Synthetic DNA acts as a tie that connects nucleic acid chemistry and synthetic biology, and the novel allylic phosphate linked dinucleotide phosphoramidite provide a promising dinucleotide agent that will enable the applications of oligonucleotide synthesis, gene assembly and protein expression. More details are discussed in the article by Shi et al. on pages 1945—1952.

An innovative base-promoted efficient coupling strategy has been developed: leveraging weak C/N/O nucleophiles in synergy with the Cu-catalyst. This one-pot approach enables the highly selective synthesis of significant unsaturated chemicals via vinylation, allylation, and propargylation reactions of commodity dihalides with high efficiency. More details are discussed in the article by Zhang et al. on pages 2005—2014.

Natural coumarin skeleton-based benzopyronyl thiazolylbenzonitriles as new antibacterial scaffolds were developed through multi-step reactions. Medicinal chemobiological evaluations revealed that BTBs with multitargeting supramolecular antibacterial potential showed large promise to combat Staphylococcus aureus 29213 infection.

Structural and electrical analyses reveal that self-assembled monolayers with longer and more ordered hydrogen bond network exhibit enhanced proton conduction, as evidenced by a stronger dependence of current density on relative humidity.

We first developed heterogeneous polystyrene-supported bisoxazolines ligands through the alkylation in the indene moiety, which ensured essential steric environment for copper coordination and achieved high catalytic efficacy in two representative asymmetric cyanation reactions.

A blood-brain barrier-penetrable PET tracer was developed for imaging of H₂O₂ in the neurodegenerative model.

A block-wise solid-phase oligonucleotide synthesis methodology based on novel allylic phosphate linker dimer phosphoramidite has been developed. these dimer block-wise synthesized oligonucleotides were of sufficient quality for gene assembly and protein expression required in synthetic biology.

Solvent-mediated stimuli responsive emission behavior of phosphine-copper iodide hybrid complexes 1 and 2 by excitation and thermal stimulation. The reversible crystal transformation between complexes 1 and 2 was achieved. By leveraging the high emission efficiency and controlled stimulus-responsive dual-emission behaviors, we realized high-security-level anti-counterfeiting and information encryption applications.

In this work, we construct a highly efficient triphase interface photocatalytic system based on a three-dimensional ordered TiO₂ porous (OTP) film. We tuned the triphase interfacial microenvironment by adjusting the thickness of the OTP films to demonstrate the synergistic effect of dye adsorption and interfacial O₂ concentration in the triphase system.

A solid-liquid-gas three-phase indirect electrolysis system based on a kind of microwave-synthesized polyoxometalate-based metal-organic framework (MW-POMOF) has been developed that enables kilo-scale conversion of S–S bond substrates into valuable C–S bond products.

An efficient dual photoredox/copper-catalyzed diphosphorothiolation of alkenes with P(O)SH compounds under oxidative conditions was developed, and a diversity of novel vicinal bisphosphorothioates were conveniently synthesized in good yields under mild conditions.

N-Heterocyclic carbene (NHC)-catalyzed [10π+2π] cycloaddition between indene-2-carbaldehyde and isatins delivers spirooxindole-γ-butyrolactones with moderate yields (up to 68%) and excellent enantioselectivity (up to 93% ee). This transformation proceeds via NHC-bound isobenzofulvene intermediates and represents the first successful application of all-carbon higherene in NHC-catalyzed [10π+2π] cycloadditions.

A dual catalytic manifold that combines photoredox catalysis and phthalate-catalyzed hydrogen-atom abstraction process has been developed to realized diverse fragmentation-functionalization reactions. Key to success is photocatalytic generation of TDRAs as PCET mediators, enabling polarity-matching-based formation of heteroatom-centered radicals that allows for further controlled exploration of chemical space via C–C β-scission.

A visible-light photoredox-catalyzed multicomponent reaction of diazosulfonium triflates with amines and CS₂ or CO₂ has been developed. This reaction provides a new and efficient approach to synthesizing S-alkyl di-dithiocarbamates and O-alkyl di-carbamates in a single step.

The present study describes a pragmatic and innovative strategy for the sequential allylation of dihalides in large-scale chemical manufacturing, employing a diverse array of C/N/O nucleophilic reagents with attenuated reactivity.

A novel cyano-hydroxylation of readily accessible alkenes is established by merging 1,3-dipolar cycloaddition with photoredox promoted halogen atom transfer-induced radical ring-opening elaboration. This method enables the efficient preparation of a diverse array of synthetically valuable and biologically active β-hydroxy nitrile scaffolds in a one-pot two-step synthesis.

12-Hydroxystearic acid (CA) and its derivatives with different alkyl chain (CA3, CA4, CA6 and CA8) were synthesized as low-molecular-weight gelators (LMMGs), and D-1 with CA attached on DPA unit was synthesized as annihilator. By self-assembling D-1 with the LMMGs to achieve an ordered arrangement of D-1, efficient UC emissions both in organo- and dried-gels were achieved.

A catalytic enantioselective non-cyclic α-functionalization of 1,3-fused cyclic azomethine ylides has been developed by taking advantage of the remote-controlled asymmetric desymmetrization, affording a series of enantioenriched 3,4-dihydroisoquinoline derivatives bearing multiple stereogenic elements/centers.

Microfluidic technology is an emerging arena that manipulates tiny fluids through the use of microchannels, which typically range in dimensions from tens to hundreds of micrometers. This review covers the mechanisms of droplet formation, innovative applications in synthesis of nanomaterials, small molecules, and polymers as well as potential integration with advanced techniques.

Dynamic covalent bonds and noncovalent bonds based self-assembled biomaterials have been thoroughly summarized. We also explored self-assembled biomaterials across two main sections, covering their molecular design, methods of conjugation, responsive and functional attributes, and prospective biomedical applications.

The rapid development of synthetic biology in recent years has led to breakthroughs in numerous fields, mainly based on DNA sequencing, synthesis, and editing. DNA assembly technology is relatively mature, and the future development direction is focused on reduced costs, increasing automation, and multiplatform integration. In this article, we systematically summarize the research progress on DNA synthesis and assembly technologies.

An NHC-catalyzed asymmetric [10π+2π] cycloaddition employs indene-2-carbaldehyde as an all-carbon 10π precursor to forge chiral spirooxindole-γ-butyrolactones (up to 93% ee). This method bypasses nitrogen-based higherene substrates, operates via NHC-bound isobenzofulvene intermediates, and scales to 4 mmol with retained efficiency, offering a versatile route to complex spirocycles. More details are discussed in the article by Deng et al. on pages 1983—1987.

The cover design centers on molecular dynamic transformation as its core visual element, utilizing dual-color conversion pathways to illustrate the dual functionality of P(O)SH (serving as both phosphorothioate radical source and coupling group). It visually highlights the synthetic advantage of "simple raw materials → high-value products" and the innovative breakthrough of the photoredox/copper dual-catalytic system in achieving efficient 1,2-diphosphorothiolation of alkenes under oxidative conditions. More details are discussed in the article by Zhang et al. on pages 1977—1982.