Volume 42, Issue 10 pp. 1157-1160
Emerging Topic

Organic Synthesis through Radical Innovation: Frustrated Radical Pairs

Zhibin Hu

Zhibin Hu

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191 China

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Zengrui Cheng

Zengrui Cheng

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191 China

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Ning Jiao

Corresponding Author

Ning Jiao

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191 China

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai, 200062 China

E-mail: [email protected]Search for more papers by this author
First published: 25 December 2023

Dedicated to the Memory of Professor Xiyan Lu.

Abstract

Frustrated Lewis Pairs (FLPs) represent a unique class of interactions in Lewis acid-base chemistry, driven by spatial hindrance or incongruent orbital energy levels that hinder the formation of effective coordination bonds. FLPs have received significant attention for their application in activating small molecules and facilitating organic synthesis reactions. Recent developments have led to the emergence of Frustrated Radical Pairs (FRPs) as an extension of the radical family. FRPs are formed from FLPs through Single Electron Transfer (SET) and exhibit the ability to activate a variety of chemical bonds. While research on FLPs is well-established, investigations into FRPs in organic reactions remain limited. This review highlights the current state of FRPs in organic synthesis, delves into mechanistic insights, explores their potential, and underscores the challenges in this emerging field.image

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