The cover image is based on the Case Report Tooth adornment among siblings living in an urban slum in Nigeria: Health implications for a vulnerable population by Mary E. Osuh et al., https://doi.org/10.1002/ccr3.6563.

The cover image is based on the Case Report Surgical strategy for airway management and bleeding control in penetrating neck injury in zone II: A case report by Tomohiro Akutsu et al., https://doi.org/10.1002/ccr3.6862.

The cover image is based on the Case Report Healing of large endodontic lesions using a new combination of triple antibiotics: A case report by Saeed Asgary et al., https://doi.org/10.1002/ccr3.6879.

Bartholin gland neoplasms are rare tumors, commonly misdiagnosed as Bartholin's cysts. Excision is the treatment of choice. Short time follow-up allows prompt management of potential postoperative complications. Continuing long-term follow-up is recommended due to recurrence risk.

COVID-19-associated thrombosis is becoming well documented in the literature and clinical practice. Treating physicians must be cognizant to the less known thrombotic microangiopathy which can be a consequence of COVID-19. Clinical findings overlap with thrombotic thrombocytopenic purpura (TTP), although it may not be responsive to mainstay treatment of TTP.

Extramammary-myofibroblastomas are rare tumors, especially in the head and neck region. The long-term prognosis of these tumors post-excision is favorable. The patient remains under close surveillance but has yet to present with clinical recurrence.

Self-adornment with dental jewels among youth living in low socioeconomic environments has multiple health implications. Professional dentists are essential to advise, treat, and maintain good oral health in areas where the practice is prevalent.

Radiotherapy offers a feasible, safe, and effective therapy to VT storms refractory to pharmacotherapy and ablation. Radiotherapy can be therapeutic, palliative, or a bridge to transplant. More studies are needed to further investigate the use of SBRT.

Surgical treatment for aortic disease remains challenging and demanding. Treatment often needs to be tailored to the patient or the group of patients being referred. A hybrid approach may have a role to play as an additional option to the surgical armamentarium. Cooperation between different specialists is essential.

The picture is the necrotic tissue in the left lower leg 20 days after injury from a bicycle accident.

A patchy high-density shadow in the right frontal lobe was revealed by a head computed tomography scan due to the rupture of an undiagnosed intracranial aneurysm during endoscopic endonasal dacryocystorhinostomy.

Streptococcus intermedius is part of the commensal oral flora, but it has been described in a few cases as the causal agent of lung abscesses. We describe an unusual case of lung abscess caused by Streptococcus intermedius in pregnancy.

Simplified schematic representation of the effects of the inactivation of vitamin B12 by nitrous oxide. Nitrous oxide oxidizes cobalt ions in vitamin B12 leading to inactivation, which results in an increase in homocysteine and methylmalonic acid and the inability to synthesize or maintain myelin leading to SACD. SACD, subacute combined degeneration.

The use of monoclonal antibodies directed against SARS-CoV-2 in combination with molnupiravir in a patient with CVID and GLILD is safe.

A man with long-term dyspnea diagnosed with a laryngeal angiomyolipoma. This diagnosis is clinically significant because a common complaint manifested from a rare cause that has the potential to cause airway obstruction and difficulty intubating.

When conventional therapy is exhausted in advanced malignancies, evaluation with next-generation sequencing can identify targetable gene expression patterns like ALK overexpression in this PNET case, which led to a durable response with crizotinib.

Adrenal crisis is a rare life-threatening condition that can occur after segment elevation myocardial infarction. Because it can mimic cardiogenic shock and can lead to the development of takotsubo syndrome, it is important to recognize it in order to initiate appropriate treatment and reduce mortality.

Mayo Clinic's Advance Care at Home program can deliver both inpatient-level care as well as postacute, skilled nursing-level wound care, and rehabilitative therapy. Decompensations were treated in the home setting, preventing escalations to the emergency department.

The association between acute suppurative thyroiditis (AST) and COVID-19 is rare but very important. The early treatment and diagnosis of AST, with complete aspiration and antibiotic therapy, can induce full recovery in patients without surgery.

Although Sideroblastic anemia is a rare type of anemia, it should be considered in cases of unexplained pregnancy-relapsing anemia. Identification of possible revisable causes like pyridoxine deficiency is crucial to avoid both maternal and fetal adverse effects. Extensive workup including deep genetic testing might be required, guided by each case's clinical and histopathological findings..

Surgical revascularization is effective for repeated coronary artery spasms resulting in circulatory collapse. Spasms can sometimes occur in other coronary arteries and may also occur in arteries of other organs.

Nocardiosis is a rare bacterial infection that requires applied microbiology laboratory techniques to establish its diagnosis and to provide a targeted treatment.

Tumor-to-tumor metastasis to salivary gland tumors is extremely rare. We present a case in which lobular breast carcinoma metastases were found within a Warthin tumor of the left parotid gland. The pathology of the distant metastases steered the diagnostics of the primary breast tumor. This patient case serves as a reminder that a new distant primary cancer might be the cause of a parotid lump.

Although bleeding complications are the primary cause of sudden cardiac tamponade in acute myocardial infarction, purulent pericarditis is also a possibility. It is rare but must be diagnosed promptly because it can worsen rapidly by sepsis.

The biallelic germline pathogenic variants of CHEK2 gene confer a high risk of early-onset breast cancer development to their female carriers that calls in for their more aggressive management and surveillance.

The colon is an exceptional site of goblet cell adenocarcinoma (GCA). For appropriate management, metastasis of a primary appendiceal GCA should be excluded.

Adult onset still's disease is a rare autoinflammatory disease displaying with a wide range of non-specific symptoms and budd-chiari syndrome is an uncommon disorder characterized by obstruction of hepatic venous outflow. AOSD complicated with BCS is a rare but potentially life-threatening entity. Clinicians should be aware of this complication.

Pituitary magnetic resonance imaging showing empty sella.

In this paper, we report a rare case with several notable features. coexistence of MDS and CAD and observation of phagocytized red blood cell precursor nuclei are the most remarkable aspects of this case.

Due to the limited access to the proper pediatric-size of non-invasive ventilation interfaces, using an adult-size nasal mask as an oro-nasal pediatric interface may overcome this limitation. However, it cannot be generalizable from this report.

When sharks bite humans, the removal of large pieces of flesh or bones indicates a feeding motivation. The shark size can be assessed through average interdental distances. Prompt and effective emergency first-aid measures are crucial for survival.

The purpose of this report was to illustrate the occurrence of bilateral ischemic optic neuropathy and choroidal ischemia following COVID-19. We aimed to shed light on the potential and multiplicity of ophthalmic presentation in a patient with COVID-19 infection.

Early surgical treatment could be beneficial for patients with Hedinger Syndrome.

Lymphoma rarely presents with co-existent lactic acidosis and hypoglycemia. Prompt recognition of this unusual presentation and careful management with consideration of chemotherapy is important as the prognosis is poor.

Orbital apex syndrome is a rare complication of herpes zoster ophthalmicus, associated with poor outcome. Clinical suspicion should be high in immunocompromised cases, especially those with chronic kidney disease.

Subcutaneous anaerobic bacterial infections can occur secondary to COVID-19. We describe a rare case of subcutaneous anaerobic bacterial abscess due to Peptoniphilus olsenii and Gleimia europaea after COVID-19.

Distalization of full cusp class IIs always poses therapeutic challenges, more so with clear aligner therapy. This case report illustrates efficient class II correction with CA by judicious use of short class II elastics, 14-day aligner change, sequential distalization by optimizing staging prescriptions, and efficient anchorage planning with attachment protocols.

The management of penetrating neck injuries is difficult due to the complicated anatomy and very small area of the neck. Training in cervical lymph node dissection for esophageal cancer could be useful in managing penetrating neck injuries.

Left atrial wall dissection is a rare complication of mostly mitral valve interventions and is often underrecognized given its wide clinical presentations. Diagnosis requires a multimodality imaging approach. Although its management approaches are controversial, conservative treatment should be considered. Increased incidence in the future is likely because of increased percutaneous interventions.

Radical debridement and necrosectomy in necrotizing fasciitis.

Pregnancy in an isthmocele or previous scar site should be a differential diagnosis in an unexplained bleeding in post-cesarean section cases.

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare clinical condition that has emerged during mass vaccination against SARS-CoV-2. The diagnosis of VITT requires a high index of suspicion because many aspects of the syndrome are not yet fully understood, and unusual presentations may occur.

This article offers support for recently emerging literature on the morbidity of spontaneous intracranial hypotension (SIH), a condition previously considered to have a benign course. Subdural hematoma (SDH) in the background of SIH should be assessed carefully as neurosurgical interventions aiming at hematoma evacuation can possibly lead to further exacerbation of SIH.

Pituitary haemochromatosis is an endocrine disorder caused by the accumulation of iron due to a lack of absorption during haemochromatosis. The characteristic appearance on MRI is a T2 and T2* hyposignal of the anterior pituitary gland without enhancement, respecting the pituitary stalk and the posterior pituitary gland. Diagnosis is essential for early treatment.

Differentiation syndrome should be suspected and considered on the top of the differential diagnoses whenever you encounter a patient with acute promyelocytic leukemia who deteriorates after starting chemotherapy with ATRA/ATO and prompt management with steroids is crucial in order to avoid this fatal complication.

Silicosis is rarely accompanied by pleural effusions. When pleural effusions are found in patients with silicosis, lymphoma should be considered, in addition to lung cancer and tuberculosis.

Most small cell neuroendocrine carcinomas originating in the urinary system are located in the bladder and prostate: they rarely arise from the ureter. This report presents a case confirmed with ultrasonography, computed tomography, magnetic resonance urography, and pathological analysis.

The patients after heart transplantation usually present resting tachycardia, a slower increase in heart rate (HR) at the onset of exercise, a blunted chronotropic response to exercise in general, maximal HR being attained in the recovery period.

In patients with crown dens syndrome, CT scans of head and neck show calcifications surrounding the dens.

As a complication with acute gastric dilatation, localized skin mottling disappeared immediately is a rare finding. Gastric dilatation could have caused compression of the inferior epigastric artery.

The diagnosis of sarcomatoid carcinoma is challenging and relies on histopathological examination coupled with an immunohistochemical study. Adequate sampling is mandatory to establish a correct diagnosis.

This case recalls the clinicopathological features of lipoleiomyoma and highlights the importance of a correct preoperative diagnosis to avoid unnecessary surgical morbidity.

T1 weighted MRI images showed thickening of flexor sheaths (A), intensely enhanced after injection of gadolinium (B), conforming with flexor tenosynovitis of the left hand.

Primary ADF is a life-threatening complication that should be considered in all patients with known abdominal aortic aneurysms presenting with massive bleeding. Early diagnosis and emergent surgery are crucial to patient survival.

The diagnosis of papular elastorrhexis can be challenging. It belongs to a heterogeneous elastic tissue disorder. Histology remains the main key for diagnosis especially for unusual locations.

The parietal interhemispheric approach employing gravity retraction with skeletonization of bridging veins provides an excellent operative window for safe, curative resection of splenial arteriovenous malformations.