Taking advantage of the well-known tetrazole/alkene “photoclick” chemistry, a hydrogen peroxide (H₂O₂)-initiated chemiluminescence-triggered nanoparticle (NP) aggregation strategy was herein reported to activate the photoacoustic imaging and photothermal therapeutic functions of gold NPs for specific visualization and efficient treatment of tumors in vivo. This approach could provide a valuable tool for achieving precise cancer treatment.

A protic switch was applied into the newly developed copper-catalyzed hydroxymethylation of alkynes with CO₂. Allylic alcohols and β-chiral branched alkyl alcohols were selectively delivered with high levels of Z/E, regio-, and enantioselectivity.

Charge separation is key to efficient photocatalytic solar energy conversion. The distribution of surface charge on photocatalysts can be identified and the driving forces of charge separation quantitatively determined at the nanoscale by the spatially resolved surface photovoltage technique. The identification of photocatalytic charge separation mechanisms will enable the rational design of efficient photocatalytic systems.

A new chemical mechanism for the generation of gaseous OH radicals by the reaction of H₂O with O₂ over soot was revealed, which indicates the airborne soot particles generated by the incomplete combustion of hydrocarbons may entail important catalytic oxidation capacity.

Enabled by de novo construction of the ether-linked hexopyranosyl units, the use of olefinic pyranoses as sugar precursors, and a gold(I)-catalyzed ring-closing glycosylation, the major starfish cyclic steroid glycosides, namely luzonicoside A and D and sepositoside A, have been synthesized for the first time.

The first case of zeolite-like crystalline porous organic materials, ZOF-1 with high chemical stability, large pore size (up to 16 Å), and excellent specific surface area (≈2785 m² g⁻¹) is reported. It is superior to its analogues with the same network, including traditional aluminosilicate zeolites and zeolitic imidazole frameworks.

A force-coupled enzymatic reaction was used to tune a strong covalent peptide linkage to create a reversible bond and engineer double network (DN) hydrogels that combine high mechanical strength and reversible mechanical recovery. The peptide ligase, sortase A (SrtA), can promote the proteolysis of peptides under force and re-ligation of peptides without force, allowing the sacrificial network in DN hydrogels to be ruptured and rebuilt reversibly.

We developed a molecular fusion strategy to achieve a high-efficiency photochemical afterglow system. The afterglow quantum yield was up to 2.59 %, which was significantly higher than that achieved with the physical mixing strategy and the covalent coupling strategy. This afterglow system was further used for high SNR bio-imaging and for the background-free high-sensitivity lateral flow immunoassay detection of β-hCG.

The dynamic interactions between RNA and proteins play crucial roles in regulating diverse cellular processes. Proteome-wide characterization of these interactions in their native cellular context remains desirable but challenging. A photocatalytic crosslinking (PhotoCAX) strategy for studying the composition and dynamics of protein–RNA interactions via mass spectrometry (PhotoCAX-MS) as well as RNA sequencing (PhotoCAX-seq) is reported.

A highly enantioselective C(sp²)−H functionalization of simple unprotected indoles, pyrroles, and their common analogues such as furans, thiophenes, and benzofurans by arylvinylcarbene insertion to access unique heteroarene-containing chiral diarylmethine derivatives has been developed for the first time. Mechanistic and DFT calculation studies revealed that the reductive elimination is the rate-determining step.

A novel bifunctional trifluoromethylsilyl reagent (BTR), Me₂(CH₂Cl)SiCF₃ is prepared, which enables ketone trifluoromethylations with excellent enantioselectivity and broad scope. Notably, by taking advantage of the chloromethyl group, a tandem synthesis of chiral trifluoromethylated oxasilacyclopentanes and α-CF₃ tertiary alcohols with vicinal tertiary or quaternary stereocenters was developed.

Recognizing monogenic RNA G-quadruplexes (G4s) in vivo is challenging. We developed a module-assembled multifunctional probes assay (MAMPA) for visualizing endogenous G4s in individual genes in single cells.

A carbonic anhydrase IX (CAIX)-anchored photosensitizer CA-Re was developed. It is capable of inducing and self-reporting membrane rupture upon irradiation, as well as evoking pyroptosis to activate anti-tumor immunity.

A novel Al-based MOF is described with uniform micropore size of 8.37±0.73 Å and excellent chemical-thermal stability for trace BTEX, e.g., benzene adsorption of 3.80 mmol g⁻¹ at relative pressure (P/P₀)=0.01 and 298 K, which is the largest value reported.

An open-cage fullerene derivative (trap) was prepared with a hydroxy group (bait/hook) pointing towards the center of the cavity and a diphenyl pocket above the 21-membered orifice. The hydroxy group could coordinate lithium and beryllium cations, which led to the encapsulation of LiF and [BeF]⁺ in the fullerene. The hydroxy group was also shown to form hydrogen bonds with molecules such as water, methanol, and ethanol in the diphenyl pocket.

A strategy for the conversion of inert N₂ into various nitrogen-containing organic compounds is presented. The activated N-containing species Li₂CN₂ is successfully prepared in high yields from N₂ gas, C and LiH. Li₂CN₂ can be transformed into a range of N-containing organic compounds, including cyanamides, carbodiimides, N-aryl cyanamides and 1,2,4-triazole derivatives. ¹⁵N-labeled products, including oxazolidine derivatives, have also been prepared from ¹⁵N₂ gas.

A correlation between the atomic structures of Co single-atom nanozymes and their catalase-like performance is established by both computational screening and experimental design. A strategy is elucidated for atomic-level regulation of Co single-atom nanozymes operating as catalase mimics.

C−H/C−H oxidative direct arylation polycondensation is firstly adopted to synthesize a high-performance n-type conjugated polymer using a newly developed monomer, i.e., 3,6-di(thiazol-5-yl)-diketopyrrolopyrrole (Tz-5-DPP). After n-doping, the polymer exhibited electric conductivity values up to 8 S cm⁻¹ and power factors up to 106 μW m⁻¹ K⁻².

A new local lattice distortion (LLD) manipulation strategy was demonstrated to suppress the halide migration in mixed-halide perovskite. DFT simulation and experimental data confirm that the LLD manipulation effectively suppresses the halide migration in perovskites. Mixed-halide blue PeLED with champion EQE of 14.2 % at 475 nm and impressive T₅₀ of 72 min has been achieved, representing the state-of-the-art pure-blue PeLEDs.

A glycosidic-bond-based mass-spectrometry-cleavable cross-linker has been developed that enables in vivo cross-linking for analyzing protein complexes. The MS-cleavable glycosidic bond of trehalose disuccinimidyl ester (TDS) improves the accuracy of identification while increasing the search throughput. In addition, in vivo cross-linking is enabled in the living cell microenvironment because of the high biocompatibility, bioorthogonality, and amphipathicity of TDS.