High-energy relatives of benzene have captured the imagination of chemists, especially those with cumulative double bonds which feature strained ring structure and lack any aromaticity stabilization. The integration of transition metals and Group 14 elements into six-membered cycloallene rings has been achieved by a [5+1]-cycloaddition of diethynylsilane or diethynylgermane with simple transition metal complexes. Experimental and computational studies demonstrate the stability of these unprecedent cycloallenes, i.e. metalla-isosilabenzenes and metalla-isogermabenzenes, may root in the decreasing strain on the cumulative double bonds. More details are discussed in the article by Zhang et al. on page 1121—1127.

Triphenylamine and its derivatives (TPAs) are promising for the photocatalytic oxidative coupling of thiols to disulfides, but suffer from the easy polymerization and difficult separation. In this paper, by immobilizing the TPAs into MOF with photoredox inert Sr nodes, the photo-generated electrons were successfully controlled to transfer from the excited TPAs to O₂, and finally realize the heterogeneous catalytic oxidation of thiols to disulfides. More details are discussed in the article by Zhang et al. on page 1093—1099.

A disposable monolithic column mass spectrometry analysis kit was developed for direct whole blood analysis. The monolithic column can clean whole blood matrix in 30 s as well as avoid analyte exposure to oxygen, moisture and sunlight for sample storage. This MS kit has been successfully applied to the quantitative analysis of procainamide hydrochloride in 2 μL rat blood, proving it a cost-effective and powerful tool for in vitro diagnostics in the future.

A new family of dibenzoullazine derivatives was synthesized through 1,3-dipolar cycloaddition of polycyclic aromatic azomethine ylides with alkynylbenziodoxoles followed by oxidation. The benziodoxole moiety in the resulting products was used as a versatile linchpin for the synthesis of structurally diverse functional dibenzoullazines that are difficult to access by other synthetic methods.

Bioassay-guided investigation led to the discovery of eight novel guaiane-type sesquiterpenoid trimers, artemsieverolactones A—H, which can be classified into four different types based on the connecting models of three guaianolide units. Most of the compounds showed inhibitory activity on HSC-LX2 cells. Artemsieverolactone B (2) exhibited significant inhibition on HSC-LX2 with an IC₅₀ value of 37.8 μmol/L, and inhibited the deposition of human collagen type I (Col I), human hyaluronicacid (HA) and human laminin (HL) with IC₅₀ values of 40.4, 47.3 and 55.1 μmol/L, respectively.

The immobilization of triphenylamine into MOF with photoredox inert Sr nodes can successfully control the photo-generated electrons transfer from the excited triphenylamine to O₂ and realize the heterogeneous catalytic oxidation of thiols to disulfides.

Based on rational combination of dibenzo[a,c]phenazine and pyridine as electronic acceptor and anchoring groups to perovskite layer, DPyP as a hole-transporting material in dopant-free PSC achieved high conversion efficiency of 20.45%, higher than that of DBP (19.77%) based on dibenzo[a,c]phenazine.

The invention of a well-defined Cu(III) fluoride complex Me₄N⁺[Cu(CF₃)₃(F)]^- 1 enabled to access a versatile of functionalized Cu(III) complexes [Me₄N]⁺[Cu(X)(CF₃)₃]^- (X = C₆F₅, C₆F₅C≡C, CN, Cl, N₃, ^tBuOO, SCN, OAc, SAr), many of them for the first time. The availability of these complexes allowed us to evaluate the the trans-influence order of ligand in Cu(III) complexes: Bn > CF₃^– > C₆F₅^– > N₃^– > py ~ CH₃^– ~ C₆F₅C≡C > NO₂PhO^– ~ ^tBuOO^– ~ CH₃COO^– > F^–.

A facile and robust method to prepare protein α-thioester has been developed. A series of inaccessible protein α-thioesters with limited solubility and internal Cys residues can be efficiently synthesized in one-pot via a SUMO-Protein-Intein sandwich model.

The derivatives of isosilabenzene and isogermabenzene with metal vinylidene bonds have been achieved from phantom species to stable compounds for the first time. The relative stability of these isomers has been elucidated by experimental observations and DFT calculations.

A mild and practical method for synthesizing fluorinated quinoline derivatives, which have a wide range of applications in pharmaceuticals, materials, and organic synthesis, was described through C—F bond insertion into indoles using CHBr₂F. The simple conditions, readily availability of CHBr₂F, as well as the versatility of the transformations make this strategy very powerful in synthesizing 3-fluoroquinoline and 3-fluoroquinolone.

Introducing homochirality provides an effective and universal strategy to precisely design molecular ferroelectrics. This review summarizes the recent progress on the chemical design of molecular ferroelectrics through the strategy of introducing homochirality.

Recent developments have led to the emergence of Frustrated Radical Pairs (FRPs) as an extension of the radical family. FRPs are formed from FLPs through Single Electron Transfer (SET) and exhibit the ability to activate a variety of chemical bonds. This review highlights the current state of FRPs in organic synthesis, delves into mechanistic insights, explores their potential, and underscores the challenges in this emerging field.

This review summarizes the typical nanostrategies to disrupt tumor stromal barrier for improved cancer therapy, and an up-to-date discussion on some representative studies for deep drug penetration is included, which provides exciting opportunities for designing newly emerging functional biomaterials in this field.

A mild and practical method for synthesizing fluorinated quinoline derivatives, which have a wide range of applications in pharmaceuticals, materials, and organic synthesis, was described through C—F bond insertion into indoles using CHBr₂F. The simple conditions, readily availability of CHBr₂F, as well as the versatility of the transformations make this strategy very powerful in synthesizing 3-fluoroquinoline and 3-fluoroquinolone. More details are discussed in the article by Song et al. on page 1128—1132.

A facile one-flask preparation of inaccessible protein α-thioester via a SUMO-protein-intein (SPI) sandwich model has been developed. The protein thioester with internal Cys residues can be readily produced, which is otherwise difficult to obtain using traditional methods. Furthermore, this method is compatible with the EPL-desulfurization protocol used to prepare complex proteins. More details are discussed in the article by Wang et al. on page 1114—1120.