• Issue

    American Journal of Hematology: Volume 98, Issue 8

    1165-1345, E190-E225
    August 2023
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ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 1165-1167
  • First Published: 11 July 2023

EDITORIALS

Free Access

Minimal residual disease in Philadelphia-positive acute lymphoblastic leukemia: Maximizing the clinical yield of testing

Antoine N. Saliba,  Robin Foà, 
  • Pages: 1168-1170
  • First Published: 14 June 2023
Free Access

Luspatercept use for lower risk myelodysplastic syndromes: Active but not enough

Mrinal M. Patnaik,  Ayalew Tefferi, 
  • Pages: 1171-1175
  • First Published: 22 June 2023

RESEARCH ARTICLES

Open Access

Clinical characteristics and overall survival among acute myeloid leukemia patients with TP53 gene mutation or chromosome 17p deletion

Naval G. Daver,  Shahed Iqbal,  Julie Huang,  Camille Renard,  Joyce Lin,  Yang Pan,  Mellissa Williamson,  Giridharan Ramsingh, 
  • Pages: 1176-1184
  • First Published: 04 May 2023
Free Access

Rivaroxaban versus nadroparin for thromboprophylaxis following thoracic surgery for lung cancer: A randomized, noninferiority trial

Mengmeng Zhao,  Yi Bao,  Chao Jiang,  Linsong Chen,  Lisha Xu,  Xiaogang Liu,  Jiaqi Li,  Yang Yang,  Gening Jiang,  Jian Li,  Yunlang She,  Qiankun Chen,  Lei Shen,  Chang Chen, 
  • Pages: 1185-1195
  • First Published: 04 May 2023
Free Access

Ultrasensitive NGS MRD assessment in Ph+ ALL: Prognostic impact and correlation with RT-PCR for BCR::ABL1

Nicholas J. Short,  Elias Jabbour,  Walid Macaron,  Farhad Ravandi,  Nitin Jain,  Rashmi Kanagal-Shamanna,  Keyur P. Patel,  Sanam Loghavi,  Fadi G. Haddad,  Musa Yilmaz,  Ghayas C. Issa,  Partow Kebriaei,  Steven M. Kornblau,  Sarah Pelletier,  Wilmer Flores,  Jairo Matthews,  Rebecca Garris,  Hagop Kantarjian, 
  • Pages: 1196-1203
  • First Published: 15 May 2023
Ultrasensitive NGS MRD assessment in Ph+ ALL: Prognostic impact and correlation with RT-PCR for BCR::ABL1

Highly sensitvie NGS-based assessment of MRD is prognostic in Ph+ ALL and identifies patients with low-level detectable BCR::ABL1 who are unlikely to relapse nor to benefit from therapeutic interventions.

Free Access

Kinetics of cellular and humoral immunogenicity and effectiveness of SARS-CoV-2 booster vaccination in hematologic neoplasms

Moraima Jiménez,  Candela Fernández-Naval,  Víctor Navarro,  Sandra Novoa,  Mónica Martinez-Gallo,  Daniel Medina,  Cristina Andrés,  Andrés Antón,  Soraya Peralta,  Gemma Pujadas,  Cristina Hernández,  Carlota Pagès,  Elisa Roldán,  Tomás Pumarola,  Mercedes Gironella,  Isabel Ruiz-Camps,  Xavier Martínez-Gómez,  David Valcárcel,  Manuel Hernández,  Francesc Bosch,  Marta Crespo,  Juliana Esperalba,  Pau Abrisqueta, 
  • Pages: 1204-1213
  • First Published: 08 May 2023
Kinetics of cellular and humoral immunogenicity and effectiveness of SARS-CoV-2 booster vaccination in hematologic neoplasms

Free Access

Venous thromboembolism risk in cancer patients receiving first-line immune checkpoint inhibitor versus chemotherapy

Ang Li,  Sarah B. May,  Jennifer La,  Kylee L. Martens,  Christopher I. Amos,  Christopher R. Flowers,  Nhan V. Do,  Mary T. Brophy,  Vipul Chitalia,  Katya Ravid,  John Michael Gaziano,  Nathanael R. Fillmore, 
  • Pages: 1214-1222
  • First Published: 10 May 2023
Venous thromboembolism risk in cancer patients receiving first-line immune checkpoint inhibitor versus chemotherapy

In this propensity score weighted analysis, we found that comparable cancer patients receiving first-line immune checkpoint inhibitor (ICI) and those receiving cytotoxic chemotherapy (chemo) have similar risk of incident VTE in all patients (A) and specifically lung cancer patients (B).

Open Access

FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes

Mariateresa Pettinato,  Alessandro Dulja,  Silvia Colucci,  Valeria Furiosi,  Franca Fette,  Andrea U. Steinbicker,  Martina U. Muckenthaler,  Antonella Nai,  Alessia Pagani,  Laura Silvestri, 
  • Pages: 1223-1235
  • First Published: 18 May 2023
Open Access

Impact of type 2 diabetes on mortality, cause of death, and treatment in chronic lymphocytic leukemia

Emelie Curovic Rotbain,  Cristine Allmer,  Klaus Rostgaard,  Michael Asger Andersen,  Noomi Vainer,  Caspar da Cunha-Bang,  Sameer A. Parikh,  Kari G. Rabe,  Henrik Hjalgrim,  Henrik Frederiksen,  Susan L. Slager,  Carsten Utoft Niemann, 
  • Pages: 1236-1245
  • First Published: 22 May 2023
Impact of type 2 diabetes on mortality, cause of death, and treatment in chronic lymphocytic leukemia

This real-world study includes data from two of the world's largest cohorts in chronic lymphocytic leukemia (CLL): the Danish National population-based CLL cohort and the Mayo Clinic CLL cohort. The findings demonstrate that type 2 diabetes (T2D) is associated with a shorter overall survival both from time of CLL diagnosis and from first-line treatment for CLL, while patients with T2D are less likely than patients without T2D to receive treatment for CLL. The increased mortality is attributed to causes of death both related and unrelated to CLL but largely driven by deaths due to infections. The findings emphasize unmet needs and an inferior prognosis in a substantial subgroup of CLL patients, projected to increase considerably in the coming years, requiring additional interventions including awareness of possible under-treatment.

Open Access

Sustained inhibition of complement C1s with sutimlimab over 2 years in patients with cold agglutinin disease

Alexander Röth,  Wilma Barcellini,  Shirley D'Sa,  Yoshitaka Miyakawa,  Catherine M. Broome,  Marc Michel,  David J. Kuter,  Bernd Jilma,  Tor Henrik Anderson Tvedt,  Ilene C. Weitz,  Ronnie Yoo,  Deepthi Jayawardene,  Deepthi S. Vagge,  Katarina Kralova,  Frank Shafer,  Marek Wardȩcki,  Michelle Lee,  Sigbjørn Berentsen, 
  • Pages: 1246-1253
  • First Published: 29 May 2023
Sustained inhibition of complement C1s with sutimlimab over 2 years in patients with cold agglutinin disease

Continued inhibition of the classical complement pathway with sutimlimab results in meaningful long-term benefits on hemolysis, anemia, and quality of life with a favorable safety profile in patients with cold agglutinin disease.

Free Access

Real-world effectiveness of intensive chemotherapy with 7&3 versus venetoclax and hypomethylating agent in acute myeloid leukemia

Andrew H. Matthews,  Alexander E. Perl,  Selina M. Luger,  Saar I. Gill,  Catherine Lai,  David L. Porter,  Sarah Skuli,  Ximena Jordan Bruno,  Martin P. Carroll,  Craig W. Freyer,  Alison Carulli,  Daria V. Babushok,  Noelle V. Frey,  Elizabeth O. Hexner,  Mary Ellen Martin,  Shannon R. McCurdy,  Edward A. Stadtmauer,  Alison W. Loren,  Vikram R. Paralkar,  Ivan P. Maillard,  Keith W. Pratz, 
  • Pages: 1254-1264
  • First Published: 19 June 2023
Real-world effectiveness of intensive chemotherapy with 7&3 versus venetoclax and hypomethylating agent in acute myeloid leukemia

Open Access

Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis

Jihyun Song,  Krishna M. Sundar,  Monika Horvathova,  Radhika Gangaraju,  Karel Indrak,  Robert D. Christensen,  Samuel Genzor,  Carsten Lundby,  Vladimir Divoky,  Tomas Ganz,  Josef T. Prchal, 
  • Pages: 1265-1276
  • First Published: 23 June 2023
Free Access

A phase 1/2 of carfilzomib and melphalan conditioning for autologous stem cell transplantation for multiple myeloma (CARAMEL)

Alissa Visram,  Suzanne R. Hayman,  Angela Dispenzieri,  Prashant Kapoor,  Martha Q. Lacy,  Morie A. Gertz,  Francis K. Buadi,  David Dingli,  Rahma Warsame,  Taxiarchis Kourelis,  Joselle Cook,  Moritz Binder,  Wilson Gonsalves,  Eli Muchtar,  Nelson Leung,  Vivek Roy,  S. Vincent Rajkumar,  Shaji Kumar, 
  • Pages: 1277-1285
  • First Published: 19 June 2023

CRITICAL REVIEW

Free Access

The international consensus classification of eosinophilic disorders and systemic mastocytosis

Sa A. Wang,  Attilio Orazi,  Jason Gotlib,  Andreas Reiter,  Alexandar Tzankov,  Robert P. Hasserjian,  Daniel A. Arber,  Ayalew Tefferi, 
  • Pages: 1286-1306
  • First Published: 07 June 2023

ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES

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Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management

Guillermo Garcia-Manero, 
  • Pages: 1307-1325
  • First Published: 08 June 2023
Free Access

Cutaneous B-cell lymphomas: 2023 update on diagnosis, risk-stratification, and management

Alexandra C. Hristov,  Trilokraj Tejasvi,  Ryan A. Wilcox, 
  • Pages: 1326-1332
  • First Published: 22 May 2023

CLINICAL PEARLS IN BLOOD DISEASES

MORPHOLOGY UPDATE

Free Access

Atypical lymphocytes—From chickenpox to monkey pox

Georg Nesr,  Elizabeth Whittaker,  Barbara J. Bain, 
  • Pages: 1333-1334
  • First Published: 16 February 2023

CLINICAL PROBLEM SOLVING

Free Access

Hemolytic anemia and macrothrombocytopenia: A lipid problem?

Mary Risinger,  Phyllis S. Kim,  Roberto X. Rodriguez,  Monica Narvaez Rivas,  Kenneth D. R. Setchell,  Wenying Zhang,  Theodosia A. Kalfa, 
  • Pages: 1335-1340
  • First Published: 28 March 2023

IMAGES IN HEMATOLOGY

Free Access

Acute hemolytic anemia after hematopoietic stem cell transplantation: An unusual invader

Mohammad Alhomoud,  Rosemary Soave,  Michael J. Kluk,  Tsiporah Shore, 
  • Pages: 1341-1342
  • First Published: 06 February 2023
Acute hemolytic anemia after hematopoietic stem cell transplantation: An unusual invader

69-year-old man with a history of diffuse large B-cell lymphoma (DLBCL) presented with severe acute hemolytic anemia 27 months after an autologous hematopoietic stem cell transplantation. Bone marrow aspirate revealed intracellular micro-organisms (arrows) located within the cytoplasm of red blood cells confirming the diagnosis of severe babesiosis.

Open Access

Chronic myelomonocytic leukemia transdifferentiation landscape: From histiocytosis to blastic plasmacytoid dendritic cell neoplasm

Gabriel Antherieu,  Marie Donzel,  Brigitte Balme,  Alexandra Traverse-Glehen,  Maël Heiblig, 
  • Pages: 1343-1345
  • First Published: 13 February 2023

CORRESPONDENCE

Free Access

An analysis of veterans diagnosed with large granular lymphocytic disorders at the national Veteran Affairs Healthcare System

Helen Ma,  Thomas P. Loughran Jr.,  Pankaj Gupta, 
  • Pages: E190-E192
  • First Published: 04 May 2023
Free Access

DDX41 mutations in patients with non-myeloid hematologic neoplasms

Fatima Zahra Jelloul,  Mark. J. Routbort,  Courtney D. DiNardo,  Carlos E. Bueso-Ramos,  Rashmi Kanagal-Shamanna,  Beenu Thakral,  Zhuang Zuo,  C. Cameron Yin,  Sanam Loghavi,  Chi Young Ok,  Sa A. Wang,  Zhenya Tang,  M. James You,  Keyur P. Patel,  L. Jeffrey Medeiros,  Andrés E. Quesada, 
  • Pages: E193-E196
  • First Published: 08 May 2023
Free Access

Socioeconomic marginalization and health outcomes in newly diagnosed multiple myeloma: A population-based cohort study

Alissa Visram,  Hsien Seow,  Mark A. Fiala,  Anastasia Gayowsky,  Matthew Cheung,  Gwynivere Davies,  Gregory R. Pond,  Hira Mian, 
  • Pages: E197-E199
  • First Published: 16 May 2023
Free Access

Allogeneic stem cell transplantation for children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia in the tyrosine kinase inhibitor era

Hisashi Ishida,  Hiroyuki Shimada,  Akihiko Tanizawa,  Yutaka Shimazu,  Takayoshi Tachibana,  Noriko Doki,  Takahide Ara,  Yayoi Matsuo,  Miho Nara,  Tomomi Toubai,  Kazuko Ino,  Hirohisa Nakamae,  Keisuke Kato,  Koji Kato,  Atsushi Sato,  Moeko Hino,  Kimikazu Matsumoto,  Yoshiko Atsuta,  Masahiro Yasui,  Tokiko Nagamura-Inoue, 
  • Pages: E200-E203
  • First Published: 12 May 2023
Allogeneic stem cell transplantation for children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia in the tyrosine kinase inhibitor era

The analysis of 165 children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia showed disease status at hematopoietic stem cell transplantation was a strong prognostic factor and clearly separated the patient outcomes.

Open Access

Real-world efficacy and safety of luspatercept and predictive factors of response in patients with lower risk myelodysplastic syndromes with ring sideroblasts

Luca Lanino,  Francesco Restuccia,  Alessandra Perego,  Marta Ubezio,  Bruno Fattizzo,  Marta Riva,  Angela Consagra,  Pellegrino Musto,  Daniela Cilloni,  Esther Natalie Oliva,  Raffaele Palmieri,  Antonella Poloni,  Catello Califano,  Isabella Capodanno,  Federico Itri,  Chiara Elena,  Claudio Fozza,  Fabrizio Pane,  Anna Maria Pelizzari,  Massimo Breccia,  Francesco Di Bassiano,  Elena Crisà,  Dario Ferrero,  Valentina Giai,  Daniela Barraco,  Antonella Vaccarino,  Davide Griguolo,  Paola Minetto,  Martina Quintini,  Stefania Paolini,  Grazia Sanpaolo,  Mariarosaria Sessa,  Monica Bocchia,  Nicola Di Renzo,  Elisa Diral,  Livia Leuzzi,  Angelo Genua,  Attilio Guarini,  Alfredo Molteni,  Barbara Nicolino,  Ubaldo Occhini,  Giulia Rivoli,  Roberto Bono,  Anna Calvisi,  Andrea Castelli,  Eros Di Bona,  Ambra Di Veroli,  Felicetto Ferrara,  Luana Fianchi,  Sara Galimberti,  Daniele Grimaldi,  Monia Marchetti,  Marianna Norata,  Marco Frigeni,  Rosaria Sancetta,  Carmine Selleri,  Ilaria Tanasi,  Patrizia Tosi,  Mauro Turrini,  Laura Giordano,  Carlo Finelli,  Paolo Pasini,  Ilaria Naldi,  Valeria Santini,  Matteo Giovanni Della Porta, on behalf of Fondazione Italiana Sindromi Mielodisplastiche (FISiM) Clinical network (https://www.fisimematologia.it/) , 
  • Pages: E204-E208
  • First Published: 24 May 2023
Free Access

ICC-2022 versus WHO-2022 classification systems for acute leukemias and myeloid neoplasms: The perspective from two classical morphologists

Gina Zini,  John M. Bennett, 
  • Pages: E209-E211
  • First Published: 22 May 2023
Free Access

Lung function after matched-related donor allogeneic hematopoietic stem cell transplantation in children with sickle cell disease

Marion Gros,  Corinne Pondarre,  Cécile Arnaud,  Annie Kamdem,  Françoise Bernaudin,  Bernard Maitre,  Ralph Epaud,  Céline Delestrain, 
  • Pages: E212-E215
  • First Published: 22 May 2023
Free Access

Transdifferentiation of B-lymphoblastic leukemia to histiocytic sarcoma after immunotherapy

Elena M. Fenu,  Elizabeth Margolskee,  Vinodh Pillai, 
  • Pages: E216-E218
  • First Published: 01 June 2023
Free Access

Cardiac effects 2 years after successful non-myeloablative human leukocyte antigen-matched related donor hematopoietic cell transplants in sickle cell disease

Vandana Sachdev,  Emily Limerick,  My-Le Nguyen,  Wen Li,  Neal Jeffries,  Shalini Ramachandra,  David Tofovic,  Damiano Rondelli,  Mohsen Al Zahrani,  Ahmed Aljizeeri,  Santosh Saraf,  Matthew Hsieh,  Courtney D. Fitzhugh, 
  • Pages: E219-E221
  • First Published: 07 June 2023
Open Access

CD19-negative relapse in adult patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia following treatment with blinatumomab-a post hoc analysis

Heinz-August Horst,  Gerhard Zugmaier,  Giovanni Martinelli,  Noemi Mergen,  Kelly Velasco,  Faraz Zaman,  Hagop Kantarjian, 
  • Pages: E222-E225
  • First Published: 22 June 2023