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IssueClinical and Translational Discovery: Volume 5, Issue 2
April 2025
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ISSUE INFORMATION
COMMENTARY
Commentary on ‘Lentivirus-mediated gene therapy for Fabry disease: 5-year end-of-study results from the Canadian FACTS trial’
- First Published: 27 February 2025
REVIEW ARTICLE
Involvement of S100A8 and S100A9 in nonischaemic cardiomyopathy
- First Published: 05 March 2025
1. S100 calcium binding proteins A8 and A9 (S100A8/A9) could be released from bone marrow (BM)- and non-BM-derived cells.
2. S100A8/A9 mainly activates the Toll-like receptor 4 (TLR4) and receptors of advanced glycation endproducts (RAGE) signalling pathways and drives mitochondrial dysfunction, inflammation, reactive oxygen species production and cardiac hypertrophy.
3. Therapeutic inhibitors targeting S100A8/A9 (ABR-238901, paquinimod) or NLRP3 (CY-09) may be effective interventions.
INVITED LETTER
Cell therapy based on stem cells or their extracellular vesicles during kidney graft preservation: Current state of the art and novelties
- First Published: 10 March 2025
Towards a one-time cure for Fabry disease: Lentivirus-mediated haematopoietic stem and progenitor cell gene therapy
- First Published: 11 March 2025
REVIEW ARTICLE
Structural insights into retinoic acid receptor activation and selective modulators
- First Published: 12 March 2025
1. Selective retinoic acid receptor (RAR) modulators regulate the assembly of the RAR transcription complex, which is composed of RAR, retinoic X receptor, modulators and co-regulators.
2. The RAR transcription complex recognises specific retinoic acid response elements, modulating the transcription of target genes.
3. The modulation influences differentiation, tumourigenesis and cancer metastasis, and also demonstrates potential efficacy in cancer treatment.
RESEARCH ARTICLE
Risk of gastric cancer in autoimmune gastritis and pernicious anaemia: Insights from Mendelian randomization and multi-omics analysis
- First Published: 21 March 2025
- Mendelian randomization supports a causal link between autoimmune gastritis (proxied by pernicious anemia) and gastric cancer.
- Autoimmune gastritis may promote gastric carcinogenesis via dysregulation of oncogenic pathways.
- Gastric cancer screening remains essential for autoimmune gastritis patients.
Drug Sensitivity patterns across FAB subtypes and molecular mutations in AML: A comprehensive analysis for precision medicine
- First Published: 22 March 2025
The study revealed distinct drug sensitivity patterns across acute myeloid leukaemia (AML) French–American–British (FAB) subtypes and mutations. The findings underscore the importance of integrating FAB classifications and mutation profiles in treatment decisions.
INVITED LETTER
Exploring new frontiers in lung cancer treatment: The role of cancer-associated fibroblasts (CAFs) and EGFR-TKI resistance
- First Published: 27 March 2025
RESEARCH ARTICLE
Formulation and evaluation of repurposed ketoconazole-loaded transferosomal gel for enhanced trichogenic effects
- First Published: 08 April 2025
Development and characterization of a ketoconazole-loaded transferosomal gel for enhanced trichogenic activity .
INVITED LETTER
A vital step toward targeting lymph node metastasis: Identifying APOE− cells as prognostic drivers in papillary thyroid carcinoma
- First Published: 23 April 2025
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Published in association with The Shanghai Institute of Clinical Bioinformatics (SICB)
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Understanding Open Access
As an open access journal, all articles in Clinical and Translational Discovery are freely available to read, download and share immediately on publication.
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