We report the synthesis and full characterization of a phosphinogermylyne, which could serve as a versatile synthon of a one-coordinate Ge^I radical to access a range of Ge(II) and Ge(IV) compounds. More details are discussed in the article by Tan et al. on page 736—742.

Plenty of advanced methods have been developed for tracing RNA, including directly chemical RNA labeling, metabolic RNA labeling, proximity-dependent RNA labeling, etc. These RNA labeling strategies have greatly enhanced our learning about complex roles and functions of RNA. For the deeper insight of RNA biology, there is still a constant need to develop newer RNA labeling methods. More details are discussed in the article by Weng et al. on page 790—801.

An asymmetric two-component alkenyl Catellani reaction for the construction of C—N axial chirality is reported. This method is based on a palladium/chiral norbornene cooperative catalysis and an axial-to-axial chirality transfer process.

The [2.2]paracyclophane-derived oxazole-pyrimidine ligands with planar chirality (PYMCOX) were designed, synthesized and successfully applied in nickel-catalyzed asymmetric 1,2-reduction of α,β-unsaturated ketones, affording the chiral allyilic alcohols with up to 99% yield and 99% ee. Meanwhile, this reduction reaction could be conducted on gram scale without loss of activity and enantioseletivity, and the chiral ligand could be conveniently recovered with high yield.

The first enantioselective synthesis of N-N benzimidazole atropisomers via Pd-catalyzed enantioselective intramolecular Buchwald-Hartwig amination reaction was reported. A broad range of nonbiaryl benzimidazole and indole-benzimidazole atropisomers were conveniently accessed in high yields and with excellent enantioselectivities.

The direct allylic alkylation of nucleophiles using allylic alcohols was realized by supported atomically dispersed Pd₁/TiO₂-EG under the mild neutral condition without using any additives. The distinct performance was attributed to the hydrogen bonds-assisted removing of –OH at the organic-inorganic interface.

This work firstly unravels the effect of intermolecular σ-π hyperconjugation on the molecular packing and further the optoelectronic properties.

Herein, we developed a general and mild catalytic electrophilic amination of 2-arylindoles with p-quinone diimines to construct axially chiral 2-arylindoles under mild conditions. With the proper choice of a chiral phosphoric acid and substituted 2-arylindoles, the intermolecular C—N bond formation with various p-quinonediimines proceeded with good yields and high stereoselectivities. This strategy provides a powerful method for enantioselective synthesis of 2-arylindole atropisomers which successfully overcame the challenges in catalytic asymmetric construction of axially chiral five-membered heterobiaryls.

A phosphinogermylyne was isolated and fully characterized, which could serve as a synthon of a one-coordinate GeI radical.

Polyaspers A (1) and B (2), the first ergosterol-polyether adducts, were isolated from Aspergillus sp. TJ507, possessing an unequalled 6/6/6/5/5/6/6/6/6 nonacyclic system. 3 could suppress the inflammatory response simulated with TNF-α in HaCaT cells, and in an imiquimod-induced psoriasis murine model, 3 significantly restrained the development of psoriasis symptoms and reduced the expression of IL-17 and IL-23, presenting an anti-psoriatic effect.

A novel class of low-cost unfused polymer donors was developed with the regulated backbone planarity by halogenation, which facilitates the molecular self-assembly for favorable film morphology. Our results provide insight into the effects of backbone halogenation on the optoelectronic properties of fully unfused polymer donors and demonstrate a simple backbone motif for the further commercialization of cost-effective OSCs.

Psoriasis is a chronic skin disease and the TNF-α is the therapeutic target of this disease. The experiments including SPR and in vivo tests discovered the ergosterols from the fungus Aspergillus sp. TJ507 serve as lead structures for the development of novel TNF-α inhibitory agents in the clinical treatment of psoriasis. More details are discussed in the article by Zhang et al. on page 743—751.

Developing novel unfused building blocks with simple synthesis and low cost is essential to advance cost-effective polymer donors in the field of organic solar cells, however, remains challenging. Herein, a class of low-cost and fully unfused polymer donors with precisely regulated backbone planarity via halogenation was designed and synthesized, which possess a four-step synthesis route with over 80% yield from cheap raw chemicals comparable to existing low-cost polymer donors, such as PTQ10. More details are discussed in the article by Li et al. on page 752—759.