Top Downloaded Articles 2022

14 March 2023
13 March 2023
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Top Downloaded Articles 2022

Open Access

Ferroptosis in cancer and cancer immunotherapy

Lei Zhao,  Xiaoxue Zhou,  Feng Xie,  Lei Zhang,  Haiyan Yan,  Jun Huang,  Chong Zhang,  Fangfang Zhou,  Jun Chen,  Long Zhang, 
Open Access

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

Xiao Zhang,  Yunhua Xu,  Lifang Ma,  Keke Yu,  Yongjie Niu,  Xin Xu,  Yi Shi,  Susu Guo,  Xiangfei Xue,  Yikun Wang,  Shiyu Qiu,  Jiangtao Cui,  Hong Wang,  Xiaoting Tian,  Yayou Miao,  Fanyu Meng,  Yongxia Qiao,  Yongchun Yu,  Jiayi Wang, 
Open Access

Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression

Jie Chen,  Kang Li,  Jianwen Chen,  Xiaochen Wang,  Rongsong Ling,  Maosheng Cheng,  Zhi Chen,  Fangfang Chen,  Qianting He,  Shuai Li,  Caihua Zhang,  Yizhou Jiang,  Qianming Chen,  Anxun Wang,  Demeng Chen, 
Open Access

New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer

Zi-Ting Yao,  Yan-Ming Yang,  Miao-Miao Sun,  Yan He,  Long Liao,  Kui-Sheng Chen,  Bin Li, 
Open Access

Non-small cell lung cancer in China

Peixin Chen,  Yunhuan Liu,  Yaokai Wen,  Caicun Zhou, 
Open Access

Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1

Dan Wu,  Yi Yang,  Yiran Hou,  Zifeng Zhao,  Ning Liang,  Peng Yuan,  Tao Yang,  Jinliang Xing,  Jibin Li, 
Open Access

KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer

Chengming Liu,  Sufei Zheng,  Zhanyu Wang,  Sihui Wang,  Xinfeng Wang,  Lu Yang,  Haiyan Xu,  Zheng Cao,  Xiaoli Feng,  Qi Xue,  Yan Wang,  Nan Sun,  Jie He, 
Open Access

The theory of tumor ecosystem

Xueman Chen,  Erwei Song, 
Open Access

Breast cancer: an up-to-date review and future perspectives

Ruoxi Hong,  Binghe Xu, 
Open Access

The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells

Ziliang Wang,  Wei Chen,  Ling Zuo,  Midie Xu,  Yong Wu,  Jiami Huang,  Xu Zhang,  Yongheng Li,  Jing Wang,  Jing Chen,  Husheng Wang,  Huizhen Sun, 
Open Access

Cancer-associated fibroblasts in breast cancer: Challenges and opportunities

Dengdi Hu,  Zhaoqing Li,  Bin Zheng,  Xixi Lin,  Yuehong Pan,  Peirong Gong,  Wenying Zhuo,  Yujie Hu,  Cong Chen,  Lini Chen,  Jichun Zhou,  Linbo Wang, 
Open Access

Antibody variable region engineering for improving cancer immunotherapy

Hantao Lou,  Xuetao Cao, 
Open Access

Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

Lu Tang,  Aining Zhang,  Ziyao Zhang,  Qingqing Zhao,  Jing Li,  Yijun Mei,  Yue Yin,  Wei Wang, 
Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

This review highlights the recent progress of inorganic nanomaterials in cancer photoimmunotherapy. Phototherapy, immunotherapy and innovative nanomaterials represent three of the novel technological advancement in cancer therapy. The combination of these methods will largely maximize the therapeutic efficacy and minimize the shortcoming of each treatment modality.

Open Access

Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer

Bo Cheng,  Kaikai Ding,  Pengxiang Chen,  Jianxiong Ji,  Tao Luo,  Xiaofan Guo,  Wei Qiu,  Chunhong Ma,  Xue Meng,  Jian Wang,  Jinming Yu,  Yuan Liu, 
Open Access

m6A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels

Yinan Liu,  Ertao Zhai,  Junting Chen,  Yan Qian,  Risheng Zhao,  Yan Ma,  Jianqiu Liu,  Zhixin Huang,  Shirong Cai,  Jianhui Chen, 
Open Access

Tumor-associated macrophages in liver cancer: From mechanisms to therapy

Kun Cheng,  Ning Cai,  Jinghan Zhu,  Xing Yang,  Huifang Liang,  Wanguang Zhang, 
Open Access

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program

Ming Huang,  Wen Dong,  Ruihui Xie,  Jilin Wu,  Qiao Su,  Wuguo Li,  Kai Yao,  Yuelong Chen,  Qianghua Zhou,  Qiang Zhang,  Wenwen Li,  Liang Cheng,  Shengmeng Peng,  Siting Chen,  Jian Huang,  Xu Chen,  Tianxin Lin, 
Open Access

The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China

Ziyue Zhou,  Huazhen Liu,  Yiying Yang,  Jingya Zhou,  Lidan Zhao,  Hua Chen,  Yunyun Fei,  Wen Zhang,  Mengtao Li,  Yan Zhao,  Xiaofeng Zeng,  Fengchun Zhang,  Huaxia Yang,  Xuan Zhang, 
Open Access

Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy

Ajaz A. Bhat,  Sabah Nisar,  Mayank Singh,  Bazella Ashraf,  Tariq Masoodi,  Chandra P. Prasad,  Atul Sharma,  Selma Maacha,  Thasni Karedath,  Sheema Hashem,  Syed Besina Yasin,  Puneet Bagga,  Ravinder Reddy,  Michael P. Frennaux,  Shahab Uddin,  Punita Dhawan,  Mohammad Haris,  Muzafar A. Macha, 
Open Access

Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

Jang Hee Han,  Yong Keon Kim,  Hakhyun Kim,  Jooyoung Lee,  Myung Joon Oh,  Sang Bum Kim,  Minjee Kim,  Kook Hwan Kim,  Hyun Ju Yoon,  Myung-Shik Lee,  John D. Minna,  Michael A. White,  Hyun Seok Kim,