Hepatopancreatobiliary Cancer

Cancer collection based on different tumor types
1 August 2022
20 February 2023
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Hepatopancreatobiliary Cancer

Open Access

METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression

Peng Xia,  Hao Zhang,  Haofeng Lu,  Kequan Xu,  Xiang Jiang,  Yuke Jiang,  Xiangdong Gongye,  Zhang Chen,  Jie Liu,  Xi Chen,  Weijie Ma,  Zhonglin Zhang,  Yufeng Yuan, 
Open Access

Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer: a multicenter randomized controlled trial

Qing Lin,  Shangyou Zheng,  Xianjun Yu,  Meifu Chen,  Yu Zhou,  Quanbo Zhou,  Chonghui Hu,  Jing Gu,  Zhongdong Xu,  Lin Wang,  Yimin Liu,  Qingyu Liu,  Min Wang,  Guolin Li,  He Cheng,  Dongkai Zhou,  Guodong Liu,  Zhiqiang Fu,  Yu Long,  Yixiong Li,  Weilin Wang,  Renyi Qin,  Zhihua Li,  Rufu Chen, 
Open Access

Serologic status and safety of inactivated Covid-19 vaccine for hepatocellular carcinoma patients with cirrhosis after curative liver resection

Fuchen Liu,  Xiaochen Feng,  Jin Du,  Minghao Ruan,  Hui Liu, 
Open Access

Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity

Nicolas Alejandro Fraunhoffer,  Analía Meilerman Abuelafia,  Brice Chanez,  Martin Bigonnet,  Odile Gayet,  Julie Roques,  Eduardo Chuluyan,  Nelson Dusetti,  Juan Iovanna, 
Open Access

Pancreatic cancer survival trends in the US from 2001 to 2014: a CONCORD-3 study

Maja Nikšić,  Pamela Minicozzi,  Hannah K Weir,  Heather Zimmerman,  Maria J Schymura,  Judith R Rees,  Michel P Coleman,  Claudia Allemani,  US CONCORD Working Group , 
Open Access

Elevated neutrophil extracellular traps by HBV-mediated S100A9-TLR4/RAGE-ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma

Xi Zhan,  Rui Wu,  Xue-Hua Kong,  Yan You,  Kun He,  Xiao-Yu Sun,  Yong Huang,  Wei-Xian Chen,  Liang Duan, 
Open Access

Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma

Miao Li,  Xi Zhang,  Mimi Wang,  Yaohui Wang,  Jiali Qian,  Xiaoxia Xing,  Zhiming Wang,  Yang You,  Kun Guo,  Jie Chen,  Dongmei Gao,  Yan Zhao,  Lan Zhang,  Rongxin Chen,  Jiefeng Cui,  Zhenggang Ren, 
Open Access

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Xinpeng Yin,  Ruiyuan Xu,  Jianlu Song,  Rexiati Ruze,  Yuan Chen,  Chengcheng Wang,  Qiang Xu, 
Open Access

Tumor-associated macrophages in liver cancer: From mechanisms to therapy

Kun Cheng,  Ning Cai,  Jinghan Zhu,  Xing Yang,  Huifang Liang,  Wanguang Zhang, 
Open Access

Peripheral naïve CD8+ T cells as a predictive biomarker of response to lenvatinib plus an anti-PD-1 antibody in advanced hepatocellular carcinoma: a biomarker study

Cheng Huang,  Bin Xu,  Xiao-Dong Zhu,  Ying-Hao Shen,  Mei-Ling Li,  Jin-Jin Zhu,  Jian Zhou,  Jia Fan,  Hui-Chuan Sun, 
Open Access

Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool

Nicolas A. Fraunhoffer,  Analía Meilerman Abuelafia,  Nelson Dusetti,  Juan Iovanna, 
Open Access

Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition

Christian Schneeweis,  Zonera Hassan,  Katja Ascherl,  Matthias Wirth,  Stella Koutsouli,  Felix Orben,  Lukas Krauß,  Carolin Schneider,  Rupert Öllinger,  Oliver H. Krämer,  Roland Rad,  Maximilian Reichert,  Maria S. Robles,  Dieter Saur,  Günter Schneider, 
Open Access

Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials

Sung Hwan Lee,  Yun Seong Jeong,  Sunyoung Lee,  Bo Hwa Sohn,  Ho Kyoung Hwang,  Gi Hong Choi,  Chang Moo Kang,  Jin Sub Choi,  Woo Jung Lee,  Jae-Ho Cheong,  Hee Jin Jang,  Ahmed Kaseb,  Lewis Roberts,  Sun Young Yim,  Yun Shin Chun,  Ju-Seog Lee, 
Open Access

Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1

Dan Wu,  Yi Yang,  Yiran Hou,  Zifeng Zhao,  Ning Liang,  Peng Yuan,  Tao Yang,  Jinliang Xing,  Jibin Li, 
Open Access

Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci

Jian Xu,  Mayrel Palestino Dominguez,  Christine Alewine, 
Open Access

Characterization of DNA damage response deficiency in pancreatic cancer patients from China

Xiaofei Zhang,  Tiebo Mao,  Bei Zhang,  Haiyan Xu,  Jiujie Cui,  Feng Jiao,  Dongqin Chen,  Yu Wang,  Jiong Hu,  Qing Xia,  Shumin Li,  Ming Yue,  Jingyu Ma,  Jiayu Yao,  Yongchao Wang,  Xiao Zhang,  Shiqing Chen,  Yuezong Bai,  Yuexiang Wang,  Xuebin Zhang,  Qiang Liu,  Yongwei Sun,  Deliang Fu,  Yingbin Liu,  Lei Xiong,  Liwei Wang, 
Open Access

Detection of pancreatic cancer by indocyanine green-assisted fluorescence imaging in the first and second near-infrared windows

Zhongqiang Li,  Zheng Li,  Alexandra Ramos,  J. Philip Boudreaux,  Ramcharan Thiagarajan,  Yvette Bren Mattison,  Michael E. Dunham,  Andrew J McWhorter,  Qing Chen,  Jian Zhang,  Ji-Ming Feng,  Yanping Li,  Shaomian Yao,  Jian Xu, 
Open Access

Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review

Jinshou Yang,  Ruiyuan Xu,  Chengcheng Wang,  Jiangdong Qiu,  Bo Ren,  Lei You, 
Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review

Pancreatic cancer is a highly malignant digestive system tumor with poor prognosis. Most pancreatic cancer patients are diagnosed at advanced stages or even metastasis due to its highly aggressive characteristics and the lack of early typical symptoms. Thus, the early diagnosis of pancreatic cancer is crucial for improving its prognosis

Open Access

Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma

Jingbo Li,  Rui Kang,  Daolin Tang, 
Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma

This review details the modulation, function, and detection of perineural invasion, and highlights the opportunities for further exploration that may benefit pancreatic cancer patients.

Open Access

Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis

Feiyang Ji,  Menghao Zhou,  Zeyu Sun,  Zhengyi Jiang,  Huihui Zhu,  Zhongyang Xie,  Xiaoxi Ouyang,  Lingjian Zhang,  Lanjuan Li, 
Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis

We constructed one of the largest ubiquitinome dataset obtained from human cancer tissues to date using the high-resolution mass spectrometry and immunoenrichment of diGly-modified peptides. We identified a E3 ligase, SYVN1, which potentially participated in the metastasis of HCC. We studied the interaction omics of SYVN1, and found it interacted with HSP90 and impacted the ubiquitination of EEF2K.