Electrochemiluminescence microscopy is emerging as a high-throughput spectroscopic technique capable of elucidating plasmonic-related phenomena in operando conditions. In a recent work, Wei et al. combine electrochemiluminescence microscopy and high resolution scanning electron microscopy to explore the plasmon-enhanced luminescence in gold nanostructures arrays, identifying two different enhancement mechanisms for isolated and coupled nanostructures.

The recent work from Guo and co-workers who proposed a hybrid electrolyte strategy obtained by mixing H₂O and dimethyl methylphosphonate (DMMP) as solvents to build up a high-quality phosphate-based solid-state interphase layer is highlighted. This new solid electrolyte interphase (SEI) protects Zn metal anodes from corrosion and dendrite formation. Thus, ultrahigh Coulombic efficiencies and extended lifespan can be achieved.

Oxycarbenes have emerged as useful intermediates in synthetic chemistry. This Minireview summarizes early synthetic and catalytic applications of late-transition-metal oxycarbene complexes and highlights recent advances in free oxycarbene reactions and transition-metal-catalyzed reactions involving oxycarbenes.

Protein chemistry has evolved remarkably in the past decade, which has enabled the effective production of new molecules with novel physicochemical properties for biomedical research, and therapeutic applications. This minireview summarizes recent developments in chemical protein synthesis to produce bioactive proteins, with emphasis on novel analogs with promising in vitro and in vivo activity.

This review presents an overview of supramolecular electronics, an emerging and rapidly growing field that converges supramolecular chemistry and single-molecule electronics. Intensive attention is paid to depicting the electrical properties of various individual supramolecular assemblies and the unique quantum effects during intermolecular charge transport. Moreover, the dynamic monitoring of the supramolecular assembly processes at the single-molecule scale and the application of supramolecular electronics are also discussed.

The fundamentals of 2D transition metal dichalcogenides (TMDs), their synthesis, their advantages in photocatalysis, and the strategies for boosting their photocatalytic performance are summarized in this review. Current problems and their solutions are presented.

Stepwise separation of Ca²⁺, Mg²⁺ and Li⁺ has been achieved by liquid-liquid extraction employing a series of advanced 4-phosphoryl pyrazolone ligands together with TOPO (trioctylphosphine oxide) as co-ligand via pH regulation. X-ray crystal structure determinations of selected complexes revealed diverse binding modes across all three metal species.

Preferential adsorption of ethylene oxide on Fe and chlorine on Ni enabled the electrosynthesis of ethylene chlorohydrin (ECH) with high conversion and selectivity. Scalable production of 185.1 mmol of ECH with 92.5 % yield at 55 mA cm⁻² in 1 h, paired synthesis of ECH and 4-amino-3,6-dichloropyridine-2-carboxylic acid (an herbicide), and successful fabrication of a series of other chloro- and bromoethanols highlight the potential utilities.

A lithium intercalation chemistry in layered VX₃ (X=Cl, Br, I) enabled by compatible halide-based solid electrolytes was explored for the first time. The electrode-electrolyte interfacial stability can be achieved in a thermodynamic manner instead of by passivation, ensured by the good chemical stability between the VX₃ cathode and halide electrolytes as well as the wide electrochemical stability windows.

We report bench-stable cyclobutenone surrogates that undergo Rh-catalyzed addition of aryl- and vinylboronic acids to yield cyclobutenyl enol ethers in high yields and excellent enantioselectivities. This transformation proceeds via enantioselective carbometalation to give cyclobutyl-rhodium intermediates, followed by β-oxygen elimination. The reaction is fast and proceeds under mild conditions.

Here, we discover new lithium-metal-oxy-halide materials, LiMOCl₄ (M=Nb, Ta). They exhibit extremely high ionic conductivities of 10.4 mS cm⁻¹ for M=Nb and 12.4 mS cm⁻¹ for M=Ta, respectively, even in cold-pressed powder forms at room temperature, which are comparable to or surpass those of organic liquid electrolytes used in lithium-ion batteries.

Atomically dispersed Fe was designed on TiO₂ and explored as a Janus electrocatalyst for both nitrogen oxidation reaction (NOR) and nitrogen reduction reaction (NRR) in a two-electrode system. Pulsed electrochemical catalysis (PE) was further involved to inhibit the competitive hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) for superior nitrogen fixation performance.

A method for enantioselective intermolecular benzylic C−H amidation and amination is reported. This dehydrogenative C−N bond formation displays broad substrate scope and good atom economy, is amenable to late-stage C−H functionalization, and enables easy access to ¹⁵N-labeling from cheap [¹⁵N]-NH₄Cl.

For the efficient electrocatalytic conversion of NO₃⁻ to NH₃, a two-stage process following the [2+6]-electron pathway is proposed inspired by biological nitrate respiration. This system produces NO₂⁻ and NH₃ at low overpotentials (>+0.1 vs. RHE), resulting in a low energy consumption of 17.7 kWh kg⁻¹ for NH₃ production and high energy density of 566.7 Wh L⁻¹ at 10 mA cm⁻² for Zn−NO₃⁻ battery.

We report the synthesis of a bidentate ligand featuring secondary sphere ditopic Lewis acids. We verify a Lewis acid additivity effect for the ditopic boranes compared to a monotopic analogue using hydride ion affinity and competition studies. We show chemoselective nitrite capture in the presence of other anions. Pre-organized hydrazine adducts in the second sphere of Zn and Fe are functionalized to hydrazido and diazene ligands, respectively.

MBenes are demonstrated to be a new class of tandem catalysts for electrocatalytic nitrate reduction to ammonia (NO₃RR). Taking FeB₂ as the proof-of-concept paradigm, mechanistic studies unveil that the synergistic tandem effect of Fe and B atoms promotes NO₃⁻ activation and intermediate hydrogenation to enhance the NO₃RR activity and selectivity.

The Coulomb interaction-promoted ion kinetics enables a dual-ion co-storage electrode with high energy and power densities.

The Ir-catalyzed borylation of porphine has led to the synthesis of the useful synthon 2,7,12,17-tetrakis(pinacolatoboryl) Ni^II porphyrin. This synthon was used for the preparation of tetraarylated Ni^II porphyrins, octaarylated Ni^II porphyrins, a quadruply bridged non-offset face-to-face porphyrin dimer, single-linked cross-shaped porphyrin pentamers and nonamers, as well as pentameric porphyrin tapes.

The ten-connected tetranuclear copper-based cluster node [Cu₄(PO₃)₂(μ₂-H₂O)₂(CO₂)₄] formed by the organic ligand H₄L (3,5- dicarboxyphenylphosphonic acid) leads to a novel metal–organic framework FJU-112. BPE (1,2-bis(4-pyridyl)ethane) divides the larger pore space of FJU-112 into a structure with smaller aperture size and infinite cages which greatly enhances the adsorption and selective separation performance for C₂H₂/CO₂ mixtures.

A general and efficient dendronized DNA chimera (DENTAC) strategy for targeted membrane protein degradation is reported. DENTAC comprises a protein-of-interest (POI) binder linked with a dendritic DNA, which engages cell surface scavenger receptors (SRs) to transport the POI into the lysosome for degradation.

Photoswitchable organocatalysts have been generated that undergo reversible dissolution and precipitation upon photo-irradiation. The insoluble solid-state catalysts are photo-switched to form soluble isomers that activate and complete two types of base-catalyzed reactions. Irradiation with visible light promotes the precipitation of the catalyst with a recovery rate of 87 %, which can be reused in multiple rounds of subsequent reactions.

Die Oxidation von Ferrocenyl-substituierten Boranen und Boronsäureestern ermöglicht die unkomplizierte Synthese Bor-zentrierter Lewis-Supersäuren. Die Verbindungen wurden mit NMR, XRD und FIA-Berechnungen charakterisiert. Die Ferrocenium-substituierten Borane wurden in der katalytischen Aktivierung von C-F- und S-F-Bindungen eingesetzt.

Phosphan, PH₃, ist ein hochpyrophores und toxisches Gas, welches oft mit H₂ und P₂H₄ verunreinigt ist. Das kostengünstige α-Mg Formiat-MOF adsorbiert bis zu 10 wt % PH₃ und ermöglicht eine sichere Handhabung von Phosphan an Luft. Dieses MOF ist außerdem ein Kandidat für PH₃-Reinigung und P₂H₄-Langzeitspeicherung an Luft und bei Raumtemperatur.

Schnappschüsse von Zytochrom-P450-Enzymen mit ihren Substraten in katalytisch relevanten Konformationen zu erhalten stellt eine langjährige Herausforderung dar. Unter Ausnutzung der Eigenschaften eines künstlichen Porphyrins, das der äußerst instabilen aktiven Spezies von P450 ähnelt, konnte Styrol in Konformationen erfasst werden, die mit den experimentell ermittelten Ergebnissen übereinstimmen. Dieser Ansatz stellt ein vielversprechendes Hilfsmittel für die gezielte Entwicklung leistungsfähigerer P450-Biokatalysatoren dar.

Die intramolekulare Kooperation von Cu^II, koordiniertem Acetat und einer Benzimidazolium-Einheit in der Katalysatorperipherie ermöglicht eine beispiellose Katalysatorproduktivität und eine hohe Stereokontrolle bei direkten 1,4-Additionen an Maleimide und eine Reihe weiterer Michael-Akzeptoren. Trotz ausgeklügeltem Aktivierungsprinzip ist der Katalysator leicht herzustellen und weist eine hohe Robustheit auf. Darüber hinaus erwies sich der Katalysator als vielfach wiederverwendbar.

We took advantage of site-directed spin labeling of Gd-sTPATCN to track qualitative mechanical movement in the protein AsLOV2. Experiments were done in vitro at room temperature, allowing us to elucidate mutation-induced inhibited refolding of the Jα-helix.

The relationship between molecular configuration and charge transfer process in NIR-II chromophores has been revealed, which informed the engineering of an efficient NIR photosensitizer (PS), SP@HD-PEG_2K. The dramatic improvement of the reactive oxygen species (ROS) quantum yield of the PSs enabled NIR-II image-guided in vivo pulmonary coronavirus photoablation for the first time and created a convenient paradigm for the development of NIR heavy-atom-free PSs.

A panel of new SWIR dyes based on the xanthene core was synthesized using C−H activation chemistry. We showcased the biomedical utility of these imaging agents by selecting one example for the development of a ratiometric nanosensor, which we employed to detect elevated levels of nitric oxide in a murine model of drug-induced liver injury via SWIR PA imaging.

A highly enantioselective reaction has been developed for the construction of axially chiral arylpyrazole skeletons with phosphorus unit. The reaction proceeds through a sequential Huisgen-type cycloaddition/aromatization process with central-to-axial chirality conversion using a dipeptide-phosphonium salt catalyst. Arylpyrazole-based atropisomeric phosphorus compounds are obtained in high yields with excellent enantioselectivities.

Vanadium oxide materials with the unique amorphous-crystalline heterostructure are fabricated using an electrochemical method for the first time. The electrode displays good electrochemical performances as cathode for aqueous Zn-ion batteries. Experimental and simulation results suggest that the amorphous-crystalline heterostructure exhibits the favourable cation adsorption and ion diffusion properties compared to other modelling structures.

A functional-group-tolerant, mild, formal double C−H oxidation protocol has been developed that can be used for the selective late-stage derivatization of prenylated compounds and natural products. This exocyclic-strain-driven cross-metathesis protocol allows the efficient coupling of highly substituted and electron-rich olefins.

A novel bisacridine donor enables both quasi-equatorial and quasi-axial geometries in TADF emitter, ensuring an efficient reversed intersystem crossing and an enhanced radiative decay, which results in high-performance OLEDs.

Two ring expansion strategies are reported for the synthesis of medium sized and macrocyclic sulfonamides. Both methods proceed without using classical protecting groups, initiated by nitro reduction and amine conjugate addition respectively, to make diversely functionalised cyclic sulfonamides in a range of ring sizes. The ring size dependency of the synthetic reactions is in good agreement with the outcomes modelled by Density Functional Theory.

The electron reduction of diamido-naphthyl aluminum iodide in benzene produces dialuminyl substituted Birch-type reduction product. Time dependent EPR experiments in combination with DFT calculations suggest a reaction mechanism where stable Al^II radical intermediates play a crucial role for the reaction outcome. The aluminum radical stability is a consequence of a rigid supporting ligand with silyl protective substituents.

A family of racemic polymers were induced into one-handed helices which were memorized after the chiral inducer was removed. The enantiomeric excess of one handed helix (ee_h) is up to 98 %. Interestingly, the switchable helix-induction is visible with the naked eye. Moreover, the one-handed helices exhibit enhanced stability with helicity discrimination and enantiomer separation abilities.

A novel norbornene-based hydrophobic tag was developed that expands the clinical potential of targeted protein degradation technologies. The degrader Hyt-9, which was obtained by connecting an ALK ligand with norbornene, exhibited potent antiproliferative and degradative activities in vitro and in vivo. Furthermore, norbornene could be used to degrade EZH2 when tagged with the EZH2 inhibitor tazemetostat in degrader Hyt-13.

An asymmetric Sn atomically dispersed protuberance (ADP) having a special coordination with substrate C and O atoms was designed. This unique structure could induce positive charge accumulation on Sn site for improving its N₂ adsorption, activation and thus the N₂ reduction reaction (NRR) performance. As a result, the obtained Sn ADPs displayed an outstanding electrocatalytic activity, high selectivity stability, and durability in the NRR.

The peroxidase activity of a dual-functional small-molecule (DFSM)-facilitated P450BM3-H₂O₂ system was drastically improved through mechanism-guided protein engineering for the P450-mediated direct nitration of phenols, anilines, and styrenes using nitrite as the nitrating agent. Co-crystal structures revealed the crucial role of the steric effect introduced by site-directed mutations of proximal residues in the regulation of substrate access.

The synergistic oxygen reduction reaction that occurs on the Cu₁-N₄ and Se₁-C₃ dual-hetero-atom sites is revealed by the operando X-ray absorption spectroscopy under realistic Zn-air battery conditions, in which OOH*-(Cu₁-N₄) obtains one electron and is further transformed into the O*-(Se₁-C₂) intermediate.

The sodium manganese hexacyanoferrate full-cell configurations show comparable energy density to that of the well-known LiFePO₄ full cells.

We designed a flexible amphoteric cellulose-based double-network hydrogel electrolyte. The amphoteric groups not only promoted the desolvation process of [Zn(H₂O)₆]²⁺ to eliminate side reactions, but also guided the Zn²⁺ deposition to inhibit dendrite growth, thus resulting in a ultra-stable Zn anode.

A sterically hindered and deconjugative α-regioselective asymmetric Mannich reaction of Meinwald rearrangement-intermediates was realized by using chiral N,N′-dioxide/ Sc^III catalysts, offering chiral α-quaternary allyl aldehydes and alcohols in high efficiency. Experimental and computational studies showed that the steric hindrance of the ligand and the protecting group on the imine are critical factors influencing the α/γ-regioselectivity.

A new type of chain-growth click polymerization has been developed that can proceed quickly under ambient conditions. Mechanistic studies suggest the Michael addition controls the kinetics of the propagation process. In addition, this new polymerization can be spatiotemporally regulated by ultraviolet light, and the resulting polymers can be directly used for polymer ligations.

A globally robust HOF with both rigidity and flexibility was constructed. The non-crystalline and crystalline phases of the HOF could be easily and reversibly switched at will with the specific solvent molecule. Furthermore, the obtained HOF exhibits excellent separation efficiency for benzene and cyclohexane (94.4 %).

A new family of low-dimensional Ruddlesden-Popper perovskites (GABA)₂MA_n−1Pb_nI_3n+1 (n=1, 2, 3, 4, MA⁺=CH₃NH₃⁺) with inhibited dielectric confinement were constructed with γ-aminobutyric acid (GABA) as the spacer cation. The hydrogen bonds between the spacers link the adjacent spacing sheets, enabling the charges localized in the van der Waals gap. The power conversion efficiency of (GABA)₂MA₄Pb₅I₁₆ solar cells with excellent carrier transport properties is up to 18.73 %.

A new amphiphilic solvent is rationally designed to induce self-assembly of the electrolyte solution to form a peculiar core-shell-solvation structure. Such unique solvation structure bestows improved ionic conductivity, low desolvation energy, and highly robust and conductive SEI, which overcomes the long-standing Li compatibility and deposition kinetic challenges, enabling the stable operation of Li-metal battery under ultra-low temperature.

Three families of ester-based solid polymer electrolytes consisting of polycarbonate, polyoxalate and polymalonate were prepared and investigated on their Li⁺-conductivity and antioxidation ability. The performances of solid polymer electrolytes are affected by the coordinating capability with Li⁺, molecular asymmetry and existing modes of elemental F.

A highly diastereoselective Ni-catalyzed reductive 1,2-diarylation of unactivated internal alkenes was developed. Additionally, the enantioselective variant with unactivated terminal and challenging internal alkenes was also achieved, delivering various polyarylalkanes bearing benzylic stereocenters with good to high enantioselectivities and excellent diastereoselectivities.

A 4-enzyme cell-free system transforms vinyl esters into β-hydroxy acids in the absence of ATP and ancillary electron donors through concurrent abiotic thiolysis, non-decarboxylating Claisen condensation, ketone reduction and hydrolysis steps. The same substrate provides the energy to activate the acyl group and the redox power to reduce the condensed ketone.

For thermoelectric InTe, we reveal dynamic lone-pair expression as the chemical-bonding origin of giant phonon anharmonicity and intrinsically ultralow lattice thermal conductivity. Our study provides a first detailed microscopic picture connecting dynamical chemical bonding with giant phonon anharmonicity and ultralow thermal conductivity.

Copper single-atom electron bridges (SAEB) were constructed at the contact interface between Cu₁/MoS₂ and MIL-125-NH₂ to achieve a highly active and stable catalyst for CO₂ photoreduction. Empowered by the N−Cu₁−S SAEB species, the Z-Scheme charge-transfer process was significantly promoted, leading to enhancement of the photocatalytic CO₂RR.

Copper-catalyzed chemo- and enantioselective radical 1,2-carbophosphonylation of styrenes from readily available alkyl halides and dialkyl phosphites is developed. The key to the success of the strategy lies in not only the proper choice of phosphorus reagents to suppress the reverse chemoselectivity but also the utilization of a chiral N,N,N-ligand to forge chiral C(sp³)−P bond.

The isolation, structural determination, and chemical synthesis of an N-glycan from the hyper-thermophilic archaeon Thermococcus kodakarensis are reported. The identified N-glycan possesses a highly glycosylated myo-inositol moiety, which is linked to a disaccharide unit through a phosphodiester. Although myo-inositol is ubiquitous in archaea and eukaryotes, inositol-containing N-glycans were unknown until now.

A novel aromatic polyketide containing a xanthene framework and belonging to the mutaxanthene family was discovered through genome mining. The total biosynthesis of this natural product was successfully accomplished using 14 reconstituted enzymes, revealing that a flavoprotein monooxygenase catalyzes a key ring rearrangement and generates the required xanthene ring through a multistep transformation.

Structurally explicit hydrogen-bonded organic frameworks (HOFs) were used to mimic photo-responsive oxidase. It is shown by constructing isostructural HOFs that the pore environments play an important role in mediating the oxidase-like activity. The enzyme-like activity of the HOFs is associated with the substrate-pore interaction, reminiscent of the binding effect of the native enzyme pocket.

A new evaluation method is provided to judge the glass stability and glass-forming ability. As an example, the reported novel glass KZnP₃O₉ exhibits the highest δ (δ=1, n_glass=8) that quantitatively identifies the short-range order similarity to its crystalline counterpart. The inverse δ-T_f correlation gives the direct evidence for the structural origin of fictive temperature revealing the relaxation thermodynamics.

We demonstrated a general strategy to realize repeatable photochemical afterglow (RPA) based on the reversible storage of singlet oxygen. Ultra-long near-infrared afterglow was achieved via the singlet oxygen-sensitized fluorescence approach, and its intensity shows no significant reduction over 50 excitation cycles. The RPA system was further applied for attacker-misleading information encryption, presenting a repeatable read-out.

The photoredox system that can simultaneous use photoinduced electrons and holes for solar-driven CO₂ reduction coupled with selective ethanol oxidation to one identical value-added CH₃CHO product is realized on Rb and K co-modified carbon nitride catalyst, with a benchmark C₂ product yield and near-ideal atomic economy.

We report an iridium-catalyzed highly chemo-, diastereo-, and enantioselective allyl-allyl coupling between branched allyl alcohols and α-silyl-substituted allylboronate esters resulting in enantioenriched (E)-1-boryl-substituted 1,5-dienes. All four stereoisomers with two adjacent chiral centers were obtained by chirality pairing. Mechanistic studies were conducted to understand the high levels of selectivity.

We find that the tip-molecule point contact can dramatically increase the molecular tip-enhanced Raman spectroscopy (TERS) signal via a combined physico-chemical mechanism induced by the ground-state charge transfer (GSCT). In contrast, the TERS signal from a planar molecule chemisorbed flatly on the silver substrate is significantly quenched, mainly due to the polarizability screening induced by the interfacial dynamic charge transfer (IDCT).

Here we break the bottleneck of uncontrollable inner microenvironment from the hydrophobicity-driven assembling strategy, and present a fluorescent probe based AIEgen-mediated polyelectrolyte nanoassemblies (APN) strategy. By modulating a “soft” and water-rich inner microenvironment in nanotheranostics, APN strategy has for the first time synergistically manipulated both intramolecular motion and magnetic relaxivity.

An electrochemical interfacial polymerization strategy, which actively manipulates the self-healing effect and self-inhibiting effect during electrochemical process, is developed for fabricating ultrathin and robust COF membranes for efficient brine desalination.

Supramolecular hydrogen-bonded organic superstructures are designed, which empower high-kinetics Grotthuss proton conduction to deeply access built-in protophilic oxygen motifs via a two-step nine-electron (de)coordination reaction, endowing the assembled Zn-organic battery ultrahigh energy density, superior rate capacity and ultra-stable cyclability.

We synthesized a new family of chemically recyclable polymers in a large scale from the sustainable monomers H₂O, COS, and diacrylates. Such resultant polymers manifest impressive toughness and ductility comparable to commodity polyethylene. The chemical recycling of these polymers can be readily achieved through two closed loops.

A layered double hydroxide-derived plasmonic Cu catalyst was synthesized for the photo-driven water-gas shift reaction (WGSR). Light-induced hot electrons led to efficient *H₂O activation and *H combination via a carboxyl pathway. High hydrogen production rate (114.35 μmol g_cat⁻¹ s⁻¹) was realized at 200 °C through the plasmonic Cu-mediated strategy, representing state-of-the-art performance for (photo-)thermal WGSR catalyst at low temperatures.

A highly integrated two-step strategy was developed for the selective synthesis of renewable cyclopentadiene (CPD) and methylcyclopentadiene (MCPD) with xylose or the hemicelluloses extracted from real biomass. Compared with the conventional fossil route, the new synthetic strategy has evident advantages in the renewability and higher availability of feedstock.

Record ultralarge-pores (47 Å), low density (0.106 g cm⁻³) three-dimensional non-interpenetrated stp net COF, TUS-64, was obtained by reticulating a 6-connected triptycene-based linker with a 4-connected porphyrin-based linker. TUS-64 displayed the significant qualities of a drug delivery vehicle: controlled release kinetics, sustained delivery, and site-specific targeting.

The integration of light-driven rotary motors in polymer networks leads to active hydrogels that can be engineered as macroscopic bending actuators. In this configuration, lifting experiments reveal that a single molecular motor can pick up loads of 200 times its own molecular weight.

The straightforward access to a new class of aza-polyaromatics is reported starting from fluorinated s-tetrazine. The tetrazo[1,2-b]indazoles display solid-state π-stacking, low reduction potential, absorption in the visible range up to the near-infrared and intense fluorescence, depending on the molecular structure.

A self-standing hybrid system consisting of Ni₂Al₃ and Ni₃Fe phases was constructed by laser-assisted aluminum incorporation on nickel foam (NF) for full water splitting. Ni₁₈Fe₁₂Al₇₀ (Ni₂Al₃ and Ni₃Fe) delivers an extremely low overpotential to trigger HER and OER processes with better performance than individual Ni₆₀Fe₄₀ (Ni₃Fe phase) and individual Ni₃₀Al₇₀ (Ni₂Al₃ phase), allowing a design strategy of efficient bifunctional electrocatalysts.