Die Me₃Si-Gruppe wird schon lange aus der Familie ihrer aryl- und heteroatomsubstituierten Artgenossen ausgegrenzt, da sie sich nur schwer chemoselektiv in eine andere, synthetisch nützliche funktionelle Gruppe umwandeln lässt. Es wurde nun gezeigt, dass ein hypervalentes Iodreagens mittels elektrophiler Demethylierung genau das erreicht. Im Zusammenspiel mit der Tamao-Fleming-Oxidation wird die Me₃Si-Gruppe ein Platzhalter für eine Hydroxygruppe.

Based on Markovnikov's 1870 Annalen paper, many western authors have viewed his rule as a relatively unimportant addendum to a paper on isobutyric acid derivatives, and some have suggested that the rule itself was simply an inspired guess. In this Essay, based on an analysis of his work on the structure of the double bond in his graduate dissertations, the argument is made that it was not.

This Minireview describes developments in all-polymer solar cells containing a new type of n-type conjugated polymer, polymerized small-molecule acceptors (PSMAs). PSMAs combine the merits of small-molecule acceptors (narrow band gap, strong absorption, and suitable electronic energy levels) with the good film formation, higher morphology and light-irradiation stability of polymers.

Enzymatic oxidative kinetic resolutions (OKR), in which a new oxygen atom is inserted into the substrate, are highly effective for the synthesis of enantioenriched oxygen-containing compounds. This Minireview discusses selected enzyme classes that can achieve OKR, biological advancements and protein development, and the use of these key enantioenriched intermediates in natural product synthesis.

Steuerungsmethoden zur Vergrößerung der intrinsischen Aktivität von M-N-C-Einzelatom-Katalysatoren für die elektrokatalytische Sauerstoffreduktionsreaktion werden in diesem Aufsatz besprochen. Dabei lassen sich entsprechend den Katalysator-Bestandteilen vier Teilbereiche für die Optimierung unterscheiden: Metall-Zentralatome, koordinierende Ligandatome, Umgebungsatome und Gastgruppen.

A stable derivative of [4,3]peri-acene with three rows of peri-fused tetracenes was isolated in crystalline form. It exhibits a unique structure with eight localized Clar's sextets and shows a large diradical character (94.8 %) as well as a small singlet–triplet energy gap (−0.57 kcal mol⁻¹).

Nitridophosphate zeolites AE₃P₅N₁₀X (AE=Sr, Ba; X=Cl, Br) were synthesized under medium-pressure conditions (150 MPa N₂, 1200 °C), extending the range of the degree of condensation for nitridophosphates accessible by hot isostatic pressing from κ=1/3 to 1/2. AE₃P₅N₁₀X:Eu²⁺ (AE=Sr, Ba; X=Cl, Br) reveals natural-white to deep-red emission.

Tensile-strained palladium porous nanosheets exhibited enhanced activity for nitrogen electrooxidation to nitrate at ambient conditions. ¹⁵N isotope labeling experiments showed that nitrate originated from nitrogen electrooxidation. Electrochemical in situ characterizations and theoretical simulation revealed that the tensile strain could facilitate the formation of PdO₂ active species and lead to high activity.

Enantioselective gold-catalyzed [3+2]annulations between highly substituted cyclopentadienes and α-diazo ketones yielded gold enolate intermediates. These form complex pairs with chiral phosphoric acid to enhance the enantioselectivity.

A dynamic library including an Fe^II₄L₆ irregular structure and three Fe^II₂L₃ stereoisomers was formed by subcomponent self-assembly. Glucose amplifies the formation of the (P)-Fe^II₂L₃ helicate, which in turn amplifies β-D-glucose at the expense of the α-D-anomer. Both host and guest libraries are thus geared together into a single system during equilibration.

Wacker-type reaction of cyclic alkenes, propargylic acetates and nucleophilic heteroarenes and arenes, including indoles, pyrroles, activated thiophenes, furans and anilines, proceeds to give trans isomers of 2,3-disubstituted pyrrolidines and tetrahydrofurans.

Fe₂N@C core–shell nanoparticles were highly efficient for the thermal catalytic hydrogenation of CO₂ with excellent C₂₊ selectivity of 53.96±1.33 % and outstanding lower olefins (C₂-C₄⁼) selectivity of 31.03±1.05 %. Our results revealed the in situ restructuring of Fe₂N into iron carbides via a carbonyl iron-mediated conversion mechanism. Iron carbides were identified as active species for selectively converting CO₂-H₂ to C₂₊ hydrocarbons.

We developed orthogonal chemo-optogenetic tools as a minimal regulation strategy to fine-tune in-vitro protein self-organization with light. Our chemo-optogenetic tools are designed by orthogonal translation with an expanded genetic code. Such introduced bio-orthogonal chemical groups operate at the level of single specific amino acids, but perform tight control of enzyme activity and, thereby, the ability of protein self-organization.

Acetyl azolium enolates resulted from the treatment of the N-heterocyclic carbenes IPr and SIPr with 2-propenyl acetate. Protonation converts them into acetyl azolium cations. The latter react with amines faster than with alcohols, while the azolium enolates reacted readily with alcohols, but sluggishly with amines. The use of a d₃-acetyl azolium triflate indicated that alcohol acetylation occurs at the azolium enolate stage.

A peptide-based bistable reaction network was programmed to control a cascade reaction influencing Au nanoparticle morphology, self-assembly kinetics, and shape. This study offers a clear demonstration of how bridging the fields of systems chemistry and nanotechnology can expand our repertoire of functional materials.

The carbon suboxide anion C₃O₂⁻ is generated in a solid neon matrix, and is characterized to have an unsymmetrical structure by the bonding interactions between a neutral CO in a triplet excited state and a doublet excited state of CCO⁻.

Synthetic carbohydrate polyethers, which are polysaccharide mimics, are synthesised by regioregular anionic ring-opening polymerisation of oxetanes produced from d- or l-xylose. By exploiting the chirality of xylose and varying stereochemical composition, the crystallinity of the resulting materials can be controlled. Mixing together homochiral polymers of opposite configuration results in a stereocomplex with enhanced thermal properties.

Using photoactivated NADH and EPR spectroscopy, a method to monitor the changes in redox state(s) of the metal centers in the multi-component, non-heme enzymes was developed. Combined with annealing, the detailed mechanism of the catalytic conversion of carnitine into TMA and MSA by AbCntA/AbCntB in the human microbiota are investigated.

A unique combination of hydrogen bond donor (HBD) and acid catalysis enabled rapid vinyl ether polymerization under an ambient atmosphere. This controlled polymerization furnished polymers with molecular weights above 60 kg mol⁻¹. Importantly, several key intermolecular interactions between the organic acid and HBD were crucial for successful polymerization.

The formation of exceptionally large capsular species (diameter of c. a. 30 Å) by interactions of polyphenolic macrocycles with 5-fold symmetry with anions is reported. Pyrogallol[5]arenes and resorcin[5]arenes interact with anions via hydrogen bonds involving phenolic OH groups or aromatic CH groups. A (P5H)₁₂(X⁻)₆₀ or (R5H)₁₂(X⁻)₆₀ stoichiometry and a unique dodecahedral geometry of one of the Platonic solids is postulated.

Tip-enhanced Raman spectroscopic (TERS) mapping in liquid is shown to be an efficient tool to investigate the secondary structure of the neurodegenerative peptide amyloid-β. The high heat capacity of liquid increased the capability of TERS, allowing an observation of the conformational transition from the antiparallel arrangement of β-sheets in protofibrils to parallel in fibrils, at the single aggregates level.

A highly luminescent Ag⁺ doped Pt cluster is reported. Compared to the original platinum thiolate complex, the inclusion of silver ion has boosted photoluminescent quantum yield by 18 times. The LUMO, which has the main contribution from the Ag s-orbital and Pt d-orbitals, plays a critical role in suppressing the structural distortion at the excited state.

An atom-economical strategy has been developed for the visible-light-driven synthesis of enantioenriched substituted 1-pyrroline derivatives with wide functional-group tolerance (see scheme). In this enantioselective radical approach, stereoselectivity was dictated by coordination to a chiral-at-rhodium catalyst, and water was produced as the only by-product.

A copper(I)-catalyzed asymmetric three-component interrupted Kinugasa reaction has been developed. Diverse chiral sulfur functional chiral β-lactams with two consecutive stereogenic centers were synthesized in one step in good yields with excellent diastereo- and enantioselectivity from easily available materials.

A 2,4,6-triphenylpyridinium (trippy) group is used to enhance properties of nickel olefin polymerization catalysts. Comparison with the corresponding CF₃-substituted complex shows the advantages of catalysts possessing the new substituent. High steric bulk combined with powerful electron-withdrawing properties of this substituent result in increased catalytic activity and polymer molecular weight for the trippy-substituted complex.

Metal–organic framework (CPL-1-NH₂) with keyhole-like pore apertures offers selective adsorption site properties for gas separation. Amine groups limit interactions with CO₂ molecules by decreasing the enthalpy of CO₂ adsorption, whereas the binding affinity of C₂H₂ is increased (see picture, distances in Å). CPL-1-NH₂ demonstrates a remarkably high C₂H₂ selectivity with C₂H₂/CO₂ (50/50) mixtures at 1 bar and 298 K.

Chiral supramolecular self-assembly driven by arene–perfluoroarene (AP) interactions are demonstrated in chiral polyaromatic hydrocarbons and octafluoronaphthalene. They exhibit a large figure of merit for boosting circularly polarized luminescence. The AP interaction amplifies both ground-state and excited-state chirality. Due to the high energy barrier of octafluoronaphthalene, the photoluminescence quantum efficiency of the AP complex could be significantly enhanced.

In situ observation of non-classical 2-norbornyl cation inside confined zeolite channels by taking advantage of AIMD simulations as well as ¹³C ssNMR experiments without super acidic environments at ambient temperature is described.

In PMS activation ¹O₂ becomes the predominant reactive oxygen species mediated by single-atom CoN₂₊₂ sites. The weakly positive Co atoms and CoN₂₊₂ coordination direct PMS oxidation by a non-radical pathway with simultaneous ¹O₂ generation. This work is beneficial for rational regulation of ¹O₂ generation at the atomic level.

A stable triplet-ground-state conjugated diradical with pyrazine as a linker group was synthesized with a half-life time of about 22 days under ambient conditions. The electron-deficient pyrazine unit impedes spin delocalization to the peripheral phenyl rings, which increases the spin density distribution on the central meta-pyrazine unit, leading to a large ΔE_S-T.

An enantioselective Rh-catalyzed addition of α-nitroesters to alkynes affords access to α-amino-acid precursors containing contiguous stereocenters. These motifs can be further transformed into α-amino esters without stereoablation.

A copper(I)-catalyzed asymmetric vinylogous aldol-type reaction of allylazaarenes is disclosed. It provides an array of chiral γ-hydroxyl-α,β-unsaturated azaarenes in moderate to excellent regio-, (E)/(Z)-, and enantioselectivities.

The first enantioselective Diels–Alder reaction of cyclobutenone has been developed. The 3-methoxycarbonyl group shows a remarkable effect on stability and reactivity. Based on an enantioenriched adduct, the total synthesis of (−)-kingianin F was completed.

Catalytic diastereo- and enantioselective conjugate addition of chiral secondary borylalkyl copper species derived from borylalkenes in situ to α,β-unsaturated diesters provides enantioenriched alkylboron compounds containing two contiguous carbon stereogenic centers in good yield with high diastereo- and enantioselectivity.

Die Ruthenium-katalysierte elektrooxidative Drei-Komponenten-Synthese von Isochinolinen zeigte eine breite Anwendbarkeit. Die Isolierung von Schlüsselintermediaten zusammen mit DFT-Berechnungen deutete auf einen ungewöhnlichen Ruthenium(II/III/I)-Mechanismus hin.

A racemic monomer-based polyacetylene folds into a one-handed helix assisted by a nonracemic alcohol through auto-evolution of its helical handedness over time, accompanied by successive enhancement of its optical purity adsorbed on the helical polyacetylene. The one-handed helical polyacetylene with the static helicity memory separates various enantiomers in liquid chromatography.

The new N,N′-chelating amido imidazoline-2-imine ligand (HAmIm) was designed to supersede the widely employed β-diketiminato ligand (HNacNac). The superior stability of the HAmIm system is exemplified for a series of chalcogenoboranes with confirmed B=X double bonds (X=O, S, Se, Te), which are isoelectronic and isolobal to ketones, including their heavier analogues.

A xanthene-based bis(germylene)-Ni complex is used as a molecular precursor for the synthesis of ultra-small NiGe nanostructures, which can generate a γ-NiOOH structure with intercalated species. This displays exceptional catalytic activity and long-term durability for the oxygen evolution reaction (OER).

Natural product (NP) fragments are combined in unprecedented arrangements to deliver a 155-member pseudo-NP collection. Cheminformatic analysis and biological evaluation of the collection by means of phenotyping in the morphological cell painting assay and principal component analysis revealed that the pseudo-NP classes are chemically diverse with markedly different bioactivity patterns, which are dependent on connectivity and regioisomeric arrangement of the fragments.

Ir1 effectively targets the endoplasmic reticulum of A549 lung cancer cells and triggers the production of ER stress and ROS production. Ir1 was demonstrated to induce multiple characteristics of immunogenic cell death (ICD) both in vitro and in an in vivo vaccination experiment. Ir1 is the first iridium(III) complex to induce ICD in non-small-cell lung cancer.

The radical S-adenosyl-l-methione (SAM) enzyme HydG can use S-adenosyl-l-ethionine (SAE) in place of SAM during catalysis. HydG reacts with SAE and tyrosine to form the organometallic intermediate Ω, similar to reaction with SAM. The SAE-bound [4Fe-4S]⁺ cluster of HydG undergoes cryogenic blue light photolysis to generate an ethyl radical. Upon annealing the radical forms an organometallic species in which an ethyl is bound to the unique iron of a [4Fe-4S]³⁺ cluster.

Direct capture of an intermediate species on the surface of manganese oxide nanoparticles was achieved in electrochemical water oxidation and visualized using in situ Raman spectroscopy. A Raman band position at 760 cm⁻¹ combined with isotope-labeling experiments using H₂¹⁸O and D₂O confirmed the generation of the surface terminal Mn^IV=O species, which is the water oxidation intermediate for the oxygen evolution reaction. Key: rate-determining step (RDS).

The endeavor to deliver a high specific capacity for a LiCoO₂ cathode at a voltage larger than 4.35 V is challenging. The deliberately introduced Mg ions at the Li layer of LiCoO₂ endow this promising cathode with high capacity (204 mAh g⁻¹) and excellent cycling stability and rate capability within a voltage window of 3.0–4.6 V.

Fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) are key mitochondrial pathways for cellular energetics. However, the crosstalk between them is unclear. We show that the molecular architecture of the mitochondrial Complex I assembly (MCIA) complex, required for Complex I biogenesis and thereby for activation of OXPHOS, implies an allosteric deflavination mechanism that shuts down FAO.

A radical addition reaction between glycine esters and racemic α-bromoketones catalyzed by synergistic Brønsted acid/photoredox catalysis is presented. This dual catalysis controls the reactive radical intermediate and iminium ion to facilitate the bond-forming event in a highly stereochemical manner. An array of valuable enantioenriched unnatural α-AAs bearing two contiguous stereocenters are accessible.

By taking advantage of multivalence and ligand preorganization, a series of basket-shaped cages are self-assembled by imine condensation in water. These cages are rather stable and inert against hydrolysis, and therefore they are able to take advantage of the hydrophobic effect for guest recognition.

We present efficient catalysts for green and sustainable synthesis of adipic acid from biomass-derived glucose via glucaric acid. Pt/CNT with smaller (2.5 nm) Pt nanoparticles catalyzes the selective oxidation of glucose to glucaric acid. A bifunctional Pd-ReO_x/AC catalyst offers 99 % yield of adipic acid from glucaric acid; the overall yield of adipic acid reaches 81 %.

Photosensitization-free polymeric nanocapsules are activated by photoacoustic cavitation via pulsed laser irradiation to generate distinct reactive oxygen species, which spontaneously react with in situ released nitric oxide to burst highly cytotoxic peroxynitrite, achieving prominent therapeutic efficacy. This work provides a promising modality for precision disease theranostics via extensive photosensitization-free materials.

Single-molecule junction conductance can be efficiently tuned by solvent environment. A series of expanded pyridinium molecular wires gave higher conductance with fully extended junction geometries in solvating water environment as opposed to mesitylene solvent. Environmental control efficiently operates the molecule–electrode interactions.

Bioinspired stereoselective γ-aliphatic C−H bond lactonization of α-amino acids using a manganese catalyst and H₂O₂ is reported. This method allows the oxidation of 1°, 2° and 3° C−H bonds and the enantioselective preparation of chiral α,α-disubstituted-α-amino acid derivatives.

CA molecules can anisotropically modify and protect the {110} facets of the tZIF-67 crystal from etching, causing the six {100} facets be selectively etched via an inside-out manner, and finally forming the hollow nanoframes. The surface modified hollow tZIF-67 can further be facet-selectively etched by metal salts in an outside-in manner to give metal-doped tZIF-67 nanoframes.

Strikingly different reactivity of vanadium and cobalt cationic clusters towards methanol in a low-pressure collision cell is observed by mass spectrometry. Metastable or kinetically trapped reaction intermediates of the methanol reaction with vanadium cationic clusters are verified, and their structures are proposed by exploring the reaction pathways using density functional theory calculations.

Observing single-atom catalytic sites during reactions: Single-atom catalysts supported on soluble polyoxometalates have been investigated under reaction conditions by electrospray ionization mass spectrometry. This enables us to observe the exact composition and stoichiometry of active sites as well as their dynamics during CO and alcohol oxidation reactions. Even the apparent activation barriers between intermediates become accessible.

An effective and versatile strategy to construct mesoporous ABO₃ perovskite oxides via a resol-assisted cationic coordinative co-assembly approach is developed. The as-prepared mesoporous LaMnO₃ with functionalized nanocrystal frameworks and abundant oxygen vacancy sites as catalyst exhibits remarkable catalytic activity and stability for catalytic transfer hydrogenation of furfural to furfuryl alcohol.

Legionella pneumophila is a pathogenic bacterium that exists in naturally occurring and man-made water sources. Contaminations with these bacteria in cooling towers have led to fatal disease outbreaks. An RNA-cleaving fluorogenic DNAzyme was isolated and found to selectively recognize Legionella pneumophila bacteria in cooling tower water. RNA-cleaving DNAzymes are synthetic DNA enzymes that can be easily incorporated into biosensor designs.

The incorporation of TTF radical trimers and RE₆ cluster SBUs result in a stable 2D radical MOF that is stable under harsh conditions including aqueous acid/base solutions. Exhibiting the characteristics of light absorption and excellent stability, the radical Dy-MOF shows excellent photothermal conversion with an increase in temperature of 34.7 °C upon irradiation by one unit of sunlight within 240 s.

A reactivity study on the hydrogen atom transfer (HAT) reaction between C−H substrates and an Fe-nitrido porphyrin species was achieved by employing nanosecond laser flash photolysis and by using a bis-pocket porphyrin ligand. Thermodynamic and kinetic parameters obtained in this study are fundamentally important for designing C−H amination and N₂ fixation reactions involving Fe-nitrido intermediates.

For the R⁺-B-R (R is the redox center and B is the bridging ligand) mixed-valence system with a low-lying energy bridge, the energy difference (ΔG⁰) between the bridge state (R-B⁺-R) and mixed-valence states (R⁺-B-R or R-B-R⁺) could be effectively tuned and even become zero by the fine modification of donor substitution.

Ultrathin porous carbon nitride bundles were designed based on the pyrolysis of asymmetric supramolecular precursor from L-arginine and melamine. It has a high specific surface area and adjustable band gap. Through the coupling of water-splitting and phenylcarbinol oxidation, the efficiency of hydrogen evolution was promoted and phenylcarbinol oxidation was activated.

London dispersion (LD) interactions facilitate the enantioselectivity in the Corey–Bakshi–Shibata (CBS) reduction. Employing a combination of computational and experimental studies, we provide a modern view on the origin of enantioselectivity in this powerful organocatalyzed reaction. The results demonstrate that attractive LD interactions between the catalyst and the substrate rather than steric repulsion determine the selectivity.

Phenylpyridyl-fused boroles [TipPBB1]₄ and TipPBB2 were synthesized and their properties investigated. [TipPBB1]₄ forms a tetramer in both the solid state and solution. TipPBB2 contains a 4-coordinate boron atom in the solid state but dissociates to give a 3-coordinate boron species in solution. TipPBB2 shows interesting temperature-dependent dual fluorescence in solution because of the equilibrium between 3- and 4-coordinate boron species due to weak N⋅⋅⋅B intermolecular coordination.

The effects of sulfur-coordinated organoiridium(III) complexes were explored with respect to Wnt/β-catenin signaling, apoptosis, migration, invasion and “stemness” in breast cancer cells for the first time. pbtIrSS exerted appreciable anti-tumor and anti-metastatic activities in breast cancer cells by inhibiting Wnt/ β-catenin signaling and cancer stem cells.

A series of Al₃₂-oxo clusters with hydrotalcite-like cores and π-conjugated shells were isolated, which are unique models of two-dimensional or layered materials and may be used to study boundary activity and optical limiting properties.

The formation and dissolution of the solid electrolyte interphase (SEI) in sodium-based systems is studied using a new cell setup. As a separator, β-alumina is employed as a sodium-conductive membrane to avoid crosstalk between the working electrode and sodium-metal counter electrode. The SEI dissolution in different time domains is tested and mitigated with new additive strategies. A correlation between SEI dissolution and SEI chemistry is presented.

A series of stable dioxin-linked metallophthalocyanine covalent organic frameworks (COFs) were developed and applied for photo-coupled electrocatalytic CO₂ reduction. This work represents a new insight for the future rational design of light sensitive crystalline materials for CO₂ reduction.

Energy carried by hot electrons can be liberated and used to enhance the electron-donating effect towards oxygen and reduce the potential energy surface of molecular oxygen activation (MOA). The activation energy of MOA decreased by 45.1 % and exhibited a substantial light dependence.

The facet effect of copper crystals to promote CO adsorption and C−C coupling and consequently yield a superior selectivity (87 % Faradaic efficiency) for C₂₊ products is described. Record-high solar conversion efficiencies of 4.47 % and 6.4 % are achieved for C₂H₄ and C₂₊ products, respectively.

Double fence porphyrin dyes bJS1–bJS3 were designed and synthesized for high-efficiency dye-sensitized solar cells (DSSCs). Compared to typical single fence porphyrin dyes, double fence porphyrins show reduced dye aggregation and charge recombination, which has been evidenced with photovoltaic data and an improved solar cell device performance.

Supra-nanoparticle clusters (SNPCs) were synthesized by convergence of metal–organic polyhedron scaffolds with precise giant building blocks. The mechanical properties and structural dynamics can be regulated by fine-tuning the surface functionalization of the terminal POSS moieties. Unexpected elasticity with high Young's modulus of the OPOSS-ended SNPCs was found to be highly correlated with the interpenetration of the neighboring GLs.

A mild copper-mediated protocol has been developed that allows for dichotomic borylation of alkynyl-substituted carbonates, affording either 1,2-diborylated 1,3-dienes or α-hydroxy allenes as the principal products, depending on the nature of the diboron(4) reagent. A mechanistic rationale is presented that reveals the crucial role of the relative kinetics of the second borylation step versus i-PrOH-assisted protodemetalation.

Amine-rich biomolecules as consumed coreactants drive electrochemiluminescence with Ru(bpy)₃²⁺, enabling bio-coreactant-enhanced single-cell electrochemiluminescence microscopy. This allows the imaging of intracellular hierarchical structures without the use of multiple labels. Dynamic signals disclose the universal edge effect of cellular electroporation and enable the visualization of heterogeneous molecular transport.

Catalytic and magnetic Janus micromotors based on 2D graphene are combined here with the lanbiotic Nisin for highly efficient capture/killing of Staphylococcus Aureus bacteria and biofilms. The strategy opens new avenues to nanoengineer micromotors with antimicrobial peptides for effective treatment of antibiotic-resistant bacteria.

Copolymere aus Acrylsäure (AA) und Butylacrylat (BA) mit gleichmäßiger Zusammensetzung (1:1 AA:BA) und kontrollierten Zusammensetzungsprofilen zeigen, im Gegensatz zu den kinetisch gehemmten Mizellen, die durch Poly(AA-block-BA)-Blockcopolymere gebildet werden, ein dynamisches, pH-responsives Selbstassemblierungsverhalten mit reversiblen Änderungen bezüglich der Größe und Bildung von Kugel-, Wurm- und Vesikelmorphologien.

Die Selbstassemblierung und Rekonfigurierbarkeit von DNA-Origami-Nanostrukturen wird genutzt, um selbstreparierende funktionelle Nanogeräte zu realisieren. Eine selbstregenerierende Helligkeitsmarkierung wird durch den ständigen Austausch von Markiersträngen aus der Lösung realisiert. Die Selbstheilung eines DNA-Origami-Nanolineals wird durch einen Überschuss an Staple-Strängen erreicht, die beschädigte Stränge austauschen.

Höhergeordnete G-Quadruplexstrukturen wie Dimere und Sandwichkomplexe mit G-Quadruplexbindern werden mit gepulster dipolarer EPR-Spektroskopie untersucht. Eingebaute Cu(Pyridin)₄-Komplexe ermöglichen die Messung präziser intermolekularer Cu²⁺-Cu²⁺-Abstände und decken neue Bindungsmodi auf. Die hohe Rigidität des Spinmarkers resultiert in beispiellos schmalen Peaks in den Abstandsverteilungen.