Chemical synthesis of mirror-image D-version of the immunoglobulin-like domain of TrkA (^DlgC^TrkA), a protein molecule needed for mirror-image screening of D-peptide ligands targeting TrkA, was found to be difficult due to the poor efficiency of intermediate synthesis and final protein folding. To solve this problem, the strategy of removable glycosylation modification was used and found to effectively improve the yield of peptide segment synthesis and ligation. Interestingly, it is important to note that temporary glycosylation at distinct sites of ^DlgC^TrkA led to significant differences in the process of protein folding. More details are discussed in the article by Li et al. on pages 2316—2322.

Divergent protein engineering of the natural transaminase Vf-ω-TA produced two effective mutants for synthesizing chiral amine precursors of Rivastigmine and Apremilast. Guided by crystal structures and focused mutagenesis, these mutants efficiently addressed challenging ketone substrates with high steric hindrance. Optimized reaction parameters achieved smooth transamination with excellent conversions and perfect stereochemical control (> 99% ee). More details are discussed in the article by Zhong et al. on pages 2335—2340.

The "mutual doping" effect led to a simultaneous increase in WF and conductivity. The PCT-F:POM HTL was easily processed using the blade-coating method for the fabrication of 1 cm^–2 OSC, resulting in an achieved PCE of 15.1%.

A highly efficient chemoenzymatic approach was developed for the concise and practical synthesis of TMG-chitotriomycin and its analogues.

Selective activation and transformation of multiple inert chemical bonds is a challenging yet intriguing direction in synthetic chemistry. We report a copper-mediated complete cleavage and selective transformation of sp²C—H bond in indoles, three sp³C—H bonds and one C—N bond in a methyl carbon atom in TMEDA, and the C≡N triple bond in CH₃CN for cyanation of indoles via tandem carbon and nitrogen atom transfer.

In this study, we introduce a decaging strategy utilizing Pd-catalyzed reductive amination of azides to activate biomolecules, encompassing fluorescent probes, prodrugs, and RNA functionalities. This approach offers an efficient and controllable "OFF to ON" biological switch, enabling substantial regulatory effects even at substoichiometric levels.

We report the study on the use of removable glycosylation modification strategy to overcome the low-efficiency problem encountered in the chemical synthesis of the mirror-image D-version of the immunoglobulin (Ig)-like domain of tropomyosin receptor kinase A (^DlgC^TrkA). It is interesting to note that temporary glycosylation at distinct sites of ^DlgC^TrkA led to significant differences in the process of protein folding.

A novel visible-light-induced radical cascade 6-endo cyclization of dienes (N-(2-vinylphenyl)acryl amides) is developed utilizing α-carbonyl bromides as alkyl reagents. This approach affords an efficient way for synthesizing six-membered benzo-fused lactam derivatives with chemo- and regio-selectivity and good functional group tolerance. Primary, secondary, and tertiary bromides are well-compatible with this cascade cyclization reaction.

Enabled by merging halogen atom transfer and hydrogen atom transfer, a novel photocatalytic [3+2] cycloaddition of alkynes and alkyl/aryl iodides is accomplished, providing a highly regio- and diastereoselective approach for the direct assembly of ubiquitous and important cyclopentane derivatives from readily available chemicals.

Wide-type transaminase Vf-ω-TA was rationally engineered in a divergent way to accommodate non-natural bulky ketones substrates, facilitating the enzymatic synthesis of chiral amine precursors of Rivastigmine and Apremilast in good yields and > 99% ee.

Herein, an isothiourea (ITU)-catalyzed dynamic kinetic resolution and asymmetric acylation reaction of 3-hydroxyphthalides has been achieved with good yields (up to 99%) and excellent enantioselectivities (up to 96% ee).

A radical-polar crossover (RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino strategy was developed.

HpnG, identified as a purine nucleoside phosphorylase, converts adenosylhopane to phosphoribosylhopane and exhibits broad substrate specificity.

Herein, we report a palladium-catalyzed three-component reaction of 2-alkynyl-1,4-diol dicarbonates, organoboronic acids, and nitrogen nucleophiles forming 2,3-allenyl amines. The reaction shows an excellent regio- and chemoselectivity and a broad substrate scope. The mechanistic experiments demonstrate an unique β-O elimilation pathway generating 1,2,3-triene intermediate.

Six kinds of fluorescent dyes A—F are constructed based on the structure of cyclic chalcone. Fluorescent anti-counterfeiting Powder X and Y are constructed by mixing dye with montmorillonite. They have the same orange appearance and fluorescence, but upon contact with the acid developer, the fluorescence of Powder X redshifts and the fluorescence of Powder Y blueshifts. Anti-counterfeiting and information storage can be synchronously achieved by using Powder X and Y.

A series of M_xS_y/S@C composites were designed for R-T sodium ion batteries, which have rich porous structure, in situ sulfide catalysts and high sulfur elemental loading capacity, achieving a high storage capacity, splendid rate performance and long cycling performance (over 10000 cycles). The work is expected to provide promising insights for designing advanced cathode materials for RT-Na/S batteries.

A series of Co^II complexes ([Co(terpy-CH₂OH)₂]A₂∙sol (A = Br^–, I^–, N₃^–, H₃BCN^–, OTf^–, and TsO^–, sol = solvents) with different structures and SCO properties have been prepared. Detailed studies revealed different SCO properties, including gradual transitions and hysteretic SCO transitions with loops. Their structures and SCO properties can be effectively tuned by the size, shape, and hydrogen bonding ability of the anions.

In this article, the current understanding of the adsorption of DNA to gold nanoparticles is summarized, and related application of attaching DNA is described. In addition, problems of using gold nanoparticles to signaling aptamer binding is discussed. Finally, re-selection of aptamers for previously reported targets using the new library-immobilization method is reviewed.

Tetracoordinate organoborons are a highly important class of molecules, that have found wide applications in areas ranging from synthetic chemistry, medicinal chemistry, to materials science. In this review, we summarized and discussed the significant progress and recent advances in the synthesis and application of enantioenriched tetracoordinate boron-stereogenic compounds, according to the synthetic method: (1) resolution of racemates, (2) chiral substrate induced asymmetric synthesis, and (3) asymmetric catalysis.

Chiral radical covalent catalysis represents an emerging strategy for the stereocontrol of radical cyclization reactions. This distinct catalytic strategy mainly involves three key steps: (1) reversible intermolecular addition of chiral radical catalyst toward substrates to form new radical intermediates poised for subsequent new-bond-forming cyclization, (2) intramolecularly stereo-determining radical cyclization process, (3) final elimination process with regeneration of chiral radical catalyst.

The serious dissolution of polysulfides restricted the practical application of Room-temperature sodium-sulfur (RT-Na/S) batteries which displayed attractive potential in large-scale energy-storage. Utilizing the double-helix structure of carrageenan-metal hydrogels as precursors, in-situ metal sulfide (M_xS_y) nanostructure/3D carbon aerogels (3D CAs) can be successfully constructed. Importantly, with the assistance of the vulcanization process, 3D carbon architecture was maintained in the composites and acted as a skeleton to optimize Storage environment of sulfur element. More details are discussed in the article by Yang et al. on page 2370—2380.

Bacteriohopanepolyols are a group of triterpenoids that play important roles in cell membrane function. As an essential step in bacteriohopanepolyol biosynthesis, HpnG phosphorolyzes adenosylhopane to form phosphoribosylhopane, and demonstrates remarkable tolerance to various nucleoside substrates. More details are discussed in the article by Zhang et al. on page 2351—2356.