Concise Report
Photochemical Radical Cascade 6-endo Cyclization of Dienes with α-Carbonyl Bromides for the Synthesis of Six-Membered Benzo-Fused Lactams
Jia-Li Sui,
Yang Guo,
Bi-Quan Xiong,
Ke-Wen Tang,
Peng-Fei Huang,
Yu Liu,
Jin-Heng Li,
Jia-Li Sui
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorYang Guo
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorBi-Quan Xiong
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorKe-Wen Tang
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorCorresponding Author
Peng-Fei Huang
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yu Liu
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jin-Heng Li
State Key Laboratory Base of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, Shandong, 266042 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorJia-Li Sui,
Yang Guo,
Bi-Quan Xiong,
Ke-Wen Tang,
Peng-Fei Huang,
Yu Liu,
Jin-Heng Li,
Jia-Li Sui
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorYang Guo
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorBi-Quan Xiong
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorKe-Wen Tang
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
Search for more papers by this authorCorresponding Author
Peng-Fei Huang
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yu Liu
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jin-Heng Li
State Key Laboratory Base of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, Shandong, 266042 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorThese authors contributed equally to this work.
Comprehensive Summary
A novel visible-light-induced radical cascade 6-endo cyclization of dienes (N-(2-vinylphenyl)acryl amides) is developed utilizing α-carbonyl bromides as alkyl reagents. This approach affords an efficient way for synthesizing six-membered benzo-fused lactam derivatives with chemo- and regio-selectivity and good functional group tolerance. Primary, secondary, and tertiary bromides are well-compatible with this cascade cyclization reaction.
Supporting Information
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Appendix S1: Supporting Information |
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