Ferroptosis in cancer and cancer immunotherapy
Lei Zhao,
Xiaoxue Zhou,
Feng Xie,
Lei Zhang,
Haiyan Yan,
Jun Huang,
Chong Zhang,
Fangfang Zhou,
Jun Chen,
Long Zhang,
Lei Zhao
Epartment of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
These authors contributed equally to this work.
Search for more papers by this authorXiaoxue Zhou
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
These authors contributed equally to this work.
Search for more papers by this authorFeng Xie
Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorLei Zhang
Department of Orthopaedic Surgery, the Third Affiliated Hospital of Wenzhou Medical University, Rui'an, Jiangsu, 325000 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorHaiyan Yan
School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015 China
Search for more papers by this authorJun Huang
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorCorresponding Author
Chong Zhang
School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015 China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Fangfang Zhou
Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123 P. R. China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Jun Chen
Epartment of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Long Zhang
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorLei Zhao,
Xiaoxue Zhou,
Feng Xie,
Lei Zhang,
Haiyan Yan,
Jun Huang,
Chong Zhang,
Fangfang Zhou,
Jun Chen,
Long Zhang,
Lei Zhao
Epartment of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
These authors contributed equally to this work.
Search for more papers by this authorXiaoxue Zhou
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
These authors contributed equally to this work.
Search for more papers by this authorFeng Xie
Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorLei Zhang
Department of Orthopaedic Surgery, the Third Affiliated Hospital of Wenzhou Medical University, Rui'an, Jiangsu, 325000 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorHaiyan Yan
School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015 China
Search for more papers by this authorJun Huang
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorCorresponding Author
Chong Zhang
School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015 China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Fangfang Zhou
Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123 P. R. China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Jun Chen
Epartment of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Long Zhang
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Correspondence
Long Zhang, School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
E-mail: [email protected]
Jun Chen, Department of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
E-mail: [email protected]
Fangfang Zhou, Institutes of Biology and Medical Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
E-mail: [email protected]
Chong Zhang, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, 310015, P. R. China.
E-mail: [email protected]
Search for more papers by this authorAbstract
The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology, physiology and biochemistry. The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure. The effective rate of tumor immunotherapy as a new treatment method is less than 30%. Ferroptosis can be seen in radiotherapy, chemotherapy, and tumor immunotherapy; therefore, ferroptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments. In this review, the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described. In addition, the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized. Collectively, these findings suggest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy, chemotherapy and radiotherapy, thus, indicating the remarkable potential of ferroptosis in cancer treatment.
CONFLICT OF INTEREST
The authors declare that they have no competing interests.
Open Research
DATA AVAILABILITY STATEMENT
Not applicable
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