Clinical and Translational Discovery is a journal publishing on all aspects of clinical and translational medicine-associated discovery.

We're interested in topics related to the interaction and intercommunication between cells, genes, proteins, transcriptional networks, genome constructions, structures, functions, and regulations. We also cover topics that advance gene- and protein-based editing, detection, diagnosis, analysis, intelligence, imaging, therapy, and ethics of clinical and translational medicine.

Journal Metrics

  • 1.9CiteScore
  • 1.9Journal Impact Factor
  • 62%Acceptance rate
  • 8 days Submission to first decision
view all metrics

We are pleased to announce that Clinical and Translational Discovery is now indexed by DOAJ and SCOPUS!

Skip slideshow






Call for papers
  

Clinical and Translational Discovery welcomes submissions of original articles and review articles for the upcoming Special Topic Issues on Nano-Biomedicine and Endothelial Discovery. To submit a manuscript for consideration in the Special Topic Issues, please follow the journal author guidelines and select the name of the issue from the Special Issue dropdown list when reaching step 1 of submission in the journal ScholarOne.

Deadline for submission: December 31, 2023

Aims and Scope

Clinical and Translational Discovery aims at being the world-leading communication channel of science related to gene and protein-based structure and function, regulation and editing, detection and diagnosis, analysis and intelligence, imaging and therapy, and ethics and regulations. 

The journal focuses on the early phase of bench to bedside approach, favoring studies and clinical observations which generate hypotheses and questions relevant to the patient and disease, and guide the investigations of clinical and translational medicine.





  
Why publish in Clinical and Translational Discovery?

  • Fast review and publication times. You’ll receive a first decision within 8 days on average.
  • Your work will be open access making it available to read, download and share.
  • Achieve greater impact with open access work typically receiving more citations.
  • Quality guaranteed with rigorous and robust peer review.
  • A global Editorial Board ensures scientific accuracy and diversity of coverage.


Submit your paper here







  

Receive the latest research from Clinical and Translational Discovery – create a FREE Wiley Online Library account and register for Content Alerts today!

  • Receive personalized alerts at a frequency that suits you.
  • Keep track of papers of interest with citation alerts.
  • Easily save content to manage your reading list.
  • Save searches to review later.

Get Content Alerts here

Articles

RESEARCH ARTICLE
Open access

Evaluating the potential risks of employing large language models in peer review

Lingxuan Zhu, Yancheng Lai, Jiarui Xie, Weiming Mou, Lihaoyun Huang, Chang Qi, Tao Yang, Aimin Jiang, Wenyi Gan, Dongqiang Zeng, Bufu Tang, Mingjia Xiao, Guangdi Chu, Zaoqu Liu, Quan Cheng, Anqi Lin, Peng Luo, 
  •  27 June 2025

Graphical Abstract

Evaluating the potential risks of employing large language models in peer review Issue 4, 2025

Claude was used to generate peer review reports, rejection recommendations, citation requests and refutations for 20 cancer-related articles. AI detection tools assessed whether the reviews were identifiable as LLM-generated, while experts evaluated their quality and ethical implications.

REVIEW ARTICLE
Open access

Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation

Keyin Zheng, Aimin Jiang, Zhengrui Li, Li Chen, Kailai Li, Junyi Shen, Hank Z. H. Wong, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo, 
  •  23 June 2025

Graphical Abstract

Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation Issue 3, 2025

This review elucidates distinct (hepatitis B virus [HBV] DNA integration, oncoproteins; hepatitis C virus [HCV] metabolic dysregulation, fibrosis) and shared (chronic inflammation, epigenetic alterations, genomic instability) molecular mechanisms driving viral hepatitis (HBV/HCV)-induced hepatocellular carcinoma. It highlights how viral infection remodels the tumour microenvironment and discusses emerging diagnostic, preventive and therapeutic strategies targeting these pathways.

REVIEW ARTICLE
Open access

Molecular mechanisms of ageing in cancer development and therapeutic response: Translational implications for precision oncology

Laiba Husain, 
  •  23 June 2025

Graphical Abstract

Molecular mechanisms of ageing in cancer development and therapeutic response: Translational implications for precision oncology Issue 3, 2025

Molecular ageing mechanisms including genomic instability, cellular senescence, and epigenetic alterations drive cancer development while affecting therapeutic response. Artificial intelligence-powered biomarkers and ageing clocks enable precision oncology approaches that optimize treatment selection based on biological rather than chronological age, improving outcomes for older cancer patients.

REVIEW ARTICLE
Open access

Therapeutic potential of the annexin A family in atherosclerosis

Suha Jarad, Da-wei Zhang, 
  •  22 June 2025

Graphical Abstract

Therapeutic potential of the annexin A family in atherosclerosis Issue 3, 2025

Annexin A (AnxA) family members, including AnxA1, AnxA2, AnxA5, AnxA6, AnxA7 and AnxA8, play diverse roles in the development and progression of atherosclerosis and present promising therapeutic targets for its treatment.

INVITED LETTER
Open access

Endothelial single‐cell sequencing: A new way to understand endothelial biomedicine

Zehua Shao, Hao Tang, Wanxin Duan, Hongwei Guo, 
  •  2 June 2025
REVIEW ARTICLE
Open access

Current advances in the role of classical non‐homologous end joining in hematologic malignancies

Pengcheng Liu, Zizhen Xu, 
  •  29 May 2025

Graphical Abstract

Current advances in the role of classical non-homologous end joining in hematologic malignancies Issue 3, 2025

As depicted in the graphics, the classical NHEJ pathway can either take place in cells with DSBs or normal lymphocytes, reinforcing the stability of genome, and simultaneously maintaining the function of the immune system. While complete deletion causes immunodeficiency and tumourigenesis, some inhibitions could promote cancer therapies.

REVIEW ARTICLE
Open access

A snapshot of the role of estrogen‐regulated divergent non‐coding transcripts

Barbara Yang, Melina J. Sedano, Kimberly Diwa, Johnathan Dominguez, Gabriela Boisselier, Alana L. Harrison, Victoria A. Reid, Enrique I. Ramos, Maria V. Jimenez, Laura A. Sanchez-Michael, Shreya Kolli, Jai Patel, Debra Lee, Mahalakshmi Vijayaraghavan, Jessica Chacon, Subramanian Dhandayuthapani, Shrikanth S. Gadad, 
  •  25 May 2025

Graphical Abstract

A snapshot of the role of estrogen-regulated divergent non-coding transcripts Issue 3, 2025

The expansion of genome-wide studies has identified widespread transcription that may result in previously unstudied transcripts, such as divergent long non-coding RNAs.

REVIEW ARTICLE
Open access

Friend or foe: The paradoxical roles of cancer‐associated fibroblasts in tumour immunotherapy

Minying Xiong, Aimin Jiang, Zhengrui Li, Hank Z. H. Wong, Jian Zhang, Anqi Lin, Suyin Feng, Peng Luo, 
  •  19 May 2025
INVITED LETTER
Open access

Senescence as a pathogenic driver in chronic kidney disease: From cellular fate to clinical stratification

Samuel Chauvin, Ariane Coutrot, Camille Cohen, 
  •  19 May 2025
EDITORIAL
Open access

Complex, cell‐type‐specific role of EEPD1: Bridging TNF‐α, inflammation and apoptosis in endothelial cells

Rong Li, Cindy Xinyu Zhang, Gaohui Zhu, Da-Wei Zhang, 
  •  15 May 2025
More articles

Articles with the most citations published in the Last 2 Years according to CrossRef. The citation counts listed reflect the total number of all citations to date.

COMMENTARY
Open access

Clinical trial status of exosomes‐based cancer theranostics

Swarup Sonar, 
COMMENTARY
Open access

Engineered cell versus modified exosomes in cancer therapy

Rajib Dhar, Arikketh Devi, 
COMMENTARY
Open access

Clinical signature of exosomal tetraspanin proteins in cancer

Asmit Das, Priyanka Saha, Ketki Kalele, Swarup Sonar, 
COMMENTARY
Open access

Milk exosomes: Harnessing nature's duality for cancer therapy

Asmit Das, Swarup Sonar, Ketki Kalele, Vetriselvan Subramaniyan, 
REVIEW ARTICLE
Open access

Lymph node metastasis in oral squamous cell carcinoma: Where we are and where we are going

Lei-Ming Cao, Nian-Nian Zhong, Zi-Zhan Li, Fang-Yi Huo, Yao Xiao, Bing Liu, Lin-Lin Bu, 

Graphical Abstract

Lymph node metastasis in oral squamous cell carcinoma: Where we are and where we are going Issue 4, 2023

  1. The neck management of lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC) has transitioned from radical approaches towards more minimally invasive techniques.
  2. Significant research gaps persist in the field of OSCC LNM.
  3. The advent of advanced technology promises to expedite and enhance such research.

RESEARCH ARTICLE
Open access

Intrarenal pressure monitoring via flexible and navigable suction ureteral access sheath in retrograde intrarenal surgery: A preclinical animal study and a pilot clinical study

Wei Zhu, Steffi Kar Kei Yuen, Jianwei Cao, Chu Ann Chai, Shusheng Liu, Jingzeng Du, Wen Zhong, Zhijian Zhao, Yongda Liu, Guohua Zeng, 

Graphical Abstract

Intrarenal pressure monitoring via flexible and navigable suction ureteral access sheath in retrograde intrarenal surgery: A preclinical animal study and a pilot clinical study Issue 1, 2025

  • Traditional ureteral access sheath (UAS) relies on the repetitive and tedious process of basketing of lasered stone fragments in achieve stone-free in retrograde intrarenal surgery.
  • Flexible and navigable suction ureteral access sheath (FANS) improves upon traditional UAS by enabling active suction and aspiration of stone dust and fragments, but is unable to monitor real-time IRP. Without real-time IRP monitoring, irrigation cannot be maximised safely for efficient stone retrieval.
  • IRP-monitoring FANS features real-time IRP monitoring, allowing increased irrigation rates whilst keeping IRP within safe limits, thus enhancing stone retrieval efficiency with increased flow and ensuring surgical safety.

COMMENTARY
Open access

Signature of click chemistry in exosome modification for cancer therapeutic

Nobendu Mukerjee, Swarup Sonar, 
COMMENTARY
Open access

Plant‐derived exosomes: A new frontier in nano‐medicine for cancer and microbial infection therapy

Swastika Maitra, Subham Sarkar, Bikram Dhara, 
COMMENTARY
Open access

Plant‐derived exosomes: A Green Nanomedicine for Cancer

Swarup Sonar, Krishnan Anand, 
REVIEW ARTICLE
Open access

Chances and challenges in intranasal administration delivery for brain disease treatment

Shuyu Zheng, Yuanyuan Guo, Furong Yan, Feng Yan, Ruogu Qi, Jianliang Shen, 

Graphical Abstract

Chances and challenges in intranasal administration delivery for brain disease treatment Issue 6, 2023

Graphical Highlights

Intranasal administration (INA) has emerged as an unconventional method for drug delivery, offering distinct advantages such as non-invasiveness and enhanced pharmacokinetic characteristics within the brain.

INA route effectively delivers therapeutic agents through the olfactory and/or trigeminal nerve systems.

With introducing appropriate improvements to the drug formulation, such as the incorporation of nanocarriers, the efficacious delivery via the INA approach has gained considerable traction for the treatment of neurological disorders.

With introducing appropriate improvements to the drug formulation, such as the incorporation of nanocarriers, the efficacious delivery via the INA approach has gained considerable traction for the treatment of neurological disorders.

More articles

The most read articles published in the Last 2 Years

Open access

GWAS advancements to investigate disease associations and biological mechanisms

Oluwaferanmi Omidiran, Aashna Patel, Sarah Usman, Ishani Mhatre, Habiba Abdelhalim, William DeGroat, Rishabh Narayanan, Kritika Singh, Dinesh Mendhe, Zeeshan Ahmed, 
Open access

Cervical collar use in spinal cord injury management

Shruti Kolli, Robert Medina, Chloe DeYoung, Brandon Lucke-Wold, 
Open access

Lymph node metastasis in oral squamous cell carcinoma: Where we are and where we are going

Lei-Ming Cao, Nian-Nian Zhong, Zi-Zhan Li, Fang-Yi Huo, Yao Xiao, Bing Liu, Lin-Lin Bu, 
Open access

Role of DNA methylation in cancer development and its clinical applications

Swarup Sonar, Sidhanti Nyahatkar, Ketki Kalele, Manab Deb Adhikari, 
Open access

Deep learning for predicting synergistic drug combinations: State‐of‐the‐arts and future directions

Yu Wang, Junjie Wang, Yun Liu, 
Open access

The relationship between folic acid and nonalcoholic fatty liver disease

Bing'er Xu, Xinyu Yang, Xiaopeng Zhu, Qiling Liu, Yuying Zhang, Miao Zhang, Chenmin Fan, Xilei Ban, Guligeina Aikebaier, Hua bian, 
Open access

Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

Xu Zhang, Rongrong Gao, Liuke Yang, Youwei Zhu, Tiancheng Zhang, Xiaorong Shen, Wenwen Gu, Long Yang, Shenjie Peng, 
Open access

Intervertebral disc degeneration and regenerative medicine

Mariam Farag, Rogina Rezk, Hunter Hutchinson, Alina Zankevich, Brandon Lucke-Wold, 
Open access

Clinical trial status of exosomes‐based cancer theranostics

Swarup Sonar, 
More articles

Latest news

More news >

Recent issues