A Three-Phase Indirect Electrolysis System for Kilo-scale Generation of C–S Bond Products
Gang Liu
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorCorresponding Author
Xianqiang Huang
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorYingjie Li
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorShiqi Fu
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorGuodong Shen
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorZhen Li
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorYalin Zhang
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorQingde Zhang
State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan, Shanxi, 030001 China
Search for more papers by this authorCorresponding Author
Fei Yu
Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Jiangsu Key Laboratory of New Power Batteries, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yifa Chen
Guangdong Provincial Key Laboratory of Carbon Dioxide Resource Utilization, School of Chemistry, South China Normal University, Guangzhou, Guangdong, 510006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorGang Liu
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorCorresponding Author
Xianqiang Huang
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorYingjie Li
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorShiqi Fu
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorGuodong Shen
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorZhen Li
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorYalin Zhang
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry & Chemical Engineering, Liaocheng University, Liaocheng, Shandong, 252059 China
Search for more papers by this authorQingde Zhang
State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan, Shanxi, 030001 China
Search for more papers by this authorCorresponding Author
Fei Yu
Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Jiangsu Key Laboratory of New Power Batteries, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yifa Chen
Guangdong Provincial Key Laboratory of Carbon Dioxide Resource Utilization, School of Chemistry, South China Normal University, Guangzhou, Guangdong, 510006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
The development of new strategy for environmentally friendly, cost-effective and large-scale electro-synthesis of anticancer drugs is highly desirable to replace high-cost traditional methods and realize high atomic economy. GW 610, an antitumor agent with potent and selective anticancer activity against lung, colon, and breast cancer cell lines in real medical treatment processes, has a market price of ~107 USD/kg and calls for novel methods like electro-synthesis to reduce the cost. Here, for the first time, we design a solid-liquid-gas three-phase indirect electrolysis system based on a kind of microwave-synthesized polyoxometalate-based metal-organic framework (MW-POMOF) that can converse S–S bond substrates into valuable C–S bond products like anticancer drug molecules (e.g., GW 610). Specifically, the solid-phase MW-POMOF as heterogeneous redox mediator exhibits the excellent electrocatalytic efficiency for the formation of liquid-phase C–S bond products (yields up to 95%) coupling with the generation of gas-phase H2 product (~402 μmol·g–1·h–1), resulting in an interesting three-phase indirect electrolysis system. Remarkably, it enables the kilo-scale production (~1 kg in a batch experiment) of GW 610 at one thousandth of the market price (from ~107 to ~3200 USD/kg). This work may inaugurate a new electrocatalytic avenue to explore porous crystalline materials in electrocatalysis field.
Supporting Information
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Appendix S1: Supporting Information |
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