adding order of the monomer mixtures.

A naphthotube-based polyrotaxane-containing hydrogel was constructed through one-pot photo-initiated copolymerization. Naphthotube can slide along the PEG chain upon repeated stretching. The slide motion further induces the zipping of adjacent polymer chains to form compact hydrogen bonded nanocrystalline domains through integrated hydrogen bonds, which enabled the hydrogel to achieve reinforcement.

A MOF/MXene heterostructure, which exhibits a molecular-scale hybridized MOF (Cu-HHTP) and MX (V₂CT_x MXene) nanosheets, is successfully synthesized. The results show that the Zn²⁺ storage capability of such a 2D heterostructure is boosted by enhancing the structural stability, electrical conductivity, and the utilization of active sites.

The construction of CdS/pyrene-alt-difluorinated benzothiadiazole (PDB) inorganic/organic S-scheme heterojunction leads to efficient photocatalytic H₂ production coupled with selective 1,2-diols oxidation. The interfacial S-scheme charge-transfer process was explored with transient absorption spectroscopy.

Ap₄A was investigated for its potential applicability as a cosubstrate in AMPylation mediated by FICD, instead of the common cosubstrate ATP. Proficient AMPylation capability of Ap₄A was observed, and new potential target proteins were found by chemical proteomics. Interestingly, AMPylation targets of FICD may differ depending on the cosubstrate.

A rational catalyst design strategy is vital for a highly efficient conversion of NO₃⁻ to NH₃. Cu₂O+Co₃O₄ tandem catalyst exhibit a much higher NH₃ yield rate than the single component alone. More importantly, we confirmed tandem catalysis by placing individual single Cu₂O and Co₃O₄ on carbon nanoelectrode. Using single-entity electrochemistry and identical-location TEM we unveiled the dynamic transformation caused by tandem catalysis.

Blue-to-UVB photon upconversion (UC) enabled by a benzene-based annihilator is presented for the first time. The annihilator's unprecedented singlet-excited energy of 4.15 eV was successfully employed to activate inert carbonyls via a subsequent FRET energy transfer. This UC-FRET reaction scheme was directly monitored by laser techniques and exploited in lab-scale NMR experiments demonstrating its potential in light-to-chemical energy conversion.