Visible-Light-Induced Domino Cyclization to Access Pyrido[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction
Wanqing Zuo
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
Search for more papers by this authorYu Cheng
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Search for more papers by this authorZhizhen Zhu
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Search for more papers by this authorLingling Zuo
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Search for more papers by this authorCorresponding Author
Xiao Geng
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorZhifang Li
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
Search for more papers by this authorCorresponding Author
Lei Wang
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
E-mail: [email protected]; [email protected]Search for more papers by this authorWanqing Zuo
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
Search for more papers by this authorYu Cheng
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Search for more papers by this authorZhizhen Zhu
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Search for more papers by this authorLingling Zuo
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Search for more papers by this authorCorresponding Author
Xiao Geng
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorZhifang Li
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
Search for more papers by this authorCorresponding Author
Lei Wang
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical-polar crossover (RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino cyclization. The reaction exhibited a broad substrate scope (> 40 examples) including complex molecules, which highlighted the utility of this strategy for the construction of a library of bioactive analogs.
Supporting Information
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Appendix S1: Supporting Information |
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