An integrative score incorporating genetically predicted gene expression and DNA methylation and other genomic and non-genomic information advanced our understanding of using genomic information to stratify subjects for prostate cancer.

Our data suggested that m5C may play a critical role in hypoxia/glycolysis network and targeting HIF-1α/ALYREF/PKM2 signaling may be a promising therapeutic strategy to treat bladder cancer.

MIC-1 production was increased in PCa cells, which was affected by adipocyte infiltration and adipolysis. MIC-1 directly stimulated the surrounding PrSC cells to secrete protumorigenic cytokines such as IL-8 and IL-6 in the PCa stromal microenvironment, especially under a HFD condition. These upregulated functional cytokines directly and/or indirectly stimulated PCa cell proliferation, invasion, and metastasis.

We provide a mechanism by which the tumor suppressor JUP interact with the HIF2α transcription factor in ccRCC cells. JUP downregulation is likely to trigger the aberrant upregulation of HIF2α stability and transactivity, which further exerts effects on tumorigenesis in ccRCC. These results have important implications in both the diagnosis and treatment of RCC.