American Journal of Hematology

Morphology Updates

2024:

• Presentation of chronic myeloid leukemia in basophilic blast crisis
• Echinocytes in pyruvate kinase deficiency, post-splenectomy
• Where hematology meets rheumatology—VEXAS syndrome (November)
• Beware of methylene blue in possible G6PD deficiency (October)
• Accurate identification of a precursor B-cell neoplasm (September)
• From the eosinophil to a novel FGFR1 fusion gene (August)
• Neutrophilic leukemoid reaction or chronic neutrophilic leukemia—not always so simple (July)
• Wiskott–Aldrich syndrome (May)
• To be hematopoietic, or not to be: That is the neoplastic cell's question (April)
• Pseudo-Chédiak–Higashi anomaly in acute myeloid leukemia (March)
• Bone marrow granulomatous reaction to silicone from breast implants (February)
• Thrombopoietin mimetic-induced bone marrow fibrosis (January)

2023:

• Hematological features of scrub typhus (December)
• Megakaryocyte morphology with GATA2 germline mutation (November)
• Peripheral blood evidence of iron overload (October)
• Putting unstable hemoglobins on the map of London (September)
• Atypical lymphocytes—From chickenpox to monkey pox (August)
• The distinctive blood film features of severe burns (June)
• Diagnosis of histiocytic sarcoma by bone marrow aspiration (May)
• Hemophagocytic lymphohistiocytosis and hemozoin deposition in bone marrow macrophages in falciparum malaria (April)
• Pearson syndrome (March)
• G6PD deficiency in patients identified as female (February)
• Granular B lymphoblastic leukemia (January)

2022:

• An unexpected finding during microscopy for urinary hemosiderin (December)
• Peripheral CD5+ CD10+ B-cell proliferation with atypical morphology attributable to human herpesvirus 6 infection following umbilical cord blood transplantation (November)
• A new diagnosis of monoclonal B-cell lymphocytosis with cytoplasmic inclusions in a patient with COVID-19 (October)
• Breast implant-associated anaplastic large cell lymphoma (September)
• Pseudo-Pelger-Huët neutrophil morphology due to sodium valproate toxicity (August)
• Hyposplenism in adult T-cell leukemia/lymphoma (July)
• Voxelotor in sickle cell disease (June)
• Fresh water-induced hemolysis in near-drowning (May)
• Persistent neonatal jaundice resulting from hereditary pyropoikilocytosis (April)
• Eosinophil morphology in the reactive eosinophilia of Hodgkin lymphoma (March)
• Peripheral blood features of iron overload in post-splenectomy, type I congenital dyserythropoietic anemia (February)
• Atypical lymphocytosis due to CD8-positive T-cell expansion in unsuspected HIV infection (January)

2021:

• A normal mean cell volume does not exclude a diagnosis of megaloblastic anemia (December)
• Coexistence of multiple myeloma and a CSF3R-mutated myeloid neoplasm (November)
• Granular Mott cells in multiple myeloma (October)
• Unexpected Leishmania in a bone marrow aspirate (September)
• An aggressive NK-cell lymphoma with hemophagocytosis (August)
• Severe babesiosis due to Babesia divergens acquired in the United Kingdom (July)
• Covid-19 and acute kidney injury (June)
• Alpha chain inclusions in peripheral blood erythroblasts and erythrocytes (May)
• Erythrophagocytosis by monocytes: An unusual observation in autoimmune hemolytic anemia (April)
• Large granular lymphocytosis induced by dasatinib (March)
• Erdheim-Chester disease in bone marrow (February)
• Acute myeloid leukemia with a severe coagulopathy and t(8;16)(p11;p13) (January)

2020:

• Schistocytosis is not always microangiopathic hemolytic anemia (November)
• A myeloid neoplasm with FIP1L1-PDGFRA presenting as acute myeloid leukemia (October)
• Beta thalassemia major and Noonan syndrome — Two genetic disorders manifest in the blood film (September)
• Giant proerythroblasts in pure red cell aplasia due to parvovirus B19 infection in a patient with rheumatoid arthritis (August)
• Plasmacytoid lymphocytes in SARS‐CoV ‐2 infection (Covid‐19) (July)
• Stress erythropoiesis in hereditary spherocytosis (June)
• When things don't add up ‐ methotrexate unexpectedly revealed as the cause of pancytopenia (May)
• The hematological effects of copper deficiency (April)
• Hodgkin lymphoma in a bone marrow aspirate (March)
• Large granular lymphocytic leukemia as a cause of pancytopenia (February)
• Delta beta thalassemia (January)

2019:

• Reactive lymphocytes in an allergic drug reaction (December)

• It's a black day—metastatic melanoma in the bone marrow (November)

• Pleomorphic mantle cell lymphoma mimicking diffuse large B‐cell lymphoma in peripheral blood and bone marrow (October)

• Sézary syndrome: The cause of erythema revealed by the blood film (September)

• Sézary syndrome: The cause of erythema revealed by the blood film (September)

• Unexpected babesiosis with dramatic morphological features (August)

• Splenic rupture in cytomegalovirus infection (July)

• Pure erythroid leukemia: The value of E‐cadherin in making the diagnosis (June)

• A confusing “white cell count”: Circulating micromegakaryocytes in post‐thrombocythemia myelofibrosis (May)

• Infantile pyknocytosis (April)

• Striking dyserythropoiesis in sickle cell anemia following an aplastic crisis (March)

• Pertussis: An uncommon cause of microangiopathic hemolytic anemia in an infant (February)

• An unusual hemoglobinopathy: compound heterozygosity for hemoglobins C and E (January)

2018:

• Monocyte adhesion with platelet satellitism and phagocytosis in Hodgkin lymphoma (December)

• The distinctive cytology and disease evolution of blastic plasmacytoid dendritic cell neoplasm (November)

• Transformation of follicular lymphoma (October)

• Congenital sideroblastic anemia in a female (September)

• Diagnosis of follicular lymphoma from the peripheral blood (August)

• Unusual inclusions in hemoglobin H disease post‐splenectomy (July)

• Chronic neutrophilic leukemia (June)

• Methylene blue‐induced Heinz body hemolytic anemia in a premature neonate (May)

• Macrophage activation syndrome and post‐transplant microangiopathy following haploidentical bone marrow transplantation for sickle cell anemia (April)

• Lymphoplasmacytoid cytology in plasma cell leukemia (March)

• Marked leukemoid reaction in a patient with metastatic breast carcinoma (February)

• Acute leukemic transformation of myelodysplastic syndrome: Is cytochemistry still relevant? (January)

2017:

• Botryoid nuclei resulting from cocaine abuse (November)

• A puzzling case of methemoglobinemia (October)

• The significance of irregularly contracted cells and hemighosts in sickle cell disease (September)

• The distinctive cytological features of T-cell prolymphocytic leukemia (August)

• Plasmodium knowlesi (July)

• Can we have some platelets please? A reason not to put your microscope on eBay (June)

• Howell–Jolly bodies in acute hemolytic anemia (May)

• Early leukemic transformation of adult T-cell leukemia/lymphoma presenting as meningeal lymphoma (April)

• Circulating lymphoma cells in intravascular large B-cell lymphoma (March)

• Striking dyserythropoiesis in a myelodysplastic syndrome (February)

• Cold autoimmune hemolytic anemia secondary to atypical pneumonia (Janurary)

2016:

• Neuroblastoma in the bone marrow (December)

• Transplant-associated thrombotic microangiopathy (November)

• Erythroblast morphology in refractory anemia with ring sideroblasts and thrombocytosis (October)

• Unusual cytological features in multiple myeloma (September)

• Basophilic differentiation in transient abnormal myelopoiesis (August)

• Hemoglobin St Mary's (July)

• Phytosterolemia (June)

• Gray platelets- artificial or real? (May)

• The fortuitous diagnosis of Burkitt lymphoma in a patient with chronic myelomonocytic leukemia (April)

• The distinctive micromegakaryocytes of transformed chronic myeloid leukemia (March)

• Dehydrated hereditary stomatocytosis (February)

• Emperipolesis in a patient receiving a romiplostim (Janurary)

2015:

• Mechanial hemolysis: A low mean cell volume does not always represent microcytosis (December)

• Neutrophilic leukemoid reaction in multiple myeloma (November)

• Congenital acute megakaryoblastic leukemia (October)

• Compound heterozygosity for hemoglobins S and DCompound heterozygosity for hemoglobins S and D (September)

• ALK-positive anaplastic large cell lymphoma presenting with hemophagocytic lymphohistiocytosis (August)

• The complex morphology of acute kidney injury with microangiopathic hemolytic anemia and hyposplenism (July)
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• The cytological features of NPM1-mutated acute myeloid leukemia (June)

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• Neutrophil vacuolation in acetaminophen-induced acute liver failure (page 461) (May)

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• Systemic EBV‐positive lymphoproliferative disease of childhood (April)

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• Dengue fever in returning travellers (March)

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• Hemogolbin C disease (February)

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• Interpreting a post-partum Kleihauer test (January)

2014:

• Lead poisoning (December)

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• Acute myeloid leukemia with myelodysplasia-related changes showing basophilic differentiation (November)

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• Peripheral blood features of acute myeloid leukemia with myelodysplasia-related changes developing in a patient with sickle cell anemia (October)

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• A blood film that could have averted a splenectomy (September)

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• Prominent Howell-Jolly bodies when megaloblastic anemia develops in a hyposplenic patient (August)

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• Salmonella colonies in a bone marrow film (July)

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• Thiamine-responsive megaloblastic anemia in an Iraqi girl (June)

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• Teardrop poikilocytes in metastatic carcinoma of the breast (May)

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• Azurophilic granules in myeloma cells (April)

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• Auer-rod like inclusions in multiple myeloma (March)

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• Persistent polyclonal B lymphocytosis (February)

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• Systematic mastocytosis - the importance of looking within bone marrow fragments: AJH Educational Material (January)

2013:

• Diagnosis of pyrimidine 5'-necleotidase deficiency suspected from a blood film (December)

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• The peripheral blood features of acute myeloid leukemia with inv (16) (November)

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• What is a promonocyte? (October)

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• Choreo-acanthocytosis (August)

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• Hyperlipidemia revealed by erythrocyte morphology (July)

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• Endothelial cells (June)

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• Dysplasia of all granulocyte lineages in myelodysplastic evolution of essential thrombocythemia (May)

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• South-East Asian ovalocytosis (page 328) (April)

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• Observation of auer rods in crushed cells helps in the diagnosis of acute promyelocytic leukemia (March)

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• Diagnosis of cystinosis from a bone marrow aspirate (February)

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• “Flatland: A romance of many dimensions” (January)