In the entire Danish population of older people aged 65+, influenza vaccination was associated with a slightly higher risk of dementia. This increased risk was probably due to differences between vaccinated and unvaccinated people which could not be controlled for in the study. Unlike previous observational studies, no convincing evidence of a preventive or adverse effect of influenza vaccination on the risk of dementia was found.

This longitudinal study (N = 89) revealed distinct trajectories of behavior and social cognition between patients with behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD). bvFTD showed worsening of symptoms over time, whereas PPD remained stable or improved, with patient-reported measures detecting no change, highlighting the need to optimize social cognitive assessment methods. Additionally, higher baseline serum neurofilament light levels were associated with faster behavioral decline, suggesting its potential as a prognostic marker in neuropsychiatric populations.

In this work, we investigated microstructural abnormalities in patients with myoclonus dystonia using neurite orientation dispersion and density imaging applied to diffusion magnetic resonance imaging. We showed abnormalities in the motor cerebellum of patients compared to controls. Moreover, structural change in the cerebellar afferent pathways that relay inputs from the spinal cord and the cerebral cortex was associated with the severity of dystonia.

This meta-analysis revealed that individuals with high lipoprotein(a) (Lp[a]) levels experienced a 2.13-fold increased risk of poor functional outcomes among patients with ischemic stroke (IS) during follow-up. Subgroup analyses showed that the impact of elevated Lp(a) on functional outcomes was more pronounced in the acute phase poststroke and gradually diminished over time. Moreover, this association remained significant even in studies that adjusted for low-density lipoprotein cholesterol. These findings support the potential of measuring Lp(a) as a predictor of poor functional outcomes after IS.

Our randomized controlled pilot study in patients with critical illness polyneuropathy after sepsis undergoing early in-patient neurological rehabilitation provides pilot data suggesting that heart rate variability biofeedback can improve neurocardiac function with a predominant effect on the parasympathetic nervous system. We also observed a beneficial effect on regaining functional independence in this severely ill population.

Real-world, multicenter Italian study of monthly versus quarterly fremanezumab for migraine prevention.

Behavior therapy is a useful tool with long-lasting value. Long-term migraine treatment should focus on adherence to therapy as well as on medical information and lifestyle modification options. Data from this study encourage the incorporation of nonpharmacological interventions in migraine treatment and the investigation of these techniques to profile the patient features for which each evaluated technique may be more suitable and thus to obtain a greater return on the investment made while working on it.