A Self-immobilizing PET Tracer for Imaging of H2O2 Level in the Brain
Ke Li
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
Search for more papers by this authorShiliang Zhu
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
Search for more papers by this authorYing Peng
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
Search for more papers by this authorCorresponding Author
Ling Qiu
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jianguo Lin
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
E-mail: [email protected]; [email protected]Search for more papers by this authorKe Li
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
Search for more papers by this authorShiliang Zhu
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
Search for more papers by this authorYing Peng
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
Search for more papers by this authorCorresponding Author
Ling Qiu
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jianguo Lin
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
Reactive oxygen species (ROS) are involved in the onset and development of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Hydrogen peroxide (H2O2), a key type of ROS, is overexpressed in the early stages of AD and PD and is involved in the disease progression. Assessing H2O2 levels in the brain is considered to be a valuable tool for detecting neurodegenerative diseases and exploring their pathogenesis. In this study, we developed two self-immobilizing PET tracers ([18F]HYAS and [18F]HYAT) based on a quinone methide (QM) scaffold for non-invasive imaging of H2O2 in the brain. Both tracers can respond to H2O2 by forming a QM intermediate, which rapidly reacts with nucleophiles. [18F]HYAT, with proper physicochemical properties, is able of crossing the blood-brain barrier. Increased uptake of [18F]HYAT was observed in the brains of mice treated with 1-methyl-4-phenyl- l,2,3,6-tetrahydropyridine (MPTP), indicating that [18F]HYAT is a useful tracer for PET imaging of H2O2 in the brain.
Supporting Information
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