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Lung cancer ranks as the leading cause of cancer death in 2020 worldwide. Approximately 85% of newly diagnosed lung cancers are non-small cell lung cancer (NSCLC). However, the benefit of Endostar used in treating patients with advanced NSCLC of different ages is still unclear in real-world clinical settings. This study aimed to assess the effectiveness and safety of Endostar combined with chemotherapy in the treatment of patients with NSCLC in different age groups (≤60 years vs.>60 years) in a real-world study and indicated the potential of the combination of Endostar and chemotherapy in treating older patients with NSCLC in real clinical settings.

Due to the concept of oligometastasis in lung cancer, thermal ablation combined with other therapies is gradually recognized.This article reviews the concept, classification, local treatment and prognosis of extracranial oligometastasis.

The curative treatment for patients with potentially curable non-small cell lung cancer was low at 59% in New South Wales, Australia. Significant variation was noted in the use of curative treatment between local health districts (24%–70%).

Tepotinib have high retention in the tumor and sustained inhibition of MET and its downstream pathways. Tepotinib is a key drug for cancer patients with MET exon 14 skipping mutation. However, its bioavailability in the CSF in humans has not been elucidated. The blood brain barrier protects the CNS from toxicity, but also prevents therapeutic drugs from accessing the brain. We report a case of leptomeningeal metastasis successfully treated with tepotinib in a patient with poor PS and on the bioavailability of tepotinib in the CSF in humans.

Targeted therapy for EGFR-mutant lung cancers has been developed based on data regarding mainly common mutations. However, recent studies revealed that rare genotypes could be targetable if appropriate TKIs are selected.

1. Chaetocin demonstrated strong antineoplastic activities against non-small cell lung carcinoma cell lines.
2. Cell cycle arrest via CDKN1A expression and the comprehensive replicative stress of Chaetocin would be key factors of Chaetocin working mechanisms.

1. LysoPC reprograms lipid metabolisms by increasing the accumulation of fatty acids and activating acyl-CoA-dominated metabolic mode under the control and regulation of ACSL5.
2. LysoPC up-regulates the expression of ACSL5 and activates the ACSL5-oriented lipid metabolism by promoting the phosphorylation of PI3K/mTOR and Ras/ERK signal pathways.
3. LysoPC inhibited lung cancer cell proliferation by promoting ACSL5, leading to the disorder of FA degradation.

• Abnormally high expression of BC correlates with poor survival of LUAD patients.
• BC is involved in acquired resistance to EGFR-targeted therapies.
• BC restores the epithelial–mesenchymal transition suppressed by IMPAD1.
• BC promotes IMPAD1 alternative splicing via an interaction with hnRNPK and NCL.

The Interobserver variability for target volume delineation in the SBRT of pulmonary lesions - could have major negative dosimetric consequences, which could threaten the tumour control probability. In this study, we introduce an easy-use semi-automated delineation tool for peripheral lung lesions in free breathing (FB) and four-dimensional (4D) planning CT and cone beam CT (CBCT). The Dice similarity coefficient (DSC) showed the reliability of the tool alone or better in a supervised application. The semi-automated delineation tool can accurately track the interfraction and intrafraction changes or deformations of tumours through the therapy in CBCT, opening the door for its use in adaptive planning.

This paper evaluates the dosimetry of volumetric arc therapy in comparison to 3D-Conformal technique in delivery of lung stereotactic ablative radiotherapy. No significant dosimetric differences were found between the two techniqiues that could potentially lead to an increased risk of radiation pneumonitis.

GPX8 is highly expressed both in lung cancer cells and CAFs, which is a potentially therapeutic target in lung cancer. Knockdown of GPX8 obviously inhibited lung cancer metastasis through the modulation of focal adhesion pathway and GPX8-mediated IL6 and CCL2 production of CAF may play crucial role for lung cancer metastasis. BET proteins is involved in transcriptional regulation of GPX8 and BET inhibitor is a potential strategy against GPX8-mediated lung cancer metastasis.

The ligands are combined with nano-zinc hydroxide carriers to guide aptamer and siUSP14 to specifically bind to the surface of DDP-resistant A549/DDP cells. After internalization of the paired aptamer and carriers, intracellular pH changes cause the active release of the siUSP14, followed by inactivation of epidermal growth factor receptor (EGFR)/PI3K/protein kinase B (AKT) signaling pathway, resulting in decreased DDP resistance in A549/DDP cells.

With the development of medical image analysis, many successful cases have shown the clinical potential of Transformer. Thus, this paper collected 273 latest (2021–2022) works that based their frameworks on Transformer. To facilitate the readers, 76 public medical image datasets have also been listed. Considering the diversity of these 273 works, we organize this paper as the following sequences: task-modality-disease.

Overexpression of death-associated protein kinase 1 (DAPK1) under oxygen and glucose deprivation (OGD) promoted A549 cell apoptosis and autophagy. Moreover, knockdown of Beclin1 inhibited autophagy. While overexpression of Beclin1 promoted A549 cell apoptosis. Collectively, overexpression of DAPK1 and upregulation of Beclin1 under OGD promoted excessive autophagy and aggravated apoptosis in A549 cells.

There remain considerable uncertainties regarding molecular residual disease (MRD) detection in lung cancer. Drug holiday based on the negative predictive value of MRD merit further exploration.