Journal list menu
Export Citations
Download PDFs
ISSUE INFORMATION
INVITED LETTER
The FACTs trial for Fabry disease highlights the promise and challenges of gene therapy
- First Published: 02 January 2025
REVIEW ARTICLE
Roads diverged in a wood: Proteins and RNAs encoded by cytochrome b (CYTB) gene in health and disease
- First Published: 03 January 2025

- The latest groundbreaking study uncovers a dual translation pattern of the CYTB gene, which uses a standard genetic codon at the cytosolic ribosome to encode a novel protein CYTB-187AA.
- The CYTB gene also generates long non-coding RNAs that are engaged in a variety of physiological and pathological processes.
- The CYTB gene is associated with a variety of biological processes and mutations, deletions or translocations in the gene can precipitate a myriad of diseases.
Recent advances in mitochondrial replacement therapy and its future expectations
- First Published: 06 January 2025
RESEARCH ARTICLE
Thyroglobulin mRNA ectopic expression was an excellent marker to detect lymph node metastasis for patients with papillary thyroid cancer
- First Published: 08 January 2025
Utilisation of a national database to characterise renal function in patients with COVID19 infection
- First Published: 10 January 2025

• 15 608 patients hospitalised with COVID19 were identified within the National COVID Cohort Collaborative (N3C) database to assess alterations in renal function.
• 11 274 patients had all variables required for univariate and multivariate logistic regression.
• Risk factors for acute kidney injury (AKI) included male sex, increased weight, Hispanic ethnicity and history of diabetes.
• Risk factors for augmented renal clearance (ARC) included female sex, increased weight and Hispanic ethnicity while a history of hypertension decreased this risk.
Intrarenal pressure monitoring via flexible and navigable suction ureteral access sheath in retrograde intrarenal surgery: A preclinical animal study and a pilot clinical study
- First Published: 21 January 2025

- Traditional ureteral access sheath (UAS) relies on the repetitive and tedious process of basketing of lasered stone fragments in achieve stone-free in retrograde intrarenal surgery.
- Flexible and navigable suction ureteral access sheath (FANS) improves upon traditional UAS by enabling active suction and aspiration of stone dust and fragments, but is unable to monitor real-time IRP. Without real-time IRP monitoring, irrigation cannot be maximised safely for efficient stone retrieval.
- IRP-monitoring FANS features real-time IRP monitoring, allowing increased irrigation rates whilst keeping IRP within safe limits, thus enhancing stone retrieval efficiency with increased flow and ensuring surgical safety.
REVIEW ARTICLE
Utilising single-cell sequencing in clinical nutraceutical research: Recent progress and perspectives
- First Published: 23 January 2025

This review highlights the importance of integrating single-cell sequencing and spatial transcriptomics in clinical nutraceutical research to enhance understanding of mechanisms, identify biomarkers, and inform applications. These advanced methods address the limitations of traditional bulk profiling, facilitating insights into cellular heterogeneity and promoting the development of functional foods and personalised nutrition strategies.
INVITED LETTER
Post-COVID-19 pulmonary fibrosis: Mechanisms, biomarkers, and therapeutic perspectives
- First Published: 04 February 2025
From multi-omics to cancer digital twins: Novel paradigm in cancer research and treatment response
- First Published: 16 February 2025