The cancer spectrum of China is changing, with a rapidly increase incidence and burden of "cancers of the rich" (lung, breast, colorectal, and prostate cancer) in addition to a high incidence and heavy burden of “cancers of the poor” (liver, stomach, esophageal, and cervical cancer).

In this review, we preliminarily looked into the various roles that the EMT-associated miRNAs play in the stem-like nature of malignant cells. Then we reviewed the interaction between drug resistance and EMT-associated miRNAs with elaborated signal pathways, especially the opposite roles in various cancer types. We finally arrived at a conclusion concerning the relationship between EMT, stemness and drug resistance and discussed the potential application of miRNA therapy for malignant tumors.

In this review, we present a clear view of the major factors and regulators associated with cancer immunotherapy and to provide our point of view on the latest available technologies and treatment methods for resolving clinical problems.

Our data suggested that m5C may play a critical role in hypoxia/glycolysis network and targeting HIF-1α/ALYREF/PKM2 signaling may be a promising therapeutic strategy to treat bladder cancer.

Pancreatic cancer is a highly malignant digestive system tumor with poor prognosis. Most pancreatic cancer patients are diagnosed at advanced stages or even metastasis due to its highly aggressive characteristics and the lack of early typical symptoms. Thus, the early diagnosis of pancreatic cancer is crucial for improving its prognosis

Prevalence of gastrointestinal cancers was positively correlated with national human development index levels, but negatively with hypertension and diabetes rates. Age-specific trends were observed in stomach cancer and esophagus cancer for incidence and in liver cancer and pancreatic cancer for mortality, as well as sex-specific trends for stomach cancer and pancreatic cancer in the elder.These findings suggest that future research has to focus on the specific etiology of gastrointestinal cancers behind these epidemiologic transitions and improve therapeutic strategies for patients with comorbid metabolic diseases.

The mechanisms of drug resistance are intricate and involve drug efflux, epithelial mesenchymal transition, DNA damage repair, and autophagy. Nano-delivery and self-cellular drug delivery platforms have a broad prospective for alleviating OSCC drug resistance. In particular, the combined application of new technologies (including CRISPR systems) opens up new horizons for treatment of OSCC drug resistance.

RC48 is safe and efficacious for HER2-overexpressing gastric cancer patients. Patients received trastuzumab showed similar efficacy with trastuzumab-naïve patients. HER2 status doesn't have significant effect on clinical outcomes.

This 15-year longitudinal study described cancer burden of a rapid changing country with significant regional and urban-rural disparities, which is important in evaluating the effect of population ageing, risk factor exposure, and public health efforts on cancer mortality. Lung and liver cancers were the 1st leading cause of immature death in women and men, respectively. Lung, colorectal, and pancreatic cancers kept increasing in rural areas. These findings are references for policy making to control cancer.

The overall trend in the combined total mortality from four major cancers (lung, liver, stomach, and esophagus) is predicted to decline in China over the next decade, but the corresponding death toll is expected to surge in the context of China's population aging and high smoking prevalence. This study provides an evidence-based assessment of the trends in mortality from these cancers ove

CRC represents the third most commonly diagnosed cancer and the second cause of cancer death;

Cell signaling pathways are dysregulated in CRC stem cells;

Cell signaling pathways are target to eradicate CRC stem cells.

In this review, mechanisms of VEGF-induced immunosuppression based on results from preclinical and translational studies and recent progress in randomized clinical trials were discussed. Key challenges associated with dual targeting of VEGF and PD-1/PD-L1 pathways were also defined in order to stimulate collaboration and help galvanize a broader effort.

In colorectal cancer, S100A8 in tumor cells predicts poor prognosis but that in stroma cells indicates good prognosis. We first proved that TGF-β promotes metastasis through upregulated intracellular USF2/S100A8 axis, and USF2 maybe is the switcher on the opposite function of intracellular and extracellular S100A8.