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    Hepatology: Volume 68, Issue 1

    1-392
    July 2018
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Cover Image

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Cover Image

  • First Published: 05 July 2018

Issue Information

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Masthead

  • First Published: 05 July 2018
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Table of contents

  • First Published: 05 July 2018

Hepatology Highlights

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Hepatology highlights

Nicholas Russo,  Robert S. Brown Jr.,  Nicole T. Shen,  Joseph F. Pisa,  Saurabh Mukewar,  Zaid H. Tafesh,  Russell Rosenblatt,  Robert E. Schwartz,  Vikas Gupta,  Aleksey Novikov,  Shirley Cohen-Mekelburg, 
  • Pages: 1-3
  • First Published: 05 July 2018

Comments from the Editors

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Social media: Why AASLD and its members must lead the conversation

Theo Heller M.D., FAASLD,  Christopher Koh M.D., M.H.Sc.,  Sonal Kumar M.D., M.P.H., 
  • Pages: 4-6
  • First Published: 14 April 2018

Editorials

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Hepatocellular carcinoma screening is associated with survival benefit in silico but needs confirmation in an in vivo analysis

Ruben Hernaez M.D., M.P.H., Ph.D.,  Fasiha Kanwal M.D., MSHS,  Hashem B. El-Serag M.D., M.P.H., 
  • Pages: 7-9
  • First Published: 09 January 2018
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Identification of theranostic biomarkers to improve the stratification of patients with pediatric liver cancer: Opportunities and challenges

Carolina Armengol Ph.D.,  Stefano Cairo Ph.D., 
  • Pages: 10-12
  • First Published: 12 January 2018
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Hepatocellular carcinoma: Liver biopsy in the balance

David E. Kleiner M.D., Ph.D., 
  • Pages: 13-15
  • First Published: 05 February 2018
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Quality of life and primary sclerosing cholangitis: The business of defining what counts

Katherine Arndtz M.D.,  Gideon M. Hirschfield M.D., Ph.D., 
  • Pages: 16-18
  • First Published: 09 January 2018
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Primary biliary cholangitis, DNA, and beyond: The Relative contribution of genes

Aliya F. Gulamhusein M.D., M.P.H.,  Konstantinos N. Lazaridis M.D., 
  • Pages: 19-21
  • First Published: 13 January 2018

Original Articles

VIRAL HEPATITIS

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Serologic responses and effectiveness of hepatitis A vaccination among human immunodeficiency virus–positive individuals during the outbreak of acute hepatitis A

Kuan-Yin Lin,  Szu-Min Hsieh,  Hsin-Yun Sun,  Yi-Chun Lo,  Wang-Huei Sheng,  Yu-Chung Chuang,  Aristine Cheng,  Sung-Ching Pan,  Guan-Jhou Chen,  Chien-Ching Hung,  Shan-Chwen Chang, 
  • Pages: 22-31
  • First Published: 12 January 2018
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All-oral direct-acting antiviral therapy against hepatitis C virus (HCV) in human immunodeficiency virus/HCV–coinfected subjects in real-world practice: Madrid coinfection registry findings

Juan Berenguer,  Ángela Gil-Martin,  Inmaculada Jarrin,  Ana Moreno,  Lourdes Dominguez,  Marisa Montes,  Teresa Aldámiz-Echevarría,  María J. Téllez,  Ignacio Santos,  Laura Benitez,  José Sanz,  Pablo Ryan,  Gabriel Gaspar,  Beatriz Alvarez,  Juan E. Losa,  Rafael Torres-Perea,  Carlos Barros,  Juan V. San Martin,  Sari Arponen,  María T. de Guzmán,  Raquel Monsalvo,  Ana Vegas,  María T. Garcia-Benayas,  Regino Serrano,  Luis Gotuzzo,  María Antonia Menendez,  Luis M Belda,  Eduardo Malmierca,  María J. Calvo,  Encarnación Cruz-Martos,  Juan J. González-García, 
  • Pages: 32-47
  • First Published: 29 January 2018

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

Yuli Cai,  Honggui Li,  Mengyang Liu,  Ya Pei,  Juan Zheng,  Jing Zhou,  Xianjun Luo,  Wenya Huang,  Linqiang Ma,  Qiuhua Yang,  Shaodong Guo,  Xiaoqiu Xiao,  Qifu Li,  Tianshu Zeng,  Fanyin Meng,  Heather Francis,  Shannon Glaser,  Lulu Chen,  Yuqing Huo,  Gianfranco Alpini,  Chaodong Wu, 
  • Pages: 48-61
  • First Published: 09 January 2018
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Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis

Xiaolei Wang,  Heng Du,  Shanshan Shao,  Tao Bo,  Chunxiao Yu,  Wenbin Chen,  Lifang Zhao,  Qiu Li,  Li Wang,  Xiaojing Liu,  Xiaohui Su,  Mingqi Sun,  Yongfeng Song,  Ling Gao,  Jiajun Zhao, 
  • Pages: 62-77
  • First Published: 21 January 2018

HEPATOBILIARY MALIGNANCIES

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Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis

Ju Dong Yang,  Ajitha Mannalithara,  Andrew J. Piscitello,  John B. Kisiel,  Gregory J. Gores,  Lewis R. Roberts,  W. Ray Kim, 
  • Pages: 78-88
  • First Published: 12 October 2017
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New insights into diagnosis and therapeutic options for proliferative hepatoblastoma

Katarzyna B. Hooks,  Jérôme Audoux,  Helena Fazli,  Sarah Lesjean,  Tony Ernault,  Nathalie Dugot-Senant,  Thierry Leste-Lasserre,  Martin Hagedorn,  Benoit Rousseau,  Coralie Danet,  Sophie Branchereau,  Laurence Brugières,  Sophie Taque,  Catherine Guettier,  Monique Fabre,  Anne Rullier,  Marie-Annick Buendia,  Thérèse Commes,  Christophe F. Grosset,  Anne-Aurélie Raymond, 
  • Pages: 89-102
  • First Published: 20 November 2017
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Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance

Marianne Ziol,  Nicolas Poté,  Giuliana Amaddeo,  Alexis Laurent,  Jean-Charles Nault,  Frédéric Oberti,  Charlotte Costentin,  Sophie Michalak,  Mohamed Bouattour,  Claire Francoz,  Georges Philippe Pageaux,  Jeanne Ramos,  Thomas Decaens,  Alain Luciani,  Boris Guiu,  Valérie Vilgrain,  Christophe Aubé,  Jonathan Derman,  Cécile Charpy,  Jessica Zucman-Rossi,  Nathalie Barget,  Olivier Seror,  Nathalie Ganne-Carrié,  Valérie Paradis,  Julien Calderaro, 
  • Pages: 103-112
  • First Published: 27 December 2017
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cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

Elizabeth Brunt,  Shinichi Aishima,  Pierre-Alain Clavien,  Kathryn Fowler,  Zachary Goodman,  Gregory Gores,  Annette Gouw,  Alex Kagen,  David Klimstra,  Mina Komuta,  Fukuo Kondo,  Rebecca Miksad,  Masayuki Nakano,  Yasuni Nakanuma,  Irene Ng,  Valerie Paradis,  Young Nyun Park,  Alberto Quaglia,  Massimo Roncalli,  Tania Roskams,  Michiie Sakamoto,  Romil Saxena,  Christine Sempoux,  Claude Sirlin,  Ashley Stueck,  Swan Thung,  W.M.S. Tsui,  Xin-Wei Wang,  Aileen Wee,  Hirohisa Yano,  Matthew Yeh,  Yoh Zen,  Jessica Zucman-Rossi,  Neil Theise, 
  • Pages: 113-126
  • First Published: 23 January 2018
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Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma

Hongping Zheng,  Yotsawat Pomyen,  Maria Olga Hernandez,  Caiyi Li,  Ferenc Livak,  Wei Tang,  Hien Dang,  Tim F. Greten,  Jeremy L. Davis,  Yongmei Zhao,  Monika Mehta,  Yelena Levin,  Jyoti Shetty,  Bao Tran,  Anuradha Budhu,  Xin Wei Wang, 
  • Pages: 127-140
  • First Published: 09 January 2018
Open Access

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Shan-Ying Wu,  Sheng-Hui Lan,  Shang-Rung Wu,  Yen-Chi Chiu,  Xi-Zhang Lin,  Ih-Jen Su,  Ting-Fen Tsai,  Chia-Jui Yen,  Tsung-Hsueh Lu,  Fu-Wen Liang,  Chung-Yi Li,  Huey-Jen Su,  Chun-Li Su,  Hsiao-Sheng Liu, 
  • Pages: 141-154
  • First Published: 12 January 2018

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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Development and validation of a primary sclerosing cholangitis–specific patient-reported outcomes instrument: The PSC PRO

Zobair M. Younossi,  Arian Afendy,  Maria Stepanova,  Andrei Racila,  Fatema Nader,  Rachel Gomel,  Ricky Safer,  William R. Lenderking,  Anne Skalicky,  Leah Kleinman,  Robert P. Myers,  G. Mani Subramanian,  John G. McHutchison,  Cynthia Levy,  Christopher L. Bowlus,  Kris Kowdley,  Andrew J. Muir, 
  • Pages: 155-165
  • First Published: 20 November 2017
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Using the Icelandic genealogical database to define the familial risk of primary biliary cholangitis

Kristjan T. Örnolfsson,  Sigurdur Olafsson,  Ottar M. Bergmann,  M. Eric Gershwin,  Einar S. Björnsson, 
  • Pages: 166-171
  • First Published: 21 November 2017
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MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation

Katrin Böttcher,  Krista Rombouts,  Francesca Saffioti,  Davide Roccarina,  Matteo Rosselli,  Andrew Hall,  TuVinh Luong,  Emmanuel A. Tsochatzis,  Douglas Thorburn,  Massimo Pinzani, 
  • Pages: 172-186
  • First Published: 12 January 2018
Open Access

Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A Cl− channels

Qin Li,  Amal Dutta,  Charles Kresge,  Abhijit Bugde,  Andrew P. Feranchak, 
  • Pages: 187-199
  • First Published: 23 January 2018
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Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice

Andrea Kristina Horst,  Claudia Wegscheid,  Christoph Schaefers,  Birgit Schiller,  Katrin Neumann,  Sebastian Lunemann,  Annika E. Langeneckert,  Karl J. Oldhafer,  Christina Weiler-Normann,  Karl S. Lang,  Bernhard B. Singer,  Marcus Altfeld,  Linda Diehl,  Gisa Tiegs, 
  • Pages: 200-214
  • First Published: 29 January 2018

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Cardiovascular predictors of death in patients with cirrhosis

Maurizio Cesari,  Anna Chiara Frigo,  Marta Tonon,  Paolo Angeli, 
  • Pages: 215-223
  • First Published: 13 September 2017
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Fractional excretion of urea: A simple tool for the differential diagnosis of acute kidney injury in cirrhosis

Kavish R. Patidar,  Le Kang,  Jasmohan S. Bajaj,  Daniel Carl,  Arun J. Sanyal, 
  • Pages: 224-233
  • First Published: 08 January 2018
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Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort

Jasmohan S. Bajaj,  Ramazan Idilman,  Leila Mabudian,  Matthew Hood,  Andrew Fagan,  Dilara Turan,  Melanie B. White,  Fatih Karakaya,  Jessica Wang,  Rengül Atalay,  Phillip B. Hylemon,  Edith A. Gavis,  Robert Brown,  Leroy R. Thacker,  Chathur Acharya,  Douglas M. Heuman,  Masoumeh Sikaroodi,  Patrick M. Gillevet PhD, 
  • Pages: 234-247
  • First Published: 19 January 2018
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Khat chewing increases the risk for developing chronic liver disease: A hospital-based case–control study

Stian Magnus Staurung Orlien,  Irene Sandven,  Nega Belay Berhe,  Nejib Yusuf Ismael,  Tekabe Abdosh Ahmed,  Kathrine Stene-Johansen,  Svein Gunnar Gundersen,  Marsha Yvonne Morgan,  Asgeir Johannessen, 
  • Pages: 248-257
  • First Published: 25 January 2018

LIVER INJURY/REGENERATION

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Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside

Shoichi Kageyama,  Kojiro Nakamura,  Takehiro Fujii,  Bibo Ke,  Rebecca A. Sosa,  Elaine F. Reed,  Nakul Datta,  Ali Zarrinpar,  Ronald W. Busuttil,  Jerzy W. Kupiec-Weglinski, 
  • Pages: 258-273
  • First Published: 19 January 2018

Liver Biology and Pathobiology

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Patterning of the hepato-pancreatobiliary boundary by BMP reveals heterogeneity within the murine liver bud

Amrita Palaria,  Jesse R. Angelo,  Taylor M. Guertin,  Jesse Mager,  Kimberly D. Tremblay, 
  • Pages: 274-288
  • First Published: 05 January 2018
Open Access

Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1

Zilong Zhao,  Daqian Xu,  Zheng Wang,  Lin Wang,  Ruomei Han,  Zhenzhen Wang,  Lujian Liao,  Yan Chen, 
  • Pages: 289-303
  • First Published: 13 January 2018
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Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice

Xiaoying Liu,  Grace L. Guo,  Bo Kong,  David B. Hilburn,  Susan C. Hubchak,  Seong Park,  Brian LeCuyer,  Antony Hsieh,  Li Wang,  Deyu Fang,  Richard M. Green, 
  • Pages: 304-316
  • First Published: 29 January 2018
Open Access

Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress

Meng Lu,  Jiao Wu,  Zhi-Wei Hao,  Yu-Kui Shang,  Jing Xu,  Gang Nan,  Xia Li,  Zhi-Nan Chen,  Huijie Bian, 
  • Pages: 317-332
  • First Published: 21 January 2018
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Hepatic stellate cell–derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2

Enis Kostallari,  Petra Hirsova,  Alena Prasnicka,  Vikas K. Verma,  Usman Yaqoob,  Nicha Wongjarupong,  Lewis R. Roberts,  Vijay H. Shah, 
  • Pages: 333-348
  • First Published: 23 January 2018

Reviews

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Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

Zobair M. Younossi,  Rohit Loomba,  Quentin M. Anstee,  Mary E. Rinella,  Elisabetta Bugianesi,  Giulio Marchesini,  Brent A. Neuschwander-Tetri,  Lawrence Serfaty,  Francesco Negro,  Stephen H. Caldwell,  Vlad Ratziu,  Kathleen E. Corey,  Scott L. Friedman,  Manal F. Abdelmalek,  Stephen A. Harrison,  Arun J. Sanyal,  Joel E. Lavine,  Philippe Mathurin,  Michael R. Charlton,  Zachary D. Goodman,  Naga P. Chalasani,  Kris V. Kowdley,  Jacob George,  Keith Lindor, 
  • Pages: 349-360
  • First Published: 09 December 2017
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Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Zobair M. Younossi,  Rohit Loomba,  Mary E. Rinella,  Elisabetta Bugianesi,  Giulio Marchesini,  Brent A. Neuschwander-Tetri,  Lawrence Serfaty,  Francesco Negro,  Stephen H. Caldwell,  Vlad Ratziu,  Kathleen E. Corey,  Scott L. Friedman,  Manal F. Abdelmalek,  Stephen A. Harrison,  Arun J. Sanyal,  Joel E. Lavine,  Philippe Mathurin,  Michael R. Charlton,  Naga P. Chalasani,  Quentin M. Anstee,  Kris V. Kowdley,  Jacob George,  Zachary D. Goodman,  Keith Lindor, 
  • Pages: 361-371
  • First Published: 09 December 2017

Hepatology Elsewhere

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Thwart your destiny; effect of nonacoholic fatty liver disease genes on steatosis, liver injury and cirrhosis varies by body mass index

Elizabeth K. Speliotes M.D., Ph.D., M.P.H., 
  • Pages: 372-374
  • First Published: 18 December 2017
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Of mice, rats, and men: Small animal model of hepatitis C virus infection

Arash Grakoui Ph.D.,  Christopher M. Walker Ph.D., 
  • Pages: 374-376
  • First Published: 27 December 2017
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Proton pump inhibitors, Enterococcus, and the liver, oh my!

Rotonya M. Carr M.D., 
  • Pages: 376-379
  • First Published: 30 January 2018

Clinical Observations in Hepatology

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Nonstructural protein 5A/P32 deletion after failure of ledipasvir/sofosbuvir in hepatitis C virus genotype 1b infection

Akira Doi,  Hayato Hikita,  Ryotaro Sakamori,  Yuki Tahata,  Yugo Kai,  Ryoko Yamada,  Takayuki Yakushijin,  Eiji Mita,  Kazuyoshi Ohkawa,  Yasuharu Imai,  Kunimaro Furuta,  Takahiro Kodama,  Tomohide Tatsumi,  Tetsuo Takehara, 
  • Pages: 380-383
  • First Published: 09 February 2018
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Favorable response to mammalian target of rapamycin inhibition in a young patient with unresectable fibrolamellar carcinoma of the liver

Ruben Bill,  Matteo Montani,  Benedikt Blum,  Jean-François Dufour,  Robert Escher,  Michael Bühlmann, 
  • Pages: 384-386
  • First Published: 23 February 2018

Correspondence

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Growth factor therapy for decompensated cirrhosis: Much ado about nothing?

Cyriac Abby Philips M.D., D.M.,  Philip Augustine M.D., D.M.,  Sunil Mathew M.D., D.N.B.,  Gopakumar C Valiathan M.S., D.N.B.,  Solomon K John M.S., 
  • Pages: 387-388
  • First Published: 03 March 2018
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Reply

Nipun Verma M.D, D.M.,  Akash Singh M.B.B.S.,  Virendra Singh M.D., D.M., FASGE, 
  • Page: 388
  • First Published: 03 March 2018
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Nonalcoholic fatty liver disease: Is it time for combination treatment and a diabetes-like approach?

Stergios A. Polyzos M.D., M.Sc., Ph.D.,  Jannis Kountouras M.D., Ph.D.,  Sotiris Anastasiadis M.D.,  Michael Doulberis M.D.,  Panagiotis Katsinelos M.D., Ph.D., 
  • Page: 389
  • First Published: 30 March 2018
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Reply

Zobair M. Younossi M.D., M.P.H., 
  • Page: 390
  • First Published: 30 March 2018

Corrections

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Corrections

  • Page: 391
  • First Published: 05 July 2018

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Corrections

  • Page: 392
  • First Published: 05 July 2018

Issue Information

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Notices

  • First Published: 05 July 2018
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Instructions to authors and Information for readers

  • First Published: 05 July 2018